scholarly journals Population-Based Analysis of the Impact of Demographics on the Current and Future Blood Supply in the Saarland

2020 ◽  
pp. 1-8
Author(s):  
Hermann Eichler ◽  
Anna Katharina Feyer ◽  
Kerstin Weitmann ◽  
Wolfgang Hoffmann ◽  
Olaf Henseler ◽  
...  
Keyword(s):  
Blood Supply ◽  
Age Distribution ◽  
Population Based ◽  
Federal State ◽  
Published Data ◽  
Total Blood ◽  
Future Supply ◽  
Donation Frequency ◽  
The Impact ◽  
Rbc Transfusion

<b><i>Background:</i></b> The federal state of Saarland (SL) is experiencing the fastest demographic change in the western part of Germany. In this study, we analyzed retrospective data on the current and future supply of red blood cell concentrates (RBC) in this region and compared it to the current and future RBC demand in SL hospitals. <b><i>Methods:</i></b> The projection of the SL blood supply in 2030 was modeled based on SL demographics for age distribution and donation frequency of donors, and the RBC transfusion data for in-house patients. These results were compared to published data on the transfusion demand from the state of Mecklenburg-Western Pomerania (MV). <b><i>Results:</i></b> For the period January 1 to December 31, 2017, a total of 43,205 whole blood donations were collected. The donation frequency in SL never exceeded 80 per 1,000 inhabitants and was well below the numbers in MV. Thirty-one percent of the donors were responsible for 53.5% of the donations, and donors older than 45 years of age contributed highly to the total blood supply. In addition, 40,614 RBC transfusions at 10 SL hospitals were analyzed representing nearly all RBC transfusions for in-house patients in this region. RBC transfusions per 1,000 inhabitants increased with age from 24 (50–54) to 140 (80–84) years. Facing an already existing structural deficit of nearly 8,200 RBC in 2017, the projection predicts a dramatic increase in the regional deficit to &#x3e;18,300 RBC in 2030. <b><i>Conclusion:</i></b> Our results on RBC demand in SL are comparable but not identical to those projected for the region of MV in eastern Germany. Due to the ongoing demographic changes in Germany as a whole, regular regional monitoring of RBC demand and the age structure of blood recipients and donors should be implemented to allow for better strategic planning in blood transfusion services and hospitals.

scholarly journals The Burden of Seizures in Manitoba Children: A Population-Based Study

2004 ◽  
Vol 31 (1) ◽  
pp. 48-52 ◽  
Author(s):  
Anita L. Kozyrskyj ◽  
Asuri N. Prasad
Keyword(s):  
Health Care ◽  
Urban Areas ◽  
Census Data ◽  
Population Based ◽  
Care Utilization ◽  
Published Data ◽  
Prevalence Rates ◽  
Seizure Disorders ◽  
Urban Rural ◽  
The Impact

Background:Population-based studies are necessary to better understand the risk factors for developing seizure disorders and the impact of these conditions on children. We undertook an assessment of the prevalence of seizure disorders in a population of children on the basis of health care utilization records.Methods:Using Manitoba’s population-based prescription and health care data for 1998/99, the prevalence of children with seizure disorders, on the basis of at least one physician visit or hospitalization for epilepsy or a prescription for an antiepileptic drug, was determined by age, urban/rural region and socioeconomic status. The latter was measured as neighbourhoods stratified by income quintiles according to Census data.Results:Age-specific prevalence rates for seizure disorders in Manitoba children, determined from health care administrative records, were similar to published data on the prevalence of epilepsy, with one exception. Prevalence rates in adolescents were higher than those reported in the literature. No statistically significant differences in prevalence rates were observed between urban and rural populations. However, a higher prevalence was found among children of all ages living in lower socioeconomic neighbourhoods in urban areas, which presented as a gradient of increased prevalence with decreased levels of income.Conclusion:Population-based health care administrative data can be used to describe the geographical distribution of seizure disorders. Our data suggest that the burden of seizure disorders is not evenly distributed among children.

scholarly journals The Impact of SARS-CoV-2 Variant to COVID-19 Epidemic in Brazil

2020 ◽  
Author(s):  
S. Celaschi
Keyword(s):  
Cohort Study ◽  
Disease Transmission ◽  
Population Based ◽  
Published Data ◽  
Model Parameters ◽  
Global Dynamics ◽  
Adopted Model ◽  
Data Points ◽  
The Impact ◽  
First Time

