scholarly journals Vedolizumab-Induced Liver Injury

2020 ◽  
pp. 1-6
Author(s):  
Miguel Mascarenhas Saraiva ◽  
Tiago Ribeiro ◽  
Emanuel Dias ◽  
Joanne Lopes Lopes ◽  
Hélder Cardoso ◽  
...  
Keyword(s):  
Liver Injury ◽  
Low Dose ◽  
Complete Recovery ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
Post Marketing ◽  
Inflammatory Bowel ◽  
Immunomodulatory Therapies ◽  
Liver Tests ◽  
Probable Relation

Drug-induced liver injury is an important cause of acute liver injury. Immunomodulatory therapies, such as vedolizumab (VDZ), are being increasingly used for the treatment of several diseases, most importantly inflammatory bowel disease. Several studies have demonstrated the safety of this substance. To date, only one post-marketing study has reported a case of hepatotoxicity attributable to VDZ. The authors present the case of a 41-year-old woman followed at the gastroenterology outpatient clinic for ulcerative colitis (UC) and autoimmune hepatitis (AIH). This patient was being treated with low-dose glucocorticoids for AIH (prednisolone 10 mg), with adequate disease control. Additionally, she was being treated with oral salicylates (mesalamine 3 g/day) and oral budesonide (9 mg/day) for her UC. For uncontrolled UC, she was started on VDZ. Two weeks after the first infusion of VDZ, the patient developed a clinical and analytical phenotype compatible with acute hepatitis. Diagnostic workup for causes of hepatocellular liver injury retrieved no results. A liver biopsy corroborated the diagnosis of toxic hepatitis overlapping chronic liver disease. VDZ was withdrawn and the patient experienced complete recovery of liver tests over the following weeks. In this case report, we present the first post-marketing case of hepatocellular liver injury in probable relation to VDZ.

scholarly journals Simultaneous Detection of Drug-Induced Liver Injury Protein and microRNA Biomarkers Using Dynamic Chemical Labelling on a Luminex MAGPIX System

Analytica ◽  
2021 ◽  
Vol 2 (4) ◽  
pp. 130-139
Author(s):  
Antonio Marín-Romero ◽  
Mavys Tabraue-Chávez ◽  
Bárbara López-Longarela ◽  
Mario A. Fara ◽  
Rosario M. Sánchez-Martín ◽  
...  
Keyword(s):  
Liver Injury ◽  
Simultaneous Detection ◽  
Single Step ◽  
Qualitative And Quantitative Analysis ◽  
Serum Samples ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
Qualitative And Quantitative ◽  
Post Marketing ◽  
Mechanistic Basis

Drug-induced liver injury (DILI) is a potentially fatal adverse event and a leading cause for pre- and post-marketing drug withdrawal. Several multinational DILI initiatives have now recommended a panel of protein and microRNA (miRNA) biomarkers that can detect early liver injury and inform about mechanistic basis. This manuscript describes the development of seqCOMBO, a unique combo-multiplexed assay which combines the dynamic chemical labelling approach and an antibody-dependant method on the Luminex MAGPIX system. SeqCOMBO enables a versatile multiplexing platform to perform qualitative and quantitative analysis of proteins and miRNAs in patient serum samples simultaneously. To the best of our knowledge, this is the first method to profile protein and miRNA biomarkers to diagnose DILI in a single-step assay.

