scholarly journals Early Use of Corticosteroid May Prolong SARS-CoV-2 Shedding in Non-Intensive Care Unit Patients with COVID-19 Pneumonia: A Multicenter, Single-Blind, Randomized Control Trial

Respiration ◽  
2021 ◽  
pp. 1-11
Author(s):  
Xiao Tang ◽  
Ying-Mei Feng ◽  
Ji-Xiang Ni ◽  
Jia-Ying Zhang ◽  
Li-Min Liu ◽  
...  
Keyword(s):  
T Cells ◽  
Randomized Control Trial ◽  
Corticosteroid Treatment ◽  
Clinical Deterioration ◽  
Control Group ◽  
Number Of Patients ◽  
Early Use ◽  
Randomized Control ◽  
And Control ◽  
Single Blind

<b><i>Background:</i></b> There is still no clinical evidence available to support or to oppose corticosteroid treatment for coronavirus disease 2019 (COVID-19) pneumonia. <b><i>Objective:</i></b> To investigate the efficacy and safety of corticosteroid given to the hospitalized patients with COVID-19 pneumonia. <b><i>Methods:</i></b> This was a prospective, multicenter, single-blind, randomized control trial. Adult patients with COVID-19 pneumonia who were admitted to the general ward were randomly assigned to either receive methylprednisolone or not for 7 days. The primary end point was the incidence of clinical deterioration 14 days after randomization. <b><i>Results:</i></b> We terminated this trial early because the number of patients with COVID-19 pneumonia in all the centers decreased in late March. Finally, a total of 86 COVID-19 patients underwent randomization. There was no difference of the incidence of clinical deterioration between the methylprednisolone group and control group (4.8 vs. 4.8%, <i>p</i> = 1.000). The duration of throat viral RNA detectability in the methylprednisolone group was 11 days (interquartile range, 6–16 days), which was significantly longer than that in the control group (8 days [2–12 days], <i>p</i> = 0.030). There were no significant differences between the 2 groups in other secondary outcomes. Mass cytometry discovered CD3<sup>+</sup> T cells, CD8<sup>+</sup> T cells, and NK cells in the methylprednisolone group which were significantly lower than those in the control group after randomization (<i>p</i> &#x3c; 0.05). <b><i>Conclusions:</i></b> From this prematurely closed trial, we found that the short-term early use of corticosteroid could suppress the immune cells, which may prolong severe acute respiratory syndrome coronavirus 2 shedding in patients with COVID-19 pneumonia. <b><i>Trial Registration:</i></b> ClinicalTrials.gov, NCT04273321.

scholarly journals Efficacy of Single Pre-Operative Dose of Glucocorticoid (125mg of Solumedrol Intravenous) in Terms of Seroma Formation in Patients Undergoing Mastectomy with Axillary Clearance For Breast Cancer: A Randomized Control Trial

2020 ◽  
pp. 1-5
Author(s):  
Aliya Ishaq ◽  
Abida Parveen ◽  
Aliya Ishaq ◽  
Mariya Ishaq ◽  
Muhammad Jamshaid Hussain Khan ◽  
...  
Keyword(s):  
Single Dose ◽  
Randomized Control Trial ◽  
Removal Rate ◽  
Fluid Collection ◽  
Study Groups ◽  
Seroma Formation ◽  
Control Group ◽  
Drain Removal ◽  
Randomized Control ◽  
And Control

