scholarly journals Histopathologic Evaluation of Intralabyrinthine Schwannoma

2020 ◽  
pp. 1-8
Author(s):  
Michael Bagattini ◽  
Alicia M. Quesnel ◽  
Christof Röösli
Keyword(s):  
Slow Growth ◽  
Complete Removal ◽  
Complete Resection ◽  
Lateral Semicircular Canal ◽  
Partial Removal ◽  
Intralabyrinthine Schwannoma ◽  
Crista Ampullaris ◽  
Histopathologic Evaluation ◽  
Histopathologic Analysis ◽  
Temporal Bones

<b><i>Objectives:</i></b> The aim of this study is to perform a histopathologic analysis of temporal bones with an intralabyrinthine schwannoma (ILS) in order to characterize its extension. <b><i>Methods:</i></b> Archival temporal bones with a diagnosis of sporadic schwannoma were identified. Both symptomatic and occult nonoperated ILS were included for further analysis. <b><i>Results:</i></b> A total of 6 ILS were identified, with 4 intracochlear and 2 intravestibular schwannomas. All intracochlear schwannomas involved the osseous spiral lamina, with 2 extending into the modiolus. The intravestibular schwannomas were limited to the vestibule, but growth into the bone next to the crista of the lateral semicircular canal was observed in 1 patient. <b><i>Conclusions:</i></b> Complete removal of an ILS may require partial removal of the modiolus or bone surrounding the crista ampullaris as an ILS may extend into these structures, risking damage of the neuronal structures. Due to the slow growth of the ILS, it remains unclear if a complete resection is required with the risk of destroying neural structures hindering hearing rehabilitation with a cochlear implant.

scholarly journals Intralesional polysulphated glycosaminoglycan as treatment of equine collagenase induced tendinitis: clinical, ultrasonographic and histopathologic evaluation

2004 ◽  
Vol 56 (6) ◽  
pp. 701-708 ◽  
Author(s):  
S. Marxen ◽  
J.C. Lacerda Neto ◽  
J.C. Canola ◽  
J.R.E. Moraes ◽  
G. Ribeiro
Keyword(s):  
Intralesional Injection ◽  
Control Groups ◽  
Beneficial Effects ◽  
Thoracic Limb ◽  
Superficial Digital Flexor Tendon ◽  
Histopathologic Evaluation ◽  
Intralesional Injections ◽  
Males And Females ◽  
Histopathologic Analysis ◽  
And Control

The effect of intratendineous injections of polysulphated glycosaminoglycan (PSGAG) as treatment of collagenase-induced tendonitis was studied. Two groups (GI and GII) of five Arabian horses each, males and females, two to six year-old, were submitted to experimental tendinitis of the superficial digital flexor tendon of the left thoracic limb by intratendineous injection of 1.0ml of collagenase (2.5mg/ml). Seven days after the induced-lesions were created, the horses of GI received five intralesional injections of 1.0ml (125mg) of PSGAG, every four days. Horses of GII received injections of saline in the same dose and rate. Clinical and ultrasonographic evaluations were performed periodically, during 150 days. All animals showed lameness, increased local pain, heat and swelling 24 hours after the injury was created. All signs, except to swelling, which remained visible by the end of the study, showed regression in all animals. Lesions of variable size, shape and position were evidenced by the ultrasonographic evaluation, reaching maximum severity between the seventh and the 23rd days. By the end of the study, the echogenicity grade ranged from 1 to 2, and the grade of fiber alignment from 0 to 2. The histopathologic analysis demonstrated repair areas with intense fibroplasia and neovascularization, collagen fibers poorly organized, and thickened hypercellular endotenon. The data of this study did not show significant differences between the treated and control groups, therefore leading to the conclusion that the intralesional injection of PSGAG did not have beneficial effects in the treatment of collagenase-induced tendinitis.

scholarly journals Histopathologic Analysis of Pancreaticoduodenectomy Specimen

2016 ◽  
Vol 55 (204) ◽  
pp. 79-85
Author(s):  
Ramesh Dhakhwa ◽  
Neeta Kafle
Keyword(s):  
Pancreatic Adenocarcinoma ◽  
Perineural Invasion ◽  
Surgical Margin ◽  
College Teaching ◽  
Distal Cholangiocarcinoma ◽  
Medical College ◽  
Periampullary Neoplasms ◽  
Significant Difference ◽  
Histopathologic Evaluation ◽  
Histopathologic Analysis

