scholarly journals Assessment of clinical characteristics and mortality-associated factors in COVID-19 Critical cases in Kuwait

2020 ◽  
Author(s):  
Mariam Ayed ◽  
Abdulwahab A. Borahmah ◽  
Anwar Yazdani ◽  
Ahmad Sultan ◽  
Ahmad Mossad ◽  
...  
Keyword(s):  
Risk Factors ◽  
Early Identification ◽  
Retrospective Cohort ◽  
Associated Factors ◽  
Clinical Characteristics ◽  
Icu Patients ◽  
Factors Associated ◽  
Predicting Factors ◽  
Infected Adult ◽  
D Dimer

Objective To assess the clinical characteristics and identify mortality-predicting factors in intensive care unit (ICU)-admitted COVID-19 confirmed patients. Methods We recruited and analyzed COVID-19 infected adult patients (age≥ 18 years) who were admitted to the ICU at Jaber AlAhmad Al Sabah Hospital, Kuwait, between 1stMarch, 2020 and 30thApril 2020. The patients were followed up to 20th May, 2020. The risk factors associated with in-hospital mortality were assessed using multiple regression analysis. Results We recruited a total of 103 ICU patients in this retrospective cohort. The median age of the patients was 53 years (Interquartile Range (IQR): 44-63 years). The fatality rate was 43.7%. Among the patients, majority were males (85.5%) and 38% patients had more than two comorbidities. Pre-existing hypertension (OR:3.2,95%CI: 1.2-8.9), moderate/severe ARDS (OR: 3.4, 95%CI: 1.1-10.8),lymphocyte counts <0.5 (OR: 6.1, 95%CI: 1.2-29.8)albumin < 22 (OR: 7.5, 95%CI: 2.1-26.2), procalcitonin >0.2 (OR: 3.8, 95%CI: 1.3-7.8), D-Dimer >1200 (OR: 5.1, 95%CI: 1.2-21.6), and the need for continuous renal replacement therapy (OR: 9.3, 95%CI: 2.4-36.2) were significantly associated with mortality. Conclusion This study describes the clinical characteristics and predictors of mortality among ICU patients. Early identification of risk factors to mortality might help in their better outcome.

scholarly journals Assessment of clinical characteristics and mortality-associated factors in COVID-19 Critical cases in Kuwait

2020 ◽  
Author(s):  
Mariam Ayed ◽  
Abdulwahab A Borahmah ◽  
Anwar Yazdani ◽  
Ahmad Sultan ◽  
Ahmad Mossad ◽  
...  
Keyword(s):  
Risk Factors ◽  
Early Identification ◽  
Retrospective Cohort ◽  
Associated Factors ◽  
Clinical Characteristics ◽  
Icu Patients ◽  
Factors Associated ◽  
Predicting Factors ◽  
Infected Adult ◽  
D Dimer

AbstractPurposeTo assess the clinical characteristics and identify mortality predicting factors in intensive care unit (ICU)-admitted COVID-19 confirmed patients.MethodsWe recruited and analyzed COVID-19 infected adult patients (age≥ 18 years) who were admitted to the ICU at Jaber AlAhmad Al Sabah Hospital,Kuwait, between 1stMarch, 2020and 30thApril 2020. The patients were followed up to 20th May, 2020. The risk factors associated with in-hospital mortality were assessed using multiple regression analysis.ResultsWe recruited a total of 103 ICU patients in this retrospective cohort. The median age of the patients was 53 years (Interquartile Range (IQR): 44-63 years). The fatality rate was 43.7%. Among the patients, majority were males (85.5%) and 38% patients had more than two comorbidities. Pre-existing hypertension (OR:3.2,95%CI: 1.2-8.9), moderate/severe ARDS (OR: 3.4, 95%CI: 1.1-10.8),lymphocyte counts <0.5 (OR: 6.1, 95%CI: 1.2-29.8)albumin < 22 (OR: 7.5, 95%CI: 2.1-26.2), procalcitonin >0.2 (OR: 3.8, 95%CI: 1.3-7.8), D-Dimer >1200 (OR: 5.1, 95%CI: 1.2-21.6), and the need forcontinuous renal replacement therapy (OR: 9.3, 95%CI: 2.4-36.2) weresignificantly associated with mortality.ConclusionThis study describes the clinical characteristics and predictors ofmortality among ICU patients. Early identification of risk factors to mortality might help in their better outcome.

scholarly journals Clinical characteristics and risk factors for severity of COVID-19 outside Wuhan: a double-center retrospective cohort study of 213 cases in Hunan, China

