Meta-analysis of prognostic factors for recurrence of resected well-differentiated pancreatic neuroendocrine tumors

2020 ◽  
Author(s):  
Yuan-Liang Li ◽  
Guohui Fan ◽  
Fuhuan Yu ◽  
Chao Tian ◽  
Huang-Ying Tan
Keyword(s):  
Prognostic Factors ◽  
Lymph Node ◽  
Vascular Invasion ◽  
Curative Resection ◽  
Perineural Invasion ◽  
Resection Margin ◽  
Positive Lymph Node ◽  
Pancreatic Neuroendocrine Tumors ◽  
Well Differentiated ◽  
Surgical Resection Margin

Well-differentiated pancreatic neuroendocrine tumors (WDPNETs) are a group of rare and heterogeneous tumors. However, the prognostic factors for recurrence after curative resection still remain controversial. We aim to illustrate the prognostic factors for recurrence of resected WDPNETs. All relevant articles published through June 2020 were identified via PubMed, Embase, Web of Science and the Cochrane Library. Articles that examined the prognostic factors of WDPNETs were enrolled. 10 articles were finally included in this study. From 1993 to 2018, 2863 patients underwent curative resection and 358 patients had recurrence, the combined recurrence rate was 13%. Furthermore, the pooled data indicated that patients with G2, positive lymph node and surgical resection margin, vascular invasion and perineural invasion had a decreased disease free survival for WDPNETs. However, gender, function, and tumor size had no significant relationship with WDPNETs recurrence. These findings demonstrated that G2, positive lymph node and surgical resection margin, vascular invasion and perineural invasion could be prognostic factors for recurrence of resected WDPNETs, indicating that patients with these high-risk factors need closer postoperative follow-up, and may benefit from adjuvant therapy.

scholarly journals Prognostic Factors and Clinical Characteristics of Patients with Primary Duodenal Adenocarcinoma: A Single-Center Experience from China

2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Qing-Long Jiang ◽  
Xiang-Hui Huang ◽  
Ying-Tai Chen ◽  
Jian-Wei Zhang ◽  
Cheng-Feng Wang
Keyword(s):  
Prognostic Factors ◽  
Lymph Node ◽  
Vascular Invasion ◽  
Curative Resection ◽  
Cox Regression ◽  
Early Stage ◽  
Palliative Surgery ◽  
Duodenal Adenocarcinoma ◽  
Cox Regression Analysis ◽  
Survival Difference

Aim. To evaluate the clinical risk factors influencing overall survival of patients with duodenal adenocarcinoma after potentially curative resection. Methods. A series of 201 patients with primary duodenal adenocarcinoma who underwent surgery from 1999 to 2014 at Chinese Medical Academic Cancer Hospital were studied by retrospective chart review and subsequent telephone follow-up. Results. Resectional surgery was performed in 138 of the 201 patients to attempt curative treatment, while 63 patients were treated with palliative surgery. Median survival of patients who underwent resectional operation was 57 months, whereas that of patients who had palliative surgery was shorter, 7 months (p<0.001). For patients who underwent radical resection, the overall 1-, 3-, and 5-year survival rates were 87.3, 59.1, and 44.1%, respectively. Multivariate Cox regression analysis revealed that lymph node metastasis (HR 31.76, 2.14 to 470.8; p=0.012) and vascular invasion (HR 3.75, 1.24 to 11.38; p=0.020) were independent prognostic factors negatively associated with survival in patients undergoing curative resection. There was no survival difference between the groups treated by the pancreaticoduodenectomy (n=20) and limited resection (n=10) for early-stage duodenal adenocarcinoma (p=0.704). Conclusions. Duodenal adenocarcinoma is a rare disease. Curative resection is the best treatment for appropriate patients. Lymph node metastases and vascular invasion are negative prognostic factors.

Superior Prognostic Importance of Perineural Invasion vs. Lymph Node Involvement After Curative Resection of Duodenal Adenocarcinoma

2011 ◽  
Vol 16 (1) ◽  
pp. 113-120 ◽  
Author(s):  
Stefano Cecchini ◽  
Camilo Correa-Gallego ◽  
Vikram Desphande ◽  
Matteo Ligorio ◽  
Abdulmetin Dursun ◽  
...  
Keyword(s):  
Lymph Node ◽  
Curative Resection ◽  
Perineural Invasion ◽  
Lymph Node Involvement ◽  
Duodenal Adenocarcinoma ◽  
Node Involvement ◽  
Prognostic Importance

The prognostic significance of lymph node metastasis and intrapancreatic perineural invasion in pancreatic cancer after curative resection

Surgery Today ◽  
1999 ◽  
Vol 29 (1) ◽  
pp. 16-22 ◽  
Author(s):  
Hideo Ozaki ◽  
Takehisa Hiraoka ◽  
Ryuji Mizumoto ◽  
Seiki Matsuno ◽  
Yoshiro Matsumoto ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Curative Resection ◽  
Perineural Invasion ◽  
Prognostic Significance ◽  
Node Metastasis

scholarly journals Perineural Invasion Independent Prognostic Factors in Patients with Gastric Cancer Undergoing Curative Resection

2012 ◽  
Vol 13 (7) ◽  
pp. 3149-3152 ◽  
Author(s):  
Fatih Selcukbiricik ◽  
Deniz Tural ◽  
Evin Buyukunal ◽  
Suheyla Serdengecti
Keyword(s):  
Gastric Cancer ◽  
Prognostic Factors ◽  
Curative Resection ◽  
Perineural Invasion

scholarly journals Prognostic Factors and Clinical Characteristics of Duodenal Adenocarcinoma With Survival: A Retrospective Study

