Prevalence of the Metabolic Syndrome in Severely Obese Patients Presenting for Bariatric Surgery

2020 ◽  
Author(s):  
Benedikt A. Aulinger ◽  
Thuan To Viet ◽  
Elisa Waldmann ◽  
Klaus G. Parhofer
Keyword(s):  
Bariatric Surgery ◽  
Metabolic Syndrome ◽  
Central Obesity ◽  
Treatment Strategies ◽  
Diabetic Patients ◽  
Obese Patients ◽  
The Metabolic Syndrome ◽  
Elevated Glucose ◽  
Low Hdl ◽  
Severely Obese

Objective: Although obesity is associated with metabolic changes not all obese patients are characterized by the Metabolic Syndrome (MS). The goal of this study was to determine the prevalence of the MS, its characteristics and the associated demographic factors in a large cohort of severely obese patients presenting for potential bariatric surgery. Methods: 256 obese patients (68.7% female, 41.9±11.6 years, BMI 49±9.1 kg/m²) were evaluated using the harmonized criteria of the MS. Results: In this cohort the prevalence of MS was 78.1% with no gender difference. The prevalence did not correlate with BMI, body weight or waist circumference, however presence of MS and numbers of MS criteria met correlated with age. The prevalence of individual criteria varied considerably (central obesity (100%), hypertension (86.7%), elevated glucose (58.6%), low HDL-cholesterol (50%) and hypertriglyceridemia (43.7%)). On average 3.4±1.1 criteria were met. 3.5% fulfilled only one criterion (central obesity) and 16.4% met all 5 criteria. After adjusting for age and gender hypertriglyceridemia and hypertension were more common in diabetic than in non-diabetic patients. Similarly, low HDL and elevated glucose was more common in hypertriglyceridemic individuals. Conclusion: In severely obese patients the prevalence of the MS and the number of criteria met was high. However, over 20% of severely obese individuals have no MS and thus may be at lower risk for cardiovascular complications of obesity. It is currently unclear whether treatment strategies with respect to obesity should differ between severely obese individuals with and without the MS.

Abstract MP19: Higher Parity is Associated With Components of the Metabolic Syndrome Among U.S. Hispanic/Latina Women: Results From the HCHS/SOL Study

Circulation ◽  
2015 ◽  
Vol 131 (suppl_1) ◽  
Author(s):  
Catherine J Vladutiu ◽  
Anna Maria Siega-Riz ◽  
Alison M Stuebe ◽  
Daniela Sotres-Alvarez ◽  
Andy Ni ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Abdominal Obesity ◽  
Hispanic Women ◽  
Hdl Cholesterol ◽  
Latina Women ◽  
Live Births ◽  
The Metabolic Syndrome ◽  
Elevated Glucose ◽  
Low Hdl

Background: Physiologic adaptations occurring across successive pregnancies may increase the risk of adverse cardiovascular health outcomes in later life. Previous studies have found an association between higher parity and the metabolic syndrome (MetS). However, no studies have examined this association in a Hispanic/Latina population. Hispanic women have a higher prevalence of the MetS and higher birth rates than non-Hispanic women. Hypothesis: We assessed the hypothesis that higher parity is associated with the prevalence of components of the MetS in a cohort of Hispanic/Latina women. Methods: There were 9,482 Hispanic/Latina women of diverse backgrounds, aged 18-74 years, who participated in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) from 2008-2011. Components of the MetS were defined according to the AHA/NHLBI criteria and included abdominal obesity (waist circumference ≥88cm), elevated triglycerides (≥150 mg/dL), low HDL cholesterol (<50mg/dL), high blood pressure (systolic ≥130mmHg or diastolic ≥85mmHg or on medication), and elevated fasting glucose (≥100mg/dL or on medication). Logistic regression models were used to estimate odds ratios for the association between parity and components of the MetS, adjusting for sociodemographic, behavioral, and reproductive characteristics, and accounting for the complex survey design and sampling weights. Results: At HCHS/SOL baseline, women reported none (19.2%), one (18.9%), two (25.3%), three (19.7%), four (9.3%), and five or more (7.6%) prior live births. Compared to women with only one live birth, women with four live births had the highest odds of abdominal obesity (OR=2.5, 95% CI 1.8, 3.3) and those with five or more live births had the highest odds of low HDL cholesterol (OR=1.5, 95% CI 1.2, 1.9), elevated glucose (OR=1.8, 95% CI 1.3, 2.3), elevated triglycerides (OR=1.4, 95% CI 1.01, 1.8), and high blood pressure (OR=1.5, 95% CI 1.1, 2.0), after adjusting for age, Hispanic background, education, marital status, income, nativity, smoking, physical activity, menopause status, oral contraceptive use, hormone replacement therapy, and field center. Further adjustment for body mass index attenuated these associations for all MetS components, including abdominal obesity (OR=1.5, 95% CI 1.1, 2.2), low HDL cholesterol (OR=1.3, 95% CI 1.03, 1.7), and elevated glucose (OR=1.6, 95% CI 1.2, 2.1), but the associations for triglycerides and blood pressure were no longer statistically significant. Conclusion: Higher parity is associated with the prevalence of selected components of the MetS among U.S. Hispanic/Latina women. High parity among Latinas with a high prevalence of abdominal obesity suggests a context of high risk for metabolic dysregulation. A better characterization of the links between pregnancy, adiposity, and body fat distribution is needed.