2020 ◽  
Vol 14 ◽  
pp. 175346662096303
Author(s):  
Xingsheng Hu ◽  
Chunhong Hu ◽  
Yong Yang ◽  
Juan Chen ◽  
Ping Zhong ◽  
...  
Keyword(s):  
Risk Factors ◽  
Creatine Kinase ◽  
Cell Count ◽  
Lymphocyte Count ◽  
Clinical Characteristics ◽  
White Cell Count ◽  
Poor Appetite ◽  
Factors Associated ◽  
Independent Risk Factors ◽  
D Dimer

Aim: To investigate clinical characteristics and identify risk factors for severity of coronavirus disease 2019 (COVID-19) pneumonia outside of Wuhan, China. Materials and methods: We included 213 patients with confirmed COVID-19 who had been discharged or died by 15 March 2020. We retrospectively collected epidemiological, clinical, laboratory, computed tomography imaging and outcome data. Clinical characteristics were described and relative risk factors were compared. Results: Most clinical characteristics of this study were similar to those from studies in Wuhan, but there were lower mortality rate and milder severity. The median time from onset of symptoms to confirmation and hospitalization was 4 and 5 days, respectively. The median virus clearance and shedding times were 10 and 15 days, respectively. When the severe/critical group was compared with the mild/moderate group, significant risk factors included: older age; dyspnea; hypertension; poor appetite; fatigue; higher white cell count, neutrophil count, prothrombin time, creatine kinase, creatine kinase-MB, D-dimer, alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH) and C-reactive protein; and lower lymphocyte count and albumin ( p < 0.05). In the intensive care unit (ICU) group compared with the non-ICU group, risk factors included: older age; chronic obstructive pulmonary disease (COPD); dyspnea; poor appetite; higher white cell count, D-dimer, ALT, AST and LDH; and lower lymphocyte count and albumin ( p < 0.05). Independent risk factors associated with the severe/critical group were dyspnea [odds ratio (OR) = 19.48], ALT (OR = 6.02) and albumin (OR = 3.36). Independent risk factors associated with the ICU group were dyspnea (OR = 8.88), COPD (OR = 31.80), D-dimer (OR = 8.37), ALT (OR = 28.76) and LDH (OR = 9.95) ( p < 0.05). Conclusion: The severity of COVID-19 outside Wuhan, China was milder than that within Wuhan. The clinical infective period was long, and the longest virus shedding time was 35 days. The most important risk factors were dyspnea, COPD, D-dimer, ALT, LDH and albumin. The reviews of this paper are available via the supplemental material section.

scholarly journals Clinical characteristics and risk factors of patients with severe COVID-19 in Jiangsu province, China

2020 ◽  
Author(s):  
Songqiao Liu ◽  
Huanyuan Luo ◽  
Yuancheng Wang ◽  
Luis E. Cuevas ◽  
Duolao Wang ◽  
...  
Keyword(s):  
Risk Factors ◽  
Critically Ill ◽  
Lymphocyte Count ◽  
Retrospective Cohort ◽  
Clinical Characteristics ◽  
Clinical Laboratory ◽  
Jiangsu Province ◽  
Factors Associated ◽  
Radiological Data ◽  
Multivariable Regression

Abstract BackgroundTo describe the characteristics of patients with Coronavirus Disease-2019 (COVID-19) and factors associated with severe or critically ill presentation.MethodsMulticentre retrospective cohort study of all individuals with confirmed Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV2) infections diagnosed at 24 COVID-19-designated hospitals in Jiangsu province between the 10th January and 15th March 2020. Demographic, clinical, laboratory, and radiological data were collected at hospital admission and data on disease severity were collected at from admission. Patients were categorised as asymptomatic/mild/moderate, and severe/critically ill according to the worst level of COVID-19 recorded during hospitalisation.ResultsA total of 625 patients, 64 (10.2%) were severe/critically ill and 561 (89.8%) were asymptomatic/mild/moderate. All patients were discharged and no patients died. Multivariable regression showed that odds of being a severe/critically ill case were associated with age (year) (OR, 95%CI 1.06, 1.03–1.09), lymphocyte count (109/L) (OR 0.25, 0.08–0.74), and pulmonary opacity in CT (per 5%) on admission (OR 1.31, 95%CI 1.15–1.51).ConclusionsSevere or critically ill patients with COVID-19 is about one-tenths of patients in Jiangsu. Age, lymphocyte count, and pulmonary opacity in CT on admission were associated with risk of severe or critically ill COVID-19.# Songqiao Liu, Huanyuan Luo, Yuancheng Wang contributed equally to this manuscript

scholarly journals Epidemiological and Clinical Characteristics and Risk Factors for Mortality of Inpatients with COVID-19 in Golestan Province, Iran: A Retrospective Cohort Study

