scholarly journals Spices to Control COVID-19 Symptoms: Yes, but Not Only…

2020 ◽  
pp. 1-7
Author(s):  
Jean Bousquet ◽  
Wienczyslawa Czarlewski ◽  
Torsten Zuberbier ◽  
Joaquim Mullol ◽  
Hubert Blain ◽  
...  
Keyword(s):  
Transient Receptor Potential ◽  
Trp Channels ◽  
Receptor Potential ◽  
Oxygen Species ◽  
Large Country ◽  
Death Rates ◽  
Fermented Vegetables ◽  
Transient Receptor ◽  
Transcription Factor Nuclear Factor

There are large country variations in COVID-19 death rates that may be partly explained by diet. Many countries with low COVID-19 death rates have a common feature of eating large quantities of fermented vegetables such as cabbage and, in some continents, various spices. Fermented vegetables and spices are agonists of the antioxidant transcription factor nuclear factor (erythroid-derived 2)-like 2 (Nrf2), and spices are transient receptor potential ankyrin 1 and vanillin 1 (TRPA1/V1) agonists. These mechanisms may explain many COVID-19 symptoms and severity. It appears that there is a synergy between Nrf2 and TRPA1/V1 foods that may explain the role of diet in COVID-19. One of the mechanisms of COVID-19 appears to be an oxygen species (ROS)-mediated process in synergy with TRP channels, modulated by Nrf2 pathways. Spicy foods are likely to desensitize TRP channels and act in synergy with exogenous antioxidants that activate the Nrf2 pathway.

scholarly journals Taste the Pain: The Role of TRP Channels in Pain and Taste Perception

2020 ◽  
Vol 21 (16) ◽  
pp. 5929 ◽  
Author(s):  
Edwin Aroke ◽  
Keesha Powell-Roach ◽  
Rosario Jaime-Lara ◽  
Markos Tesfaye ◽  
Abhrarup Roy ◽  
...  
Keyword(s):  
Pain Perception ◽  
Transient Receptor Potential ◽  
Trp Channels ◽  
Receptor Potential ◽  
Taste Perception ◽  
Therapeutic Interventions ◽  
Sensory Stimuli ◽  
Transient Receptor ◽  
Trp Genes

Transient receptor potential (TRP) channels are a superfamily of cation transmembrane proteins that are expressed in many tissues and respond to many sensory stimuli. TRP channels play a role in sensory signaling for taste, thermosensation, mechanosensation, and nociception. Activation of TRP channels (e.g., TRPM5) in taste receptors by food/chemicals (e.g., capsaicin) is essential in the acquisition of nutrients, which fuel metabolism, growth, and development. Pain signals from these nociceptors are essential for harm avoidance. Dysfunctional TRP channels have been associated with neuropathic pain, inflammation, and reduced ability to detect taste stimuli. Humans have long recognized the relationship between taste and pain. However, the mechanisms and relationship among these taste–pain sensorial experiences are not fully understood. This article provides a narrative review of literature examining the role of TRP channels on taste and pain perception. Genomic variability in the TRPV1 gene has been associated with alterations in various pain conditions. Moreover, polymorphisms of the TRPV1 gene have been associated with alterations in salty taste sensitivity and salt preference. Studies of genetic variations in TRP genes or modulation of TRP pathways may increase our understanding of the shared biological mediators of pain and taste, leading to therapeutic interventions to treat many diseases.

scholarly journals TRP Channels as Drug Targets to Relieve Itch

2018 ◽  
Vol 11 (4) ◽  
pp. 100 ◽  
Author(s):  
Zili Xie ◽  
Hongzhen Hu
Keyword(s):  
Drug Targets ◽  
Transient Receptor Potential ◽  
Trp Channels ◽  
Current Knowledge ◽  
Receptor Potential ◽  
Protective Role ◽  
Chronic Itch ◽  
Transient Receptor

Although acute itch has a protective role by removing irritants to avoid further damage, chronic itch is debilitating, significantly impacting quality of life. Over the past two decades, a considerable amount of stimulating research has been carried out to delineate mechanisms of itch at the molecular, cellular, and circuit levels. There is growing evidence that transient receptor potential (TRP) channels play important roles in itch signaling. The purpose of this review is to summarize our current knowledge about the role of TRP channels in the generation of itch under both physiological and pathological conditions, thereby identifying them as potential drug targets for effective anti-itch therapies.

