scholarly journals Development of Dermatitis Herpetiformis in Chronic Plaque Psoriasis

2021 ◽  
pp. 141-147
Author(s):  
Ruby Lee ◽  
Yolanka Lobo ◽  
Lynda Spelman
Keyword(s):  
Celiac Disease ◽  
Plaque Psoriasis ◽  
Dermatitis Herpetiformis ◽  
Gluten Free Diet ◽  
Gluten Free ◽  
Chronic Plaque Psoriasis ◽  
Autoimmune Bullous Diseases ◽  
Associated Symptoms ◽  
History Of ◽  
Bullous Diseases

Chronic plaque psoriasis is often associated with autoimmune bullous diseases. Dermatitis herpetiformis (DH) is a rare immunobullous disease that has been linked to celiac disease (CD). To our knowledge, the coexistence of psoriasis and DH is uncommon, and has only been described in anecdotal reports. We report a case of chronic plaque psoriasis complicated by DH in a 60-year-old patient with no known history of CD or associated symptoms. In our patient, DH presented atypically as multiple vesicles along the edges of psoriatic plaques located on the back and hips, and as vesiculobullous eruptions on the fingers. The patient was successfully treated with a combination of dapsone and a gluten-free diet for DH, and secukinumab for psoriasis. This case highlights the importance of screening for CD in patients with psoriasis, as well as other concomitant autoimmune diseases. A gluten-free diet should be trialled in psoriatic patients with positive CD serology.

Celiac disease evolving into dermatitis herpetiformis in patients adhering to normal or gluten-free diet

2015 ◽  
Vol 50 (4) ◽  
pp. 387-392 ◽  
Author(s):  
Teea T. Salmi ◽  
Kaisa Hervonen ◽  
Kalle Kurppa ◽  
Pekka Collin ◽  
Katri Kaukinen ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Dermatitis Herpetiformis ◽  
Gluten Free Diet ◽  
Gluten Free

scholarly journals Investigation of Tissue Transglutaminase Antibody Normalization in Response to Gluten-Free Diet in Children with Celiac Disease

2021 ◽  
Vol 11 (01) ◽  
pp. e60-e64
Author(s):  
Mohsen Pour Ebrahimi ◽  
Hosein Alimadadi ◽  
Mehri Najafi ◽  
Mohammad Vasei ◽  
Parisa Rahmani
Keyword(s):  
Celiac Disease ◽  
Family History ◽  
Tissue Transglutaminase ◽  
Positive Family History ◽  
Gluten Free Diet ◽  
Histological Evaluation ◽  
Gluten Free ◽  
Significant Difference ◽  
History Of

AbstractA very limited amount of data are available regarding the follow-up of celiac disease (CD) treatment in Iran. The aim of this study is to investigate antitissue transglutaminase (atTG) normalization interval and the associated factors in CD patients. This retrospective study included CD patients enrolled in Children's Medical Center, Tehran University of Medical Sciences. The initial atTG titer and histological evaluation (with Marsh grade ≥2) were recorded. The atTG titer was assessed in each follow-up until the time of normalization where children were strictly on gluten-free diet. The age at the time of diagnosis, gender, Marsh grade at the time of diagnosis, other comorbidities, and family history of CD patients were recorded to determine the association of these factors with antibody normalization interval. In total, 71 patients were recruited in the study of which 34 (47.89%) subjects had atTG level below 20 U/mL at the average interval of 31.36 ( ±  2.89) months (95% confidence interval: 25.7–37.02). There was no significant difference between the antibody normalization interval and different age ranges and Marsh grade. Cox regression demonstrated that gender, age ranges, Marsh grade, positive family history of CD, and the presence of comorbidities did not significantly predict longer antibody normalization interval.

scholarly journals The Gluten-Free Diet for Celiac Disease and Beyond

Nutrients ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 3993
Author(s):  
Bara Aljada ◽  
Ahmed Zohni ◽  
Wael El-Matary
Keyword(s):  
Celiac Disease ◽  
Dermatitis Herpetiformis ◽  
Cognitive Disorders ◽  
Gluten Free Diet ◽  
Nutritional Deficiencies ◽  
Gluten Sensitivity ◽  
Gluten Free ◽  
Immune Mediated ◽  
The Brain

The gluten-free diet (GFD) has gained popularity beyond its main medical indication as the treatment for gluten-induced immune-mediated disorders such as celiac disease (CD), dermatitis herpetiformis, gluten ataxia, wheat allergy, and non-celiac gluten sensitivity. However, the diet carries some disadvantages such as elevated costs, nutritional deficiencies, and social and psychological barriers. The present work aims to review indications, proven benefits, and adverse events of a gluten-free diet. Close follow-up with patients following the diet is recommended. More data is needed to assess the effectiveness of the diet in managing mental and cognitive disorders and to establish a connection between the brain and gluten.

