Birthweight Differences in Adolescent Monozygotic Twins Influence Androgens, Psychological Morbidity, and Health-Related Quality of Life

2021 ◽  
pp. 1-9
Author(s):  
Lioba Schmitz ◽  
Sandra Schulte ◽  
Birgit Stoffel-Wagner ◽  
Peter Bartmann ◽  
Michaela Plamper ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Well Being ◽  
Health Related Quality ◽  
Psychological Well Being ◽  
Related Quality ◽  
Health Related ◽  
Parental Evaluation ◽  
Discordant Twins ◽  
Lower Hrqol

<b><i>Background:</i></b> Adverse prenatal conditions can exert a long-lasting impact in later life. <b><i>Patients and Methods:</i></b> Thirty-eight post-pubertal monozygotic twin pairs (16 female pairs) with divergent birthweight (bw) due to twin-to-twin transfusion syndrome were examined at a median of 15.1 years. Auxological and endocrine parameters were measured. To evaluate effects of intra-twin bw and hormone differences on mental health, adolescents and their parents completed the Strengths and Difficulties Questionnaire (SDQ), identifying psychological problems. Twins answered the questionnaire on health-related quality of life (HrQoL, KIDSCREEN-52). <b><i>Results:</i></b> Parents attributed a higher number of psychological challenges to the formerly smaller twins, for example, total difficulties (8.8 vs. 6.5, <i>p</i> = 0.009). Differences in bw were associated with differences in parental evaluation of problems, for example, peer relationship problems (<i>r</i> = −0.57 and <i>p</i> = 0.0001). In contrast, bw differences did not affect subjects’ self-assessment of psychological factors but on physical well-being (<i>r</i> = 0.42, <i>p</i> = 0.017). The formerly smaller discordant twins showed significantly lower HrQoL regarding psychological well-being (24.9 vs. 26.6, <i>T</i><sub>1,15</sub> = −2.2, and <i>p</i> = 0.043) and moods and emotions (29.8 vs. 32.0, <i>T</i><sub>1,15</sub> = −2.3, <i>p</i> = 0.039). Higher concentrations of androstenedione were linked to greater psychological well-being (<i>r</i> = 0.39 and <i>p</i> = 0.036) in all twin pairs. <b><i>Conclusion:</i></b> Our results show that the prenatal environment leading to bw differences exerts a long-lasting impact on diverging parental evaluation of mental health. Formerly smaller discordant twins showed significantly lower HrQoL regarding psychological well-being and moods and emotions. Higher androstenedione concentrations were linked to greater psychological well-being.

scholarly journals The relationship of self-reported and device-based measures of physical activity and health-related quality of life in adolescents

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Kathrin Wunsch ◽  
Claudio R. Nigg ◽  
Susanne Weyland ◽  
Darko Jekauc ◽  
Claudia Niessner ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Physical Activity ◽  
School Environment ◽  
Protective Factor ◽  
Well Being ◽  
Health Related Quality ◽  
Psychological Well Being ◽  
Related Quality ◽  
Health Related

Abstract Background Physical activity (PA) has beneficial effects on health and health-related quality of life (HRQoL), which is a protective factor of illness and mortality. The purpose of this examination was to investigate if self-reported and device-based measures of PA were related to HRQoL in adolescents. Methods Participants (N = 1565; 54.3% female; Mage = 14.37 years, SDage = 1.99) were recruited from 167 sample points across Germany. Adolescents self-reported their PA, supplemented by a 1-week examination of device-based PA using accelerometry. Additionally, they completed the multidimensional KIDSCREEN-27 to assess HRQoL. Results Results showed that self-reported PA was correlated with overall HRQoL, Physical Well-Being, Psychological Well-Being, Social Support & Peers, and School Environment, whereas device-based PA was only correlated with Physical as well as Psychological Well-Being. Further, self-reported PA significantly predicted all facets of HRQoL except for Autonomy and Parent Relations, whereas device-based PA solely heightened the amount of explained variance in the Physical Well-Being subscale. Conclusions Findings demonstrate the importance of self-reported PA as it is related to almost all facets of HRQoL. Both measures of PA are not congruent in their relationship with HRQoL and thus implications have to be carefully considered. Future studies should investigate the direct effect of PA on HRQoL and health in a longitudinal approach to account for the causality of effects.

scholarly journals Inferior health-related quality of life and psychological well-being in immigrant cancer survivors: A population-based study

2013 ◽  
Vol 49 (8) ◽  
pp. 1948-1956 ◽  
Author(s):  
Phyllis N. Butow ◽  
Lynley Aldridge ◽  
Melanie L. Bell ◽  
Ming Sze ◽  
Maurice Eisenbruch ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Cancer Survivors ◽  
Well Being ◽  
Population Based ◽  
Health Related Quality ◽  
Population Based Study ◽  
Psychological Well Being ◽  
Related Quality ◽  
Health Related

scholarly journals Sleep and Its Importance for Health-Related Quality of Life in 3–10-year-old Children

2020 ◽  
Author(s):  
Charlotte Angelhoff ◽  
Anna Lena Sundell
Keyword(s):  
Quality Of Life ◽  
School Environment ◽  
Sleep Problems ◽  
Well Being ◽  
Health Related Quality ◽  
Psychological Well Being ◽  
Related Quality ◽  
Health Related ◽  
Children’S Sleep

