scholarly journals A Case Report of Prurigo Nodularis-Like Lesions in a Patient with Lepromatous Leprosy

2020 ◽  
Vol 12 (3) ◽  
pp. 236-240
Author(s):  
Siwanon Nawalerspanya ◽  
Siripan Sangmala ◽  
Kumpol Aiempanakit
Keyword(s):  
Case Report ◽  
Peripheral Nerves ◽  
Clinical Presentation ◽  
Clinical Manifestations ◽  
Lepromatous Leprosy ◽  
Histological Subtypes ◽  
Prurigo Nodularis ◽  
Biopsy Specimens ◽  
Variant Pattern ◽  
Erythematous Plaques

Leprosy or Hansen’s disease is a chronic granulomatous infection that primarily affects the peripheral nerves and, consequently, the skin. Clinical manifestations vary from hypopigmentation to erythematous plaques, and it can present with leonine facies. We report a case of a patient with an uncommon clinical presentation of prurigo nodularis-like lesions without loss of sensation, for which two biopsy specimens demonstrated different histological subtypes. The first was the classic histology of lepromatous leprosy, whereas the other specimen revealed an atypical histoid leprosy variant pattern. This case report describes a patient with an atypical presentation of leprosy.

Hypertrophic Interstitial Neuropathy of the Trigeminal Nerve: Case Report and Literature Review

Neurosurgery ◽  
2019 ◽  
Vol 87 (1) ◽  
pp. E41-E47 ◽  
Author(s):  
Alick P Wang ◽  
Dragos Catana ◽  
John P Provias ◽  
Kesava K V Reddy
Keyword(s):  
Case Report ◽  
Trigeminal Neuralgia ◽  
Trigeminal Nerve ◽  
Peripheral Nerves ◽  
Complete Resolution ◽  
Clinical Presentation ◽  
Histopathological Examination ◽  
The Third ◽  
Neoplastic Lesion ◽  
Microscope Images

Abstract BACKGROUND AND IMPORTANCE Hypertrophic interstitial neuropathy (HIN) is an uncommon, non-neoplastic lesion typically affecting peripheral nerves. Cranial nerve (CN) involvement is exceedingly rare. We present a case of isolated trigeminal nerve HIN manifesting with V3 distribution neuralgia. CLINICAL PRESENTATION A 50-yr-old male presented with left sided trigeminal neuralgia refractory to medical management. The patient underwent retromastoid craniectomy for possible microvascular decompression. Intra-operatively, the trigeminal nerve appeared to be focally enlarged with a sausage-like configuration. We selectively resected 1 fascicle which was predominantly involved. Histopathological examination revealed onion bulb formations composed of Schwann cells around centrally placed axons. A diagnosis of HIN was made. Postoperatively, the patient experienced complete resolution of symptoms. CONCLUSION This is the third case of isolated trigeminal nerve HIN in the literature. We performed a selective resection in a patient presenting with trigeminal neuralgia, resulting in complete resolution of symptoms. It is reported here with intraoperative microscope images, along with a review and analysis of this topic as it related to CN.

scholarly journals Clinical and Immunopathologic Profile of Mexican Patients with IgG4 Autoimmune Pancreatitis

2012 ◽  
Vol 2012 ◽  
pp. 1-4 ◽  
Author(s):  
María T. Bourlon ◽  
Christianne Bourlon ◽  
Yemil Atisha-Fregoso ◽  
Fredy Chable-Montero ◽  
Marco A. Teliz ◽  
...  
Keyword(s):  
Weight Loss ◽  
Autoimmune Pancreatitis ◽  
Clinical Presentation ◽  
Clinical Manifestations ◽  
Serum Levels ◽  
Current Data ◽  
Histological Subtypes ◽  
Sclerosing Pancreatitis ◽  
The Mean ◽  
Mexican Patients