AbstractThe impact of SARS-CoV-2 dominant global lineages to COVID-19 epidemics is for the first time modeled by an adaptation of the deterministic SEIR Model. Such a strategy may be applied worldwide to predict forecasts of the outbreak in any infected country. The objective of this study is to forecast the outcome of the epidemic in Brazil as a first cohort study case. The basic modeling design takes under consideration two of SARS-CoV-2 dominant strains, and a time-varying reproduction number to forecast the disease transmission behavior. The study is set as a country population-based analysis. Brazilian official published data from February 25 to August 30 2020 was employed to adjust a couple of epidemiological parameters in this cohort study. The population-based sample in this study, 4.2 Million Brazilians during the study period, is the number of confirmed cases on exposed individuals. Model parameters were estimated by minimizing the mean squared quadratic errors. The main outcomes of the study follows: The percentage values of non-symptomatic and symptomatic COVID-19 hosts were estimated to be respectively (54 ± 9) % and (46 ± 9) %. By the end of 2020, the number of confirmed cases in Brazil, within 95% CI, is predicted to reach 6 Million (5-7), and fatalities would account for 180.103 (160–200).103. Estimated forecast obtained preserving or releasing the NPIs during the last quarter of 2020, are included. Data points for extra three weeks were added after the model was complete, granting confidence on the outcomes. In 2020 the total number of exposures individuals is estimated to reach 13 ± 1 Million, 6.2% of the Brazilian population. Regarding the original SARS-CoV-2 form and its variant, the only model assumption is their distinct incubation rates. The variant SARS-CoV-2 form, as predicted by the SEIR adopted model, reaches a maximum of 96% of exposed individuals as previously reported for South America. By the end of 2020, a fraction in the range of 15–35 percentages of susceptible Brazilian individuals is to be depleted. Sufficient depletion of susceptibility (by NPIs or not) has to be achieved to weaken the global dynamics spread.

scholarly journals Total Blood Loss After Transfemoral Amputations Is Twice the Intraoperative Loss: An Observational Cohort Study of 81 Nontraumatic Amputations

2017 ◽  
Vol 8 (3) ◽  
pp. 123-127 ◽  
Author(s):  
Christian Wied ◽  
Peter T. Tengberg ◽  
Morten T. Kristensen ◽  
Gitte Holm ◽  
Thomas Kallemose ◽  
...  
Keyword(s):  
Cohort Study ◽  
Blood Loss ◽  
Renal Disease ◽  
Multivariable Analysis ◽  
Final Analysis ◽  
Total Blood Loss ◽  
Medical Complications ◽  
Total Blood ◽  
The Impact ◽  
Rbc Transfusion

Introduction: Underestimation of the actual blood loss in patients undergoing nontraumatic transfemoral amputation (TFA) can impact negatively on outcome in these often frail patients, with very limited physiological reserves. The primary aim of this study is to estimate the total blood loss (TBL) after TFA, and second, to evaluate the impact of blood loss on 30-day mortality and medical complications. Methods: A single-center retrospective cohort study conducted from 2013 to 2015. The TBL was calculated on the fourth postoperative day. It was based on the hemoglobin levels, transfusions, and the estimated blood volume. Results: Eighty-one patients undergoing TFA were included for final analysis. The median TBL was 964 mL (interquartile range [IQR]: 443-1558). The intraoperative blood loss (OBL) was 400 mL (IQR: 200-500). The median difference between TBL and OBL was 688 mL (IQR: 124-1075). The patient received red blood cell (RBC) transfusion of a median amount of 2 units. Higher number of transfusions (>2) did not impact the outcome. From multivariable analysis, it was evident that the TBL increased significantly in patients with renal disease prior to surgery, ( P = .034). The TBL itself was not independently associated with increased 30-day mortality or medical complications. Conclusion: The TBL after TFAs is significantly greater than the volume estimated intraoperatively and increases significantly in the presence of renal disease prior to surgery. An increased TBL and requirement for RBC transfusion is not directly associated with 30-day mortality or medical complications. A high vigilance for anemia seems advisable when planning for TFA surgery. Research on optimum blood conservation and transfusion strategies during TFA is warranted.

scholarly journals Partial lockdown on unvaccinated individuals promises breaking of fourth COVID-19 wave in Bavaria

2021 ◽  
Author(s):  
Tobias Krebs ◽  
Michael J Moeckel
Keyword(s):  
Public Health ◽  
Local Population ◽  
Federal State ◽  
Published Data ◽  
Model Parameters ◽  
Home Office ◽  
Agent Based ◽  
Public Health Burden ◽  
Work Related ◽  
The Impact