2020 ◽  
Author(s):  
Mohammad Reza Honarvar ◽  
Gholamreza Roshandel ◽  
Hesamaddin Shirzad-Aski ◽  
Alijan Tabarraei ◽  
Alireza Tahamtan ◽  
...  
Keyword(s):  
Risk Factors ◽  
Acute Respiratory Distress Syndrome ◽  
Cohort Study ◽  
Respiratory Distress ◽  
Retrospective Cohort ◽  
Clinical Characteristics ◽  
Distress Syndrome ◽  
Multiple Logistic Regression ◽  
Factors Associated ◽  
Golestan Province

Abstract Background: Coronavirus disease 2019 (COVID-19) is an emerging infectious disease that was first reported in Wuhan, China, and has subsequently spread worldwide. We aimed to further clarify the epidemiological and clinical characteristics of 2019-nCoV pneumonia and risk factors associated for mortality. Methods: In this retrospective cohort study, we included inpatient with acute respiratory distress syndrome at Golestan University of Medical Sciences Hospitals (Golestan province, Iran) who had been discharged or had died in 2020. Epidemiological, clinical, and laboratory data, including samples for viral RNA detection, were extracted from electronic medical records and compared between recovered and died cases. We used multiple logistic regression methods to explore the risk factors associated with in-hospital death.Results: In overall 2,835 acute respiratory distress syndrome patients were included in this study, of these patients, 874 (30.83.9%) were positive for 2019­nCoV, and 1,046 (36.90%) were negative and 915 (32.28%) were not available for PCR result. Five hundred and sixty-three patients (19.86%) died, 1,687 patients (59.51%) were recovered, and 585 (20.63%) under treatment. Of the total deaths, only 288 (10.15%) were attributed to COVID-19. The most common symptoms at onset of illness were respiratory distress (1,795 [63.32%]), fever (1,601 [56.47%]), dry cough (1,595 [56.26%]), Sore throat (445 [15.70%]), and myalgia (342 [12.06%]).One thousand and twelve (35.7%) had 1 or more coexisting medical conditions. In multiple logistic regression analysis, risk factors associated with the death included older age (OR (Odds Ratio), 1.03; 95% CI; 1.02-1.04), blood oxygen level (SpO2<93%) (OR, 2.44; 95% CI; 1.79-3.31), comorbidities (OR, 2.15; 95% CI; 1.62-2.84), respiratory distress (OR, 1.74; 95% CI; 1.28-2.37), and headache (OR, 0.44 95% CI; 0.21-0.92). Conclusions: The 2019-nCoV infection caused collections of severe respiratory illness and was associated high ratio of hospitalization in ICU and high mortality. Older age and comorbidities were associated with more risk of death among patients with 2019­nCoV.

scholarly journals Risk Factors for In-hospital Progression of Ordinary COVID-19 in Wuhan, China: A Retrospective Cohort Study

2020 ◽  
Author(s):  
Ying Zhang ◽  
Xing Fan ◽  
Yan Zhao ◽  
Fan Zhou ◽  
Linlin Zhao ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Lactate Dehydrogenase ◽  
Odds Ratio ◽  
Retrospective Cohort ◽  
Clinical Characteristics ◽  
Early Stage ◽  
Potential Risk Factors ◽  
Multivariable Regression ◽  
D Dimer

Abstract Objective: To describe the clinical characteristics and outcomes of ordinary COVID-19 when admitted, to describe how these patients were treated and risk factors for in-hospital progression.Methods: In this retrospective study, we included 291 adult patients diagnosed as ordinary COVID-19 on admission who had been discharged or had died between Jan 20, 2020 and Mar 16, 2020 from General Hospital of Central Theatre Command (Wuhan, China).Results: Of the 291 patients diagnosed as ordinary COVID-19 when admitted, 65 (22.34%) had been recorded COVID-19 progressing at least once, and 226 (77.66%) had been recorded COVID-19 improving during hospitalization. The median time from admission to disease progressed was 5.0 days (2.0-7.0). Multivariable regression showed increasing odds of in-hospital progression associated with male (odds ratio 2.333, 95% CI 1.135-4.395; P=0.020), preexisting cardiovascular diseases (2.433, 1.044-5.671; P=0.039), and lymphopenia (3.482, 1.783-6.799; P<0.001), elevated IL-6 (2.669, 1.084-6.574; P=0.033), d-dimer (2.829, 1.420-5.636; P=0.003) and lactate dehydrogenase (2.855, 1.458-5.591; P= 0.002) on admission.Conclusions: The potential risk factors of male, preexisting cardiovascular disease, lymphopenia, elevated IL-6, and lactate dehydrogenase, d-dimer could help clinicians to identify in-hospital progression among ordinary COVID-19 at early stage to optimize medical treatment.