Genetic risk factors for drug-induced liver injury in rheumatoid arthritis patients using low-dose methotrexate

2013 ◽  
Vol 14 (1) ◽  
pp. 63-73 ◽  
Author(s):  
Cristina Lucía Dávila-Fajardo ◽  
Jesse J Swen ◽  
José Cabeza Barrera ◽  
Henk-Jan Guchelaar
Keyword(s):  
Rheumatoid Arthritis ◽  
Risk Factors ◽  
Liver Injury ◽  
Genetic Risk ◽  
Low Dose ◽  
Genetic Risk Factors ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
Dose Methotrexate

Liver injury associated with dimethyl fumarate in multiple sclerosis patients

2017 ◽  
Vol 23 (14) ◽  
pp. 1947-1949 ◽  
Author(s):  
Monica A Muñoz ◽  
Corrinne G Kulick ◽  
Cindy M Kortepeter ◽  
Robert L Levin ◽  
Mark I Avigan
Keyword(s):  
Multiple Sclerosis ◽  
Liver Injury ◽  
Health Professionals ◽  
Elevated Serum ◽  
Dimethyl Fumarate ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
Post Marketing ◽  
Clinically Significant ◽  
Multiple Sclerosis Patients

Background: In pre-approval trials, there was an increased incidence of mild, transient elevations of liver aminotransferases in study subjects treated with dimethyl fumarate (DMF). Objective/methods: To evaluate post-marketing cases of drug-induced liver injury associated with DMF. Results: We identified 14 post-marketing cases of clinically significant liver injury. Findings included newly elevated serum liver aminotransferase and bilirubin levels that developed as early as a few days after the first dose of DMF. The pattern of liver injury was primarily hepatocellular. No cases resulted in liver failure. Conclusion: Health professionals should be alerted to possible serious liver injury in patients receiving DMF.

scholarly journals Predicting drug-induced liver injury from anti-tuberculous medications by early monitoring of liver tests

2020 ◽  
Author(s):  
Benjamin Patterson ◽  
Aula Abbara ◽  
Simon Collin ◽  
Merle Henderson ◽  
Monicka Shehata ◽  
...  
Keyword(s):  
Liver Injury ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
Liver Tests

scholarly journals Efek pemberian metilprednisolon oral terhadap gambaran histopatologik hati tikus wistar (Rattus norvegicus)

2016 ◽  
Vol 4 (2) ◽  
Author(s):  
Muhammad Rifaldi ◽  
Poppy M. Lintong ◽  
Meilany F. Durry
Keyword(s):  
Liver Injury ◽  
Low Dose ◽  
Clinical Manifestations ◽  
Control Group ◽  
High Dose ◽  
Drug Induced ◽  
Treatment Groups ◽  
Drug Induced Liver Injury ◽  
Histopathological Features ◽  
Group B

Abstract: Drug-induced liver injury (DILI) is an adverse drug reaction which vary in its clinical manifestations, ranging from an asymptomatic increase in liver enzymes to fulminant hepatic failure. Several drugs can cause DILI, one of which is corticosteroid. Methylprednisolone (MT) is a kind of corticosteroid drug which is considered to be a safe drug and it is not believed to cause DILI and often used for the treatment of severe hepatitis. However, there are some reports of DILI in patients treated with high-dose MT. The objectives of this study was to determine the effect of oral administration of MT on liver’s histological changes of witar rats. This study was using 15 rats which were divided into 3 groups; 1 negative control group (group A) and 2 treatment groups (group B and group C). Group B was given a low-dose oral MT, 2 mg/day, while group C was given oral high-dose MT, 4 mg/day for 14 consecutive days. The results showed steatohepatitis features in both low-dose and high-dose MT administration groups. Histopathological features of both treatment groups are similar. Qualitatively, high-dose MT group showed worse histopathological features than the low-dose MT group. Conclusion: Administration of MT by 2mg/day and 4mg/day may induced steatohepatitis in wistar rat’s liver.Keywords: methylprednisolone, liver histopathological features Abstrak: Drug-induced liver injury (DILI) atau cedera hati akibat obat merupakan reaksi efek samping obat dengan manifestasi klinis yang beragam, mulai dari peningkatan enzim-enzim hati yang bersifat asimptomatik sampai dengan timbulnya gagal hati fulminan. Banyak obat-obatan yang dapat menyebabkan DILI, salah satunya adalah golongan kortikosteroid. Metilprednisolon (MT) adalah obat golongan kortikosteroid yang dianggap sebagai obat yang aman dan tidak diyakini dapat menyebabkan DILI, bahkan sering digunakan untuk terapi pasien hepatitis berat. Akan tetapi, beberapa klinisi melaporkan kasus DILI pada pasien-pasien yang diterapi dengan MT dosis tinggi. Penelitian ini bertujuan untuk mengetahui efek pemberian MT oral terhadap perubahan histologik hati tikus wistar. Jenis penelitian yang dilakukan adalah eksperimental laboratorik menggunakan 15 ekor tikus yang dibagi dalam 3 kelompok; 1 kelompok kontrol negatif (kelompok A) dan 2 kelompok perlakuan (kelompok B dan kelompok C). Kelompok B diberikan MT oral dosis rendah sebanyak 2 mg/hari sedangkan kelompok C diberikan MT oral dosis tinggi sebanyak 4 mg/hari setiap hari selama 14 hari berturut-turut. Hasil penelitian menunjukkan gambaran yang sama secara mikroskopik pada kedua kelompok perlakuan yaitu terjadinya steatohepatitis. Tetapi secara kualitatif, kelompok tikus yang mendapatkan MT dosis tinggi memberikan gambaran histopatologik yang lebih jelek dibandingkan kelompok yang diberi dosis rendah. Simpulan: Pemberian metilprednisolon dosis 2mg/hari dan dosis 4 mg/hari dapat mencetuskan terjadinya steatohepatitis pada hati tikus wistar. Kata kunci: metilprednisolon, gambaran histopatologik hati