scholarly journals Roux-en-Y-Bariatric Surgery Reduces Markers of Metabolic Syndrome in Morbidly Obese Patients

2019 ◽  
Vol 30 (2) ◽  
pp. 391-400 ◽  
Author(s):  
G. Rega-Kaun ◽  
C. Kaun ◽  
G. Jaegersberger ◽  
M. Prager ◽  
M. Hackl ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Metabolic Syndrome ◽  
Gastric Bypass ◽  
Bypass Surgery ◽  
Gastric Bypass Surgery ◽  
Morbidly Obese ◽  
Diabetic Patients ◽  
Obese Patients ◽  
C Peptide ◽  
Hepatic Insulin Clearance

Abstract Background Obesity is closely linked to increased markers of metabolic syndrome and development of diabetes. Roux-en-Y bariatric surgery reduces hyperinsulinemia and improves insulin sensitivity and hence benefits morbidly obese patients. Aim To determine changes in markers of metabolic syndrome, pancreatic function, and hepatic insulin sensitivity in patients before and 1 year after undergoing Roux-en-Y gastric bypass surgery. Methods We enrolled 43 consecutive patients in a single center. Markers for metabolic syndrome included proinsulin, insulin, C-peptide, liver enzymes, and serum levels of selected microRNAs hsa-miR-122, hsa-miR-130, hsa-miR-132, and hsa-miR-375. Results After surgery, all patients showed a significant 37% drop of body mass index (p < 0.001). Furthermore, proinsulin (59% reduction, p < 0.001), insulin (76% reduction, p < 0.001), and C-peptide (56% reduction, p < 0.001) were all reduced 1 year after surgery. Using the hepatic insulin clearance score, we determined a significant increase in hepatic insulin clearance after surgery (76% increase, p < 0.001). Especially diabetic patients showed a marked 2.1-fold increase after surgery. Hepatic enzymes ALT (35% reduction, p = 0.002) and γGT (48% reduction, p < 0.001) were significantly reduced in all patients with similar improvement in diabetic and non-diabetic patients. miRNAs hsa-miR-122, hsa-miR-130, and hsa-miR-132 were all significantly reduced whereas hsa-miR-375 was increased after gastric bypass surgery (p < 0.001 for all miRNAs). Conclusion Both liver and pancreatic stress parameters were reduced significantly 1 year after Roux-en-Y gastric bypass surgery suggesting an overall amelioration of the metabolic syndrome in all patients regardless of previous health status.

The Role of Adipose Tissue Hypercortisolemia in the Development of the Metabolic Syndrome in Severely Obese Patients.

2010 ◽  
pp. P2-467-P2-467
Author(s):  
M Michalaki ◽  
V Kyriazopoulou ◽  
A Antonacopoulou ◽  
M Nikolaou ◽  
A Tsoukas ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Adipose Tissue ◽  
Obese Patients ◽  
The Metabolic Syndrome ◽  
Severely Obese

scholarly journals Association between 24 h urinary sodium and potassium excretion and the metabolic syndrome in Chinese adults: the Shandong and Ministry of Health Action on Salt and Hypertension (SMASH) study

2015 ◽  
Vol 113 (6) ◽  
pp. 996-1002 ◽  
Author(s):  
Zeng Ge ◽  
Xiaolei Guo ◽  
Xiaorong Chen ◽  
Junli Tang ◽  
Liuxia Yan ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Central Obesity ◽  
Hdl Cholesterol ◽  
Elevated Blood Pressure ◽  
Potassium Excretion ◽  
Elevated Blood ◽  
Chinese Adults ◽  
The Metabolic Syndrome ◽  
Low Hdl