Purpose of this report: The aim of this rapid communication is a projection of the development of the fourth COVID-19 wave in the federal state of Bavaria in Germany, taking into account different lockdown scenarios especially for unvaccinated individuals. In particular, the number of infections and the occupancy of intensive care facilities are considered. Applied Methods: We use the agent-based epidemiological simulator Covasim for discussing various epidemiological scenarios. Firstly, we adapt and calibrate our model to reproduce the historical course of the COVID-19 pandemic in Bavaria. For this, we model and integrate numerous public health interventions imposed on the local population. As for some of the political actions rigorous quantification is currently not available, we fit those unknown (free) model parameters to published data on the measured epidemiological dynamics. Finally, we define and analyse scenarios of different lockdown scenarios with restrictions for unvaccinated individuals in different areas of life. Key message: The results of our simulations show that in all scenarios considered, the number of infections, but also the number of severe cases, exceed previous maximum values. Interventions, especially restrictions on contacts of unvaccinated persons, can still mitigate the impact of the fourth COVID-19 wave on populations substantially. Excluding unvaccinated students from attending classes has only a small impact on the public health burden. However, many severe cases can be prevented by reducing community and/or work related contacts of unvaccinated people, e.g, by achieving high home office rates.

scholarly journals Comparsion of Liver and Spleen Elastometry Features

2021 ◽  
Vol 102 (4) ◽  
pp. 247-254
Author(s):  
S. V. Morozov ◽  
V. А. Izranov
Keyword(s):  
Portal Hypertension ◽  
Food Intake ◽  
Blood Supply ◽  
Liver Stiffness ◽  
Published Data ◽  
Splenic Lesion ◽  
Measurement Results ◽  
Spleen Stiffness ◽  
Health And Disease ◽  
The Impact

The review presents data on the comparison of the features of liver and spleen stiffness measurements and those on the impact of various conditions on the measurement results (the type of a sensor used, food intake, number of measurements, patient position, breathing phase, etc.). Literature has been sought in the PubMed and eLibrary databases. In particular, the liver and spleen stiffness values vary differently at the height of inspiration and expiration. This is due to organ engorgement with a change in intrathoracic and intraabdominal pressures, as well as to a reduction in splenic arterial flow during exhalation. The review gives published data on liver and spleen stiffness values in healthy volunteers. The spleen is a stiffer organ than the liver. The different liver and spleen stiffness is explained by the features of blood supply (the spleen receives the most blood supply from the intensive-flow artery; the liver does from the portal vein). The reasons for increasing the stiffness of these organs in both health and disease are described. Estimation of liver stiffness can be used to diagnose cirrhosis and portal hypertension. That of spleen stiffness can help in the diagnosis of portal hypertension and in the indirect diagnosis of the presence of esophageal varices and the nature of a splenic lesion.

Observations on Cardiac Output and ”Pulmonary Blood Volume” in Normal Man by External Recording of the Intracardiac Flow of 131I Labelled Albumin

1961 ◽  
Vol 1 (04) ◽  
pp. 353-379
Author(s):  
Jacques Lammerant ◽  
Norman Veall ◽  
Michel De Visscher
Keyword(s):  
Cardiac Output ◽  
Blood Volume ◽  
Normal Subjects ◽  
Published Data ◽  
Total Blood Volume ◽  
Total Blood ◽  
Pulmonary Blood Volume ◽  
Intracardiac Flow ◽  
Normal Man ◽  
Mean Circulation

Summary1. The technique for the measurement of cardiac output by external recording of the intracardiac flow of 131I labelled human serum albumin has been extended to provide a measure of the mean circulation time from right to left heart and hence a new approach to the estimation of the pulmonary blood volume.2. Values for the basal cardiac output in normal subjects and its variations with age are in good agreement with the previously published data of other workers.3. The pulmonary blood volume in normal man in the basal state was found to be 28.2 ± 0.6% of the total blood volume.4. There was no correlation between cardiac output and pulmonary blood volume in a series of normal subjects in the basal state.5. The increase in cardiac output during digestion was associated with a decrease in pulmonary blood volume equal to 6.3 ± 1.2% of the total blood volume, that is, about 280 ml.6. The increase in cardiac output during exercise was associated with a decrease in pulmonary blood volume equal to 4.5 ± 1.0% of the total blood volume, that is, about 200 ml.7. The increase in cardiac output attributed to alarm is not associated with a decrease in pulmonary blood volume, the latter may in fact be increased.8. The total blood volume is advocated as a standard of reference for studies of this type in normal subjects in preference to body weight or surface area.9. The significance of these results and the validity of the method are discussed.

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