scholarly journals Case Report of a Rare Incidence of IgH Amplification Leading to Acute Kidney Injury in a Multiple Myeloma Patient

2021 ◽  
pp. 274-278
Author(s):  
Sowmya Thanikachalam ◽  
Vijay Kumar Srinivasalu ◽  
K.S. Nataraj ◽  
Sharat Damodar ◽  
Manjula Das
Keyword(s):  
Multiple Myeloma ◽  
Acute Kidney Injury ◽  
Case Report ◽  
Heavy Chain ◽  
Kidney Injury ◽  
Bone Marrow Aspiration ◽  
Structural Abnormality ◽  
Cell Transplant ◽  
Multiple Myeloma Patient ◽  
First Case

We present a case report of a 62-year-old male, treated for kappa light chain multiple myeloma with chemotherapy followed by autologous stem cell transplant (ASCT) in 2014. He has been in complete remission for 4 years. In 2018, he was evaluated for hypercreatinemia and acute kidney injury(AKI) with a suspicion of disease relapse; he underwent evaluation with bone marrow aspiration cytology which showed no evidence of relapse. However, careful cytogenetic analyses showed IgH amplification (14q32) which probably was the cause for AKI in the absence of any structural abnormality in the kidney. Heavy chain deposition leads to AKI in multiple myeloma, and its association with IgH amplification leading to AKI is reported here. Though heavy chain deposition leading to AKI is common, IgH amplification at chromosome level is the first case observed.

scholarly journals The Use of Supra-Hemodiafiltration in Traumatic Rhabdomyolysis and Acute Kidney Injury: A Case Report

2021 ◽  
pp. 26-35
Author(s):  
Gabriele Donati ◽  
Maria Cappuccilli ◽  
Federica Di Filippo ◽  
Simone Nicoletti ◽  
Marco Ruggeri ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Case Report ◽  
Septic Patient ◽  
Medical Therapy ◽  
Kidney Injury ◽  
First Case ◽  
Successful Recovery

Oliguric acute kidney injury due to traumatic rhabdomyolysis can be potentially lethal if the proper medical therapy combined with extracorporeal detoxification is not performed. Different extracorporeal techniques are available to overcome this syndrome. Here, we report the first case of removal of myoglobin and successful recovery from acute kidney injury in an elderly septic patient using supra-hemodiafiltration with endogenous reinfusion technique (HFR-Supra) combined with the medical therapy.

scholarly journals Acute Liver Rejection in a Multiple Myeloma Patient Treated with Lenalidomide

2020 ◽  
Vol 2020 ◽  
pp. 1-4
Author(s):  
Iuliana Vaxman ◽  
John Eaton ◽  
Hee Eun Lee ◽  
Morie A. Gertz
Keyword(s):  
Multiple Myeloma ◽  
Mycophenolate Mofetil ◽  
Case Report ◽  
Allograft Rejection ◽  
Acute Cellular Rejection ◽  
Primary Biliary Cholangitis ◽  
Myeloma Patient ◽  
Multiple Myeloma Patient ◽  
First Case ◽  
Cellular Rejection

Herein we present a patient that underwent a liver transplant due to primary biliary cholangitis (PBC) and after 9 years developed multiple myeloma. Following the cessation of mycophenolate mofetil and 2 weeks after lenalidomide treatment was started, the patient experienced acute cellular rejection. The patient recovered after treatment with corticosteroids, resumption of mycophenolate mofetil, and cessation of lenalidomide. Lenalidomide-associated allograft rejection has been reported in other organs. However, this is the first case report of liver rejection induced by lenalidomide.

Coagulopthy, acute kidney injury and death following Hypnale zara envenoming – The first case report from Sri Lanka

Toxicon ◽  
2011 ◽  
Vol 58 (8) ◽  
pp. 641-643 ◽  
Author(s):  
Kalana Maduwage ◽  
Keerthi Kularatne ◽  
Abdul Wazil ◽  
Indika Gawarammana
Keyword(s):  
Acute Kidney Injury ◽  
Case Report ◽  
Sri Lanka ◽  
Kidney Injury ◽  
First Case

Ribociclib induced acute kidney injury: A case report

2021 ◽  
pp. 107815522110072
Author(s):  
Ilkay Gulturk ◽  
Mesut Yilmaz ◽  
Aykut Ozmen ◽  
Seher Yıldız Tacar ◽  
Gülçin Sahingoz Erdal ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Acute Kidney Injury ◽  
Case Report ◽  
Dose Reduction ◽  
Metastatic Breast ◽  
Kidney Injury ◽  
Treatment Discontinuation ◽  
Close Monitoring ◽  
First Case ◽  
Grade 3

