Not Only Preterm Neonates Mature but Also Traditional Dosing Regimens Have to Mature: The Role of Mathematical Modeling

Neonatology ◽  
2021 ◽  
Vol 118 (1) ◽  
pp. 114-115
Author(s):  
Gilbert Koch ◽  
John N. van den Anker
Keyword(s):  
Mathematical Modeling ◽  
Preterm Neonates ◽  
Dosing Regimens

Technique of scientific and technical forecasting using neural networks

2018 ◽  
pp. 103-110
Author(s):  
V. V. Nefedev
Keyword(s):  
Mathematical Modeling ◽  
Neural Networks ◽  
Artificial Neural Networks ◽  
Original Method ◽  
Forecasting Methods ◽  
Expert Assessments ◽  
Artificial Neural

For the definition and implementation of breakthrough technologies the most important is the role of scientific and technical forecasting. Well-known forecasting methods based on extrapolation, expert assessments and mathematical modeling are not universal and have a number of significant disadvantages. The article proposes an original method of scientific and technical forecasting based on the use of the methodology of artificial neural networks. 

scholarly journals Potential role of IFN-γ and IL-5 in sepsis prediction of preterm neonates

Open Medicine ◽  
2021 ◽  
Vol 16 (1) ◽  
pp. 139-145
Author(s):  
Jelena Vucic ◽  
Miodrag Vucic ◽  
Tatjana Stankovic ◽  
Hristina Stamenkovic ◽  
Sandra Stankovic ◽  
...  
Keyword(s):  
Plasma Levels ◽  
Late Onset ◽  
Complex Function ◽  
Preterm Neonates ◽  
Control Group ◽  
Premature Neonates ◽  
Early Onset Sepsis ◽  
Ifn Γ ◽  
Venous Plasma

Abstract Not fully maturated immune system in preterm neonates may contribute to the increased susceptibility to infection. The levels of some cytokines can be useful in the prediction and diagnosis of sepsis in premature neonates. In the present study, we evaluated the potential predictive role of IFN-γ and IL-5 in cord and venous blood, together with the determination of C-reactive protein and procalcitonin (PCT) for sepsis development in premature neonates. A total of 80 participants were included. The laboratory results and clinical histories showed that 21 participants had sepsis. Early onset sepsis was detected in 3 patients while late onset sepsis was observed in 18 participants. The venous plasma levels of IFN-γ and PCT was markedly increased in sepsis groups when compared to the participants without sepsis. On the other hand, levels of IL-5 did not significantly change in the evaluated groups of sepsis and in the control group of participants. Simultaneously, plasma venous levels were not altered in any of the evaluated groups. Obtained findings suggest that venous plasma levels of IFN-γ, rather than levels of IFN-γ in cord blood plasma, and PCT may have predictive potential for sepsis development in preterm neonates. Further studies are necessary to get more comprehension of the complex function of cytokines for sepsis development in preterm neonates.

scholarly journals Role of activated CaMKII in abnormal calcium homeostasis and INa remodeling after myocardial infarction: Insights from mathematical modeling

2008 ◽  
Vol 45 (3) ◽  
pp. 420-428 ◽  
Author(s):  
Thomas J. Hund ◽  
Keith F. Decker ◽  
Evelyn Kanter ◽  
Peter J. Mohler ◽  
Penelope A. Boyden ◽  
...  
Keyword(s):  
Mathematical Modeling ◽  
Myocardial Infarction ◽  
Calcium Homeostasis

THE ROLE OF OXYGEN IN TISSUE MAINTENANCE: MATHEMATICAL MODELING AND QUALITATIVE ANALYSIS

2008 ◽  
Vol 18 (08) ◽  
pp. 1409-1441 ◽  
Author(s):  
AVNER FRIEDMAN ◽  
BEI HU
Keyword(s):  
Mathematical Modeling ◽  
Free Boundary ◽  
Qualitative Analysis ◽  
Phase I ◽  
Stationary Solution ◽  
Oxygen Concentration ◽  
Existence And Uniqueness ◽  
Symmetric Case ◽  
Special Case

The cells in a tissue occupying a region Ωt are divided according to their cycling phase. The density pi of cells in phase i depends on the spatial variable x, the time t, and the time si since the cells entered in phase i. The pi(x, t, si) and the oxygen concentration w(x, t) satisfy a system of PDEs in Ωt, and the boundary of Ωt is a free boundary. We denote by [Formula: see text] the oxygen concentration on the free boundary and consider the radially symmetric case, so that Ωt = {r < R(t)}. We prove that R(t) is always bounded; furthermore, if [Formula: see text] is small, then R(t) → 0 as t → ∞, and if [Formula: see text] is large, then R(t) ≥ c > 0 for all t. Finally, we prove the existence and uniqueness of a stationary solution in a special case.

scholarly journals THEORETICAL AND METHODOLOGICAL APPROACHES TO EVALUATION OF INVESTMENT ATTRACTIVENESS OF REGIONS OF UKRAINE

2021 ◽  
Author(s):  
Liudmyla Sokolova ◽  
Anita Lytvynova
Keyword(s):  
Mathematical Modeling ◽  
Public Administration ◽  
External Environment ◽  
Comparative Assessment ◽  
Financial Resources ◽  
Its Regions ◽  
Methodological Approaches ◽  
Statistical Indicators ◽  
Integral Indicator