Objective: The study aimed to determine the efficacy of single dose of glucocorticoid (125 mg of Solumedrol intravenous) in terms of seroma formation after mastectomy in patient with carcinoma of breast. Study Design: Randomized control trial. Place and Duration of Study: Study was conducted in the Department of General Surgery, Liaquat National Hospital Karachi, Pakistan from july 1 to dec 31, 2010. Patients and Methods: Patients were randomly divided in two groups (study and control) each group consisting of 30 patients. Randomization was done by opening of a sealed envelope which had a slip bearing the name of study medication (solumederol or saline as placebo) to be administered. The study group received a single dose of inj 125mg solumedrol IV half an hour prior to surgery by resident scrub in surgery. A similar procedure was applied to the control group and patients in controlled group were administered an equal volume of saline intravenously. After drain removal patients in both groups were observed for a duration of 2 weeks for sermoa formation. Detection of seroma formation was based on clinical grounds by absence of any fluid collection at mastectomy bed as detected by manual palpation. SPSS 10 was used for analysis. Results: Seroma formation was observed in 66.7% (40/60) women 2 weeks post drain removal. Rate of seroma formation was significantly low in study groups than control groups (33.3% vs. 100%; p=0.0001). Conclusion: Single dose of steroid is efficacious in reducing the post mastectomy seroma formation.

scholarly journals POTENSI TEH JANTUNG PISANG BATU (Musa balbisiana Colla) SEBAGAI GALAKTAGOG DALAM MENINGKATKAN KADAR PROLAKTIN SERUM SELAMA MASA LAKTASI

Jurnal JKFT ◽  
2020 ◽  
Vol 5 (2) ◽  
pp. 54
Author(s):  
Giyawati Yulilania Okinarum ◽  
Lestariningsih Lestariningsih ◽  
Afroh Fauziah
Keyword(s):  
Camellia Sinensis ◽  
Randomized Control Trial ◽  
Control Group ◽  
Musa Balbisiana ◽  
Randomized Control ◽  
Single Blind

Kadar prolaktin yang kurang pada ibu menyusui dapat menghambat proses laktogenesis, akibatnya produksi ASI menurun hingga menjadi salah satu penyebab kegagalan pemberian ASI eksklusif. Jantung pisang batu (Musa balbisiana Colla) menjadi salah satu tanaman yang dapat meningkatkan kadar prolaktin karena adanya efek galaktagog serta kandungan flavonoid dan polifenol yang mampu memengaruhi sistem endokrin dan fungsi hormon untuk merangsang sekresi air susu. Pengembangan jantung pisang batu dalam sediaan teh yang praktis dikonsumsi dan terstandar dapat menjadi salah satu olahan alternatif guna meningkatkan kadar prolaktin serum. Tujuan penelitian ini untuk mengetahui potensi teh jantung pisang batu dalam meningkatkan kadar prolaktin serum. Sebanyak 60 responden dalam penelitian ini adalah ibu menyusui kurang dari 6 bulan di Wilayah Kabupaten Sleman dan Kota Yogyakarta. Sampel diamil secara acak dengan blok permutasi. Desain yang digunakan yaitu single blind randomized control trial pretest posttest control group. Kelompok intervensi mendapatkan teh jantung pisang batu sebanyak dua kantong teh per hari (@2,5 gram) yang harus dikonsumsi selama tujuh hari, sementara itu kelompok intervensi diberikan teh (Camellia sinensis). Kadar prolaktin serum diukur sebelum konsumsi di hari pertama dan setelah konsumsi di hari ke delapan menggunakan analisis biokimia darah VIDAS. Data dianalisis menggunakan uji Wilcoxon dan Uji Mann Whitney, karena data tidak berdistribusi normal. Terdapat perbedaan kadar prolaktin serum yang signifikan anatara kelompok intervensi dan kontrol (p<0,05). Ibu menyusui yang mengkonsumsi teh jantung pisang batu selama tujuh hari berturut-turut mengalami kenaikan kadar prolaktin serum sebesar 30,85%. Teh jantung pisang batu memiliki efek galaktagog yang dapat meningkatkan kadar prolaktin serum selama masa laktasi.

scholarly journals Pemberian Minuman dan Cookies Galohgor Terhadap Kadar Blood Urea Nitrogen (Bun) dan Kreatinin Plasma Penderita Diabetes Melitus Tipe 2

