Investigation of Allergic Sensitization Pattern in 4,203 Children in Northern China

2020 ◽  
pp. 1-4
Author(s):  
Wei Wang ◽  
Xian-hui Zhang ◽  
Lei Zhu ◽  
Yu-xiang Liu
Keyword(s):  
Immunoglobulin E ◽  
Allergic Sensitization ◽  
Epidemiological Data ◽  
Northern China ◽  
Allergic Diseases ◽  
Egg White ◽  
Specific Immunoglobulin E ◽  
Sensitization Rate ◽  
Positive Rate ◽  
Sensitization Pattern

<b><i>Objective:</i></b> The objective of this study is to investigate the allergen sensitization pattern among 4,203 children in the Shanxi region of China and to provide guidance for diagnosis and prevention of allergic diseases. <b><i>Methods:</i></b> A retrospective analysis was conducted on the allergen-specific immunoglobulin E (sIgE) results of 4,203 children aged 0–12 years from January to December in 2019. SIgE antibodies to 19 allergens in the serum sample were detected by enzyme ALLERGO-SORBENT testing. <b><i>Results:</i></b> In total, 49.70% (2,089/4,203) of children with allergic diseases were positive for sIgE, and the top 5 allergens were egg white 18.63% (783/4,203), artemisia 14.47% (608/4,203), milk 13.04% (548/4,203), ragweed 8.66% (364/4,203), and poplar/willow/elm 8.52% (358/4,203). Significant differences in the positive rate of food allergens and aeroallergens in different ages were found (<i>p</i> &#x3c; 0.05). 50.98% (1,065/2,089) patients were sensitive to 2 or more allergens. The high sensitization rate in the &#x3e;3-year group was significantly higher than the ≤3-year group (<i>p</i> &#x3c; 0.05). <b><i>Conclusion:</i></b> Egg white and artemisia are the most common allergens in children in northern China. This study provides allergic sensitization pattern of children and clinical epidemiological data in the region.

scholarly journals Allergic diseases attributable to atopy in a population sample of Asian children

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Chao-Yi Wu ◽  
Hsin-Yi Huang ◽  
Wen-Chi Pan ◽  
Sui-Ling Liao ◽  
Man-Chin Hua ◽  
...  
Keyword(s):  
Immunoglobulin E ◽  
Population Attributable Risk ◽  
Population Sample ◽  
International Study ◽  
Allergic Diseases ◽  
Population Based ◽  
School Age Children ◽  
Specific Immunoglobulin E ◽  
Asian Children ◽  
Specific Immunoglobulin

AbstractThe proportion of allergic diseases attributable to atopy remains a subject of controversy. This study aimed to estimate the population risk of physician-diagnosed asthma, rhinitis and eczema attributed to atopy among a population sample of Asian school-age children. Asian children aged 5–18 years (n = 1321) in the Prediction of Allergies in Taiwanese CHildren (PATCH) study were tested for serum allergen-specific immunoglobulin E. Physician-diagnosed asthma, rhinitis and eczema were assessed by a modified International Study of Asthma and Allergies in Childhood questionnaire. Atopy was defined as the presence of serum allergen-specific immunoglobulin E. In this population-based study, 50.4% of the subjects with asthma, 46.3% with rhinitis, and 46.7% with eczema were attributable to atopy. The population attributable risk (PAR) of atopy for three allergic diseases was higher in adolescents (asthma, 54.4%; rhinitis, 59.6%; eczema, 49.5%) than younger children aged less than 10 years (asthma, 46.9%; rhinitis, 39.5%; eczema, 41.9%). Among the seven allergen categories, sensitization to mites had the highest PARs for all three allergic diseases (51.3 to 64.1%), followed by sensitization to foods (asthma, 7.1%; rhinitis, 10.4%; eczema 27.7%). In conclusion, approximately half (46.3 to 50.4%) of Asian children in Taiwan with allergic diseases are attributable to atopy.

scholarly journals Total and Specific Immunoglobulin E and Their Relationship to Respiratory Symptoms in Quebec Children and Adolescents

