Eruptive Cherry Angiomas and Skin Melanoma: Further Insights into an Intriguing Association

Dermatology ◽  
2020 ◽  
pp. 1-7
Author(s):  
Alessandro Borghi ◽  
Emi Dika ◽  
Elisa Maietti ◽  
Valeria Scuderi ◽  
Riccardo Forconi ◽  
...  
Keyword(s):  
Risk Factors ◽  
Multiple Logistic Regression Analysis ◽  
Cross Sectional Study ◽  
Endothelial Cell Proliferation ◽  
Cross Sectional ◽  
Malignant Skin ◽  
Melanocytic Naevi ◽  
The One ◽  
Heterogeneous Variables ◽  
Strength Of Association

<b><i>Background:</i></b> Some risk factors for malignant melanoma (MM) are recognized. <b><i>Objective:</i></b> To compare the strength of association between MM and eruptive cherry angiomas (CAs) with that of other well-known associations. <b><i>Methods:</i></b> This cross-sectional study included all subjects referred to the Outpatient Dermatology-Oncology and Dermoscopy Units of the Universities of Ferrara and Bologna, Italy, over a 5-month period and submitted to total body skin examination. We recorded: age, sex, cutaneous and non-cutaneous malignancies, presence of CAs, arbitrarily considered as “eruptive” when &#x3e;10, &#x3e;40 common melanocytic naevi or &#x3e;2 clinically atypical naevi. The strength of association between the possible risk factors and MM was calculated by odds ratio in both the whole population and age quartiles. Variables associated with MM were included in multiple logistic regression analysis. <b><i>Results:</i></b> 1,190 subjects were included; 615 had malignant skin tumours, 462 MM, 85 extracutaneous tumours. Five hundred and eighty-seven subjects had eruptive CAs, 485 subjects &#x3e;40 melanocytic naevi and 368 more than 2 atypical melanocytic naevi. Eruptive CAs, especially in subjects younger than 70, and &#x3e;2 atypical melanocytic naevi, mostly in subjects older than 50, were significantly associated with MM. The strength of these 2 associations was similar. The presence of &#x3e;40 melanocytic naevi was not associated with MM. <b><i>Conclusions:</i></b> These findings confirmed an association between MM and eruptive CAs, which was as strong as the one between MM and &#x3e;2 atypical melanocytic naevi. CAs seem an intriguing model of interaction between heterogeneous variables, like immunocompetence, stimuli inducing endothelial cell proliferation, and oncogenesis, which deserves further investigation.

scholarly journals Risk factors for monoinfections and coinfections with HIV, hepatitis B and hepatitis C viruses in northern Spanish prisoners

1999 ◽  
Vol 123 (1) ◽  
pp. 95-102 ◽  
Author(s):  
J. PALLÁS ◽  
C. FARIÑAS-ÁLVAREZ ◽  
D. PRIETO ◽  
J. LLORCA ◽  
M. DELGADO-RODRÍGUEZ
Keyword(s):  
Risk Factors ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Northern Spain ◽  
Cross Sectional ◽  
Independent Variables ◽  
Sexual Behaviours ◽  
Hepatitis C Viruses ◽  
Hcv Coinfection ◽  
Strength Of Association

A cross-sectional study was conducted in prisons of Cantabria (northern Spain) from June 1992 to December 1994. Inmates were asked to participate in a survey on prevalence and risk factors for monoinfections and coinfections with HIV, HBV and HCV. Crude and multiple odds ratios of risk factors were calculated (by polychotomous logistic regression). Prevalence of coinfections was higher than that of monoinfections. IDU risk factors were the main independent variables associated with monoinfections and coinfections with these agents. The strength of association increased with the degree of coinfection for IDU risk factors and penal status, e.g. duration of injecting drug use for more than 5 years yielded an adjusted OR ranging from 1·3 (95% CI: 0·4–5·1) for HBV monoinfection to 180 (95% CI: 61·0–540·0) for HIV–HBV–HCV coinfection. In comparison, sexual behaviours were less important than IDU risk factors.

scholarly journals Hepatitis E virus seroprevalence and associated risk factors in high-risk groups: A cross-sectional study from Turkey