Pivotal role of Transient Receptor Potential Channels in oral physiology

2021 ◽  
Vol 28 ◽  
Author(s):  
Andreas Chalazias ◽  
Grigorios Plemmenos ◽  
Evangelos Evangeliou ◽  
Christina Piperi
Keyword(s):  
Salivary Gland ◽  
Oral Cavity ◽  
Periodontal Ligament ◽  
Transient Receptor Potential ◽  
Trp Channels ◽  
Receptor Potential ◽  
Dental Pain ◽  
Temporomandibular Joints ◽  
Transient Receptor

Background: Transient Receptor Potential (TRP) Channels constitute a large family of non-selective permeable ion channels involved in the perception of environmental stimuli with a central and continuously expanding role in oral tissue homeostasis. Recent studies indicate the regulatory role of TRPs in pulp physiology, oral mucosa sensation, dental pain nociception and salivary gland secretion. This review provides an update on the diverse functions of TRP channels in the physiology of oral cavity, with emphasis on their cellular location, the underlying molecular mechanisms and clinical significance. Methods: A structured search of bibliographic databases (PubMed and MEDLINE) was performed for peer reviewed studies on TRP channels function on oral cavity physiology the last ten years. A qualitative content analysis was performed in screened papers and a critical discussion of main findings is provided. Results: TRPs expression has been detected in major cell types of the oral cavity, including odontoblasts, periodontal ligament, oral epithelial, salivary gland cells, and chondrocytes of temporomandibular joints, where they mediate signal perception and transduction of mechanical, thermal, and osmotic stimuli. They contribute to pulp physiology through dentin formation, mineralization, and periodontal ligament formation along with alveolar bone remodeling in dental pulp and periodontal ligament cells. TRPs are also involved in oral mucosa sensation, dental pain nociception, saliva secretion, swallowing reflex and temporomandibular joints' development. Conclusion: Various TRP channels regulate oral cavity homeostasis, playing an important role in the transduction of external stimuli to intracellular signals in a cell type-specific manner and presenting promising drug targets for the development of pharmacological strategies to manage oral diseases.

scholarly journals Transient Receptor Potential (TRP) Channels in Haematological Malignancies: An Update

Biomolecules ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 765
Author(s):  
Federica Maggi ◽  
Maria Beatrice Morelli ◽  
Massimo Nabissi ◽  
Oliviero Marinelli ◽  
Laura Zeppa ◽  
...  
Keyword(s):  
Transient Receptor Potential ◽  
Trp Channels ◽  
Haematological Malignancy ◽  
Receptor Potential ◽  
Progression Free Survival ◽  
Free Survival ◽  
Channel Expression ◽  
Transient Receptor

Transient receptor potential (TRP) channels are improving their importance in different cancers, becoming suitable as promising candidates for precision medicine. Their important contribution in calcium trafficking inside and outside cells is coming to light from many papers published so far. Encouraging results on the correlation between TRP and overall survival (OS) and progression-free survival (PFS) in cancer patients are available, and there are as many promising data from in vitro studies. For what concerns haematological malignancy, the role of TRPs is still not elucidated, and data regarding TRP channel expression have demonstrated great variability throughout blood cancer so far. Thus, the aim of this review is to highlight the most recent findings on TRP channels in leukaemia and lymphoma, demonstrating their important contribution in the perspective of personalised therapies.

scholarly journals Role of TRP Channels in the Regulation of the Endosomal Pathway

Physiology ◽  
2011 ◽  
Vol 26 (1) ◽  
pp. 14-22 ◽  
Author(s):  
Ken Abe ◽  
Rosa Puertollano
Keyword(s):  
Membrane Trafficking ◽  
Transient Receptor Potential ◽  
Trp Channels ◽  
Ion Homeostasis ◽  
Receptor Potential ◽  
Trp Channel ◽  
Endosomal Pathway ◽  
Transient Receptor

Some members of the transient receptor potential (TRP) channel superfamily have proved to be essential in maintaining adequate ion homeostasis, signaling, and membrane trafficking in the endosomal pathway. The unique properties of the TRP channels confer cells the ability to integrate cytosolic and intraluminal stimuli and allow maintained and regulated release of Ca2+ from endosomes and lysosomes.

scholarly journals A novel strategy for treating cancer: understanding the role of Ca2+ signaling from nociceptive TRP channels in regulating cancer progression