2020 ◽  
Vol 12 (1) ◽  
pp. 1-10
Author(s):  
Laeli Nur hasanah ◽  
Katrin Roosita ◽  
Rimbawan
Keyword(s):  
Blood Urea Nitrogen ◽  
Randomized Control Trial ◽  
Control Group ◽  
Post Intervention ◽  
Urea Nitrogen ◽  
Randomized Control ◽  
Single Blind ◽  
Type 2 Diabetic ◽  
Different Levels

The aim of this research was to analyze the effect of drinks and cookies contained Galohgor extract on Blood Urea Nitrogen (BUN) and creatinine plasma in type 2 diabetic subjects. This study used single blind Randomized Control Trial (RCT) with cross-over design applied on 11 type 2 diabetic subjects in Cikarawang, Babakan and Balumbang Jaya Village-Dramaga, Bogor District, West Java. Each subject received powdered drinks and cookies contained Galohgor extract 2 grams/day (1 gram of Galohgor extract in the form of drink 8 grams and 1 gram of Galohgor extract in the form of cookies 24 grams) and without Galohgor extract (control) for 38 days treatment with four wash-out period between treatment periods. BUN and creatinine levels were conducted by plasma blood sample at pre and post intervention. The result showed that the different levels of BUN between post and pre intervention for Galohgor group compared to control group were -4,9±11,2 mg/dL and -9,6±12,5 mg/dL (p>0,05). The different levels of creatinine between post and pre intervention for Galohgor group compared to control group were -0,1±0,2 mg/dL and -0,1±0,2 mg/dL (p>0,05). Therefore, drinks and cookies contained Galohgor extract 2 gram/day does not affect the BUN and creatinine level of type 2 diabetic subjects. Abstrak : Penelitian ini bertujuan untuk menganalisis pengaruh minuman dan cookies Galohgor terhadap kadar Blood Urea Nitrogen (BUN) dan kadar kreatinin plasma penderita DM tipe 2. Jenis penelitian ini adalah single blind Randomized Control Trial (RCT) dengan desain cross-over pada 11 subjek DM tipe 2 yang dilakukan di desa Cikarawang, Babakan dan Balumbang Jaya, Kecamatan Dramaga, Kabupaten Bogor, Jawa Barat. Masing-masing subjek mendapatkan  minuman dan cookies yang mengandung ekstrak Galohgor  sebesar 2 gram/hari (1 gram ekstrak Galohgor dalam bentuk 8 gram minuman serbuk dan 1 gram ekstrak Galohgor dalam bentuk 24 gram cookies) dan minuman serbuk dan cookies tanpa ekstrak Galohgor (kontrol) selama 38 hari dengan empat bulan periode wash-out antar perlakuan. Kadar BUN dan kreatinin dikumpulkan dari sampel plasma darah pada sebelum dan setelah intervensi. Hasil penelitian menunjukkan rata-rata selisih kadar BUN pada kelompok Galohgor dibandingkan dengan kelompok kontrol yaitu -4,9±11,2 mg/dL dan -9,6±12,5 mg/dL (p>0,05). Kadar kreatinin pada kelompok Galohgor dibandingkan dengan kelompok Galohgor yaitu -0,1±0,2 mg/dL dan -0,1±0,2 mg/dL (p>0,05). Oleh karena itu, pemberian minuman dan cookies yang mengandung ekstrak Galohgor 2 gram/hari tidak berpengaruh terhadap kadar ureum dan kreatinin penderita DM tipe 2.

scholarly journals Prevention of Oculocardiac Reflex by Premedication With Low Dose I/V Ketamine during Strabismus Surgery

2021 ◽  
Vol 15 (10) ◽  
pp. 2652-2655
Author(s):  
Mehreen Akram ◽  
Iqra Mushtaq ◽  
Rafia Kousar
Keyword(s):  
Randomized Control Trial ◽  
Low Dose ◽  
Nmda Receptor Antagonist ◽  
Strabismus Surgery ◽  
Control Group ◽  
Case Report Form ◽  
Trial Methodology ◽  
Oculocardiac Reflex ◽  
Randomized Control ◽  
And Control

