scholarly journals Evaluation of Biomarkers in Myoma Patients: A Prospective Study Investigating the Role of LDH, CA 125, and IGF-1 after Uterus-Preserving Surgical Therapy

2021 ◽  
pp. 1-8
Author(s):  
Michaela Jacob ◽  
Rolf Richter ◽  
Jalid Sehouli ◽  
Matthias David
Keyword(s):  
Surgical Therapy ◽  
Ca 125 ◽  
Blood Levels ◽  
Surgical Removal ◽  
Lower Abdomen ◽  
Future Studies ◽  
Diagnostic Standards ◽  
Vaginal Sonography ◽  
A Prospective Study

<b><i>Objective:</i></b> Myomas are one of the most common tumors of the lower abdomen in women. At present, sonography and clinical examination are the prevalent diagnostic standards for these tumors, and no biomarkers have been established yet. The primary aim of this study was to determine if the surgical removal of myomas leads to a drop of lactate dehydrogenase (LDH), CA 125, and/or insulin-like growth factor (IGF-1) and therefore if these parameters are suitable as potential biomarkers for the presence or recurrence of a myoma. <b><i>Study Design:</i></b> The blood levels of LDH, CA 125, and IGF-1 were determined in 83 patients (age 18–50) with a verified diagnosis of myomas and surgical therapy at 3 different timepoints: preoperative (T0), 2 days postoperative (T1), and 6 months postoperative (T2). Vaginal sonography was performed preoperatively and once again at 6 months postoperatively. <b><i>Results:</i></b> The median (Q1–Q3) LDH values dropped significantly postoperatively: 239 (217–266) U/L at T0 versus 217 (190–255) U/L at T1, <i>p</i> &#x3c; 0.001. The median (Q1–Q3) IGF-1 values also dropped: 140.4 (118.6–179.0) ng/mL versus 112.4 (99.5–143.0), <i>p</i> &#x3c; 0.001. By contrast, the CA 125 values rose slightly but not significantly. At 6 months (<i>n</i> = 34), the LDH values were not significantly different from either the preoperative or the immediate postoperative values. This was observed both in patients with and without a recurrence of myoma. In contrast, the median (Q1–Q3) IGF-1 level at T2 was significantly elevated both in patients with sonographic evidence of new myomas (129.0 [116.0–163.1] ng/mL, <i>p</i> = 0.023) and in patients with sonographic proof of no new myomas (161.0 [130.2–198.5] ng/mL, <i>p</i> &#x3c; 0.001). <b><i>Conclusion:</i></b> Both LDH and IGF-1 dropped significantly in the immediate postoperative days in women with myomas after uterus-preserving surgeries were performed. The postoperative concentration of IGF-1 was correlated with the evidence of new myomas and can be potentially used for further monitoring. Future studies should be able to confirm these results. This study concludes that myomas do influence LDH and IGF-1 and could possibly be suitable as biomarkers.

scholarly journals Ultra-sonographic image of ovarian mass and increased CA 19-9 levels as a pre-operative diagnostic predictor of mature cystic teratoma of ovary

2018 ◽  
Vol 6 (2) ◽  
pp. 47-51
Author(s):  
Sameer Malla ◽  
Jiangtao Fan ◽  
Tripti Vaidya
Keyword(s):  
Serum Level ◽  
Cystic Teratoma ◽  
Mature Cystic Teratoma ◽  
Reproductive Age ◽  
Ca 125 ◽  
Surgical Removal ◽  
Tumor Diameter ◽  
Significant Difference ◽  
Before And After ◽  
A Prospective Study