2021 ◽  
Author(s):  
H. Yasemin Balaban ◽  
Abdullah Tarık Aslan ◽  
Fatma Nur Akdoğan Kittana ◽  
Alpaslan Alp ◽  
Osman Dağ ◽  
...  
Keyword(s):  
Risk Factors ◽  
Hepatitis E Virus ◽  
Multiple Logistic Regression Analysis ◽  
Hepatitis E ◽  
Cross Sectional Study ◽  
Transplant Recipients ◽  
Sectional Study ◽  
Cross Sectional ◽  
Independent Risk Factors ◽  
Undercooked Meat

AbstractBackgroundThe renal transplant recipients (RT), allogeneic hematopoietic stem cell transplant recipients (allo-HSCT), patients with acute hepatitis (AH), and chronic hepatitis C patients (CHC) are at risk of hepatitis E virus (HEV) infection. However, seroepidemiology, risk factors to HEV exposure, and the prevalence of HEV viremia has not yet been investigated among these patients in Turkey.Materials&MethodsIn this cross-sectional study, 292 consecutive serum samples were tested for HEV immunoglobulin IgG/IgM and HEV RNA using commercial ELISA and in-house nested PCR with Sanger sequencing, respectively. Sociodemographic, clinical, laboratory data, and risk factors were collected using a questionnaire and hospital database. Multiple logistic regression analysis was employed to identify independent predictors for anti-HEV seropositivity.ResultsAmong all patients (n=292) tested for HEV RNA reactivity, only 2 patients (one RT recipient and one patient with AH) were identified as having HEV3 viremia. HEV viremia rate was 0.6% in whole group. These patients had shown no signs of chronic HEV infection for 6 months and was found to spontaneously seroconverted 6 months after enrollment. Anti-HEV IgG was positive in 29 patients yielding an HEV seroprevalence of 9.9%. Older age (aOR:1.03, 95% CI, 1.00-1.06; p:0.022) and eating undercooked meat (aOR:3.11, 95% CI, 1.08-8.92; p:0.034) were independent risk factors to anti-HEV seropositivity in all patients. Similarly, multiple logistic regression analysis demonstrated that age (aOR:1.03, 95% CI, 0.99-1.07, p:0.058) and eating undercooked meat (aOR:5.77, 95% CI, 1.49-22.25, p:0.011) were independent risk factors for anti-HEV IgG positivity in the non-immunosuppressive subgroup consisting of AH and CHC patients.ConclusionThe HEV seroprevalence rate was high (9.9%), despite low viremia rate (0.6%) in high-risk patients. The emergence of HEV3 might indicate a serious problem for these patients. Future investigations are needed to elucidate foodborne transmission routes of HEV in Turkey.

scholarly journals Prevalence and Risk Factors of Bovine Tuberculosis in Cattle in Mymensingh Sadar

2014 ◽  
Vol 12 (2) ◽  
pp. 179-183 ◽  
Author(s):  
MAH Mondal ◽  
MS Parvin ◽  
SC Sarker ◽  
AKMA Rahman ◽  
MT Islam
Keyword(s):  
Risk Factors ◽  
Logistic Regression ◽  
Bovine Tuberculosis ◽  
Multiple Logistic Regression Analysis ◽  
Herd Size ◽  
Cross Sectional Study ◽  
Multiple Logistic Regression ◽  
Cross Sectional ◽  
Test Kit ◽  
Associated Risk Factors

Bovine tuberculosis (bTB) is a disease of zoonotic importance as well as high priority all over the world. Risk factors for bovine tuberculosis in cattle are not well investigated in Bangladesh. Therefore, the objective of this study was to identify the associated risk factors for bTB along with determination of prevalence in cattle of Mymensingh Sadar. A cross-sectional study was carried out to elucidate on 101 cattle from 56 households during January to May 2012. The direct interview using a questionnaire and physical examination of cattle was performed to collect farm and animal level data. Besides data collection, blood samples were collected from study cattle and subjected to immunochromatographic assay (ICGA) by using Anigen Rapid Bovine TB Ab test kit for the diagnosis of bTB. Risk factors analysis was done using bivariable followed by multiple logistic regression with stepwise backward elimination method. The results of the study revealed an overall tuberculosis prevalence of 5.9%. Multiple logistic regression analysis revealed significant association of bovine tuberculosis with herd size (more than 4) (Odds Ratio, OR = 5.9, p = 0.03) and history of coughing (OR = 8.9, p = 0.005). The effect of herd size (more than 4) could be minimized by maintaining the cattle in a herd with adequate floor space and better ventilation facilities as it would not be practicable to keep the herd size minimum. Further study should be done to find out more associated risk factors for the occurrence of bTB.DOI: http://dx.doi.org/10.3329/bjvm.v12i2.21283 Bangl. J. Vet. Med. (2014). 12 (2): 179-183 

