A ‘watch and wait’ strategy involving regular endoscopic surveillance is safe for many patients with small, sporadic, grade 1, non-ampullary, non-functioning duodenal neuroendocrine tumours

2020 ◽  
Author(s):  
Klaire Exarchou ◽  
Andrew R. Moore ◽  
Howard L. Smart ◽  
Carrie A. Duckworth ◽  
Nathan Howes ◽  
...  
Keyword(s):  
Neuroendocrine Tumours ◽  
Endoscopic Surveillance ◽  
Watch And Wait ◽  
Duodenal Neuroendocrine Tumours

scholarly journals Survival and Disease Recurrence in Patients with Duodenal Neuroendocrine Tumours—A Single Centre Cohort

Cancers ◽  
2021 ◽  
Vol 13 (16) ◽  
pp. 3985
Author(s):  
Oddry Folkestad ◽  
Hans H. Wasmuth ◽  
Patricia Mjønes ◽  
Reidun Fougner ◽  
Øyvind Hauso ◽  
...  
Keyword(s):  
Overall Survival ◽  
Recurrence Rate ◽  
Surgical Resection ◽  
Endoscopic Treatment ◽  
Neuroendocrine Tumours ◽  
Disease Recurrence ◽  
Tumour Grade ◽  
Single Centre ◽  
Duodenal Neuroendocrine Tumours

Background: Duodenal neuroendocrine tumours (D-NETs) are rare but increasingly diagnosed. This study aimed to assess the overall survival and recurrence rate among patients treated for D-NETs. Methods: Patients with D-NETs were retrospectively reviewed with a median follow-up time of 4.8 years (range 0.0–17.2 years). Results: A total of 32 patients with median age 68.0 years were identified. Fifteen patients underwent surgery while ten patients underwent endoscopic treatment. Mean estimated overall survival for the entire population was 12.1 years (95% CI 9.5–14.7 years), while 5-year overall survival was 81.3%. Tumour grade G1 was associated with longer mean estimated survival compared to G2 tumours (13.2 years versus 4.4 years, p = 0.010). None of the 23 patients who underwent presumed radical endoscopic or surgical resection had disease recurrence during follow-up. Tumours <10 mm could be treated endoscopically whereas a high proportion of patients with tumours 10–20 mm should be considered for surgery. Conclusion: Patients with D-NETs had long overall survival, and mortality was more influenced by other diseases. Both endoscopic and surgical resections were effective as no recurrences were diagnosed during follow-up.

scholarly journals Disección endoscópica submucosa de tumor neuroendocrino primario de duodeno. Reporte de caso y revisión de la literatura

2020 ◽  
Vol 50 (2) ◽  
Author(s):  
Martín Edgardo Rojano Rodríguez ◽  
Elisafat Arce Liévano ◽  
Orlando Bada Yllán ◽  
Carlos Valenzuela Salazar ◽  
Roberto Délano Alonso ◽  
...  
Keyword(s):  
Endoscopic Resection ◽  
Neuroendocrine Tumours ◽  
Neuroendocrine Tumour ◽  
Low Frequency ◽  
Resection Margins ◽  
R0 Resection ◽  
Nodal Involvement ◽  
Mucosal Layer ◽  
Duodenal Neuroendocrine Tumours ◽  
Duodenal Carcinoid

Background. Duodenal neuroendocrine tumours are very rare, if they are limited to the mucosal layer and have no nodal involvement, endoscopic resection may be curative. Case report. We present the case of a Mexican 52 years old female with a duodenal neuroendocrine tumour who underwent successful endoscopic submucosal dissection with no complications. Pathology of the specimen revealed a complete R0 resection with negative resection margins. Endoscopic biopsies 4 weeks later showed no malignant cells. Conclusions. Because of their low frequency the management of primary duodenal carcinoid tumours is controversial; for tumours less than 1 cm endoscopic resection is recommended, for those bigger than 2 cm surgical resection is advised. Management of tumours between 1 and 2 cm is controversial and should be individualized.

scholarly journals A82 SUCCESSFUL RESECTION OF GRADE 1 DUODENAL NEUROENDOCRINE TUMOURS USING ENDOSCOPIC TECHNIQUES IN TWO CANADIAN HOSPITALS

2020 ◽  
Vol 3 (Supplement_1) ◽  
pp. 96-97
Author(s):  
N K Klemm ◽  
D Lu-Cleary ◽  
D Chahal ◽  
R Trasolini ◽  
E Lam ◽  
...  
Keyword(s):  
Literature Review ◽  
Endoscopic Resection ◽  
Neuroendocrine Tumours ◽  
Residual Disease ◽  
Duodenal Bulb ◽  
Muscularis Propria ◽  
Duodenal Perforation ◽  
En Bloc ◽  
Well Differentiated ◽  
Duodenal Neuroendocrine Tumours

