The Connection between Urinary Equol Levels and the Prevalence of Atopic Dermatitis

2020 ◽  
Vol 182 (1) ◽  
pp. 32-38
Author(s):  
Takahito Chiba ◽  
Takuya Nagai ◽  
Futoshi Kohda ◽  
Takeshi Nakahara ◽  
Michihiro Kono
Keyword(s):  
Atopic Dermatitis ◽  
High Performance ◽  
Clinical Symptoms ◽  
Laboratory Data ◽  
Normal Subjects ◽  
Cross Sectional Study ◽  
Soy Isoflavones ◽  
University Hospital ◽  
Healthy Controls ◽  
Cross Sectional

<b><i>Background:</i></b> Soy isoflavones and their metabolites such as equol have been associated with a reduced risk of hormone-sensitive tumors and metabolic syndromes. However, individual soy isoflavones and equol levels in atopic dermatitis remain uninvestigated. <b><i>Objective:</i></b> The aim of this study is to compare the levels of urinary daidzein, genistein, and equol between atopic dermatitis patients and normal subjects and to examine the correlation between equol concentration and the severity of clinical symptoms. <b><i>Methods:</i></b> A cross-sectional study was conducted at Akita University Hospital and Aso Iizuka Hospital in Japan. Fifty patients with confirmed atopic dermatitis diagnosis and 67 healthy controls were recruited. Daidzein, genistein, and equol in urine were measured by using a high-performance liquid chromatography-mass spectrometry system. <b><i>Results:</i></b> Urinary equol levels were significantly lower in the atopic dermatitis patients than in the healthy controls (<i>p</i> = 0.002). The difference was particularly noticeable in young people (6–19 years, <i>p</i> &#x3c; 0.001). No correlations were found between urinary equol levels and the severity of clinical symptoms and laboratory data in the atopic dermatitis patients. <b><i>Conclusion:</i></b> Equol levels in childhood might be involved in the development of atopic dermatitis.

scholarly journals Is suicidal ideation associated with allergic asthma and allergic rhinitis?

2018 ◽  
Vol 44 (1) ◽  
pp. 31-35 ◽  
Author(s):  
Martín Bedolla-Barajas ◽  
Norma Angélica Pulido-Guillén ◽  
Bolívar Vivar-Aburto ◽  
Jaime Morales-Romero ◽  
José Raúl Ortiz-Peregrina ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Suicidal Ideation ◽  
Allergic Asthma ◽  
Allergic Diseases ◽  
Cross Sectional Study ◽  
University Hospital ◽  
Control Group ◽  
Healthy Controls ◽  
Cross Sectional ◽  
And Control

ABSTRACT Objective: To investigate whether there is an association between suicidal ideation (SI) and allergic diseases in adults. Methods: This was a comparative cross-sectional study involving individuals ranging from 20 to 50 years of age recruited from a university hospital in the city of Guadalajara, Mexico. We included patients with a confirmed diagnosis of allergic asthma, those with a confirmed diagnosis of allergic rhinitis, and healthy controls. All subjects completed the Beck Depression Inventory-II (BDI-II), which includes an item that evaluates the presence of suicidal thoughts or desires within the last two weeks, in order to identify SI. Results: The sample comprised 115 patients with allergic asthma, 111 patients with allergic rhinitis, and 96 healthy controls. The number of individuals identified with SI in the three groups were, respectively, 17 (14.8%), 13 (11.7%), and 8 (8.3%). Regarding the presence of SI, no statistically significant association was found in the allergic asthma group (OR = 1.98; 95% CI: 0.78-4.64; p = 0.154) or in the allergic rhinitis group (OR = 1.46; 95% CI: 0.58-3.68; p = 0.424) when they were compared with the control group. However, the presence of depression was associated with SI in the three groups: allergic asthma (OR = 12.36; 95% CI: 2.67-57.15; p = 0.001); allergic rhinitis (OR = 6.20; 95% CI: 1.66-23.14; p = 0.006); and control (OR = 21.0; 95% CI: 3.75-117.36; p < 0,001). Conclusions: In comparison with the control group, no association was found between SI and the groups with allergic diseases. In contrast, there was association between SI and depression in the three groups.