scholarly journals Prevalence and risk factors for pterygium: a cross-sectional study in Han and Manchu ethnic populations in Hebei, China

BMJ Open ◽  
2019 ◽  
Vol 9 (2) ◽  
pp. e025725 ◽  
Author(s):  
Zhouxian Pan ◽  
Jiantao Cui ◽  
Guangliang Shan ◽  
Yuyu Chou ◽  
Li Pan ◽  
...  
Keyword(s):  
Risk Factors ◽  
Risk Factor ◽  
Multiple Logistic Regression Analysis ◽  
Cross Sectional Study ◽  
Hebei Province ◽  
Premature Menopause ◽  
Cluster Sampling ◽  
Sectional Study ◽  
Cross Sectional ◽  
Significant Difference

AimsTo investigate the prevalence, ethnic differences and associated risk factors for pterygium in Han and Manchu populations aged 40–79 years in Hebei province, China.DesignCross-sectional study, as a part of the China National Health Survey.SettingHebei province, China.ParticipantsA multistage cluster sampling method with urbanisation level-based stratification was used to select participants for this study. A total of 4591 individuals over 40 years were recruited for this study. Inclusive criteria: (1) residents who had been living in Hebei for more than 1 year; (2) Han individuals with both parents being Han, or Manchu individuals with both parents being Manchu; (3) underwent ophthalmic examinations and (4) information in the questionnaire was complete.Main outcome measuresMultiple logistic regression analysis was used to evaluate the association between pterygium prevalence and factors of interest.ResultsA total of 3790 individuals (2351 Hans and 1439 Manchus) met the study criteria, of which 248 were diagnosed with pterygium (6.5%). There was no significant difference between the prevalence rates in Hans (6.2%) and Manchus (7.2%) (p=0.232). Multivariate analysis revealed that the risk factors for grade 2 or higher pterygium were increasing age (p<0.001) and rural residence (OR 1.83; 95% CI 1.11 to 3.02; p=0.018), while the protective factors include gender (female) (OR 0.58; 95% CI 0.37 to 0.88; p=0.011), cigarette smoking (OR 0.53; 95% CI 0.34 to 0.83; p=0.005) and myopia (OR 0.50; 95% CI 0.33 to 0.77; p=0.002). Premature menopause (OR 2.66; 95% CI 1.05 to 6.72; p=0.038) increased the risk of grade 2 or higher pterygium in females, while higher high-density lipoprotein (HDL) (OR 1.94; 95% CI 1.08 to 3.47; p=0.027) was a risk factor of grade 2 or higher pterygium in males.ConclusionThe overall prevalence of pterygium in Han and Manchu population in Hebei, China was approximately 6.1%. There were no differences in the prevalence of pterygium between Hans and Manchus, and the race was not a risk factor. This is the first study to report on the positive association between premature menopause and pterygium in females and between higher HDL levels and pterygium in males.

scholarly journals An application of multiple logistic regression for identifying lipid profile changes towards assessing maternal and fetal outcomes

2020 ◽  
Vol 7 (8) ◽  
pp. 3014
Author(s):  
K. Rosaiah ◽  
Naga Saritha Kolli ◽  
N. S. Sanjeeva Rao
Keyword(s):  
Blood Pressure ◽  
Logistic Regression ◽  
Lipid Profile ◽  
Multiple Logistic Regression Analysis ◽  
Cross Sectional Study ◽  
Multiple Logistic Regression ◽  
Maternal Complications ◽  
Cross Sectional ◽  
Developmental Issues ◽  
The One