Autoimmune pancreatitis is part of the spectrum of IgG4-associated diseases. Its diagnostic criteria and histological subtypes have been formally proposed recently and although based on current data it has been suggested that there are differences in clinical presentation among populations, more research is needed to properly establish if this heterogeneity exists. In this paper, we describe 15 cases of autoimmune pancreatitis diagnosed at a Mexican centre of reference, all of them associated to the lymphoplasmocytic sclerosing pancreatitis variant. The mean age at the onset of symptoms was 47.5 ± 14.4 years, and 53% of patients were male. The main manifestations were weight loss (87%), obstructive jaundice (53%), and acute (27%) and chronic (27%) pancreatitis. Only 20% of patients had high IgG4 serum levels at the time of diagnosis. All patients receiving prednisone responded favourably, both in their pancreatic and extrapancreatic manifestations. Clinical manifestations of Mexican patients showed certain differences with respect to those usually reported.

scholarly journals Pravastatin-Induced Eczematous Eruption Mimicking Psoriasis

2017 ◽  
Vol 2017 ◽  
pp. 1-4 ◽  
Author(s):  
Michael P. Salna ◽  
Hannah M. Singer ◽  
Ali N. Dana
Keyword(s):  
Case Report ◽  
Clinical Presentation ◽  
The Elderly ◽  
Case Presentation ◽  
Dermatology Clinic ◽  
Systemic Treatments ◽  
Eczematous Dermatitis ◽  
Erythematous Plaques ◽  
New Onset

Background. Statins, an example of the most commonly prescribed medications to the elderly, are not without side effects. Dermatologic events are often overlooked as arising from medications, particularly those which are taken chronically. Moreover, elderly patients are prone to pharmacologic interactions due to multiple medications. In this report, we describe a case of a statin-induced eczematous dermatitis with a psoriasis-like clinical presentation and review the skin manifestations that may arise from statin therapy.Case Presentation. An 82-year-old man with gout and hypercholesterolemia presented to dermatology clinic with new onset of pruritic, scaly erythematous plaques bilaterally on the extensor surfaces of his arms. He had never had similar lesions before. Despite various topical and systemic treatments over several months, the rash continued to evolve. The patient was then advised to discontinue his long-term statin, which led to gradual resolution of his symptoms. He was subsequently diagnosed with statin-induced eczematous dermatitis.Conclusions. This case report describes an adverse cutaneous reaction to statins that is rarely reported in the literature. Medications, including longstanding therapies, should be suspected in cases of refractory dermatologic lesions.

Frontal Linear Scleroderma (en coup de sabre): A Case Report

2021 ◽  
pp. 105566562110131
Author(s):  
Yo Han Oh ◽  
Soo Hyang Lee
Keyword(s):  
Case Report ◽  
Rare Case ◽  
Clinical Presentation ◽  
Disease Onset ◽  
Clinical Manifestations ◽  
Localized Scleroderma ◽  
Radiological Findings ◽  
Laboratory Results ◽  
Unusual Variant ◽  
Over Time

En coup de sabre is an unusual variant of localized scleroderma characterized by its distinct location involving the frontoparietal region of the forehead and scalp. The authors describe a rare case of en coup de sabre in a 3-year-old boy whose disease onset was at 12 months of age. This article presents the clinical manifestations of continuous changes in the lesion photographed over time. The clinical presentation, laboratory results, and radiological findings together with a brief discussion of the management of the disease are discussed.

scholarly journals Leprosy Mimicking as Rheumatoid Arthritis: A Case Report

2021 ◽  
Vol 9 (C) ◽  
pp. 277-279
Author(s):  
Made Edwin Sridana ◽  
Pande Ketut Kurniari ◽  
Gede Kambayana
Keyword(s):  
Rheumatoid Arthritis ◽  
Case Report ◽  
Physical Examination ◽  
Peripheral Nerves ◽  
Clinical Manifestations ◽  
Mycobacterium Leprae ◽  
History Taking ◽  
Blood Tests ◽  
The Face ◽  
Bilateral Distribution

Leprosy is a chronic granulomatous infection caused by Mycobacterium leprae, which mainly damages the skin and peripheral nerves, and can also infect joints and bones. Clinical manifestations are complex, varied, and often underdiagnosed. The clinical manifestations vary and are called "the great imitator". musculoskeletal features are common in leprosy but infrequently reported. A case of borderline lepromatous (BL) type leprosy was initially suspected as rheumatoid arthritis in a 20-year-old Balinese male who complained of pain and swelling in small joints, accompanied by lesions in the form of multiple erythema macules, round-shaped geography, indistinct boundaries, with bilateral distribution is almost symmetrical in the face, thoracoabdominal, and extremity regions. The diagnosis of BL type leprosy is based on history taking, physical examination, and investigations in the form of Ziehl-Neelsen stain and blood tests.