scholarly journals The socioeconomic variables influence in the alpha-tocopherol concentration of the maternal serum

2017 ◽  
Vol 17 (1) ◽  
pp. 179-184
Author(s):  
Karla Danielly S. Ribeiro ◽  
Luana Weigert ◽  
Talita Andrade ◽  
Amanda Lima ◽  
Jeane Medeiros ◽  
...  
Keyword(s):  
High Performance ◽  
Family Income ◽  
Cross Sectional Study ◽  
Average Concentration ◽  
Maternal Serum ◽  
Alpha Tocopherol ◽  
University Hospital ◽  
Social Characteristics ◽  
Tocopherol Concentration ◽  
Cross Sectional

Abstract Objectives: To evaluate the influence of the socioeconomic factors on the alpha-tocopherol concentration in maternal serum. Methods: a retrospective, observational, cross-sectional study with the participation of 103 adult parturient volunteers attended at Hospital Universitário Ana Bezerra (Ana Bezerra University Hospital) in Santa Cruz - Rio Grande do Norte. 5.0 mL of blood was collected from each participant in fasting before the delivery to extract alpha-tocopherol of the serum. Socioeconomic and demographic information were obtained by a previously structured questionnaire. Alpha-tocopherol serum was determined by a High-Performance Chromatography Liquid (Cromatografia Líquida de Alta Eficiência (CLAE). Results: The average concentration of alpha-tocopherol in the serum was 1281.4 (594.8) µg/dL, and 6% of the women presented vitamin E deficiency (DVE). Most pregnant women aged between 18 and 24 years (59%), marital status was married or consensual marriage (77%), elementary schooling complete (34%), low family income (74%) and living in the urban area (73%). No significant differences were found in the alpha-tocopherol concentration according to socioeconomic characteristics and none of the studied factors were associated to the presence of DVE ( p >0.05). Conclusions: The maternal social characteristics were not determinants for the alpha-tocopherol serum and DVE. Further investigations should be carried out during lactation to assess which factors may be involved in the presence of this deficiency.

scholarly journals Changes in pulse waveforms in response to intraocular pressure elevation determined by laser speckle flowgraphy in healthy subjects

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Chie Iwase ◽  
Takeshi Iwase ◽  
Ryo Tomita ◽  
Tomohiko Akahori ◽  
Kentaro Yamamoto ◽  
...  
Keyword(s):  
Intraocular Pressure ◽  
Normal Subjects ◽  
Cross Sectional Study ◽  
Laser Speckle ◽  
University Hospital ◽  
Laser Speckle Flowgraphy ◽  
Pulse Waveform ◽  
Cross Sectional ◽  
Flow Acceleration ◽  
Iop Elevation

Abstract Background The influences of intraocular pressure (IOP) elevations on the pulse waveform in the optic nerve head (ONH) were evaluated using laser speckle flowgraphy (LSFG) in normal subjects. Methods This prospective cross-sectional study was conducted at the Nagoya University Hospital. An ophthalmodynamometer was pressed on the sclera to increase the IOP by 20 mmHg or 30 mmHg for 1 min (experiment 1, 16 subjects) and by 30 mmHg for 10 min (experiment 2, 10 subjects). The mean blur rate (MBR) and the eight pulse waveform parameters determined using LSFG were measured before, immediately after and during an IOP elevation, and after the IOP returned to the baseline pressure. Results A significant elevation in the IOP and a significant reduction in the ocular perfusion pressure (OPP) were found after applying the ophthalmodynamometer (both, P < 0.001). The blowout score (BOS) reduced significantly (P < 0.001), and the flow acceleration index (FAI; P < 0.01) and resistivity index (RI; P < 0.001) increased significantly immediately after increasing the IOP by 20 or 30 mmHg (experiment 1). The BOS reduced significantly (P < 0.001), and the FAI (P < 0.01) and RI (P < 0.001) increased significantly after the IOP elevation by 30 mmHg in both experiment 2 and 1. However, the BOS and RI recovered significantly at time 10 compared to that in time 0 (immediately after IOP elevation) during the 10-min IOP elevation (P < 0.001 and P = 0.008, respectively). Conclusions In conclusion, the BOS, FAI, and RI of the pulse waveforms changed significantly with an acute elevation in the IOP. The change should be related to the larger difference between the maximum and minimum MBRs during the IOP elevation.