2021 ◽  
Author(s):  
Wen-Li Hsu ◽  
Mami Noda ◽  
Tohru Yoshioka ◽  
Etsuro Ito
Keyword(s):  
Genomic Instability ◽  
Cancer Progression ◽  
Aging Process ◽  
Transient Receptor Potential ◽  
Trp Channels ◽  
Receptor Potential ◽  
Underlying Mechanism ◽  
Transient Receptor ◽  
Novel Strategy

Cancer is an aging-associated disease and caused by genomic instability that is driven by the accumulation of mutations and epimutations in the aging process. Although Ca2+ signaling, reactive oxygen species (ROS) accumulation, DNA damage response (DDR) and senescence inflammation response (SIR) are processed during genomic instability, the underlying mechanism for the cause of genomic instability and cancer development is still poorly understood and needs to be investigated. Nociceptive transient receptor potential (TRP) channels, which firstly respond to environmental stimuli, such as microbes, chemicals or physical injuries, potentiate regulation of the aging process by Ca2+ signaling. In this review, the authors provide an explanation of the dual role of nociceptive TRP channels in regulating cancer progression, initiating cancer progression by aging-induced genomic instability, and promoting malignancy by epigenetic regulation. Thus, therapeutically targeting nociceptive TRP channels seems to be a novel strategy for treating cancers.

scholarly journals Changes in TRP Channels Expression in Painful Conditions

2013 ◽  
Vol 6 (1) ◽  
pp. 10-22 ◽  
Author(s):  
Mahendra Bishnoi ◽  
Louis S. Premkumar
Keyword(s):  
Transient Receptor Potential ◽  
Trp Channels ◽  
Receptor Potential ◽  
Trp Channel ◽  
Current Status ◽  
Behavioral Models ◽  
Tremendous Progress ◽  
Analgesic Agents ◽  
Transient Receptor

Over the last fifteen years after the successful cloning of the first nociceptive Transient Receptor Potential (TRP) channel, TRP Vanilloid 1, other members of the TRP channel family have been cloned, characterized and implicated in different modalities of pain. Tremendous progress has been made with regard to the specific role of these TRP channels in nociception using electrophysiological and molecular methods, along with behavioral models combined with gene disruption techniques. This review summarizes the evidence supporting the role of TRP channels (TRP Vanilloid 1, TRP Vanilloid 2, TRP Vanilloid 3, TRP Vanilloid 4, TRP Ankyrin 1, TRP Melastatin 2, TRP Melastatin 3, TRP Melastatin 8, TRP Mucolipin 3 and TRP Canonical 1, 6) involved in nociception. The review also highlights the current status and future avenues for developing TRP channel modulators as analgesic agents.

scholarly journals Store-operated Ca2+ entry: a key component of the insulin secretion machinery

2016 ◽  
Vol 57 (3) ◽  
pp. F35-F39 ◽  
Author(s):  
Jessica Sabourin ◽  
Florent Allagnat
Keyword(s):  
Insulin Secretion ◽  
Transient Receptor Potential ◽  
Trp Channels ◽  
Receptor Potential ◽  
Leading Role ◽  
Voltage Dependent ◽  
Intracellular Ca ◽  
Transient Receptor ◽  
Insulin Exocytosis

Normal plasma glucose level is ensured by the action of insulin, the major hypoglycemic hormone. Therefore, it is not surprising that insulin release from pancreatic β-cells of the islets of Langerhans is controlled by an array of balanced mechanisms in which glucose plays the leading role. Glucose triggers insulin secretion through the well-described pathway of ATP-driven closure of ATP-sensitive potassium channels (KATP), depolarization of the plasma membrane, and opening of the voltage-dependent Ca2+ channels (VDCC). The subsequent rapid rise in cytoplasmic free Ca2+ concentration triggers insulin exocytosis. However, despite more than 40 years of investigation, certain aspects of the intracellular Ca2+ responses to glucose and secretagogues remain unexplained, suggesting the involvement of additional Ca2+ channels. Here, we discuss the emerging role of store-operated Ca2+ channels carried by Orai1 and transient receptor potential canonical 1 (TRPC1) proteins and regulated by the stromal interaction molecule 1 (STIM1) in the control of glucose-induced insulin secretion. The role of other voltage-independent cation channels formed by other members of the TRP channels family is also addressed.

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