Introduction Among females, breast cancer is the most common type of cancer. Hormon receptor positive (HR+) subtype constitutes 75% of the diagnosed breast cancers. Combination of the cyclin D-cyclin-dependent kinase 4/6 (CDK4/6) inhibitor and endocrine therapy significantly improves overall survival and progression-free survival. Ribociclib is an oral CDK 4/6 inhibitor and some adverse effects are identified. According to MONALEESA 2-3-7 studies, no adverse effect (AE) were reported due to grade 3 or 4 acute kidney injury (AKI) that caused treatment discontinuation. Case report We report a ribociclib-induced grade 3 AKI in an elderly woman who was treated for metastatic breast cancer. During first cycle of therapy, she was admitted to the oncology clinic with diagnosis of AKI. Management and outcome: Ribociclib treatment was discontinued and secondary causes of AKI were excluded. During the follow-up, kidney function values returned to the normal range spontaneously. Ribociclib treatment was re-initiated by reducing the dose (400 mg daily). Despite dose reduction; grade 3 AKI recurred when ribociclib was re-initiated and the drug was permanently discontinued. Discussion According to MONALEESA 2-3-7 studies; no AE were reported due to grade 3 or 4 AKI. Despite these studies, the FDA reported that 20% of patients with ribociclib + letrozole combination therapy may have any stage elevation of creatinine. Ribociclib induced creatinine elevations are generally mild (grade 1–2) and can be managed by dose reduction or close monitoring of creatinine levels. We report the first case of grade 3 AKI that caused treatment discontinuation following administration of ribociclib.

scholarly journals PENATALAKSANAAN SEPSIS AKI PADA PASIEN MULTIPLE MYELOMA DENGAN HIPERKALSEMIA BERAT

2018 ◽  
Vol 1 (1) ◽  
pp. 54-65
Author(s):  
Agus Sumedi
Keyword(s):  
Intensive Care Unit ◽  
Multiple Myeloma ◽  
Mechanical Ventilation ◽  
Acute Kidney Injury ◽  
Intensive Care ◽  
Case Report ◽  
Light Chain ◽  
Bone Lesion ◽  
Kidney Injury ◽  
Vasoactive Agents

This case report talking about a female 56 yo with Multiple Myeloma (MM) suffer from Pneumonia and Acute Kidney Injury (AKI). MM is haematology cancer produce free light chain that impair renal tubulus, cause anemia, bone lesion and hypercalcemia. This patient came to hospital withsevere pneumonia, acute kidney injury andsevere hypercalcemia. In intensive care unit supported by mechanical ventilation, diuretic, antibiotics administration,haemodialysis,vasoactive agents, bisphosphonat and others.The acitenobacter baumanni was identified from sputum culture and then developed become multidrugs resistant leading to septic syock and multi organs dysfunction and death in two weeks.

scholarly journals Pseudohypercalcemia in a patient with multiple myeloma and acute kidney injury; a case report

2019 ◽  
Vol 8 (2) ◽  
pp. 15-15
Author(s):  
Mohammad Khaledi ◽  
Rezvan Salehidoost ◽  
Mohammadreza Khosravifarsani ◽  
Ashraf Aminorroaya
Keyword(s):  
Multiple Myeloma ◽  
Acute Kidney Injury ◽  
Case Report ◽  
Kidney Injury

scholarly journals Brain abscesses caused by Nocardia paucivorans in a multiple myeloma patient treated with lenalidomide and dexamethasone: a case report and review of literature.

2014 ◽  
Vol 7 ◽  
pp. e2015011 ◽  
Author(s):  
Jacopo Monticelli ◽  
Roberto Luzzati ◽  
Cristina Maurel ◽  
Chiara Rosin ◽  
Romina Valentinotti ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Case Report ◽  
Adverse Effects ◽  
Infectious Complication ◽  
Chemotherapy Regimen ◽  
Review Of Literature ◽  
Myeloma Patient ◽  
Multiple Myeloma Patient ◽  
First Case ◽  
Brain Abscesses

We report the first case of multiple brain abscesses caused by Nocardia paucivorans in a patient suffering from multiple myeloma on treatment with lenalidomide and dexamethasone. Nocardia  paucivorans is a recently described species of the genus Nocardia, which is supposed to have a heightened neurotropism in cases of disseminated infection. Although nocardiosis itself is an uncommon infectious complication in multiple myeloma so far, nocardial brain abscess should be added to the spectrum of adverse effects due to this novel chemotherapy regimen.

St. John’s Wort (Hypericum perforatum)-Related Acute Kidney Injury

2021 ◽  
pp. 1-3
Author(s):  
Zelal Adibelli ◽  
Ilayda Karacay ◽  
Murat Demir ◽  
Cevdet Duran
Keyword(s):  
Acute Kidney Injury ◽  
Case Report ◽  
Sleep Disorder ◽  
Kidney Failure ◽  
Hypericum Perforatum ◽  
Kidney Injury ◽  
Acute Kidney Failure ◽  
Normal Kidney ◽  
Herbal Products ◽  
First Case

Some herbal products were reported to cause nephrotoxicity through different mechanisms. This case report defines an acute kidney injury (AKI) in a patient who used <i>Hypericum perforatum</i> tea as a sleep disorder remedy. The patient developed AKI after ingestion of tea prepared from <i>Hypericum perforatum</i> and underwent hemodialysis because of acute kidney failure. After 1 week, the kidney recovered, and she was discharged with normal kidney function. This is the first case reported having acute kidney failure caused by ingestion of <i>Hypericum perforatum</i>.

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