Introduction: Whipple’s Pancreaticoduodenectomy has increasingly been used as an appropriate resectional procedure for tumors of the periampullary region which are pancreatic, periampullary, ampullary and biliary tumors. Our aim was to study the distribution and histopathologic features of these tumors and to examine local trends of periampullary neoplasms resected with a PD.Methods: A descriptive study was conducted in the department of Pathology, Kathmandu Medical College Teaching Hospital from July 2013 to June 2016.Results: Thirty five patients underwent Whipple’s Pancreaticoduodenectomy procedure during a period of 36 months from July 2013 to June 2016. Malignant tumor was present in 31 (88.57%) cases where as four cases (11.43%) harboured benign lesions. Periampullary mixed carcinoma was the predominant tumor (34.28%) followed by periampullary duodenal (20%), ampullary (14.28%), pancreatic adenocarcinoma (11.42%) and distal cholangiocarcinoma (5.71%). There was no significant difference in tumor size among periampullary, ampullary, pancreatic and biliary carcinomas. Ampullary carcinomas were predominantly well differentiated (80%) where as the other tumors were mostly moderately differentiated. Lymphovascular and perineural invasion varied in different tumor types. Four pancreatic adenocarcinomas showed lymphovascular and perineural invasion. Adequate surgical margin clearance was achieved in most of the cases except in one case each of periampullary duodenal carcinoma and distal cholangiocarcinoma and two cases of pancreatic adenocarcinoma..Conclusions: Pancreaticoduodenectomy specimen requires thorough histopathological evaluation. Pathologists should also be aware of possibility of a benign diagnosis in PD specimens which have been resected presuming malignancy based on clinical judgement and radiological data. Keywords: histopathologic evaluation, pancreaticoduodenectomy, periampullary carcinoma. | PubMed

Studies on Human Onchocerciasis and Simulium in Nyanza Province, Kenya

1951 ◽  
Vol 25 (3-4) ◽  
pp. 213-222 ◽  
Author(s):  
J. J. C. Buckley
Keyword(s):  
Adult Population ◽  
Complete Removal ◽  
Steady Increase ◽  
First Year ◽  
Partial Removal ◽  
Nyanza Province ◽  
The Third ◽  
Endemic Focus ◽  
Second Year

1. An experiment in bush-clearing was carried out at a small endemic focus of onchocerciasis in South Kavirondo district with a view to observing its effect on the adult population of S. neavei.2. The clearing consisted of the complete removal of undergrowth and partial removal of trees, from the banks of fly-infested portions of two confluent rivers, the Riana and the Yabe.3. In the first year of the experiment the clearing was carried out on the infested section of the Riana River, after which there was a decrease in the incidence of S. neavei on this section compared with that on the uncleared Yabe River.4. In the second year a similar clearing was effected on the infested section of the Yabe River, after which the S. neavei incidence on both sections came together again and during the third year showed a steady increase.

A memory system in Octopus vulgaris Lamarck

1955 ◽  
Vol 143 (913) ◽  
pp. 449-480 ◽  
Keyword(s):  
Optic Lobe ◽  
Complete Removal ◽  
Frontal Lobes ◽  
Octopus Vulgaris ◽  
Partial Removal ◽  
Retinal Surface ◽  
Optic Lobes ◽  
Neural Activities ◽  
Inhibitory Region ◽  
Set Up

An octopus that has attacked a crab shown with a square and received a shock rapidly learns not to attack when this situation appears again, while continuing to attack crabs shown alone. The memory preventing attack on crabs shown with a white square may last for 2 or 3 days if the crab and square are not shown during that period. If the situation is shown three times a day the memory may last for 6 days or longer. The memory is not erased by anaesthesia nor by electrical stimulation of the supra-oesophageal lobes. After complete removal of the vertical lobe, or of the medial superior frontal lobe, or section of the tract between the two, the memory preventing attack is lost and cannot again be acquired. Animals operated in this way attack a crab and square if shown at 2-hourly intervals in spite of the numerous shocks they receive. A transitory memory lasting a few minutes can still be set up if the frequency of presentation is increased to about once every 5 min. Partial removal of the vertical lobe system does not interrupt the memory. A memory set up by the use of one eye is not abolished if the optic lobe of that side is later removed. The memory is not interrupted by slashes in both optic lobes. After lesions to the lateral parts of the superior frontal lobes an octopus makes few or no further attacks on crabs, unless these are placed close to the animal. The effect of such an operation is to upset the balance of central neural activities in such a way that a region responsible for inhibiting attacks on distant objects assumes control. This inhibitory region may be the first subvertical lobe, whose action is normally balanced by the lateral superior frontal lobes and the vertical lobe. The tangle of fibre bundles within the optic lobes allows for a wide degree of interaction between impulses arriving from different parts of the retinal surface. In addition, these lobes receive afferent fibres from the arms. They thus provide a system within which associations between given sets of inputs can be set up in such a way as to ensure that there is no attack when a similar set of inputs occurs again. Further plexiform arrangements are found in the pathway from the optic to the superior frontal lobes and from the latter to the vertical lobe. These plexuses make possible the interaction in each succeeding lobe of impulses arriving from distant parts of the preceding lobe. Each lobe can thus serve to record the pattern of associations present in the previous one. Since the arrangement is circular the pattern originating in the optic lobe is then re-presented back to it. It is suggested that the vertical lobe system serves to prolong memories set up in the optic lobes by re-presenting them from within, and thus allowing them to persist for long enough to produce some change of a more permanent nature.