scholarly journals Drug-Induced Liver Injury Caused by Kratom Use as an Alternative Pain Treatment Amid an Ongoing Opioid Epidemic

2019 ◽  
Vol 7 ◽  
pp. 232470961982616 ◽  
Author(s):  
Caroline Stokes Osborne ◽  
Amanda N. Overstreet ◽  
Don C. Rockey ◽  
Andrew D. Schreiner
Keyword(s):  
Liver Injury ◽  
Pain Treatment ◽  
Assessment Method ◽  
Alternative Methods ◽  
Opioid Epidemic ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
Extensive Evaluation ◽  
Loss Of Appetite ◽  
Liver Tests

Kratom ( Mitragyna speciosa) is a prevalent medicinal plant used mainly for the stimulant and analgesic properties provided through multiple alkaloid compounds. Over the past decade, use of kratom has increased despite the limited knowledge of toxicities and adverse side effects. With the current opioid epidemic, both patients and providers are seeking alternative methods to treat both addiction and pain control, and kratom as an alternative means of treatment has increasingly entered the mainstream. In this article, we present the clinical course of a 47-year-old male who developed fatigue, pruritus, and abnormal liver tests (with a mixed hepatocellular/cholestatic pattern) approximately 21 days after beginning kratom. After extensive evaluation including a negligible alcohol history, negative hepatitis serologies, and inconclusive imaging, the patient was diagnosed with drug-induced liver injury (DILI) caused by kratom. Nine months after his liver tests returned to normal, he took kratom again, and after a latency of 2 days, he developed fatigue, pruritus, and loss of appetite along with abnormal liver tests (with the same biochemical profile as previously), consistent with a positive rechallenge. We believe, through the use of the Roussel-Uclaf Causality Assessment Method and expert opinion, that this is a highly likely or definite example of kratom-induced DILI. With the gaining popularity of this drug, it appears that DILI may be an important complication of kratom for providers to recognize.

scholarly journals Drug-induced liver injury in inflammatory bowel disease: 1-year prospective observational study

2017 ◽  
Vol 23 (22) ◽  
pp. 4102 ◽  
Author(s):  
Tomas Koller ◽  
Martina Galambosova ◽  
Simona Filakovska ◽  
Michaela Kubincova ◽  
Tibor Hlavaty ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Liver Injury ◽  
Observational Study ◽  
Bowel Disease ◽  
Prospective Observational Study ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
Inflammatory Bowel
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