scholarly journals The Correlation Between Asthma Severity and Neutrophil to Lymphocyte Ratio

2020 ◽  
Vol 2 (2) ◽  
Author(s):  
Meena Abdul-Sattar Darwesh ◽  
Ibtihal Shukri Abd Alhaleem ◽  
Muhammed Waheeb Salman Al-Obaidy
Keyword(s):  
Clinical Symptoms ◽  
Asthma Severity ◽  
Cross Sectional Study ◽  
Neutrophil To Lymphocyte Ratio ◽  
Healthy Controls ◽  
Cross Sectional ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Asthmatic Patients ◽  
Significant Difference

Background—The prognosis is essential in management and follows up of asthmatic patients. Neutrophil to lymphocyte ratio is considered as the common prognostic marker for many diseases especially the asthma. Aim of study—To assess the relationship between asthma severity and neutrophil to lymphocyte ratio in comparison to healthy controls. Patients and methods—This study is a cross sectional study conducted in Respiratory Consultancy Clinic in Baghdad Teaching Hospital in Medical City during the period from 1st of October, 2018 to 31st of March, 2019 on sample of 50 asthmatic patients and 50 healthy controls. The diagnosis of asthma was confirmed by the supervisor through clinical symptoms, signs, spirometery with reversibility test (according to GINA guideline.). Results—A highly significant difference was observed between asthmatic cases and controls regarding age (p<0.001). A significant association was observed between obesity and asthmatic cases (p=0.001). There was a highly significant association between high neutrophil/lymphocyte ratio and asthmatic cases (p<0.001). The neutrophil/lymphocyte ratio was significantly increased with advanced age, females, severe and uncontrolled asthma. Conclusions—The neutrophil to lymphocyte ratio is useful biomarker in assessment of asthma severity.

scholarly journals Clinical characteristics and long-term survival differences of the ANCA-associated vasculitis group: a cross-sectional study of 27 patients

2017 ◽  
Vol 24 (2) ◽  
pp. 107-112 ◽  
Author(s):  
Jolanta Dadonienė ◽  
Gintarė Kumžaitė ◽  
Rimvydė Mačiulytė ◽  
Dalia Miltinienė
Keyword(s):  
Life Expectancy ◽  
Clinical Characteristics ◽  
Laboratory Data ◽  
Cross Sectional Study ◽  
University Hospital ◽  
Sectional Study ◽  
Cross Sectional ◽  
Term Survival ◽  
Vilnius University

Objective. The goal of this study was to describe long-term patient survival and possible prognostic factors of a  group of patients diagnosed with granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA) hospitalized at the  tertiary Rheumatology Centre in Vilnius. Material and Methods. A cross-sectional study of 27 patients hospitalized at the Rheumatology Centre of Santaros klinikos of Vilnius University Hospital from 1  January 2001 to 31  December 2015 with diagnoses of GPA and MPA were carried out. Data on demographics, clinical characteristics, laboratory data, and the Birmingham Vasculitis Activity Score were collected. Results. Seven (25.9%) patients during the  onset of the  disease received only oral glucocorticoids and 20 (74.1%) patients took additional medication. The BVAS median was 7 (minimum [min] – 2; maximum [max] – 23). The age median was 52 years (min  –  12; max  –  75). The  overall mortality rate was 18.5%. Mean survival time was 126.6 months (95% confidence interval [CI] = 104.5 to 148.6) limited to 154.6 months for the longest-surviving patient. Conclusions. Life expectancy during past 15  years for AAV patients increased from 99.4 to 126.6 months. A high BVAS score at the  onset of the  disease is a  bad prognostic factor related to shorter life expectancy. The growth of Staphylococcus aureus from nasopharynx might be associated with higher mortality rates and relapses in AAV patients.