Background: OCR commonly occurs during strabismus surgery, producing bradycardia, arrhythmias and even cardiac arrest after manipulation of orbital structures. Ketamine is NMDA receptor antagonist and acts as an analgesic. Aim: To determine the effect of ketamine premedication on prevention of OCR during strabismus surgery. Study design: Randomized control trial Methodology: 60 patients were randomly divided into two groups i.e., Ketamine 0.75mg/kg (Group K) and control (Group C). Group K patients were premedicated with 0.75mg/kg ketamine while Group C patients did not receive any premedication. Heart rate and ECG were observed 30 sec before and continuously after traction on extraocular muscles was applied upto end of surgery for bradycardia and arrhythmias. Percentage change in HR and presence of arrhythmias was documented. All the data was collected using case report form and analyzed using SPSS version 15. Results: In Group C, 15(50%) cases had arrhythmias while in Group K, only 4(13.33%) cases had arrhythmias. Mean HR in Group C was 118.77±6.92/min and in Group K was 101.57±15.65/min. In Group C, oculocardiac reflex was present in 23(76.7%) cases and in Group K, OCR was present in 6 (20%) cases and prevented in 24 (80%) cases. Conclusion: Premedication with 0.75mg/kg IV ketamine significantly reduces the occurrence of oculocardiac reflex during strabismus surgery. Keywords: Ketamine, Oculocardiac Reflex, Premedication, Prevention, Strabismus

The Impact of a Foot-Toe Orthosis on Dynamic Balance: An Exploratory Randomized Control Trial

2020 ◽  
Vol 29 (7) ◽  
pp. 871-878
Author(s):  
Adam Kelly ◽  
Justin Stanek
Keyword(s):  
Randomized Control Trial ◽  
Daily Living ◽  
Dynamic Balance ◽  
Intervention Group ◽  
Control Group ◽  
Control Groups ◽  
Balance Test ◽  
Randomized Control ◽  
And Control ◽  
The Impact

Context: The influence of custom and over-the-counter foot orthoses on dynamic balance has been investigated in the past. However, there has not been an exploration of the use of a foot-toe orthosis for improving balance. The ability of clinicians to influence balance could have important implications for injury prevention and rehabilitation. Objective: To determine the impact of a foot-toe orthosis on dynamic balance in healthy, young adults. Design: Randomized control trial. Setting: Athletic training laboratory. Participants: In total, 64 healthy, recreationally active participants aged 18–29 years were randomly allocated to one of the following groups: the foot-toe orthosis and laboratory-issued shoe group, the laboratory-issued shoe only (SO) group, or the control group. Interventions: Subjects in the intervention group wore the foot-toe orthosis and laboratory-issued shoe with activities of daily living for 4 weeks. Subjects in the SO intervention group wore the laboratory-issued shoe with activities of daily living for 4 weeks. Participants in the control group did not receive any intervention. Main Outcome Measures: The instrumented version of the Star Excursion Balance Test, known as the Lower Quarter Y-Balance Test, was used to quantify the dynamic balance at baseline and follow-up. Reaches were normalized for leg length. Results: There were statistically significant differences in postintervention scores on the Lower Quarter Y-Balance Test for both the dominant (P = .03, effect size = 0.84; 95% confidence interval, 0.25 to 1.43) and nondominant (P = .002, effect size = 0.74; 95% confidence interval, 0.15 to 1.32) legs when comparing dynamic balance scores of the foot-toe orthosis and laboratory-issued shoe group with the SO and control groups. No significant differences were observed when comparing dynamic balance between the SO and control groups. Conclusions: A 4-week intervention with a foot-toe orthosis and laboratory-issued shoe resulted in improved dynamic balance in a healthy young adult population. These findings suggest a novel intervention for increasing balance.