Background: The millennium development goals encourage governments to address and reduce various developmental issues, two of the important ones being maternal and child health. The one of the important causes of maternal mortality in India is pregnancy induced hypertension (PIH) and present study is to identify the relationship between disturbed lipid profile and preeclampsia its effect on fetal and maternal outcome.Methods: This was a descriptive cross-sectional study done on data of maternal care and outcomes from the NRI General Hospital, Guntur district in the year 2013. Multiple logistic regression analysis is applied and results are adjusted to covariates maternal age and gravida.Results: Systolic blood pressure, diastolic blood pressure of normal group (n=50) and PIH group (n=60) are 116.08±7.77, 76.08±4.93, and 165.66±16.8 105.5±14.07 respectively. Birth weights of infants in normotensives and PIH group are 2.85±0.33 and 1.93±0.659 respectively. Percentages of fetal and maternal complications in PIH group are 88.33% and 25%. Still births are present in 31.66% of PIH cases. Mean and SD of gestational age in weeks in normal and PIH groups are 37.92±1.94 and 34.36±3.44 respectively.Conclusions: The model showed significant association between the selected independent variable, covariates and outcomes. The study demonstrates that multiple logistic regression may be applied to medical data in developing predictor models which are useful in clinical settings.

scholarly journals Alcohol consumption in young people between 18 and 24 years according to sociodemographic characteristics

2013 ◽  
Vol 21 (5) ◽  
pp. 1144-1150 ◽  
Author(s):  
Maria Belen Villace ◽  
Alicia Ruth Fernandez ◽  
Moacyr Lobo da Costa Junior
Keyword(s):  
Risk Factors ◽  
Alcohol Consumption ◽  
Young People ◽  
Cross Sectional Study ◽  
Bivariate Analysis ◽  
Sociodemographic Characteristics ◽  
Cross Sectional ◽  
Area Of Concern ◽  
One Year ◽  
The One

OBJECTIVE: to identify alcohol consumption in young people between 18 and 24 years of age in the province of Córdoba who participated in the National Survey of Risk Factors, according to sociodemographic characteristics. METHOD: a quantitative, analytic and cross-sectional study was undertaken in a sample of 240 young people. The alcohol consumption and sociodemographic characteristics were analyzed using bivariate analysis, risk ratio and confidence intervals. RESULTS: the lifetime prevalence of alcohol consumption corresponded to 79.17%, the one-year prevalence to 72.91% and the one-month prevalence to 57.08%, while episodic abuse and regular hazardous consumption corresponded to 25.55% and 24.19%. Consumption levels in the last month were higher among males (p=0.0028), single people (p=0.0001), with a secondary education degree (p=0.0306). CONCLUSION: in the province of Córdoba, drugs use, including alcohol, has not been an area of research interest in recent years, although alcohol abuse is associated with other risk factors, like accidents and violence, and is a factor of comorbidity and early mortality. Therefore, alcohol consumption in young people represents an area of concern and, once characterized, preventive actions should be adopted.

scholarly journals Yang Deficiency Body Constitution Acts as a Predictor of Diabetic Retinopathy in Patients with Type 2 Diabetes: Taichung Diabetic Body Constitution Study

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Cheng-Hung Lee ◽  
Tsai-Chung Li ◽  
Chia-I Tsai ◽  
Shih-Yi Lin ◽  
I-Te Lee ◽  
...  
Keyword(s):  
Risk Factors ◽  
Diabetic Retinopathy ◽  
Independent Predictor ◽  
Medical Center ◽  
Multiple Logistic Regression Analysis ◽  
Cross Sectional Study ◽  
Patient Classification ◽  
Cross Sectional ◽  
Body Constitution

Objective. Diabetic retinopathy (DR), the most common microvascular complication of diabetes mellitus (DM), can cause severe visual impairment and blindness. To prevent the development of DR, identifying the associated risk factors for patient classification is critical. We conducted a cross-sectional study to determine whether body constitution (BC) is an independent predictor of DR.Method. 673 type 2 DM (T2DM) patients were recruited from a medical center, all received DR examination and body constitution questionnaire to assess BC. Other risk factors for DR were also recorded, including life style, history of diabetes, and blood pressure, etc. Multiple logistic regression analysis was conducted to calculate the odds ratios (ORs) for DR.Results. The prevalence of DR was significantly lower in Yang deficiency patients compared with non-Yang deficiency patients (24.69% versus 38.18%P=0.02). After adjusting for other risk factors, we observed that patients exhibiting Yang deficiency BC were less likely to present with DR (OR = 0.531; 95% confidence interval = 0.312–0.903,P=0.018).Conclusion. In addition to traditional risk factors, Yang deficiency BC might be an independent predictor of DR among T2DM patients and the results can be used as evidence for traditional Chinese medicine patient classification.