Introduction: Mature cystic teratoma of ovary, categorized as germ cell tumor is commonly seen in females of reproductive age group. The main aim of this study is to evaluate the serum level of CA 19-9 in those patients.Methods: A prospective study on 65 patients at First Affiliated Hospital, Guangxi Medical University, China within the period of one year. Patients underwent pelvic examination, ultra-sonograph and evaluation of serum level of CA 19-9, CA 125, CEA, AFP and SCCA prior to surgery. Following the surgery, samples were subjected for histo-pathological analysis where confirmatory diagnosis of Mature Cystic teratoma of ovary was established. Serum CA 19-9 was then re-analyzed following surgical removal of the tumor.Results: Mean age of patients with mature Cystic teratoma was 32.5±12.1 years (range 15-71). Mean tumor diameter was 5.8±2.4cm (range 2.3-12.2). Serum level of CA19-9 was the only tumor marker with a mean serum level (49.9±73.4IU/ml) above the cut-off value and its elevated rate was 30.76 %. Rate of bilateral tumors was 16.9%. The tumor size was significantly higher in patients with elevated CA 19-9 than those with normal CA 19-9. There was significant difference in the serum level of CA 19-9 before and after the surgery (p<0.002) in patients with elevated level of CA 19-9 pre-operatively.Conclusion: Among all subjects who underwent pelvic ultrasonography imaging and analysis of tumor markers (CA 19-9, CA 125, CEA, AFP and SCCA) prior to surgery, serum level of CA 19-9 has the highest positivity rate in mature cystic teratomas of ovary and its level decreases following surgical removal.

Mesophyll conductance: the leaf corridors for photosynthesis

2020 ◽  
Vol 48 (2) ◽  
pp. 429-439 ◽  
Author(s):  
Jorge Gago ◽  
Danilo M. Daloso ◽  
Marc Carriquí ◽  
Miquel Nadal ◽  
Melanie Morales ◽  
...  
Keyword(s):  
Molecular Mechanisms ◽  
Current Knowledge ◽  
Main Role ◽  
Mesophyll Conductance ◽  
Future Studies ◽  
Cell Structures ◽  
Leaf Tissues ◽  
Change Framework ◽  
Chloroplast Stroma

Besides stomata, the photosynthetic CO2 pathway also involves the transport of CO2 from the sub-stomatal air spaces inside to the carboxylation sites in the chloroplast stroma, where Rubisco is located. This pathway is far to be a simple and direct way, formed by series of consecutive barriers that the CO2 should cross to be finally assimilated in photosynthesis, known as the mesophyll conductance (gm). Therefore, the gm reflects the pathway through different air, water and biophysical barriers within the leaf tissues and cell structures. Currently, it is known that gm can impose the same level of limitation (or even higher depending of the conditions) to photosynthesis than the wider known stomata or biochemistry. In this mini-review, we are focused on each of the gm determinants to summarize the current knowledge on the mechanisms driving gm from anatomical to metabolic and biochemical perspectives. Special attention deserve the latest studies demonstrating the importance of the molecular mechanisms driving anatomical traits as cell wall and the chloroplast surface exposed to the mesophyll airspaces (Sc/S) that significantly constrain gm. However, even considering these recent discoveries, still is poorly understood the mechanisms about signaling pathways linking the environment a/biotic stressors with gm responses. Thus, considering the main role of gm as a major driver of the CO2 availability at the carboxylation sites, future studies into these aspects will help us to understand photosynthesis responses in a global change framework.

Motives for Social Isolation Following a Negative Emotional Episode

2018 ◽  
Vol 77 (3) ◽  
pp. 127-131
Author(s):  
Gérald Delelis ◽  
Véronique Christophe
Keyword(s):  
Social Isolation ◽  
Social Affiliation ◽  
Semantic Categorization ◽  
Future Studies ◽  
Cognitive Regulation ◽  
Emotional Event ◽  
Regulation Strategies ◽  
Emotional Events

Abstract. After experiencing an emotional event, people either seek out others’ presence (social affiliation) or avoid others’ presence (social isolation). The determinants and effects of social affiliation are now well-known, but social psychologists have not yet thoroughly studied social isolation. This study aims to ascertain which motives and corresponding regulation strategies participants report for social isolation following negative emotional events. A group of 96 participants retrieved from memory an actual negative event that led them to temporarily socially isolate themselves and freely listed up to 10 motives for social isolation. Through semantic categorization of the 423 motives reported by the participants, we found that “cognitive clarification” and “keeping one’s distance” – that is, the need for cognitive regulation and the refusal of socioaffective regulation, respectively – were the most commonly and quickly reported motives for social isolation. We discuss the findings in terms of ideas for future studies aimed at clarifying the role of social isolation in health situations.