scholarly journals Clinical Characterisation of Rota Virus Infection Associated with Most Commonly Circulating Genotypes in Children Hospitalised in Children’s University Hospital: A Cross-Sectional Study in Latvia

2019 ◽  
Vol 73 (4) ◽  
pp. 312-316
Author(s):  
Gunta Laizāne ◽  
Anda Ķīvīte ◽  
Ilze Grope ◽  
Liene Smane ◽  
Edvīns Miklaševics ◽  
...  
Keyword(s):  
Acute Gastroenteritis ◽  
Clinical Symptoms ◽  
Clinical Signs ◽  
Clinical Manifestations ◽  
Significant Negative Correlation ◽  
Cross Sectional Study ◽  
University Hospital ◽  
Sectional Study ◽  
Cross Sectional ◽  
Routine Immunisation

Abstract In developed and developing countries, most cases of acute gastroenteritis in children are caused by viruses, and rotaviruses are known as the leading cause. The aim of our study was to estimate the main circulating serotypes of rotavirus before the introduction of routine immunisation in Latvia, and to search for their possible correlation with clinical symptoms and circulating genotypes. A cross-sectional study was carried out among children who had been hospitalised in the Children’s Clinical University Hospital from April 2013 to December 2015. Genotyping was done for 462 stool samples. Among G/P combinations, the most predominant genotypes were G4P[8] (61.3%), G9P[8] (12.4%) and G2P[4] (10.0%) in children of age < 5 years, G4P[8] (45.5%), G2P[4] (18.2%), G9P[8], G3P[8], and G1P[8] (9.1%) in children of age > 5 years. There was a statistically significant correlation (p < 0.05) between clinical signs (vomiting, dehydration, chronic diseases) and G1P[8] and G8P[8] genotypes. Infants infected with genotype G4P[4] had a statistically significant negative correlation with severity of acute gastroenteritis episodes (p < 0.05). We detected nine different rotavirus G genotypes, and two different P genotypes. G4P[8], G9P[8], and G2P[8] were predominant. We observed correlation between the dominant genotypes and clinical manifestations of rotavirus infection.

scholarly journals Frequency of Hydrocephalus in Cases of Tuberculous Meningitis

2021 ◽  
Vol 15 (6) ◽  
pp. 1387-1389
Author(s):  
M. U. Waheed ◽  
M. Abubakar ◽  
M. A. Malik ◽  
J. Mustafa ◽  
F. Ali ◽  
...  
Keyword(s):  
Tuberculous Meningitis ◽  
Clinical Symptoms ◽  
Laboratory Data ◽  
Previous History ◽  
Cross Sectional Study ◽  
Male Gender ◽  
Stage Ii ◽  
P Value ◽  
Cross Sectional ◽  
Csf Analysis