Abstract Purpose Considering the reports of increasing sleep problems in children, affecting health and well-being in young children and their families, we found it important to gain more knowledge about sleep and its correlation to health-related quality of life (HRQoL) in young, healthy children. The aim with this study was to describe sleep quality, sleep duration, and HRQoL in healthy 3–10-year-old children and to test associations between children’s sleep and HRQoL. Methods Parents of 160 children (average age: 6.9 years, SD ±2.2) participated in the study. Sleep onset problems (SOP), sleep maintenance problems (SMP), and sleep duration were measured by the Pediatric Insomnia Severity Index (PISI). KIDSCREEN-27 was used to measure HRQoL in five dimensions: physical well-being, psychological well-being, autonomy and parent relation, social support and peers, and school environment. Results The average score was 2.2 for SOP (SD +/-2.2) and 1.3 for SMP (SD +/-1.6). Almost all children (98%) slept between 8 and 13 hours per night. Younger children had statistically significantly more sleep problems than older children. Correlations were found between SOP and poor psychological well-being ( p < 0.05, ρ = - 0.16), and between SMP and poor psychological well-being ( p < 0.05, ρ = - 0.21), poor school environment ( p < 0.01, ρ = - 0.29), and poor social support and peers ( p < 0.05, ρ = - 0.19). Conclusion Children’s sleep associates with psychosocial well-being, school functioning and relations to peers, and need to be acknowledged in child health care settings and schools.

scholarly journals Sleep and Its Relation to Health-Related Quality of Life in 3–10-year-old Children

2020 ◽  
Author(s):  
Anna Lena Sundell ◽  
Charlotte Angelhoff
Keyword(s):  
Quality Of Life ◽  
School Environment ◽  
Well Being ◽  
Health Related Quality ◽  
Psychological Well Being ◽  
Related Quality ◽  
Health Related ◽  
Children’S Sleep ◽  
Parent Relation

Abstract Background: Considering the reports of increasing sleep problems in children, affecting health and well-being in young children and their families, we found it important to gain more knowledge about sleep and its correlation to health-related quality of life (HRQoL) in young, healthy children. The aims with this study were to describe sleep quality, sleep duration, and HRQoL in healthy 3–10-year-old children and to test associations between children’s sleep and HRQoL. Methods: Parents of 160 children (average age: 6.9 years, SD ±2.2) participated in the study. Sleep onset problems (SOP), sleep maintenance problems (SMP), and sleep duration were measured by the Pediatric Insomnia Severity Index (PISI). KIDSCREEN-27 was used to measure HRQoL in five dimensions: physical well-being, psychological well-being, autonomy and parent relation, social support and peers, and school environment. Results: The average score was 2.2 for SOP (SD +/-2.2) and 1.3 for SMP (SD +/-1.6). Few children (2%) were reported to sleep less than eight hours per night. Younger children had statistically significant higher SOP and SMP than older children. Correlations were found between SOP and poor psychological well-being (p < 0.05, ρ = - 0.16), and between SMP and poor physical wellbeing (p < 0.05, ρ = -0.16), psychological well-being (p < 0.05, ρ = - 0.21), poor school environment (p < 0.01, ρ = - 0.29), autonomy and parent relation (p < 0.05, ρ = - 0.16), and poor social support and peers (p < 0.05, ρ = - 0.19).Conclusion: Children’s sleep associates with health-related quality of life and needs to be acknowledged in child health care settings and schools.

scholarly journals Improvement of health-related quality of life and psychological well-being after HCV eradication with direct-acting antiviral agents. Real life setting data of an Italian cohort valued by Hepatitis Quality of Life Questionnaire (HQLQv2)

2021 ◽  
Vol 8 (3) ◽  
Author(s):  
Gaetano Bertino ◽  
Rosalia Ragusa ◽  
Liberato Simone Corsaro ◽  
Evelise Frazzetto ◽  
Vincenzo Messina ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Well Being ◽  
Life Questionnaire ◽  
Health Related Quality ◽  
Psychological Well Being ◽  
Related Quality ◽  
Health Related ◽  
Chronic Hcv ◽  
Direct Acting

HCV (Hepatitis C Virus) decreases Health-Related Quality of Life with detriments to physical, mental and social health domains. Interferon and Ribavirin treatment is associated with depression and anxiety that further impairs HRQoL (Health- Related Quality of Life). IFN-free (interferon-free) regimes (Direct Acting Antivirals, DAAs) are safe and highly effective drugs, with improvement also of HRQoL and related Psychological Well-Being. Our aim is to describe how the latest generation IFN-free treatment can change quality of life and related Psychological Well-Being in Italian Chronic Hepatitis C/Cirrhosis affected patients. SF-36v2 (Short Form Health Survey is a 36-item, patient-reported survey of patient health) – HQLQv2 (Hepatitis Quality of Life Questionnaire) was administered at two time points: baseline (n=72) and 12 weeks after the end of therapy [n=72, SVR=72 - Sustained Virologic Response (SVR)]. Patients with chronic HCV undergoing DAAs treatment from two Italian centers were enrolled. The overall average of the answers is configured for most of the domains that make up the questionnaire, with scores above 50. The quality of life of this sample is very close to the average of the US population, with a minimum average score of 45.9 for the Role Emotional scale and an average maximum score of 56.4 for the Vitality scale. Both are significant results from statistical analysis. It seems that DAAs treatment therapy does not affect but improves the general quality and psychological state of adult patients with Chronic HCV infection.

scholarly journals Health-related quality of life and psychological well-being in elderly patients with haemophilia

Haemophilia ◽  
2011 ◽  
Vol 18 (3) ◽  
pp. 345-352 ◽  
Author(s):  
S. VON MACKENSEN ◽  
A. GRINGERI ◽  
S. M. SIBONI ◽  
P. M. MANNUCCI ◽  
Keyword(s):  
Quality Of Life ◽  
Elderly Patients ◽  
Well Being ◽  
Health Related Quality ◽  
Psychological Well Being ◽  
Related Quality ◽  
Health Related
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