2005 ◽  
Vol 12 (8) ◽  
pp. 426-432 ◽  
Author(s):  
Benoît Levesque ◽  
Jean-François Duchesne ◽  
Suzanne Gingras ◽  
Pierre Allard ◽  
Edgar Delvin ◽  
...  
Keyword(s):  
Children And Adolescents ◽  
Respiratory Symptoms ◽  
Immunoglobulin E ◽  
Geometric Mean ◽  
Allergic Sensitization ◽  
Population Sample ◽  
Ethnic Origin ◽  
Total Ige ◽  
Specific Immunoglobulin E ◽  
Specific Immunoglobulin

BACKGROUND: Respiratory disease is a major cause of morbidity in young people. It is now recognized that atopy plays an important role in the development of chronic respiratory symptoms in children.OBJECTIVE: To examine the determinants and consequences of serum total and specific immunoglobulin E (IgE) in a general population sample of Québec children and adolescents.METHODS: In 1999, 2349 children and adolescents (nine, 13 or 16 years of age) who had participated in a respiratory symptom and disease questionnaire had their total IgE measured. Of these participants, a subsample of 451 children and adolescents was analyzed to detect antibodies to eight specific allergens (ie, allergens of dust mites [Dermatophagoides farinae and Dermatophagoides pteronyssinus], cat, dog, ragweed, Timothy grass, mould [alternaria] and cockroach).RESULTS: The geometric mean of the total IgE was 44.4 U/mL among all participants. Concentrations were higher in boys and increased with age. More than 41% of the participants were sensitized to at least one specific allergen. Such sensitization was strongly associated with the occurrence of respiratory conditions and symptoms, namely asthma, wheezing and rhinitis. Family history, school location and ethnic origin had an impact on the prevalence of atopy and total IgE levels.CONCLUSIONS: Allergic sensitization is a major determinant in the development of asthma, wheezing and rhinitis in children and adolescents in the province of Québec.

scholarly journals Sensitization rate and sum of sige-antibodies to apple grades of various colours. Association of these indices with severity of atopic dermatitis

2019 ◽  
Vol 36 (2) ◽  
pp. 44-50
Author(s):  
A. S. Prilutsky ◽  
K. E. Tkachenko ◽  
O. V. Baranova ◽  
O. V. Sorokina
Keyword(s):  
Atopic Dermatitis ◽  
Statistical Analysis ◽  
Detection Rate ◽  
Immunoglobulin E ◽  
Enzyme Analysis ◽  
Specific Immunoglobulin E ◽  
Specific Immunoglobulin ◽  
Sensitization Rate ◽  
Coating Colour ◽  
Degree Of Severity

Aim. To assess the rate of sensitization to the grades of apples of various colours and analyze the association of the obtained indices and total sIgE levels of these grades with the severity of atopic dermatitis. Materials and methods. The blood sera of 215 patients, suffering from alimentary allergy, were studied. The detection rate of sensitization and that of specific immunoglobulin E (sIgE) concentration sum to allergens of apple grades with various coating colours as well as the association of these indices with the degree of severity of atopic dermatitis (AD) was analyzed. Test-systems were used for immune-enzyme analysis of production. Statistical analysis of the obtained results was performed using the program “MedStat” (Donetsk). Results. It was shown that the detection rate of sensitization to the grades with mixed red colour is reliably higher (p < 0.001) compared to the grades without coating colour. The degree of AD severity correlates with the total quantity of apple grades, to which sensitization has been revealed (p < 0.01), with the quantity of grades with mixed red colour, to which sensitization has been found (p < 0.01) and with sIgE sum to the grades with mixed red colour (p < 0.01). Reliable differences (p = 0.006) in the degree of severity of atopic dermatitis among persons, sensitized to apple grades and with no sensitization to this fruit were established. Conclusions.The obtained data are to be used when choosing a diet and correcting it for persons with alimentary allergy and atopic dermatitis.

Diagnostic and Therapeutic Principles In Allergy

2018 ◽  
Author(s):  
Mitchell H. Grayson ◽  
Peter Mustillo
Keyword(s):  
Food Allergy ◽  
Immunoglobulin E ◽  
Skin Testing ◽  
Allergic Sensitization ◽  
Allergic Diseases ◽  
Specific Ige ◽  
Severe Form ◽  
Therapeutic Principles ◽  
Anticytokine Therapy ◽  
Release Assay