Aim: To determine the frequency of hydrocephalus in cases of Tuberculous meningitis Methods: This was a cross sectional study conducted during 01-07-16 to 31-12-2017 at Department of Medicine, Sheikh Zayed Hospital, Rahim Yar Khan. The cases of tuberculosis meningitis of age range of 15 to 50 years of either gender with tuberculous meningitis were included in this study. The diagnosis of TBM was made on the basis of combination of clinical symptoms and laboratory data. The symptoms were fever, weight loss and neck rigidity with or without fits. These cases then underwent CSF analysis under aseptic measures. The findings to label TBM on CSF were low glucose (< 40 mg/dl), increased protein content (> 100 mg/dl) and high WBC count with predominance of lymphocytes. The cases of TBM were divided according to standard BMRC scale into three stages. The cases with bacterial meningitis, having any SOL in brain and those with any previous history of neurosurgery were excluded from this study. Then these cases underwent CT brain in the same institute and diagnosis of Hydrocephalus was made when any of the ventricle is dilated more than 25% of the baseline. Results: In this study there were total 93 cases of TBM with mean age of 37.11±08.67years. There were 54(58.06%) males and 39(41.94%) females. Maximum cases were seen in stage II of TBM which affected 65 (69.89%) cases. Hydrocephalus was seen in 61(65.59%) of the cases as shown in figure 01. Hydrocephalus was significantly high in male gender as compared to females where it affected 39(72.22%) of cases with p value of 0.03. It was also more common in cases that had age group 15-29 years affecting 40(67.79%) of cases with p= 0.86. Hydrocephalus was also significantly high in cases with stage II and III of TB affecting 66.15% and 77.27% of cases respectively with p= 0.01. Conclusion: Hydrocephalus is very common in cases of TBM and it is significantly high in male gender and stage II and III of TBM. Key words: TBM, Hydrocephalus

Frequency and Clinical Manifestations of Caesarean Section Scar Defects

2020 ◽  
Author(s):  
Ome Kulsoom
Keyword(s):  
Pelvic Pain ◽  
Clinical Symptoms ◽  
Clinical Manifestations ◽  
Cross Sectional Study ◽  
University Hospital ◽  
Menstrual Irregularity ◽  
Chi Square ◽  
Cross Sectional ◽  
Caesarean Scar ◽  
Caesarean Scar Defect

Background: Caesarean Sections (CS), significantly on the rise worldwide, have been found frequently complicated with the presence of a scar at the site of CS. It is associated with various gynecological problems like postmenstrual spotting, infertility, miscarriage, and uterine rupture. The objective of this study was to determine the frequency of CS scar defects and associated gynaecological symptoms. Methods: This cross-sectional study was conducted at the Department of Obstetrics and Gynaecology, Ziauddin University Hospital Karachi from October 1st, 2017 to March 1st, 2018. A total of 162 patients’ (aged 20-40 years) were included, with CS history (elective or emergency) and complaints of chronic pelvic pain, infertility or menstrual irregularities, after an informed consent. Demographic details and medical history were recorded on performa. Chi-square was used to establish association between categorical variable such presence of scar defect, clinical symptoms and the shape of the defect. Results: Out of 162 patients, 86(53.1%) had one and 76(46.9%) had more than one caesarean scar. Majority of the patients 97(59.9%) were found to have scar defect (NICHE) present while in 65 (40.1%) patients had no caesarean scar defect. Regarding menstrual cycle, 58(35.8%) had heavy bleeding, 39(24.1%) continuous bleeding, and 27 (16%) irregular cycle. Significant association (p˂0.05) was found between menstrual irregularity, pelvic pain, infertility and scar defects. Different shapes of scar (niche) were noted triangular 46(28.4%) droplet 26(16%), oval and others such as rectangular and inclusion cyst on ultrasonographic . Conclusion: Multiple Caesarean sections are predisposing factors for Caesarean scar defects. Menstrual irregularity, pelvic pain, infertility and scar defects were found significantly associated with Caesarean sections (p˂0.05).

scholarly journals The Biochemical Outcome of two Treatment Protocols in Patients With Opium-associated Lead Poisoning: A Cross-sectional Study in North of Iran

2021 ◽  
Vol 11 (1) ◽  
pp. 32329.1-32329.8
Author(s):  
Alireza Badsar ◽  
◽  
Zeynab Gholami ◽  
Morteza Rahbar Taramsari ◽  
Zahra Atrkar Roshan ◽  
...  
Keyword(s):  
Blood Cell ◽  
Lead Poisoning ◽  
Clinical Symptoms ◽  
Lead Toxicity ◽  
Cross Sectional Study ◽  
University Hospital ◽  
Sectional Study ◽  
Cross Sectional ◽  
Treatment Protocols ◽  
Before And After