scholarly journals Characteristics, outcomes and risk factors for mortality of 522 167 patients hospitalised with COVID-19 in Brazil: a retrospective cohort study

BMJ Open ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. e049089
Author(s):  
Marcia C Castro ◽  
Susie Gurzenda ◽  
Eduardo Marques Macário ◽  
Giovanny Vinícius A França
Keyword(s):  
Risk Factors ◽  
Cohort Study ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Cox Proportional Hazards ◽  
Secondary Outcome ◽  
Hospital Death ◽  
Factors Associated ◽  
Icu Admission ◽  
Hospitalised Patients

ObjectiveTo provide a comprehensive description of demographic, clinical and radiographic characteristics; treatment and case outcomes; and risk factors associated with in-hospital death of patients hospitalised with COVID-19 in Brazil.DesignRetrospective cohort study of hospitalised patients diagnosed with COVID-19.SettingData from all hospitals across Brazil.Participants522 167 hospitalised patients in Brazil by 14 December 2020 with severe acute respiratory illness, and a confirmed diagnosis for COVID-19.Primary and secondary outcome measuresPrevalence of symptoms and comorbidities was compared by clinical outcomes and intensive care unit (ICU) admission status. Survival was assessed using Kaplan Meier survival estimates. Risk factors associated with in-hospital death were evaluated with multivariable Cox proportional hazards regression.ResultsOf the 522 167 patients included in this study, 56.7% were discharged, 0.002% died of other causes, 30.7% died of causes associated with COVID-19 and 10.2% remained hospitalised. The median age of patients was 61 years (IQR, 47–73), and of non-survivors 71 years (IQR, 60–80); 292 570 patients (56.0%) were men. At least one comorbidity was present in 64.5% of patients and in 76.8% of non-survivors. From illness onset, the median times to hospital and ICU admission were 6 days (IQR, 3–9) and 7 days (IQR, 3–10), respectively; 15 days (IQR, 9–24) to death and 15 days (IQR, 11–20) to hospital discharge. Risk factors for in-hospital death included old age, Black/Brown ethnoracial self-classification, ICU admission, being male, living in the North and Northeast regions and various comorbidities. Age had the highest HRs of 5.51 (95% CI: 4.91 to 6.18) for patients≥80, compared with those ≤20.ConclusionsCharacteristics of patients and risk factors for in-hospital mortality highlight inequities of COVID-19 outcomes in Brazil. As the pandemic continues to unfold, targeted policies that address those inequities are needed to mitigate the unequal burden of COVID-19.

scholarly journals Epidemiology, clinical characteristics, and treatment outcomes of patients with COVID-19 at Thailand’s university-based referral hospital

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Rujipas Sirijatuphat ◽  
Yupin Suputtamongkol ◽  
Nasikarn Angkasekwinai ◽  
Navin Horthongkham ◽  
Methee Chayakulkeeree ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cohort Study ◽  
Retrospective Cohort ◽  
Clinical Characteristics ◽  
Drug Regimen ◽  
Rt Pcr ◽  
Antiviral Therapies ◽  
Outbreak Period ◽  
Siriraj Hospital ◽  
Antiviral Medications

Abstract Background The epidemiology and outcomes of COVID-19 patients in Thailand are scarce. Methods This retrospective cohort study included adult hospitalized patients who were diagnosed with COVID-19 at Siriraj Hospital during February 2020 to April 2020. Results The prevalence of COVID-19 was 7.5% (107 COVID-19 patients) among 1409 patients who underwent RT-PCR for SARS-CoV-2 detection at our hospital during the outbreak period. Patients with COVID-19 presented with symptoms in 94.4%. Among the 104 patients who were treated with antiviral medications, 78 (75%) received 2-drug regimen (lopinavir/ritonavir or darunavir/ritonavir plus chloroquine or hydroxychloroquine), and 26 (25%) received a 3-drug regimen with favipiravir added to the 2-drug regimen. Disease progression was observed in 18 patients (16.8%). All patients with COVID-19 were discharged alive. Conclusions The prevalence of COVID-19 was 7.5% among patients who underwent RT-PCR testing, and 10% among those having risk factors for COVID-19 acquisition. Combination antiviral therapies for COVID-19 patients were well-tolerated and produced a favorable outcome.

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