scholarly journals Multiple Cavernous Malformations: A Case Report

2020 ◽  
Vol 3 (1) ◽  
pp. 5-13
Author(s):  
Fernando Gutiérrez Rincón Oscar ◽  
◽  
Moreno García Santiago ◽  
José Hoyos Bedoya Maria ◽  
Juliana Builes Cerón Sarah ◽  
...  
Keyword(s):  
Case Report ◽  
Medical Management ◽  
Clinical Case ◽  
Autosomal Dominant ◽  
Clinical Presentation ◽  
Clinical Manifestations ◽  
Epileptic Seizures ◽  
Cavernous Malformations ◽  
Arteries And Veins ◽  
Main Clinical Manifestation

Cavernous malformations are alterations in the conformation of arteries and veins that can be found both intracranial and intraspinal; however, the variables are very important for the diagnosis and treatment of patients. The main clinical manifestation is epileptic seizures in cases of bleeding, but in many cases they are asymptomatic in the course of life and are found as findings related to neuroimaging studies for other reasons. It is more common to find unique lesions, but in cases of multiple lesions it is likely to find an autosomal dominant hereditary factor, which makes the person more likely to convulse due to sporadic bleeding. Medical management focuses on the clinical presentation and management of epileptic seizures, while surgical management takes into account the size, location and bleeding. Below is a clinical case that represents one of the different clinical manifestations and the approach that was given in said patient.

scholarly journals The frequency and clinical presentation of Zika virus coinfections: a systematic review

2020 ◽  
Vol 5 (5) ◽  
pp. e002350
Author(s):  
Ludmila Lobkowicz ◽  
Anna Ramond ◽  
Nuria Sanchez Clemente ◽  
Ricardo Arraes de Alencar Ximenes ◽  
Demócrito de Barros Miranda-Filho ◽  
...  
Keyword(s):  
Systematic Review ◽  
Case Report ◽  
Zika Virus ◽  
Clinical Presentation ◽  
Clinical Signs ◽  
Clinical Manifestations ◽  
Case Series ◽  
Signs And Symptoms ◽  
Cross Sectional ◽  
Epstein Barr

BackgroundThere is limited knowledge on the influence of concurrent coinfections on the clinical presentation of Zika virus (ZIKV) disease.MethodsTo better understand the types, frequencies and clinical manifestations of ZIKV coinfections, we did a systematic review of four databases (PubMed, Embase, Web of Science, LILACS) without restrictions for studies on ZIKV coinfections confirmed by nucleic acid (quantitative real-time-PCR) testing of ZIKV and coinfecting pathogens. The review aimed to identify cohort, cross-sectional, case series and case report studies that described frequencies and/or clinical signs and symptoms of ZIKV coinfections. Conference abstracts, reviews, commentaries and studies with imprecise pathogen diagnoses and/or no clinical evaluations were excluded.ResultsThe search identified 34 articles from 10 countries, comprising 2 cohort, 10 cross-sectional, 8 case series and 14 case report studies. Coinfections were most frequently reported to have occurred with other arthropod-borne viruses (arboviruses); out of the 213 coinfections described, ZIKV infections co-occurred with chikungunya in 115 cases, with dengue in 68 cases and with both viruses in 19 cases. Other coinfecting agents included human immunodeficiency, Epstein-Barr, human herpes and Mayaro viruses, Leptospira spp, Toxoplasma gondii and Schistosoma mansoni. ZIKV-coinfected cases primarily presented with mild clinical features, typical of ZIKV monoinfection; however, 9% of cases in cohort and cross-sectional studies were reported to experience complications.ConclusionBased on the evidence collated in this review, coinfections do not appear to strongly influence the clinical manifestations of uncomplicated ZIKV infections. Further research is needed to confirm whether risk of severe complications is altered when ZIKV infection co-occurs with other infections.PROSPERO registration numberCRD42018111023.

scholarly journals CONGENITAL CARDITIS IN A NEWBORN (case report)