TO DETERMINE THE ROLE OF CA125 IN THE DIAGNOSIS OF ACUTE APPENDICITIS

2020 ◽  
Vol 4 (7) ◽  
Author(s):  
Vinod Kumar ◽  
Bhupen Songra ◽  
Richa Jain ◽  
Deeksha Mehta
Keyword(s):  
Acute Appendicitis ◽  
Clinical Diagnosis ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Ca 125 ◽  
Care Hospital ◽  
Serum Samples ◽  
Roc Curve Analysis ◽  
Surgery Department

Background: the present study was under taken to determine the role of CA-125 in the diagnosis of acute appendicitis (AA), to prevent its complications and also in preventing negative appendicectomies in tertiary care hospital. Methods: The study was conducted at a tertiary care and research center between 01/03/2018 to 30/06/2019. Patients admitted to the surgery department with diagnosis of AA were considered for the study. After informed consent, a, standardized history was obtained as a case Performa. Serum samples from all the cases with clinical diagnosis of AA were obtained and stored. Only the cases with histopathologically approved AA were included in the study. Cases operated for clinical diagnosis of AA, but not histopathologically proven AA was not included in the study. CA125 levels in cases with definitive diagnosis of AA were measured. Results: In present study, ROC curve analysis revealed the sensitivity of 87.27 % and specificity of 90.91 % when the CA 125 cut-off value of > 16.8 was taken to diagnose acute appendicitis. AUC was 0.911 with a standard error of 0.0292. Conclusion: In this study we have observed that CA125 showed a positive correlation with acute appendicitis, that was statistically not significant (P>0.05). We didn’t evaluate the correlation with the disease severity. We consider that CA125 can be used as a marker in acute appendicitis cases although further research is still needed. Keywords: CA125, Acute Appendicitis, Surgery.

Role of Pro-inflammatory biomarkers in Hashimoto's thyroiditis: A prospective study

2018 ◽  
Author(s):  
B Ramesh ◽  
B Rajesh ◽  
Reddy B Rajkiran ◽  
G Gayathri ◽  
Reddy M Venkateshwara ◽  
...  
Keyword(s):  
Prospective Study ◽  
Hashimoto’S Thyroiditis ◽  
Inflammatory Biomarkers ◽  
Hashimoto's Thyroiditis ◽  
A Prospective Study

A prospective study of the role of coxsackie B and other enterovirus infections in the pathogenesis of IDDM. Childhood Diabetes in Finland (DiMe) Study Group

Diabetes ◽  
1995 ◽  
Vol 44 (6) ◽  
pp. 652-657 ◽  
Author(s):  
H. Hyoty ◽  
M. Hiltunen ◽  
M. Knip ◽  
M. Laakkonen ◽  
P. Vahasalo ◽  
...  
Keyword(s):  
Prospective Study ◽  
Study Group ◽  
Childhood Diabetes ◽  
A Prospective Study ◽  
Coxsackie B

The role of blood inflammatory markers in the diagnosis of appendicitis in children: a prospective study from a University Hospital in Greece

2020 ◽  
Vol 178 (11) ◽  
Author(s):  
George Sakellaris ◽  
Dimitra Dimopoulou ◽  
Maria Niniraki ◽  
Anastasia Dimopoulou ◽  
Athanasios Alegakis ◽  
...  
Keyword(s):  
Prospective Study ◽  
Inflammatory Markers ◽  
University Hospital ◽  
A Prospective Study

Role of Perioperative Factor XIII in Intracerebral Hemorrhage after Brain Tumor Surgery: A Prospective Study

2019 ◽  
Author(s):  
Estela Val Jordan ◽  
Agustín Nebra Puertas ◽  
Juan Casado Pellejero ◽  
Maria Dolores Vicente Gordo ◽  
Concepción Revilla López ◽  
...  
Keyword(s):  
Brain Tumor ◽  
Intracerebral Hemorrhage ◽  
Prospective Study ◽  
Factor Xiii ◽  
Tumor Surgery ◽  
Brain Tumor Surgery ◽  
A Prospective Study
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