scholarly journals Peculiarities of clinical manifestations of perilymphatic fistulas and evaluation of the effectiveness of treatment in patients with middle ear cholesteatoma

2021 ◽  
pp. 23-30
Author(s):  
Ilona A. Srebniak ◽  
Olga V. Sherbul-Trokhymenko ◽  
Anastasia E. Pedachenko
Keyword(s):  
Clinical Manifestations ◽  
Chronic Otitis Media ◽  
Semicircular Canals ◽  
Good Time ◽  
Early Exposure ◽  
Lateral Semicircular Canal ◽  
Membranous Labyrinth ◽  
Perilymphatic Fistula ◽  
Middle Ear Cholesteatoma ◽  
Temporal Bones

By the analysis of the 410 histories of illnesses of patients in 38 (9,26 %) are set perilymphatic fistula of different localization. Clinical, radiological intraoperative differences and going are set near the choice of method reconstructively operation depending on the type of perilymphatic fistula. After motion the extensive is certain more aggressive perilymphatic fistula is widespread, especially in the cases of cholesteatoma destruction of bone wall of labyrinth and simultaneous adhesion with a membranous labyrinth. On the stage of preoperative diagnostics from data of КТ of temporal bones of perilymphatic fistula set for 21 (55,3 %) patients and determined almost for all patients with extensive widespread perilymphatic fistula (in 12 patients from 13) and in 9 patients with limit perilymphatic fistula. By the preoperative inspection the positive test of fistula was determined only in 7 % patients. After localization more often perilymphatic fistula was determined at the level of lateral semicircular canal – for 23 patients (60,5 %). Plural localization of perilymphatic fistula with the united defeat of bone wall two and more semicircular canals educed 5 patients (13,1 %). The open variant of tympanoplasty is executed in 30 patients (78,9 %). The closed variant of tympanoplasty is in 6 (15,8 %) patients. Early exposure of perilymphatic fistula after the presence of not staggered endost and in good time reconstructive surgical interference is conducted with optimal combined by microscopically-endoscopic visualization for patients with chronic otitis media with cholesteatome will allow saving a rumor and will prevent development of irreversible complications from the side of internal ear.

Effect of thermal energy produced by drilling on the facial nerve: histopathologic evaluation in guinea pigs

2005 ◽  
Vol 119 (8) ◽  
pp. 600-605 ◽  
Author(s):  
Asim Aslan ◽  
H Seda Vatansever ◽  
Gulay Guclu Aslan ◽  
Gorkem Eskiizmir ◽  
Gulsen Giray
Keyword(s):  
Facial Nerve ◽  
Thermal Energy ◽  
Guinea Pigs ◽  
Control Group ◽  
Temperature Changes ◽  
Bony Canal ◽  
Before And After ◽  
Histopathologic Evaluation ◽  
Temporal Bones ◽  
Oxide Synthase

The effect of thermal energy due to drilling around the facial nerve canal on the facial nerve was histopathologically evaluated in four guinea pigs. The bony canal of the facial nerve was drilled using a 3mm diamond burr for one minute. The temperature changes on the facial nerve canalwere noted before and after dissection. The temporal bones of the animals were histopathologically examined under light microscopy using haematoxylin & eosin (H&E) and solochrome cyanine staining for myelin, and immunohistochemical staining for neuronal nitric oxide synthase (nNOS). Compared to the control group, it was observed with H&E staining that there was oedema among the axonal fibres and with solochrome cyanine staining that the thickness of the myelin fibres was decreased, and that the severity and extent of nNOS activity was decreased in the axonal fibres. It was concluded that a temperature increase on the facial canal may potentially lead to inflammation of the nerve, and may also cause deterioration of nerve conduction to some extent.