Background: Lead is a potent toxin that targets heme synthesis and some antioxidant enzymes that induce oxidative stress. Lead exposure remains one of the significant health concerns all over the world. Chelating agents have been used as antidotes for acute and chronic lead poisoning. The present study was conducted to evaluate the biochemical outcome of two different chelating therapies. Methods: This descriptive cross-sectional study was performed in the Razi University Hospital, Rasht, Guilan. Fifty-six patients with a history of opium use were enrolled in the study who were treated symptomatically. Blood lead Llevels (BLL), Hemoglobin (Hb), Red Blood Cell (RBC), White Blood Cell (WBC), urea, creatinine, Alanine aminotransferase (ALT), Aspartate aminotransferase (AST), and Alkaline Phosphatase (ALP) were evaluated before and after treatment. The BLL more than 100μg/dl with clinical symptoms was considered as severe lead poisoning (n=34) who received 4 days of DMPS (2,3-dimercaptopropane-1-sulfonate) injection. Other cases with BLL of 20-100μg/dl were considered as those with mild poisoning (n=22) that were treated with oral D-Penicillamine for 14 days. Results: The mean age of patients was 49.73±14.11 years. Data analysis indicated no significant differences between the groups at baseline regarding the demographic variables. A significant reduction was observed in BLL before and after the intervention using the D-Penicillamine from 75.88±26.22 to 44.3±17.51 μg/dl (P=0.0001). The BLL reduced from 105.5±34.04 to 24.51±24.08 μg/dl after treatment with DMSP (P=0.0001). The levels of ALT, AST, and WBC significantly decreased post-treatment following using D-penicillamine and DMPS (P<0.05). The D-Penicillamine-treated group showed an increase in Hb and RBC (P<0.05). Conclusion: According to the results, penicillamine improves low to moderate lead toxicity. Although DMSP decreases BLL significantly and reverses liver enzymes, further investigations on Hb and RBC, are needed.

Laboratory Abnormalities in Patients with COVID-19 in Mazandaran Province, Iran

2020 ◽  
Vol 22 (7) ◽  
Author(s):  
Reza Alizadeh-Navaei ◽  
Majid Saeedi ◽  
Reza Valadan ◽  
Fatemeh Roozbeh ◽  
Omolbanin Amjadi ◽  
...  
Keyword(s):  
Clinical Symptoms ◽  
Rna Virus ◽  
Laboratory Data ◽  
Age Groups ◽  
Laboratory Diagnosis ◽  
Cross Sectional Study ◽  
Clinical Findings ◽  
Mazandaran Province ◽  
Cross Sectional ◽  
Significance Level

Background: Coronavirus is a single-stranded RNA virus, causing an epidemic of pneumonia and acute respiratory distress syndrome (ARDS) worldwide in late 2019. Objectives: In addition to the clinical symptoms, laboratory diagnosis can greatly help diagnose the diseases; therefore, this study aimed to analyze laboratory parameters in patients with COVID-19. Methods: In this cross-sectional study, the laboratory data of 2563 patients with COVID-19 admitted to hospitals affiliated with Mazandaran University of Medical Sciences were extracted from hospital information systems (HIS). The data were recorded on Excel and analyzed through t-test, chi-squared, and Fisher’s exact tests in SPSS 19 at the significance level of P < 0.05. Results: Out of 2563 patients with a mean age of 55.1 ± 16.7 years, 1409 (55%) were male, and 1154 (45%) were female with a mean age of 55.7 ± 16.8, and 54.3 ± 16.6 years, respectively. As the most frequent clinical findings, ESR, CRP, and LDH were increased by 83.5%, 71%, and 69.3% of the patients, respectively. Other research findings included lymphopenia, disturbed INR, abnormal SGOT, abnormal alkaline phosphatase (ALP), and increased lactate dehydrogenase (LDH), which were significantly higher in men than in women and was different between age groups. Conclusions: Conducting simple, convenient, and inexpensive laboratory tests can be helpful in the diagnosis of COVID-19.

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