The incidence of allergic diseases, like asthma, allergic rhinitis, and food allergy, is increasing in Westernized countries. This chapter discusses the importance of taking a careful and focused history and physical examination, as well as the laboratory studies that can be used to demonstrate the presence of allergic sensitization. Treatment for allergic disease is discussed, with an emphasis on new biologic therapies that have been developed. Finally, the chapter explores relatively new studies on the potential for interventions to prevent food allergy.  Allergy is defined as an untoward physiologic event mediated by immune mechanisms, usually involving the interaction between an allergen and the allergic antibody, immunoglobulin E (IgE). Allergic reactions typically occur due to exposure to either airborne allergens, foods, drugs, chemicals, or Hymenoptera (such as wasps, bees and fire ants). Allergies manifest in numerous ways, including allergic asthma, allergic rhinoconjunctivitis, urticaria, eczema, and in its most severe form, anaphylaxis. This review contains 4 videos, 5 figures, 4 tables and 42 references Key Words: Delayed allergic reaction (Alpha-gal), Allergy diagnosis, Measurement of specific IgE, Allergy and asthma therapies, Anticytokine therapy (dupilumab, mepolizumab, reslizumab), AntiIgE therapy (omalizumab), Allergy skin testing, Basophil histamine release assay

scholarly journals Association Between Allergen Sensitization and Anaphylaxis in Patients Visiting a Pediatric Emergency Department

2021 ◽  
Vol 9 ◽  
Author(s):  
Won Seok Lee ◽  
Lily Myung-Jin Cha ◽  
Man Yong Han ◽  
Kyung Suk Lee
Keyword(s):  
Immunoglobulin E ◽  
Allergic Sensitization ◽  
Pediatric Emergency ◽  
Allergen Sensitization ◽  
Severe Anaphylaxis ◽  
Specific Immunoglobulin E ◽  
Specific Immunoglobulin ◽  
Facial Edema ◽  
Inhalant Allergens ◽  
Symptoms And Signs

Background and Objectives: Anaphylaxis, a severe allergic disease, can be triggered by various causes. This study investigated the association between allergic sensitization and anaphylactic symptoms and the severity of anaphylaxis in children.Patients and Methods: A retrospective review of 107 pediatric patients with anaphylaxis was performed between January 1, 2015, and December 31, 2017; 74 patients underwent allergen testing for specific immunoglobulin E. Allergic sensitizations and associations with anaphylactic symptoms and severity were investigated.Results: Overall, 64 (86.5%) patients were sensitized to food or inhalant allergens. In children under 2 years of age, 90.5% were sensitized to food (P = 0.001); in those over 6 years of age, 84.6% were sensitized to inhalant allergens (P = 0.001). Milk sensitization was significantly associated with severe anaphylaxis (P = 0.036). The following symptoms showed significant associations with certain allergen sensitizations: facial edema with food; wheezing with milk; dyspnea with mite, etc. Certain allergen sensitizations presenting as risk factors for anaphylactic symptoms: wheat (adjusted odds ratio [aOR] = 4.644, P = 0.044) and nuts (aOR=3.614, P = 0.041) for wheezing, nuts (aOR=5.201, P = 0.026) for dyspnea, and milk (aOR=4.712, P = 0.048) for vomiting.Conclusion: The allergen sensitization status differed according to the age of the children experiencing anaphylaxis. The severity, symptoms, and signs of anaphylaxis differed depending on the allergen sensitization status.

scholarly journals Laboratory screening test with inhalant and food allergens in atopic Brazilian children and adolescents: a performance

2021 ◽  
Vol 49 (5) ◽  
pp. 42-48
Author(s):  
Ana Carolina Rozalem-Reali ◽  
Felipe Faria Pierotti ◽  
Aranda Carolina ◽  
Renata Rodrigues Cocco ◽  
Emanuel Cavalcanti Sarinho ◽  
...  
Keyword(s):  
Children And Adolescents ◽  
Immunoglobulin E ◽  
Allergic Sensitization ◽  
Screening Method ◽  
High Sensitivity ◽  
Allergic Diseases ◽  
Cross Sectional Study ◽  
Food Allergens ◽  
Cross Sectional ◽  
Brazilian Children