scholarly journals Clinical factors predicting risk for aspiration and respiratory aspiration among patients with Stroke

2015 ◽  
Vol 23 (2) ◽  
pp. 216-224 ◽  
Author(s):  
Ana Railka de Souza Oliveira ◽  
Alice Gabrielle de Sousa Costa ◽  
Huana Carolina Cândido Morais ◽  
Tahissa Frota Cavalcante ◽  
Marcos Venícios de Oliveira Lopes ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cross Sectional Study ◽  
Clinical Judgments ◽  
Cross Sectional ◽  
Respiratory Aspiration ◽  
Physical Mobility ◽  
Nursing Diagnosis ◽  
Gag Reflex ◽  
The Relationship ◽  
Strength Of Association

Objective: to investigate the association of risk factors with the Risk for aspiration nursing diagnosis and respiratory aspiration. Method: cross-sectional study assessing 105 patients with stroke. The instrument used to collect data addressing sociodemographic information, clinical variables and risk factors for Risk for aspiration. The clinical judgments of three expert RNs were used to establish the diagnosis. The relationship between variables and strength of association using Odds Ratio (OR) was verified both in regard to Risk for aspiration and respiratory aspiration. Results: risk for aspiration was present in 34.3% of the patients and aspiration in 30.5%. The following stood out among the risk factors: Dysphagia, Impaired or absent gag reflex, Neurological disorders, and Impaired physical mobility, all of which were statistically associated with Risk for aspiration. Note that patients who develop such a diagnosis were seven times more likely to develop respiratory aspiration. Conclusion: dysphagia, Impaired or absent gag reflex were the best predictors both for Risk for aspiration and respiratory aspiration.

scholarly journals Prevalence and risk factors of uncorrected refractive error among an elderly Chinese population in urban China: a cross-sectional study

BMJ Open ◽  
2018 ◽  
Vol 8 (3) ◽  
pp. bmjopen-2017-021325
Author(s):  
Hehua Ye ◽  
Yiyong Qian ◽  
Qi Zhang ◽  
Xiaohong Liu ◽  
Xuan Cai ◽  
...  
Keyword(s):  
Risk Factors ◽  
Visual Acuity ◽  
Refractive Error ◽  
Chinese Population ◽  
Protective Factor ◽  
Multiple Logistic Regression Analysis ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Uncorrected Refractive Error

ObjectivesTo investigate the prevalence and risk factors of uncorrected refractive error (URE) in an elderly urban Chinese population in China.DesignA population-based cross-sectional study.MethodsThe study was conducted using a cluster random sample of residents aged 50 years or older living in the Jiangning Road subdistrict, Shanghai, China. All participants underwent a standardised interview and eye examinations, including presenting visual acuity (PVA) and best-corrected visual acuity (BCVA) between November 2012 and February 2013. URE was defined as an improvement of two lines or more in the BCVA compared with the PVA in the better eye of <20/40.ResultsA total of 1999 subjects (an 82.5% response rate) completed both the questionnaire and ophthalmic examination. The prevalence of URE was 20.1% (95% CI 18.0% to 22.2%) in the study sample. After age standardisation, the prevalence of URE in Chinese people aged 50 years or older was 18.7% (95% CI 17.0% to 20.4%). Under multiple logistic regression analysis, older age (per 1-year increase, OR 1.04, 95% CI 1.03 to 1.05) and a lower level of education (OR 1.34, 95% CI 1.07 to 1.69) were significantly related to URE. A history of ocular diseases (OR 0.71, 95% CI 0.55 to 0.92) was a protective factor for URE.ConclusionsURE is highly prevalent among the elderly urban Chinese population, which should raise awareness of the URE burden in China to meet the Vision 2020 goal to eliminate preventable blindness.

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