scholarly journals Twelve-Year-Old Girl with Acute Macular Neuroretinopathy: A Multimodal Retinal Evaluation

2020 ◽  
Vol 11 (3) ◽  
pp. 620-625
Author(s):  
Luis Filipe Nakayama ◽  
Camila Kase ◽  
Vinicius Campos Bergamo ◽  
Nilva Simeren Bueno de Moraes
Keyword(s):  
Optical Coherence Tomography ◽  
Female Patient ◽  
Optical Coherence Tomography Angiography ◽  
Optical Coherence ◽  
Normal Flow ◽  
Fluorescein Angiogram ◽  
Acute Macular Neuroretinopathy ◽  
Vascular Flow

We report a 12-year-old female patient with acute macular neuroretinopathy assessed with multimodal retinal exams. Initial fluorescein angiogram and optical coherence tomography angiography (OCT-A) were both normal, and after 4 months OCT-A showed abnormal vascular flow with normal flow in superficial retina layers, choroid, and choriocapillaris.

Study of peripapillary vascular flow using optical coherence tomography angiography in optic nerve head drusen

2020 ◽  
Vol 48 (6) ◽  
pp. 775-782 ◽  
Author(s):  
Mercedes Leal‐González ◽  
Filipa Pessanha ◽  
Martim Azevedo González‐Oliva ◽  
Elia Pérez‐Fernández ◽  
Pablo Gili
Keyword(s):  
Optical Coherence Tomography ◽  
Optic Nerve ◽  
Optic Nerve Head ◽  
Optical Coherence Tomography Angiography ◽  
Optical Coherence ◽  
Vascular Flow ◽  
Optic Nerve Head Drusen

Retinal Vascular Changes on Optical Coherence Tomography Angiography and Ultra-widefield Fluorescein Angiography in Patients With Chronic Leukemia

2019 ◽  
Vol 3 (6) ◽  
pp. 420-427 ◽  
Author(s):  
T. Y. Alvin Liu ◽  
B. Douglas Smith ◽  
Karen Mackey ◽  
Marguerite O. Linz ◽  
Adrienne W. Scott
Keyword(s):  
Optical Coherence Tomography ◽  
Fluorescein Angiography ◽  
Multimodal Imaging ◽  
Optical Coherence Tomography Angiography ◽  
Optical Coherence ◽  
Vascular Changes ◽  
Chronic Leukemia ◽  
Vascular Flow ◽  
Flow Loss ◽  
Sd Oct

Purpose: This article describes pathological retinal vascular changes on multimodal imaging in patients with chronic leukemia. Methods: A prospective, observational study was conducted. Patients with chronic leukemia and concurrent leukocytosis were recruited from a tertiary-referral, academic medical center. Eligible patients received complete ophthalmic examinations and multimodal retinal imaging: spectral-domain optical coherence tomography (SD-OCT), optical coherence tomography angiography (OCTA), and ultra-widefield fluorescein angiography (UWF FA). Results: Six patients (11 eyes) were consecutively enrolled. At presentation, mean age was 56.9 years, median visual acuity was Snellen 20/20, and median leukocyte count was 114.5 K/mm3 (upper limit of normal: 11.00). Three of 11 eyes had SD-OCT abnormalities, including focal retinal thinning and hyperreflective material at the level of the retinal pigment epithelium. Five of 11 eyes showed OCTA abnormalities, including focal vascular flow loss and a diffuse decrease in vascular density. Four of 11 eyes had peripheral retinal abnormalities on UWF FA, including microaneurysms and nonperfusion. Five of 11 eyes showed pathological vascular changes on retinal imaging, and of these 5 eyes, 3 had unremarkable retinal examinations. Conclusions: Retinal vascular pathologies are frequently seen in patients with chronic leukemia and concurrent leukocytosis, though these patients are rarely symptomatic. Multimodal imaging allows for more sensitive detection of these pathologies compared with clinical examination alone. On OCTA, pathological vascular flow loss is more evident in the superficial capillary plexus. There may be a correlation between pathologies seen in the central and peripheral retina, but this observation will need to be confirmed by a future study with a larger cohort.

