Uncommon Nail Involvement during Bullous Pemphigoid

2021 ◽  
pp. 1-3
Author(s):  
Anissa Zaouak ◽  
Soumaya Gara ◽  
Samy Fenniche ◽  
Houda Hammami
Keyword(s):  
Bullous Pemphigoid ◽  
Immune Reaction ◽  
Middle Finger ◽  
Basement Membrane Zone ◽  
Clinical Aspect ◽  
Roller Coaster ◽  
Nail Changes ◽  
High Doses ◽  
Left Middle ◽  
Proximal Border

Bullous pemphigoid (BP) is the most frequent autoimmune blistering disorder. The immune reaction targets BP180 and BP230 antigens, 2 components of junctional adhesion complexes at the basement membrane zone. Clinical aspect includes multiple tense bullae on urticarial plaques of the skin. Although the nail apparatus may be affected by the immune process, nail changes have been rarely reported during BP. We report a case of a 72-year-old woman diagnosed with BP who subsequently developed a secondary nail loss of the 2 thumbs and the left middle finger. Also, she presented onycholysis of the fourth left finger with the aspect of roller-coaster of the proximal border at dermoscopy. Steroid therapy at high doses was ineffective and the nail atrophy was permanent.

Subungual Pigmented SCC on the Left Middle Finger

2019 ◽  
Vol 81 (2) ◽  
pp. 83-84
Author(s):  
Shunichi JINNAI ◽  
Kenjiro NAMIKAWA ◽  
Taisuke MORI ◽  
Naoya YAMAZAKI
Keyword(s):  
Middle Finger ◽  
Left Middle

scholarly journals Effects of vitamin C supplementation on acute phase Chagas disease in experimentally infected mice with Trypanosoma cruzi QM1 strain

2012 ◽  
Vol 54 (6) ◽  
pp. 319-323 ◽  
Author(s):  
Ricardo Guimarães Marim ◽  
Alex Silva de Gusmão ◽  
Roberto Esteves Pires Castanho ◽  
Rafael Deminice ◽  
Altino Luiz Silva Therezo ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Vitamin C ◽  
Chagas Disease ◽  
Acute Phase ◽  
Immune Reaction ◽  
Parasite Clearance ◽  
Vitamin C Supplementation ◽  
Affected Tissue ◽  
Tissue Changes ◽  
High Doses

The tissue changes that occur in Chagas disease are related to the degree of oxidative stress and antioxidant capacity of affected tissue. Studies with vitamin C supplementation did not develop oxidative damage caused by Chagas disease in the host, but other studies cite the use of peroxiredoxins ascorbate - dependent on T. cruzi to offer protection against immune reaction. Based on these propositions, thirty "Swiss" mice were infected with T. cruzi QM1 strain and treated with two different vitamin C doses in order to study the parasitemia evolution, histopathological changes and lipid peroxidation biomarkers during the acute phase of Chagas disease. The results showed that the parasite clearance was greater in animals fed with vitamin C overdose. There were no significant differences regarding the biomarkers of lipid peroxidation and inflammatory process or the increase of myocardium in animals treated with the recommended dosage. The largest amount of parasite growth towards the end of the acute phase suggests the benefit of high doses of vitamin C for trypomastigotes. The supplementation doesn't influence the production of free radicals or the number of amastigote nests in the acute phase of Chagas disease.

scholarly journals Plant Thorn Synovitis of the Hand in an Adult Patient: A Case Report and Review of the Current Literature

2019 ◽  
Vol 5 ◽  
pp. 2513826X1987650
Author(s):  
Sarah L. Zhu ◽  
Cameron F. Leveille ◽  
Emily E. Dunn ◽  
Michael J. Cooper
Keyword(s):  
Case Report ◽  
Current Literature ◽  
Foreign Bodies ◽  
Middle Finger ◽  
Proximal Interphalangeal Joint ◽  
Interphalangeal Joint ◽  
The Past ◽  
Left Middle ◽  
Exploratory Surgery ◽  
Plum Tree

This is a case of plant thorn synovitis of the hand in an adult following a plum tree thorn injury, the first reported case in the hands in the past decade. The patient initially presented with persistent joint discomfort following removal of a retained plum thorn fragment from the skin overlyin the proximal interphalangeal joint of the left middle finger. Initial radiography and sonography imaging following the removal revealed no foreign bodies. However, the patient’s symptoms were worsening and refractory to anti-inflammatory and antibiotic treatment. An exploratory surgery was carried out, which revealed multiple plant thorn fragments within the synovium, each measuring approximately 1 mm in size. A synovectomy was performed and the patient recovered with full function. Our case of plant thorn synovitis is discussed along with a review of the current literature on plant thorn synovitis in the hands.

scholarly journals Treatment of a patient suffering from posttraumatic painful neuromas formed at the bilateral digital nerves of the left middle finger using two neurovascular island flaps

JPRAS Open ◽  
2019 ◽  
Vol 19 ◽  
pp. 1-5
Author(s):  
Shunki Iemura ◽  
Ryosuke Kakinoki ◽  
Kazuhiro Ohtani ◽  
Kazuhiko Hashimoto ◽  
Fumihisa Nakamura ◽  
...  
Keyword(s):  
Middle Finger ◽  
Left Middle

scholarly journals Immune Reaction to Type XVII Collagen Induces Intramolecular and Intermolecular Epitope Spreading in Experimental Bullous Pemphigoid Models

2019 ◽  
Vol 10 ◽  
Author(s):  
Hideyuki Ujiie ◽  
Norihiro Yoshimoto ◽  
Ken Natsuga ◽  
Ken Muramatsu ◽  
Hiroaki Iwata ◽  
...  
Keyword(s):  
Bullous Pemphigoid ◽  
Immune Reaction ◽  
Epitope Spreading ◽  
Xvii Collagen
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