scholarly journals RANDOMIZED CONTROL TRIAL ON ERANDAMULA GHANAVATI WITH NASYA IN MANYAGRAHA WITH SPECIAL REFERENCE TO CERVICAL SPONDYLOSIS

2021 ◽  
Vol 12 (6) ◽  
pp. 20-25
Author(s):  
Sunil Solanke ◽  
Prakash Kabra
Keyword(s):  
Cervical Spine ◽  
Randomized Control Trial ◽  
Cervical Spondylosis ◽  
Group Discussion ◽  
The Elderly ◽  
Control Group ◽  
Trial Group ◽  
Effect Of Therapy ◽  
Randomized Control ◽  
And Control

Background: Cervical spondylosis is defined as degenerative changes occurring in the discs and cervical spine. Stating these changes is to be almost universal in the elderly. Cervical Spondylosis correlated with Manyagraha in Ayurvedic perspective. Aim: Aim of the study was to evaluate the effect of Erandamula Ghanavati and Anu Taila Nasya in Manyagraha. Methods: The Group in which Erandamula Ghanavati and Anutaila Nasya were given to patients was termed as Trial Group. The Group in which Panchatikta Ghrita Guggulu and Anutaila Nasya were given to patients was termed as Control Group. During this study 104 patients out of 150 were equally divided into Trial and Control Group by lottery method and comparative study was done. Statistical analysis was done using appropriate tests. Results: Erandamula Ghanavati along with Anu Taila Nasya has reduces symptoms of Manyagraha. Total effect of therapy is more in Trial group as compared to the Control Group. Discussion: As stated by Charak Erandamula is best Vatahara drug. Its Rasa, Virya and Vipak are helpful to alleviate Vata. Erandamula having Snigdha, Madhuraproperties is going to be beneficial in Dhatukshayajanya Vatavyadhi. Conclusion: Erandamula Ghanavati along with Anu Taila Nasya has beneficial for patients of Manyagraha.

scholarly journals Use of Lubricant at Meatus and Circumcision Site in Younger Children Prevent Post Circumcision Meatal Stenosis : A Randomized Control Trial

2013 ◽  
Vol 5 (1) ◽  
pp. 35-38 ◽  
Author(s):  
Susankar Kumar Mondal ◽  
Md Ansar Ali ◽  
Md Kausar Alam ◽  
Kaniz Hasina ◽  
Abdur Rabban Talukder ◽  
...  
Keyword(s):  
Randomized Control Trial ◽  
Study Groups ◽  
Late Complications ◽  
Control Group ◽  
Petroleum Jelly ◽  
Control Groups ◽  
Topical Medication ◽  
Meatal Stenosis ◽  
Randomized Control ◽  
And Control

Background: Circumcision is the most common surgical procedure performed in boys through out the world. Meatal stenosis is one of its late complications. Objective: The aim of the present study is to see the effectiveness of use of lubricants vaseline-petrelium jelly) during arumcision meatal stenosis. Methodology: A randomized control trial was performed, in which two groups of boys younger than two years old underwent circumcision according to dissection (sleeve) method. The parents in the study groups were strictly instructed to use petroleum jelly on the meatus and circumcision site at every morning or after each diaper change where necessary for three months. On the other hand parents in the control group were instructed not to use any lubricants or topical medication on the same site. The boys were followed up regularly and evaluated for meatal stenosis, bleeding and infection. Results: A total of 120 boys were recruited & in each group comprised of 60 boys. None of the boys in the study group develop meatal stenosis , but 6(10%) in the control group develop meatal stenosis (p< 0.05 ). Infection of the circumcision site was seen in 1 (0.6%) and 3 (5%) children in the lubricant and control groups, respectively (p<0.05) and bleeding was seen in 3 (5.0%) and 6(10.0%) respectively. Conclusion: Based on the findings of this study, it seems logical to use a lubricant jelly for prevention of post circumcision meatal stenosis and other complications. DOI: http://dx.doi.org/10.3329/jssmc.v5i1.16204 J Shaheed Suhrawardy Med Coll, 2013;5(1):35-38

scholarly journals A Collaborative Deprescribing Intervention in a Subacute Medical Outpatient Clinic: A Pilot Randomized Controlled Trial