scholarly journals Missing Insight Into T and B Cell Responses in Dermatitis Herpetiformis

2021 ◽  
Vol 12 ◽  
Author(s):  
Esko Kemppainen ◽  
Teea Salmi ◽  
Katri Lindfors
Keyword(s):  
T Cells ◽  
Celiac Disease ◽  
Small Bowel ◽  
B Cell ◽  
Plasma Cells ◽  
Dermatitis Herpetiformis ◽  
Gluten Free Diet ◽  
Cell Populations ◽  
Gluten Free ◽  
Cell Responses

Dermatitis herpetiformis is a cutaneous form of celiac disease manifesting as an itching rash typically on the elbows, knees and buttocks. It is driven by the ingestion of gluten-containing cereals and characterized by granular deposits of immunoglobulin A in the papillary dermis. These antibodies target transglutaminase (TG) 3 and in the majority of patients they are also found in circulation. The circulating antibodies disappear and skin symptoms resolve as a result of gluten-free diet but the cutaneous anti-TG3 IgA deposits may persist for several years. In dermatitis herpetiformis, plasma cells secreting antibodies against TG3 are located in the intestinal mucosa similarly to those producing TG2 antibodies characteristic for celiac disease. In fact, both TG2- and TG3-specific plasma cells and gluten responsive T cells are found in dermatitis herpetiformis patients but the interplay between these cell populations is unknown. The small bowel mucosal damage in celiac disease is believed to be mediated by co-operation of cytotoxic intraepithelial T cells and the inflammatory milieu contributed by gluten-reactive CD4+ T cells, whereas the skin lesions in dermatitis herpetiformis appear to be devoid of gluten reactive T cells. Thus, how celiac disease-type intestinal T and B cell responses develop into an autoimmune condition affecting the skin is still incompletely understood. Finally, the skin and small bowel lesions may reappear upon reintroduction of gluten in patients treated with gluten-free diet but virtually nothing is known about the long-lived B cell and memory T cell populations activating in response to dietary gluten in dermatitis herpetiformis.

scholarly journals S2279 Resolution of Itchy Feet With a Gluten-Free Diet: A Case of Celiac Disease Presenting as Dermatitis Herpetiformis

2020 ◽  
Vol 115 (1) ◽  
pp. S1205-S1205
Author(s):  
Katherine Park ◽  
Michael Abdo ◽  
Nikunj Divecha ◽  
Pedro Manibusan ◽  
Alexander J. Peckham
Keyword(s):  
Celiac Disease ◽  
Dermatitis Herpetiformis ◽  
Gluten Free Diet ◽  
Gluten Free

scholarly journals Novel Therapeutic/Integrative Approaches for Celiac Disease and Dermatitis Herpetiformis

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Alessio Fasano
Keyword(s):  
Celiac Disease ◽  
Molecular Basis ◽  
Dermatitis Herpetiformis ◽  
Protein Component ◽  
Gluten Free Diet ◽  
Gluten Free ◽  
New Concepts ◽  
Immune Mediated ◽  
New Treatments ◽  
Novel Therapeutic

Celiac disease (CD) is an immune-mediated enteropathy triggered by the ingestion of gluten in genetically susceptible individuals. Gluten is a protein component in wheat and other cereals like rye and barley. At present, the only available treatment is a strict gluten-free diet. Recent advances have increased our understanding of the molecular basis for this disorder. Last decade has seen new scientific developments in this disease and led to the formulation of new concepts of pathophysiology that offer possible targets for new treatments or interventions integrative to the gluten-free diet.

Oats can diversify a gluten-free diet in celiac disease and dermatitis herpetiformis

2004 ◽  
Vol 104 (7) ◽  
pp. 1148-1150 ◽  
Author(s):  
Markku Peräaho ◽  
Pekka Collin ◽  
Katri Kaukinen ◽  
Leila Kekkonen ◽  
Sanna Miettinen ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Dermatitis Herpetiformis ◽  
Gluten Free Diet ◽  
Gluten Free

A Clinical and Histochemical Study of Celiac Disease Before and During a Gluten-Free Diet

1965 ◽  
Vol 48 (2) ◽  
pp. 155-172 ◽  
Author(s):  
I. Michael Samloff ◽  
John S. Davis ◽  
Eric A. Schenk
Keyword(s):  
Celiac Disease ◽  
Histochemical Study ◽  
Gluten Free Diet ◽  
Gluten Free
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