2019 ◽  
Vol 6 (1) ◽  
pp. 24-31
Author(s):  
M.O. Gonchar ◽  
A.V. Senatorova ◽  
N.K. Matsievskaya ◽  
D.V. Zatoloka
Keyword(s):  
Case Report ◽  
Respiratory Failure ◽  
Infectious Diseases ◽  
Diagnostic Criteria ◽  
Clinical Presentation ◽  
Clinical Manifestations ◽  
Intrauterine Infection ◽  
High Technology ◽  
Technology Research ◽  
Atypical Clinical Presentation

CONGENITAL CARDITIS IN A NEWBORN (case report)Gonchar M.O., Senatorova A.V., Matsiyevskaya N.K., Zatoloka D.V.Diagnosis of carditis in newborns presents a number of difficulties, even with the results of high-technology research methods. Carditis is characterized by the absence of specific diagnostic criteria, similarity of clinical manifestations of cardiovascular and respiratory failure in young children, including secondary to generalized infectious diseases. The article presents a case of an atypical clinical presentation of carditis in a child with a confirmed intrauterine infection.Key words: newborns, carditis, intrauterine infection ВРОДЖЕНИЙ КАРДИТ У НОВОНАРОДЖЕНОГО (клінічне спостереження)Гончар М.О., Сенаторова А.В., Мацієвська Н.К., Затолока Д.В.Встановлення діагнозу кардит у новонароджених має ряд труднощів, навіть при наявності результатів високотехнологічних методів дослідження. Кардит характеризується відсутністю специфічних діагностичних критеріїв, схожістю клінічних проявів серцево-судинної і дихальної недостатності у дітей раннього віку, в тому числі на тлі генералізованої інфекційної патології. У статті представлений випадок нетипового клінічного перебігу розвитку кардиту у дитини з підтвердженою внутрішньоутробною інфекцією.Ключові слова: новонароджені, кардит, внутрішньоутробна інфекція ВРОЖДЕННЫЙ КАРДИТ У НОВОРОЖДЕННОГО (клиническое наблюдение)Гончарь М.О., Сенаторова А.В., Мациевская Н.К., Затолока Д.В.Установление диагноза кардит у новорождённых имеет ряд сложностей, даже при наличие  результатов высокотехнологических методов исследования. Кардит характеризуется отсутствием специфических диагностических критериев, сходством клинических проявлений сердечно-сосудистой и дыхательной недостаточности у детей раннего возраста, в том числе на фоне генерализованной инфекционной патологии. В статье представлен случай нетипичного клинического течения развития кардита у ребенка с подтвержденной внутриутробной инфекцией.Ключевые слова: новорожденные, кардит, внутриутробная инфекция  

Traumatic Leptomeningeal Cyst in a 24-Year-Old Man: Case Report

Neurosurgery ◽  
2006 ◽  
Vol 58 (1) ◽  
pp. E201-E201 ◽  
Author(s):  
Karlo Houra ◽  
Vili Beros ◽  
Tomislav Sajko ◽  
Hrvoje Cupic
Keyword(s):  
Case Report ◽  
Childhood Trauma ◽  
Clinical Presentation ◽  
Rare Complication ◽  
Clinical Manifestations ◽  
Bone Lesions ◽  
Leptomeningeal Cyst ◽  
Progressive Neurological Deficit ◽  
History Of ◽  
Subcutaneous Mass

Abstract OBJECTIVE AND IMPORTANCE: Traumatic leptomeningeal cysts represent a rare complication of a childhood cranial fracture, and occur in only 0.05 to 0.6% of all cranial fractures. In adults, clinical manifestations of a childhood trauma are very rare and usually appear in the form of nontender, nonpulsatile, subcutaneous mass, accompanied by a progressive neurological deficit and seizures, as shown in our case. CLINICAL PRESENTATION: We present the case of a 24-year-old man with seizures caused by a traumatic leptomeningeal cyst resulting from the head injury he suffered at the age of 9 months. INTERVENTION: Right-sided craniotomy was performed with consequent microsurgical removal of the leptomeningeal cyst. The dura was reconstructed in a watertight manner and a cranioplasty was performed with Palacos (Howmedica International, Limerick, Ireland). CONCLUSION: It is important to consider traumatic leptomeningeal cysts when treating adult patients with erosive bone lesions who have a history of head trauma.

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