Metabolites ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 204
Author(s):  
Anissa Aharaz ◽  
Jens Henning Rasmussen ◽  
Helle Bach Ølgaard McNulty ◽  
Arne Cyron ◽  
Pia Keinicke Fabricius ◽  
...  
Keyword(s):  
Pilot Study ◽  
Controlled Trial ◽  
Inappropriate Medication ◽  
Intervention Group ◽  
Control Group ◽  
Randomized Controlled ◽  
Patient Interviews ◽  
Number Of Patients ◽  
Multimorbid Patients ◽  
And Control

Medication deprescribing is essential to prevent inappropriate medication use in multimorbid patients. However, experience of deprescribing in Danish Subacute Medical Outpatient Clinics (SMOCs) is limited. The objective of our pilot study was to evaluate the feasibility and sustainability of a collaborative deprescribing intervention by a pharmacist and a physician to multimorbid patients in a SMOC. A randomized controlled pilot study was conducted, with phone follow-up at 30 and 365+ days. A senior pharmacist performed a systematic deprescribing intervention using the Screening Tool of Older Persons’ potentially inappropriate Prescriptions (STOPP) criteria, the Danish deprescribing list, and patient interviews. A senior physician received the proposed recommendations and decided which should be implemented. The main outcome was the number of patients having ≥1 medication where deprescribing status was sustained 30 days after inclusion. Out of 76 eligible patients, 72 (95%) were included and 67 (93%) completed the study (57% male; mean age 73 years; mean number of 10 prescribed medications). Nineteen patients (56%) in the intervention group and four (12%) in the control group had ≥1 medication where deprescribing status was sustained 30 days after inclusion (p = 0.015). In total, 37 medications were deprescribed in the intervention group and five in the control group. At 365+ days after inclusion, 97% and 100% of the deprescribed medications were sustained in the intervention and control groups, respectively. The three most frequently deprescribed medication groups were analgesics, cardiovascular, and gastrointestinal medications. In conclusion, a collaborative deprescribing intervention for multimorbid patients was feasible and resulted in sustainable deprescribing of medication in a SMOC.

EFFECT OF ACCUPRESSURE PEN ON DISTANCE VARIABLE IN SCIATICA PATIENTS -A RANDOMIZED CONTROL TRIAL

2021 ◽  
pp. 28-31
Author(s):  
Urja S. Vaidya ◽  
Roshani S. Patel
Keyword(s):  
Randomized Control Trial ◽  
Stride Length ◽  
Step Length ◽  
Control Group ◽  
Exclusion Criteria ◽  
Parametric Test ◽  
Group A ◽  
Randomized Control ◽  
Experimental Group ◽  
Distance Variable

Background: Sciatica is a radiating pain which is treated with manual accupressure and after a time electro accupressure came into introduction. Aim And Objective: Aim: To nd out the effectiveness of accupressure pen to improve the distance variable To nd out the effect of Objective: accupressure pen on pain and distance variable in sciatica patient To compare the experimental group to the control group On the basis of Method: inclusion and exclusion criteria 30 participants were selected. They were treated with electro accupressure pen for 3 alternative days / week for 3 weeks, after that re-assessment was taken with NPRS, Slump and Distance variables. The data was analyzed using SPSS Version Results: 21.Parametric test was used .In Group A improvement was seen Accupressure Conclusions: pen is effective to reduce pain and improve step length and stride length in Sciatica Patients

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