scholarly journals Diabetic vascular hyperpermeability: optical coherence tomography angiography and functional loss assessments of relationships among retinal vasculature changes

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Mitsuru Arima ◽  
Shintaro Nakao ◽  
Yoshihiro Kaizu ◽  
Iori Wada ◽  
Muneo Yamaguchi ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Optical Coherence Tomography Angiography ◽  
Flow Density ◽  
Optical Coherence ◽  
Cross Sectional ◽  
Low Leakage ◽  
Diabetic Retina ◽  
Vascular Flow ◽  
Capillary Plexus ◽  
Stratified Analysis

AbstractOur study assessed the influence of vascular permeability on vascular flow density (FD)-correlated retinal sensitivity (RS) in DR. In this cross-sectional, prospective, consecutive study, RS in the extrafoveal macula of DR patient was measured by microperimetry. FD was measured in the total, superficial, and deep capillary plexus layers (TCP, SCP, and DCP) by optical coherence tomography angiography. All measurement points were classified into four categories according to intensity of fluorescein leakage and FD, and the RS reduction was compared. A stratified analysis by retinal thickness (RT) was also performed. Fourteen eyes (14 patients) were enrolled. FDs at 207 RS measurement points were analyzable. For TCP, SCP and DCP, the leakage did not decrease RS at points where FD was maintained. The greater the leakage, the smaller the RS reduction at points with low FD in TCP (P = .020). Points with high leakage showed a significant smaller RS reduction than points with low leakage (P = .001 for TCP, P = .040 for SCP, and P = .046 for DCP) only in areas with low RT and low FD. Our results suggested that vascular hyperpermeability may inhibit the RS reduction in the non-edematous ischemic diabetic retina.

Acute macular neuroretinopathy: pathogenetic insights from optical coherence tomography angiography

2018 ◽  
Vol 103 (3) ◽  
pp. 410-414 ◽  
Author(s):  
Giuseppe Casalino ◽  
Alessandro Arrigo ◽  
Francesco Romano ◽  
Marion R Munk ◽  
Francesco Bandello ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Optical Coherence Tomography Angiography ◽  
Pigment Epithelium ◽  
Retinal Pigment ◽  
Vessel Density ◽  
Control Group ◽  
Optical Coherence ◽  
Cross Sectional ◽  
Swept Source ◽  
Acute Macular Neuroretinopathy

AimTo describe the optical coherence tomography angiography (OCT-A) features of patients affected by acute macular neuroretinopathy (AMN).Methods This is a prospective, observational, cross-sectional study. Multimodal imaging, including spectral domain OCT (Spectralis HRA+OCT; Heidelberg Engineering, Heidelberg, Germany) and 6×6 mm swept source OCT-A (ZEISS PLEX Elite 9000; ZEISS, Dublin, California), was performed on all patients. The primary outcome measure was assessment of the vascular alterations of the superficial (SCP) and deep (DCP) capillary plexuses and choriocapillaris (CC). A segmentation of the AMN lesions using enface OCT images of photoreceptors-retinal pigment epithelium complex was used to discriminate intralesional and extralesional regions on the OCT-A enface slabs of the DCP and CC reconstructions. Each OCT-A slab was imported into ImageJ V.1.50 and digitally binarised for quantitative analyses.ResultsOverall, seven patients (mean age 19.4±3.2 years, six women) affected by AMN were included. The mean best-corrected visual acuity was 0.00±0.00 logarithm of the minimum angle of resolution. Twelve healthy age-matched subjects (mean age 22±3.4 years, 10 women) represented the control group. The quantitative analysis of global vessel densities showed that the CC vessel density was significantly lower in patients with AMN (0.495±0.03) compared with the age-matched controls (0.545±0.02) (corrected p=0.0003). The intralesional vessel density of the DCP was 0.349±0.04 in AMN and vs 0.497±0.02 in the controls (corrected p=0.0002).ConclusionsOur study confirmed inner choroidal vascular flow void as a possible pathogenetic mechanism of AMN. We also found a focal impairment of the DCP within the AMN lesions. Future studies are needed to clarify which is the primary location of the vascular insult in this condition.

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