scholarly journals Skin Cancer Development in Solid Organ Transplant Recipients in Switzerland (Swiss Transplant Cohort Study)

Dermatology ◽  
2020 ◽  
pp. 1-11
Author(s):  
Nadja Angela Stenz ◽  
Susanne Stampf ◽  
Andreas W. Arnold ◽  
Antonio Cozzio ◽  
Michael Dickenmann ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cohort Study ◽  
Skin Cancer ◽  
Cell Carcinoma ◽  
Organ Transplant ◽  
Solid Organ Transplant ◽  
Solid Organ ◽  
Transplant Recipients ◽  
Organ Transplant Recipients ◽  
Solid Organ Transplant Recipients

<b><i>Importance:</i></b> Skin cancer, in particular squamous cell carcinoma, is the most frequent malignancy among solid organ transplant recipients with a higher incidence compared to the general population. <b><i>Objective:</i></b> To determine the skin cancer incidence in organ transplant recipients in Switzerland and to assess the impact of immunosuppressants and other risk factors. <b><i>Design:</i></b> Prospective cohort study of solid organ transplant recipients in Switzerland enrolled in the Swiss Transplant Cohort Study from 2008 to 2013. <b><i>Participants:</i></b> 2,192 solid organ transplant recipients. <b><i>Materials and Methods:</i></b> Occurrence of first and subsequent squamous cell carcinoma, basal cell carcinoma, melanoma and other skin cancers after transplantation extracted from the Swiss Transplant Cohort Study database and validated by medical record review. Incidence rates were calculated for skin cancer overall and subgroups. The effect of risk factors on the occurrence of first skin cancer and recurrent skin cancer was calculated by the Cox proportional hazard model. <b><i>Results:</i></b> In 2,192 organ transplant recipients, 136 (6.2%) developed 335 cases of skin cancer during a median follow-up of 32.4 months, with squamous cell carcinoma as the most frequent one. 79.4% of skin cancer patients were male. Risk factors for first and recurrent skin cancer were age at transplantation, male sex, skin cancer before transplantation and previous transplantation. For a first skin cancer, the number of immunosuppressive drugs was a risk factor as well. <b><i>Conclusions and Relevance:</i></b> Skin cancer following solid organ transplantation in Switzerland is greatly increased with risk factors: age at transplantation, male sex, skin cancer before transplantation, previous transplantation and number of immunosuppressive drugs.

Low-Dose Acitretin for Secondary Prevention of Keratinocyte Carcinomas in Solid-Organ Transplant Recipients

Dermatology ◽  
2021 ◽  
pp. 1-6
Author(s):  
Efrat Solomon-Cohen ◽  
Shiran Reiss-Huss ◽  
Emmilia Hodak ◽  
Batya Davidovici
Keyword(s):  
Secondary Prevention ◽  
Cell Carcinoma ◽  
Low Dose ◽  
Organ Transplant ◽  
Solid Organ Transplant ◽  
Solid Organ ◽  
Transplant Recipients ◽  
Organ Transplant Recipients ◽  
Pretreatment Period ◽  
Solid Organ Transplant Recipients

<b><i>Background:</i></b> Keratinocyte carcinomas, particularly squamous cell carcinoma (SCC), occur more frequently and aggressively in solid-organ transplant recipients (SOTRs) than in the general population. Systemic retinoids are effective in secondary prevention of keratinocyte carcinomas in this population, but their use is limited by adverse effects including a rebound effect in cases of treatment discontinuation. <b><i>Objective:</i></b> Our aim was to determine whether low-dose acitretin is efficient in the secondary prevention of keratinocyte carcinomas in SOTRs. <b><i>Methods:</i></b> This retrospective case-crossover study was conducted at a specialized dermatology clinic for SOTRs in a large transplantation center in 2010–2017. Patients with at least 1 previous keratinocyte carcinoma who were treated with acitretin 10 mg/day for 2 years were included. The main outcome was the difference in the number of new keratinocyte carcinomas diagnosed during treatment compared to during the 2-year pretreatment period. <b><i>Results:</i></b> The cohort included 34 SOTRs. A significant reduction in the mean number of new keratinocyte carcinomas during treatment relative to the pretreatment period was observed (1.7 vs. 3.6, –53% <i>p</i> = 0.002). Similar results were noted on analysis by tumor type, for both SCC and basal cell carcinoma. <b><i>Conclusion:</i></b> This study of SOTRs demonstrated positive results for low-dose acitretin as a chemoprevention of keratinocyte carcinomas in this population.

scholarly journals COVID‐19 in solid organ transplant recipients: A national cohort study from Sweden

2021 ◽  
Author(s):  
John Mackay Søfteland ◽  
Gustav Friman ◽  
Bengt von Zur‐Mühlen ◽  
Bo‐Göran Ericzon ◽  
Carin Wallquist ◽  
...  
Keyword(s):  
Cohort Study ◽  
Organ Transplant ◽  
Solid Organ Transplant ◽  
Solid Organ ◽  
Transplant Recipients ◽  
Organ Transplant Recipients ◽  
National Cohort ◽  
Solid Organ Transplant Recipients

scholarly journals Tocilizumab for severe COVID‐19 in solid organ transplant recipients: a matched cohort study

2020 ◽  
Vol 20 (11) ◽  
pp. 3198-3205 ◽  
Author(s):  
Marcus R. Pereira ◽  
Meghan M. Aversa ◽  
Maryjane A. Farr ◽  
Benjamin A. Miko ◽  
Justin G. Aaron ◽  
...  
Keyword(s):  
Cohort Study ◽  
Organ Transplant ◽  
Solid Organ Transplant ◽  
Solid Organ ◽  
Matched Cohort ◽  
Transplant Recipients ◽  
Organ Transplant Recipients ◽  
Matched Cohort Study ◽  
Solid Organ Transplant Recipients

scholarly journals Incidence and Risk Factors of Obesity in Childhood Solid-Organ Transplant Recipients

2019 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Bianca C. Bondi ◽  
Tonny M. Banh ◽  
Jovanka Vasilevska-Ristovska ◽  
Aliya Szpindel ◽  
Rahul Chanchlani ◽  
...  
Keyword(s):  
Risk Factors ◽  
Organ Transplant ◽  
Solid Organ Transplant ◽  
Solid Organ ◽  
Transplant Recipients ◽  
Organ Transplant Recipients ◽  
Solid Organ Transplant Recipients
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