The Phadiatop Infant® (PhInf) is a panel developed to assess allergic sensitization (immunoglobulin E [IgE]) in children aged <5 years and combines inhalant and food allergens. The test has not been evaluated outside Europe. This is a cross-sectional study conducted at 11 pediatric allergy centers to evaluate PhInf as an allergic disease screening method in Brazilian children. Children as controls and patients (aged 6 months–18 years) were grouped according to their primary disease and age group. PhInf and specific serum IgE (sIgE) screening was performed for Dermatophagoides pteronyssinus (DP), cat and dog epithelia, a mix of grasses and pollens, eggs, cow’s milk, peanuts, and shrimp. Values ≥ 0.35 kUA/L (or PAU/L) were considered positive. A total of 470 children and adolescents, which included 385 patients and 85 controls, participated in the study (47.7% boys, average age: 6.3 years). In all, 72.6% of the participants had positive PhInf test (n = 341), with a higher proportion of those having food allergy (92.6%), atopic dermatitis (91.9%), and those aged >13 years having allergy (95%). The PhInf and sIgE agreement between patients (Kappa = 0.94, P < 0.001) and controls (Kappa = 0.84, P < 0.001) was high. PhInf and DP agreement in patients aged >13 years was excellent (Kappa = 0.936, P < 0.001). Compared with sIgE dosage, PhInf had high sensitivity (97%) and specificity (93%). Positivity of PhInf test in this population was high and had an excellent correlation with the allergens comprising the panel. It is a useful method for screening children suspected of having allergic diseases in a non-European country.

scholarly journals The influence of acetylsalicylic acid and alcohol on absorption kinetics of hen ́s egg white in a human passive cutaneous anaphylaxis model

2021 ◽  
Author(s):  
Nicolaj Brandt ◽  
Esben Eller ◽  
Anja Pahlow Mose ◽  
Carsten Bindslev-Jensen ◽  
Charlotte Mortz
Keyword(s):  
Acetylsalicylic Acid ◽  
Immunoglobulin E ◽  
Egg White ◽  
Passive Cutaneous Anaphylaxis ◽  
Absorption Kinetics ◽  
Hen’S Egg ◽  
Specific Immunoglobulin E ◽  
Exercise Induced ◽  
Kinetics Of

Background: Despite the well-known fact that acetylsalicylic acid (ASA) can induce anaphylaxis in patients susceptible to wheat-dependent exercise-induced anaphylaxis, few studies have sought to investigate the effects of cofactors on type-1 food allergy and none with ASA and hen’s egg and hen’s egg and alcohol combined. Methods and results: We applied the experimental model of ‘passive cutaneous anaphylaxis’ in humans to study whether the absorption kinetics of egg white is altered while being treated with ASA or under the influence of alcohol. Donor sera from four egg allergic patients with specific immunoglobulin E (s-IgE) to ovalbumin (0.1–8.87–19.5–170 kUA/L) were injected intracutaneously into the forearm of 12 healthy volunteers who were then challenged separately to: 1) egg white 2) egg white + ASA and 3) egg white + alcohol. ‘Time to wheal’ and ‘wheal size’ were compared among the three experiments. We saw that ‘time to wheal’ with both ASA (P = 0.001) and alcohol (P = 0.019) added as cofactor significantly decreased compared with baseline. Conclusion: In this passive cutaneous anaphylaxis model, ASA and alcohol affected both reaction time and size of reactions elicited after egg ingestion. This suggests that patients with egg allergy could have faster and more severe reactions during ASA treatment or under alcohol influence.

scholarly journals Serum IgE Predicts Difference of Population and Allergens in Allergic Diseases: Data from Weifang City, China

2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
Zhang Xu-De ◽  
Guo Bei-Bei ◽  
Wang Xi-Juan ◽  
Li Hai-Bo ◽  
Zhang Li-Li ◽  
...  
Keyword(s):  
Immunoglobulin E ◽  
Allergic Inflammation ◽  
Allergic Diseases ◽  
Specific Ige ◽  
Serum Ige ◽  
Disease Spectrum ◽  
Positive Rate ◽  
Single Positive ◽  
Artemisia Pollen