2021 ◽  
Vol 11 ◽  
Author(s):  
Huapeng Sun ◽  
Yi Liu ◽  
Long Lv ◽  
Jingwen Li ◽  
Xiaofeng Liao ◽  
...  
Keyword(s):  
Overall Survival ◽  
Prognostic Factors ◽  
Lymph Node ◽  
Curative Resection ◽  
Tumor Resection ◽  
Margin Status ◽  
High Expression ◽  
Duodenal Adenocarcinoma ◽  
Gastric Type ◽  
Duodenal Carcinoma

BackgroundTo evaluate the clinical risk factors that influence the overall survival in patients with duodenal adenocarcinoma (DA) after tumor resection.MethodsThis study retrospectively analyzed 188 patients who underwent tumor resection for DA between January 2005 and June 2020 at Xiangyang Central Hospital.ResultsThe median survival of the patients who underwent resectional operation was 54 months, longer than of those who underwent palliative surgery (20.8 months) (2,916.17; 95% CI, 916.3−9,280.5; p &lt; 0.001). Survival of non-ampullary duodenal carcinoma patients (50.3 months; 95% CI, 39.7−61.8) was similar to that of ampullary duodenal carcinoma patients (59.3 months; 95% CI, 38.6−66.7) but was significantly better than that of papillary adenocarcinoma patients (38.9 months; 95% CI, 29.8−54.8; p = 0.386). Those with intestinal-type ductal adenocarcinomas had a longer median overall survival than those with the gastric type (61.8 vs. 46.7 months; p &lt; 0.01) or pancreatic type (32.2 months; p &lt; 0.001). Clinical DA samples had significantly diverse expressions of ATG12, IRS2, and IGF2. Higher expressions of the ATG12 and IRS2 proteins were significantly correlated with worse survival. Multivariate Cox regression analysis revealed that lymph node metastasis (hazard ratio (HR), 6.44; 95% CI, 3.68−11.27; p &lt; 0.0001), margin status (HR, 4.94; 95% CI, 2.85−8.54; p &lt; 0.0001), and high expression of ATG12 (HR, 1.89; 95% CI, 1.17−3.06; p = 0.0099) were independent prognostic factors negatively associated with survival in patients undergoing curative resection. There was no survival difference between the groups with ampullary, non-ampullary, and papillary adenocarcinomas treated with adjuvant chemotherapy (p = 0.973).ConclusionGastric/pancreatic type, high expression of ATG12, lymph node metastases, and margin status were negative prognosticators of survival in patients with DAs than in those with tumor anatomical location. Curative resection is the best treatment option for appropriate patients.

The prognostic factors for survival after curative resection of distal cholangiocarcinoma: perineural invasion and lymphovascular invasion

Surgery Today ◽  
2014 ◽  
Vol 44 (10) ◽  
pp. 1879-1886 ◽  
Author(s):  
Hee Joon Kim ◽  
Choong Young Kim ◽  
Young Hoe Hur ◽  
Yang Seok Koh ◽  
Jung Chul Kim ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Curative Resection ◽  
Lymphovascular Invasion ◽  
Perineural Invasion ◽  
Distal Cholangiocarcinoma

Upper urinary tract cancer: Prognostic factors for bladder tumours development and systemic relapse

2006 ◽  
Vol 24 (18_suppl) ◽  
pp. 14560-14560
Author(s):  
F. Merlin ◽  
M. Riolfi ◽  
T. Sava ◽  
F. Consoli ◽  
C. Griso ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Prognostic Factors ◽  
Urinary Tract ◽  
Vascular Invasion ◽  
Superficial Bladder Cancer ◽  
Transitional Cell ◽  
Upper Urinary Tract ◽  
Upper Tract ◽  
Well Differentiated ◽  
Systemic Relapse

14560 Background: Transitional cell carcinomas (TCC) of the renal pelvis and ureter are relatively uncommon. An important characteristic of TCC is multifocality throughout the all urinary tract simultaneously and/or subsequently. To clarify the association between UTTCC and bladder tumors, we retrospectively analysed 86 patients with UTTCC in order to evaluate prognostic factors for recurrence and to identify risk factors for development of bladder cancers. Methods: All 86 upper tract transitional cell carcinoma patients (pts) were treated surgically between January 1988 and July 2005. Median age was 69 years (range: 34–91). We observed a male predominance (71%) and 78% of patients were heavy smokers. Forty-five (52.3%) patients had a diagnosis of bladder transitional carcinoma. The median age of this group of patients was 70 range 40–87). In fifteen cases (17%), bladder tumour occurred first than upper tract neoplasia; in 14 patients bladder and upper tract tumours were synchronous. Results: Median survival was 97 months; 49 (57%) patients are alive and 43 are disease-free. Grading, stage T, lympho-vascular invasion and squamous differentiation were significant prognostic factors for systemic relapse (p < 0.05). Twenty-eight pts (32.5%) developed subsequent transitional bladder cancer after a median time of 12 months; multifocality of primitive tumours was significant predictive factor. Invasive UTTCC were less likely associated with bladder cancer. We observed that superficial bladder cancer developed more frequently in pts with well differentiated (G1–2) primitive cancer (90% of cases), without lympho-vascular invasion and with history of heavy smoke exposition. Conclusions: In our study, T, N and G confirmed to be the most important prognostic factors for systemic relapse. Lympho-vascular invasion highly predicts metastasis. Our analysis highlights that upper urinary tract cancers seem to have different history and different pattern of association with bladder tumours, according to specific prognostic factors. The development of recurrent superficial bladder cancer is more frequently associated with small well differentiated multifocal upper tract tumours.Therefore follow-up should be oriented according to these characteristics. No significant financial relationships to disclose.

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