Abstract Background Given the rarity of duodenal neuroendocrine tumours (dNETs), limited guidelines exist for resection of well-differentiated, ≤10 mm dNETS. As incidence rises, alternatives to surgery are valuable. We present 9 cases of endoscopic dNET resections and a literature review. Aims To demonstrate efficacy and safety of endoscopic resection for dNETs ≤10 mm at 2 Canadian hospitals. Methods We retrospectively analyzed data on 7 patients that had endoscopic dNET resection from 2013–2018. Endoscopic resection occurred if dNETs were ≤10 mm in diameter, did not extend to the muscularis propria and lymphovascular invasion was absent. WHO 2017 classification was used. Results All patients had biopsies and 5 (71%) had EUS prior to resection; 4 females and 3 males underwent resection of 9 dNETs; 2 via cap-assisted snare polypectomy; 4 with cap-assisted band mucosectomy; and 2 over-the-scope clip-assisted resection. The median size was 10 mm (4–11); 6 (67%) dNETS were found in the duodenal bulb, 2 at the D1/D2 junction and 1 in D2 alone. The median age was 68.5 (50–79) years. All dNETs were submucosal and well-differentiated. The dNETs were resected en bloc, but 3 did not have clear margins. Two procedures were complicated by duodenal perforation; 1 requiring surgery and 18 days in hospital. One case was complicated by bleeding with successful endoscopic hemostasis. The majority (75%) of resections were day procedures. Patients were followed for 6–12 months with an EGD or chromogrannin A. None of the patients had endoscopic residual disease, but 1 patient required a second procedure to remove a dNET left in situ following the initial resection of 2 dNETs 12 months earlier. In our literature review of 178 patients, the majority of dNETs were resected by EMR 81% (150/185) versus ESD, similar to our experience. Patients were slightly younger with a mean age of 63.28, and most dNETs (46%) were found in the duodenal bulb. Complications included intraoperative bleeding, perforation and death in 17 (9.55%), 9 (5.06%) and 1 (0.06%) patient(s) respectively. The rate of recurrence was 4/178 (2.25%) and patients had a mean follow up of 26.1 months. Conclusions Well-differentiated dNETs ≤10 mm in diameter can be successfully resected endoscopically. Complications can be managed intraoperatively and hospital stay remains minimal. Funding Agencies None

The spectrum and classification of gastric and duodenal neuroendocrine tumours

1995 ◽  
Vol 2 (1) ◽  
pp. 10-14 ◽  
Author(s):  
G. Klöppel ◽  
Ph.U. Heitz ◽  
C. Capella ◽  
E. Solcia
Keyword(s):  
Neuroendocrine Tumours ◽  
Duodenal Neuroendocrine Tumours

Endoscopic management and outcomes of gastro-duodenal neuroendocrine tumours

2019 ◽  
Author(s):  
Alexandra Victor ◽  
Michail Pizanias ◽  
Shraddha Gulati ◽  
Nishmi Gunasingham ◽  
John Keith Ramage ◽  
...  
Keyword(s):  
Neuroendocrine Tumours ◽  
Endoscopic Management ◽  
Duodenal Neuroendocrine Tumours

Gastric and Duodenal Neuroendocrine Tumours

2018 ◽  
pp. 455-465
Author(s):  
Asim Shabbir ◽  
Jimmy So ◽  
Hrishikesh Salgaonkar
Keyword(s):  
Neuroendocrine Tumours ◽  
Duodenal Neuroendocrine Tumours

scholarly journals Tu1516 SUCCESSFUL RESECTION OF GRADE 1 DUODENAL NEUROENDOCRINE TUMOURS USING ENDOSCOPIC TECHNIQUES IN TWO CANADIAN HOSPITALS.

2020 ◽  
Vol 91 (6) ◽  
pp. AB599-AB600
Author(s):  
Natasha K. Klemm ◽  
Destiny Lu-Cleary ◽  
Daljeet Chahal ◽  
Roberto Trasolini ◽  
Eric Lam ◽  
...  
Keyword(s):  
Neuroendocrine Tumours ◽  
Endoscopic Techniques ◽  
Duodenal Neuroendocrine Tumours

Outcomes of Surgical and Endoscopic Resection of Duodenal Neuroendocrine Tumours (NETs): a Systematic Review of the Literature

2018 ◽  
Vol 22 (9) ◽  
pp. 1652-1658 ◽  
Author(s):  
Bobby V. M. Dasari ◽  
Sarah Al-Shakhshir ◽  
Timothy M. Pawlik ◽  
Tahir Shah ◽  
Ravi Marudanayagam ◽  
...  
Keyword(s):  
Systematic Review ◽  
Endoscopic Resection ◽  
Neuroendocrine Tumours ◽  
Review Of The Literature ◽  
Duodenal Neuroendocrine Tumours
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