Tumour Growth Rate to predict the outcome of patients with Neuroendocrine Tumours: Performance and sources of variability

2020 ◽  
Author(s):  
Clarisse Dromain ◽  
Anders Sundin ◽  
Pavan Najran ◽  
Hector Vidal Trueba ◽  
Marco Dioguardi Burgio ◽  
...  
Keyword(s):  
Growth Rate ◽  
Tumour Growth ◽  
Neuroendocrine Tumours ◽  
Tumour Growth Rate

scholarly journals When, why and how clonal diversity predicts future tumour growth

2019 ◽  
Author(s):  
Robert Noble ◽  
John T Burley ◽  
Cécile Le Sueur ◽  
Michael E Hochberg
Keyword(s):  
Growth Rate ◽  
Tumour Growth ◽  
Evolutionary Process ◽  
Clonal Diversity ◽  
Driver Mutations ◽  
Multiple Cancer ◽  
Intratumour Heterogeneity ◽  
Cancer Types ◽  
The Relationship ◽  
Tumour Growth Rate

AbstractIntratumour heterogeneity holds promise as a prognostic biomarker in multiple cancer types. However, the relationship between this marker and its clinical impact is mediated by an evolutionary process that is not well understood. Here we employ a spatial computational model of tumour evolution to assess when, why and how intratumour heterogeneity can be used to forecast tumour growth rate, an important predictor of clinical progression. We identify three conditions that can lead to a positive correlation between clonal diversity and subsequent growth rate: diversity is measured early in tumour development; selective sweeps are rare; and/or tumours vary in the rate at which they acquire driver mutations. Opposite conditions typically lead to negative correlation. Our results further suggest that prognosis can be better predicted on the basis of both clonal diversity and genomic instability than either factor alone. Nevertheless, we find that, for predicting tumour growth, clonal diversity is likely to perform worse than conventional measures of tumour stage and grade. We thus offer explanations – grounded in evolutionary theory – for empirical findings in various cancers. Our work informs the search for new prognostic biomarkers and contributes to the development of predictive oncology.

Ki67 in the Assessment of Tumour Growth Rate: A Study on Xenografts

1989 ◽  
Vol 56 (5) ◽  
pp. 797-800 ◽  
Author(s):  
P. Price ◽  
C. Bush ◽  
C.S. Parkins ◽  
P. Imrie ◽  
M.G. Ormerod ◽  
...  
Keyword(s):  
Growth Rate ◽  
Tumour Growth ◽  
Tumour Growth Rate

P-188 Lung cancer tumour growth rate and response to radiotherapy

Lung Cancer ◽  
2003 ◽  
Vol 41 ◽  
pp. S138
Author(s):  
Noelle O'Rourke ◽  
Ather Kazmi ◽  
Jorge Curto ◽  
Jim Paul
Keyword(s):  
Lung Cancer ◽  
Growth Rate ◽  
Tumour Growth ◽  
Tumour Growth Rate
Sign in / Sign up

Export Citation Format

Share Document