Background. Immunoglobulin E (IgE) is the most important promoter of allergic inflammation. However, there are few systematic studies on IgE in age range, genders, disease spectrum, and time regularity. Aim. To screen the common allergens, allergen spectrum, and IgE difference between type 2 inflammatory allergic diseases and other allergic diseases in Weifang, China. Methods. A retrospective study was performed by estimating patients’ clinical data suffering from allergic diseases (urticaria, pollinosis, allergic rhinitis, atopic dermatitis, and bronchial asthma) between May 2019 and April 2020 using an allergen detection kit of Macro-Union Pharmaceutical. Results. 732 of the 1367 patients showed different antigen positive, and the positive rate was 53.5%. The most common allergens were dust mites, mixed fungi, Artemisia pollen, cat/dog dander, and cockroaches. There were 27.0% (369/1367) of the patients with single positive allergen-specific IgE (sIgE), 26.5% (363/1367) with multiple-positive IgE. The total immunoglobulin E (tIgE) levels varied with gender, age, and type of disease. There was a difference in the distribution of allergens between children and adults. A positive correlation between the serum-specific IgE and the corresponding local inhaled allergen density was observed. Conclusions. In this study, we found that type 2 inflammatory allergic diseases have higher serum IgE and a higher probability of inhaled sIgE positive. According to age, gender, and condition, serological IgE detection of allergens provides new insight into the early diagnosis and prevention of allergic diseases.

Sequence-Based Identification of Allergen Proteins developed by Integration of PseAAC and Statistical Moments via 5-step Rule

2020 ◽  
Vol 15 ◽  
Author(s):  
Yaser Daanial Khan ◽  
Ebraheem Alzahrani ◽  
Wajdi Alghamdi ◽  
Malik Zaka Ullah
Keyword(s):  
Data Science ◽  
Immunoglobulin E ◽  
Allergic Sensitization ◽  
Allergic Diseases ◽  
New Drugs ◽  
Statistical Moments ◽  
Type I ◽  
Computer Scientists ◽  
Protein Functions ◽  
Fold Cross Validation

Background: Allergens are antigens that can stimulate an atopic type I human hypersensitivity reaction by an immunoglobulin E (IgE) reaction. Some proteins are naturally allergenic than others. The challenge for toxicologists is to identify properties that allow proteins to cause allergic sensitization and allergic diseases. The identification of allergen proteins is a very critical and pivotal task. The experimental identification of protein functions is a hectic, laborious and costly task; therefore, computer scientists have proposed various methods in the field of computational biology and bioinformatics using various data science approaches. Objectives: Herein, we report a novel predictor for identification of Allergen proteins. Methods: For feature extraction, statistical moments and various position-based features have been incorporated into Chou’s pseudo amino acid composition (PseAAC), and are used for training of a neural network. Results: The predictor is validated through 10-fold cross-validation and Jackknife testing, which gave 99.43% and 99.87% accurate results. Conclusions: Thus, the proposed predictor can help in predicting the Allergen proteins in an efficient and accurate way and can provide baseline data for the discovery of new drugs and biomarkers.

Efficacy of hyposensitization in feline allergic diseases based upon results of in vitro testing for allergen-specific immunoglobulin E

1997 ◽  
Vol 33 (3) ◽  
pp. 282-288 ◽  
Author(s):  
RE Halliwell
Keyword(s):  
Allergic Disease ◽  
Immunoglobulin E ◽  
Clinical Signs ◽  
Allergic Diseases ◽  
Dietary Change ◽  
In Vitro Tests ◽  
Similar Response ◽  
Specific Immunoglobulin E ◽  
Specific Immunoglobulin

A survey was undertaken to evaluate the responses to hyposensitization in cats for which a diagnosis of allergic disease was made by assessment of clinical signs and evaluation of allergen-specific immunoglobulin E (IgE) using the radioallergosorbent test (RAST). Eighty-one cases were available for analysis. In 39 cases, a dietary change resulted in some subjective improvement, which usually was minimal; however, some cases had significant improvement. In 75.3% of cases, an improvement of at least 50% was noted and ascribed to a combination of immunotherapy and dietary change, when implemented. The response of the 42 cases in which immunotherapy alone was used or where there was no response to dietary change was broadly similar. Response of the specific dermatological conditions ranged from 93.6% in the case of linear granuloma to 60% in cases where self-induced hair loss was evident. Response also was good in cases of presumed allergic asthma (86.1% improvement) and suspected allergic otitis externa (62.6% improvement). In nine patients, the hyposensitization was discontinued due to lack of response. The results suggest that confirmation of a suspected diagnosis of allergic disease in cats by means of in vitro tests and subsequent therapy with hyposensitization should be a major consideration in feline practice.

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