Complete removal of an intraspinal and extraspinal cervical chordoma in one stage using the lateral approach

2006 ◽  
Vol 5 (5) ◽  
pp. 471-475 ◽  
Author(s):  
Cédric Barrey ◽  
Ghislaine Saint-Pierre ◽  
Didier Frappaz ◽  
Marc Hermier ◽  
Carmine Mottolese
Keyword(s):  
Histopathological Examination ◽  
Complete Removal ◽  
Radicular Pain ◽  
Lateral Approach ◽  
Complete Resection ◽  
Resonance Imaging ◽  
Postoperative Course ◽  
One Stage ◽  
Cervical Chordoma ◽  
Posterior Anterior

✓The authors describe a precise surgical technique in which a large intraspinal and extraspinal, multivertebral, cervical chordoma was completely removed in one stage using the lateral approach. The patient in this case was a 29-year-old woman who presented with signs of radicular pain in the left C-3 area. Computed tomography and magnetic resonance imaging demonstrated a large intra- and extraspinal multivertebral tumor from C-2 to C-5, a finding that suggested a cervical chordoma. The tumor was completely removed in one stage using the lateral approach while controlling the vertebral artery (VA), and a partial corporectomy of C2–5 was also performed. Results from a postoperative histopathological examination confirmed that the tumor was a typical chordoma. The patient’s postoperative course was uneventful. Cervical chordomas are typically excised using a posterior–anterior surgical approach with partial resection of the tumor. The lateral approach was appropriate in this patient for complete resection in one stage, because it enabled the surgeons to control the VA and access both extraspinal and intraspinal components of the chordoma.

Transection and Occlusion of Lateral Semicircular Canal in Guinea Pigs

1997 ◽  
Vol 106 (12) ◽  
pp. 1082-1086 ◽  
Author(s):  
Boo Hyun Nam ◽  
Seong Ki Yoon ◽  
Chan Il Park
Keyword(s):  
Semicircular Canal ◽  
Guinea Pigs ◽  
The Other ◽  
Histopathologic Examination ◽  
Threshold Elevation ◽  
Lateral Semicircular Canal ◽  
Profound Hearing Loss ◽  
Lateral Canal ◽  
Auditory Brain Stem ◽  
Temporal Bones

Audiologic and histopathologic examinations were made after occlusion of the lateral semicircular canal in eight guinea pigs. The lateral semicircular canal was drilled out, and then the canal lumens were plugged with muscle pieces. After a serial recording of auditory brain stem responses for 2 months, histologic specimens of the temporal bones were prepared in the lateral semicircular canal plane. One animal developed profound hearing loss due to suppurative labyrinthitis. The other seven animals showed no significant threshold elevation during this period. Histopathologic examination revealed that the bone defect on the lateral canal was replaced with newly formed bone; the perilymphatic and endolymphatic spaces maintained their compartmentalization; and the membranous endolymphatic canal healed to form complete blind ducts. These findings suggest that proper management of the injured semicircular canal is important for maintenance of postoperative hearing.

scholarly journals A Case of Elastography-Assisted Laparoscopic Fertility Preservation for Severe Deep Endometriosis Causing Ureteral Stenosis and Subtype II Adenomyosis

Endocrines ◽  
2021 ◽  
Vol 2 (3) ◽  
pp. 348-355
Author(s):  
Yoshiaki Ota ◽  
Kuniaki Ota ◽  
Toshifumi Takahashi ◽  
Yumiko Morimoto ◽  
So-Ichiro Suzuki ◽  
...  
Keyword(s):  
Transvaginal Ultrasound ◽  
Complete Removal ◽  
Posterior Wall ◽  
Complete Resection ◽  
Reproductive Age ◽  
High Recurrence Rate ◽  
Ureteral Stenosis ◽  
Deep Endometriosis ◽  
Pouch Of Douglas ◽  
Residual Lesions

Adenomyosis is commonly treated by total hysterectomy. Adenomyomectomy is considered for women of reproductive age who wish to preserve their fertility. However, a high recurrence rate following adenomyomectomy has been reported because complete removal of the lesion is difficult, and uterine rupture during pregnancy remains a complication. We previously reported that laparoscopic adenomyomectomy using a cold knife prevented thermal damage to the myometrium and elastography to avoid residual lesions. Here, we report the case of a patient who underwent complete resection of a subtype II adenomyosis and resection of deep endometriosis (DE) with the closure of the pouch of Douglas. The patient was 31 years old, had severe dysmenorrhea, and had left ureteral stenosis and subtype II adenomyosis associated with the closure of the pouch of Douglas by the DE. After resection of the DE posterior wall adenomyosis, residual lesions were confirmed by laparoscopic real-time elastography. Eight weeks after surgery, postoperative transvaginal ultrasound showed that the myometrium had shrunk from 28 to 22.7 mm, and the hydronephrosis had disappeared, although a stent remained necessary. In this study, we report the complete resection of subtype II adenomyosis and DE, combined with elastography to visualize the lesions during resection.

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