Currently, when the Ukrainian economy is developing in an unstable, uncertain, aggressive, dynamic external environment, there is an urgent need to increase the level of investment attractiveness of each region of the country and, as a consequence, the need to increase attention to scientific and methodological support for assessing the integral indicator of investment attractiveness region. In connection with the decentralization of public administration in Ukraine, the role of local authorities in improving the socio-economic situation of its regions is increasing. In the context of real limited financial resources in the country, the problem of increasing the level of investment attractiveness of each region is becoming urgent as a characteristic that allows active investors to form an idea of the state of potential investment objects, as well as ensuring the reliability of obtaining the expected results. It should be noted that the choice of assessment indicators is subjective and depends on the goal of the investor. Such a format for solving this problem requires an assessment of the investment attractiveness of regions based on economic and mathematical modeling. Although there are many developments in this area, today there is no single effective method for assessing the investment attractiveness of the region. The work reveals the essence of the concept of investment attractiveness of a region, defines the methodological provisions of its assessment, the implementation of which requires the use of certain data from official regional statistics. Based on the basic local statistical indicators of the Kharkov, Kiev and Odessa regions of the country, a comparative assessment of their investment attractiveness was carried out. The methodological approaches and parameters determining the investment attractiveness of the regions of Ukraine have been analyzed. The information on the level of investment attractiveness of Kharkiv, Kiev and Odessa regions in 2019 has been systematised, the integral indicator of its evaluation has been defined. In the future, it is recommended to calculate the integral indicator of investment attractiveness for all regions of the country in dynamics.

scholarly journals A Proof of Concept of the Role of TDM-Based Clinical Pharmacological Advices in Optimizing Antimicrobial Therapy on Real-Time in Different Paediatric Settings

2021 ◽  
Vol 12 ◽  
Author(s):  
Milo Gatti ◽  
Pier Giorgio Cojutti ◽  
Caterina Campoli ◽  
Fabio Caramelli ◽  
Luigi Tommaso Corvaglia ◽  
...  
Keyword(s):  
Drug Interactions ◽  
Real Time ◽  
Antimicrobial Therapy ◽  
Turnaround Time ◽  
Antimicrobial Treatment ◽  
Therapeutic Drug ◽  
Proof Of Concept ◽  
Paediatric Patients ◽  
Dosing Regimens

Introduction: Antimicrobial treatment is quite common among hospitalized children. The dynamic age-associated physiological variations coupled with the pathophysiological alterations caused by underlying illness and potential drug-drug interactions makes the implementation of appropriate antimicrobial dosing extremely challenging among paediatrics. Therapeutic drug monitoring (TDM) may represent a valuable tool for assisting clinicians in optimizing antimicrobial exposure. Clinical pharmacological advice (CPA) is an approach based on the correct interpretation of the TDM result by the MD Clinical Pharmacologist in relation to specific underlying conditions, namely the antimicrobial susceptibility of the clinical isolate, the site of infection, the pathophysiological characteristics of the patient and/or the drug-drug interactions of cotreatments. The aim of this study was to assess the role of TDM-based CPAs in providing useful recommendations for the real-time personalization of antimicrobial dosing regimens in various paediatric settings.Materials and methods: Paediatric patients who were admitted to different settings of the IRCCS Azienda Ospedaliero-Universitaria of Bologna, Italy (paediatric intensive care unit [ICU], paediatric onco-haematology, neonatology, and emergency paediatric ward), between January 2021 and June 2021 and who received TDM-based CPAs on real-time for personalization of antimicrobial therapy were retrospectively assessed. Demographic and clinical features, CPAs delivered in relation to different settings and antimicrobials, and type of dosing adjustments were extracted. Two indicators of performance were identified. The number of dosing adjustments provided over the total number of delivered CPAs. The turnaround time (TAT) of CPAs according to a predefined scale (optimal, &lt;12 h; quasi-optimal, between 12–24 h; acceptable, between 24–48 h; suboptimal, &gt;48 h).Results: Overall, 247 CPAs were delivered to 53 paediatric patients (mean 4.7 ± 3.7 CPAs/patient). Most were delivered to onco-haematological patients (39.6%) and to ICU patients (35.8%), and concerned mainly isavuconazole (19.0%) and voriconazole (17.8%). Overall, CPAs suggested dosing adjustments in 37.7% of cases (24.3% increases and 13.4% decreases). Median TAT was 7.5 h (IQR 6.1–8.8 h). Overall, CPAs TAT was optimal in 91.5% of cases, and suboptimal in only 0.8% of cases.Discussion: Our study provides a proof of concept of the helpful role that TDM-based real-time CPAs may have in optimizing antimicrobial exposure in different challenging paediatric scenarios.

scholarly journals Case Report: Clostridium neonatale Bacteremia in a Preterm Neonate With Necrotizing Enterocolitis

2021 ◽  
Vol 9 ◽  
Author(s):  
Nadim Cassir ◽  
Isabelle Grandvuillemin ◽  
Manon Boxberger ◽  
Priscilla Jardot ◽  
Farid Boubred ◽  
...  
Keyword(s):  
Necrotizing Enterocolitis ◽  
Potential Role ◽  
Preterm Neonate ◽  
Gastrointestinal Disorder ◽  
Etiologic Agent ◽  
Preterm Neonates ◽  
Environmental Cleaning ◽  
Life Threatening

Necrotizing enterocolitis is a life-threatening acquired gastrointestinal disorder among preterm neonates and is associated with a high mortality rate and long-term neurodevelopmental morbidity. No etiologic agent has been definitively established; nonetheless, the most implicated bacteria include members of the Clostridium genus. We reported here on a case of Clostridium neonatale bacteremia in a preterm neonate with necrotizing enterocolitis, providing more information regarding the potential role of this bacterium in pathogenesis of necrotizing enterocolitis. We emphasized the sporulating form of C. neonatale that confers resistance to disinfectants usually applied for the hospital environmental cleaning. Further works are needed to establish the causal relationship between the occurrence of NEC and the isolation of C. neonatale, with promising perspectives in terms of diagnostic and therapeutic management.

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