The association of 24 h urinary Na and potassium excretion with the risk of the metabolic syndrome (MetS) has not been studied in China. The aim of the present study was to examine this association by analysing the data from 1906 study participants living in north China. To this end, 24 h urine samples were collected. Of the 1906 participants, 471 (24·7 %) had the MetS. The mean urinary Na and K excretion was 228·7 and 40·8 mmol/d, respectively. After multivariate adjustment, the odds of the MetS significantly increased across the increasing tertiles of urinary Na excretion (1·00, 1·40 and 1·54, respectively). For the components of the MetS, the odds of central obesity, elevated blood pressure and elevated TAG, but not the odds of low HDL-cholesterol and elevated fasting glucose, significantly increased with the successive tertiles of urinary Na excretion. Furthermore, for every 100 mmol/d increase in urinary Na excretion, the odds of the MetS, central obesity, elevated blood pressure and elevated TAG was significantly increased by 29, 63, 22 and 21 %, respectively. However, urinary K excretion was not significantly associated with the risk of the MetS. These findings suggest that high Na intake might be an important risk factor for the MetS in Chinese adults.

scholarly journals Frequency of Metabolic Syndrome on Diabetes Mellitus Patients in Surabaya

2018 ◽  
Vol 1 (1) ◽  
pp. 43
Author(s):  
Dyah Peni Puspitasari ◽  
Budi Widodo ◽  
Jongky Hendro Prayitno
Keyword(s):  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Blood Glucose ◽  
Central Obesity ◽  
Fasting Blood Glucose ◽  
Density Lipoprotein ◽  
High Blood Glucose ◽  
The Metabolic Syndrome ◽  
Low Hdl ◽  
Frequency Components

Backgrounds: Metabolic syndrome is a syndrome characterized by central obesity, high blood glucose or impaired glucose tolerance, dyslipidemia, and high blood pressure. Nearly 70% to 80% of Diabetes melitus (DM) population was diagnosed with metabolic syndrome. We aimed to present the data of frequency of metabolic syndrome in patients with DM for a basis of future research.Method: This is a descriptive study design on DM patients based on NCEP ATP III criteria. The data was collected from direct measurements and laboratory results of all DM patients: waist circumference, weight, height, and blood pressure of the subjects, triglyceride status (TG), high-density lipoprotein cholesterol (HDL-C) status, and fasting blood glucose status.Results: From 77 DM patients, results were obtained in this study were 69 (89.61%) patients with DM-metabolic syndrome  (DM-MetS) and 8 (10.39%) patients with DM-non-metabolic syndrome. From 69 patients with DM-MetS, 52 (75.36%) were female and 17 (24.64%) were male.Discussions: Based on NCEP ATP III criteria, the components profile of metabolic syndrome in women patients with DM-MetS were 96,15% central obesity, 88,46% hypertension, 70,37% low HDL levels and 44,44% hypertriglycerides. While, in men patients with DM-MetS were 70.59% central obesity, 88.24% in hypertension, 70% in the low HDL levels, and 30% hypertriglycerides. Based on the number of components, can be determined the frequency components of the metabolic syndrome were 73.91% on the three components, 14.49% on four components, and 11.59% at five components.Conclusion: A total of 69 (89.61%) patients with T2DM were diagnosed as metabolic syndrome.

scholarly journals Association of Heart Failure with Preserved Ejection Fraction and Components of Metabolic Syndrome

2015 ◽  
Vol 61 (4) ◽  
pp. 261-264
Author(s):  
Cerghizan Anda-Mihaela ◽  
Băţagă Simona ◽  
L Cozlea ◽  
ID Tarţa ◽  
B Chibelean ◽  
...  
Keyword(s):  
Heart Failure ◽  
Metabolic Syndrome ◽  
Ejection Fraction ◽  
Diastolic Dysfunction ◽  
Hdl Cholesterol ◽  
Normal Weight ◽  
Obese Patients ◽  
Preserved Ejection Fraction ◽  
The Metabolic Syndrome ◽  
Low Hdl

AbstractThe aim of the current study was to find any possible associations between elements of metabolic syndrome and echocardiographic characteristics (grade of diastolic dysfunction) in normoponderal and overweight patients with heart failure with preserved ejection fraction.A retrospective observational analytical study was performed on 130 patients presenting heart failure with documented ejection fraction over 50%. They were divided into two groups based on their body mass index. The first group included 56 normal weight patients and the second group included 74 overweight patients. Elements of the metabolic syndrome analysed in the current study were arterial hypertension, high triglyceride levels, low HDL-cholesterol and diabetes.None of the components of metabolic syndrome alone had a role in the evolution of diastolic dysfunction in either group. Three or four elements present in obese patients were negatively associated with grade 2 diastolic dysfunction, high values of blood pressure (over 180/110 mmHg) were more often encountered in obese patients with first and second grade of diastolic dysfunction.

scholarly journals Impact of NMT1 Gene Polymorphisms on Features of the Metabolic Syndrome among Severely Obese Patients

2016 ◽  
Vol 2 (4) ◽  
pp. 101-110
Author(s):  
Stéphanie Bégin ◽  
◽  
Frédéric Guénard ◽  
André Tchernof ◽  
Yves Deshaies ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Gene Polymorphisms ◽  
Obese Patients ◽  
The Metabolic Syndrome ◽  
Severely Obese

scholarly journals Laparoscopic Sleeve Gastrectomy or Laparoscopic Gastric Bypass for Patients with Metabolic Syndrome: An MBSAQIP Analysis

2019 ◽  
Vol 85 (10) ◽  
pp. 1108-1112 ◽  
Author(s):  
Reza Fazl Alizadeh ◽  
Shiri Li ◽  
Sahil Gambhir ◽  
Marcelo W. Hinojosa ◽  
Brian R. Smith ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Metabolic Syndrome ◽  
Gastric Bypass ◽  
Sleeve Gastrectomy ◽  
Laparoscopic Sleeve Gastrectomy ◽  
Obese Patients ◽  
Improvement Program ◽  
Perioperative Morbidity ◽  
Significant Difference ◽  
Severely Obese

In patients undergoing bariatric surgery, the presence of metabolic syndrome (MetS) contributes to perioperative morbidity. We aimed to evaluate the utilization and outcome of severely obese patients with MetS who underwent laparoscopic sleeve gastrectomy (LSG) versus laparoscopic Roux-en-Y gastric bypass (LRYGB). Using the 2015 and 2016 Metabolic and Bariatric Surgery Accreditation and Quality Improvement Program database, data were obtained for patients with MetS undergoing LSG or LRYGB. There were 29,588 MetS patients (LSG: 58.7% vs LRYGB: 41.3%). There was no significant difference in 30-day mortality (0.1% for LSG vs 0.2% for LRYGB, adjusted odds ratio (AOR) 0.58, confidence interval (CI) 0.32–1.05, P = 0.07) or length of stay between groups (2 ± 2 for LSG vs 2.2 ± 2 days for LRYGB, P = 0.40). Compared with LRYGB, LSG was associated with significantly shorter operative time (78 ± 39 vs 122 ± 54 minutes, P < 0.01), lower overall morbidity (2.3% vs 4.4%, AOR 0.53, CI 0.46–0.60, P < 0.01), lower serious morbidity (1.5% vs 2.3%, AOR 0.64, CI 0.53–0.76, P < 0.01), lower 30-day reoperation (1.2% vs 2.3%, AOR 0.52, CI 0.43–0.63, P < 0.01), and lower 30-day readmission (4.2% vs 6.6%, AOR 0.62, CI 0.55–0.69, P < 0.01). In conclusion, LSG is the predominant operation being performed for severely obese patients with MetS, and its popularity may in part be related to its improved perioperative safety profile.

Metabolic Syndrome During Menopause

2019 ◽  
Vol 17 (6) ◽  
pp. 595-603 ◽  
Author(s):  
Sezcan Mumusoglu ◽  
Bulent Okan Yildiz
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Central Obesity ◽  
Polycystic Ovary ◽  
Ovary Syndrome ◽  
Natural Menopause ◽  
The Metabolic Syndrome ◽  
Increased Risk ◽  
Aging Women

The metabolic syndrome (MetS) comprises individual components including central obesity, insulin resistance, dyslipidaemia and hypertension and it is associated with an increased risk of cardiovascular disease (CVD) and type 2 diabetes mellitus (T2DM). The menopause per se increases the incidence of MetS in aging women. The effect(s) of menopause on individual components of MetS include: i) increasing central obesity with changes in the fat tissue distribution, ii) potential increase in insulin resistance, iii) changes in serum lipid concentrations, which seem to be associated with increasing weight rather than menopause itself, and, iv) an association between menopause and hypertension, although available data are inconclusive. With regard to the consequences of MetS during menopause, there is no consistent data supporting a causal relationship between menopause and CVD. However, concomitant MetS during menopause appears to increase the risk of CVD. Furthermore, despite the data supporting the association between early menopause and increased risk of T2DM, the association between natural menopause itself and risk of T2DM is not evident. However, the presence and the severity of MetS appears to be associated with an increased risk of T2DM. Although the mechanism is not clear, surgical menopause is strongly linked with a higher incidence of MetS. Interestingly, women with polycystic ovary syndrome (PCOS) have an increased risk of MetS during their reproductive years; however, with menopausal transition, the risk of MetS becomes similar to that of non-PCOS women.

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