scholarly journals Cytological Diagnosis of Plasmablastic Lymphoma Involving the Parotid Gland: A Case Report with Review of the Literature

2021 ◽  
pp. 244-248
Author(s):  
Ghaleb Elyamany ◽  
Ahmed Fouly ◽  
Abdulmalik Alqahtani ◽  
Assem Alrumeh ◽  
Shuaa Asiri ◽  
...  
Keyword(s):  
Needle Aspiration ◽  
Plasmablastic Lymphoma ◽  
Diagnostic Challenge ◽  
Current Case ◽  
Barr Virus ◽  
Tissue Biopsy ◽  
Parotid Swelling ◽  
Epstein Barr ◽  
Needle Aspiration Cytology ◽  
Immunodeficiency Syndrome

Plasmablastic lymphoma (PBL) is a rare subtype of non-Hodgkin’s lymphoma that is associated with acquired immunodeficiency syndrome (AIDS), characterized by its association with Epstein-Barr virus (EBV), aggressive nature, and plasmacytic/plasmablastic differentiation. PBL remains a therapeutic and diagnostic challenge. Diagnosis of PBL by fine-needle aspiration cytology (FNAC) is reported infrequently. We herein describe the cytodiagnosis of a rare case of HIV-negative PBL in a 58-year-old man without EBV infection presented by parotid swelling. The current case study highlights the cytomorphologic features that may help to distinguish PBL from other mimics. However, although the cytomorphologic features may suggest PBL, a definitive diagnosis requires additional studies including tissue biopsy and immunohistochemistry, in addition to biochemical investigations and radiological workup to establish the diagnosis and exclude similar conditions. In conclusion, FNAC is a very useful, simple, rapid and reliable procedure for diagnosis of the lymphoma. FNAC provided the earliest clue to diagnosis of PBL, which was later confirmed by tissue biopsy.

scholarly journals Plasmablastic Lymphoma: A Systematic Review

2011 ◽  
Vol 11 ◽  
pp. 687-696 ◽  
Author(s):  
Jorge J. Castillo ◽  
John L. Reagan
Keyword(s):  
Case Reports ◽  
Case Series ◽  
B Cell Lymphoma ◽  
Plasmablastic Lymphoma ◽  
Molecular Characteristics ◽  
Diagnostic Challenge ◽  
Barr Virus ◽  
Cd20 Expression ◽  
Epstein Barr ◽  
Relapse Rates

Plasmablastic lymphoma (PBL) is a very aggressive variant of diffuse large B-cell lymphoma initially described in the oral cavity of HIV-infected individuals. PBL represents a diagnostic challenge given its characteristic morphology and lack of CD20 expression, and also a therapeutic challenge, with early responses to therapy, but with high relapse rates and poor prognosis. In recent years, our understanding and clinical experience with PBL has increased in both HIV-positive and -negative settings. However, given its rarity, most of the data available rely on case reports and case series. The main goal of this article is to systematically review the most recent advances in epidemiology; pathophysiology; clinical, pathologic, and molecular characteristics; therapy; and prognosis in patients with PBL. Specific covered topics include new pathological markers for diagnosis, its association with Epstein-Barr virus, and the need of more intensive therapies.

Quantification of plasma Epstein–Barr virus DNA for assessing treatment response in a patient with plasmablastic lymphoma

2011 ◽  
Vol 91 (5) ◽  
pp. 789-791 ◽  
Author(s):  
Man Fai Law ◽  
Wai Lun Poon ◽  
Kwan Shun Ng ◽  
Hay Nun Chan ◽  
Ho Kei Lai ◽  
...  
Keyword(s):  
Treatment Response ◽  
Epstein Barr Virus ◽  
Plasmablastic Lymphoma ◽  
Barr Virus ◽  
Epstein Barr

scholarly journals Spontaneous splenic rupture in a patient with infectious mononucleosis

2019 ◽  
Vol 12 (9) ◽  
pp. e230259
Author(s):  
Charlotte Ruth Baker ◽  
Sid Kona
Keyword(s):  
Epstein Barr Virus ◽  
Splenic Rupture ◽  
Rare Complication ◽  
Young Female ◽  
Pleuritic Chest Pain ◽  
Diagnostic Challenge ◽  
Barr Virus ◽  
Ebv Infection ◽  
Epstein Barr ◽  
Atraumatic Splenic Rupture

We present a case of spontaneous, atraumatic splenic rupture secondary to Epstein-Barr virus (EBV) infection, in a young, female patient. Splenic rupture is a rare complication of EBV infection, but is associated with the highest mortality. Additionally, this case illustrates the diagnostic challenge in a patient presenting in atypical manner, with only left-sided pleuritic chest pain, and lacking any of the classical tonsillitis symptoms associated with EBV infection.

scholarly journals Relapse of Plasmablastic Lymphoma With Cutaneous Involvement in an Immunocompetent Male

2020 ◽  
pp. 014556132095219
Author(s):  
Samantha Shwe ◽  
Aditi A. Sharma ◽  
Bonnie A. Lee ◽  
Janellen E. Smith
Keyword(s):  
Nasal Cavity ◽  
Epstein Barr Virus ◽  
Recurrent Disease ◽  
Excisional Biopsy ◽  
Plasmablastic Lymphoma ◽  
Rare Type ◽  
Barr Virus ◽  
Non Hodgkin Lymphoma ◽  
Immunodeficiency Virus ◽  
Epstein Barr

Plasmablastic lymphoma (PBL) is a rare type of non-Hodgkin lymphoma frequently found in the context of immunosuppression and infection with human immunodeficiency virus (HIV) and/or Epstein-Barr virus (EBV). A 33-year-old immunocompetent male presented with recurrent episodes of epistaxis and a growing intranasal mass. Excisional biopsy of the mass revealed an immunohistochemical profile diagnostic of PBL. Upon completion of chemoradiation, he underwent a transnasal endoscopic mucosal flap tissue rearrangement to restore patency for both functional and surveillance purposes. There was no endoscopic evidence of residual or recurrent disease. However, 8 months later, he was found to have a relapse involving the skin. The nasal cavity is one of the most common sites affected by PBL. Involvement of the nasal cavity may present with symptoms of persistent epistaxis accompanied by an enlarging mass. A plasmablastic immunophenotype in combination with HIV or EBV positivity can aid diagnosis.

scholarly journals Epstein-Barr virus infection precedes clonal expansion in Burkitt's and acquired immunodeficiency syndrome-associated lymphoma [see comments]

Blood ◽  
1991 ◽  
Vol 77 (5) ◽  
pp. 1092-1095 ◽  
Author(s):  
A Neri ◽  
F Barriga ◽  
G Inghirami ◽  
DM Knowles ◽  
J Neequaye ◽  
...  
Keyword(s):  
Acquired Immunodeficiency Syndrome ◽  
Epstein Barr Virus ◽  
Clonal Expansion ◽  
Epstein Barr Virus Infection ◽  
Barr Virus ◽  
Ebv Infection ◽  
Non Hodgkin Lymphoma ◽  
Acquired Immunodeficiency ◽  
Epstein Barr ◽  
Immunodeficiency Syndrome

Abstract The Epstein-Barr virus (EBV) is associated with distinct forms of human lymphoid malignancies, including the endemic (eBL) and sporadic forms of Burkitt's lymphoma (sBL) and acquired immunodeficiency syndrome- associated non-Hodgkin lymphoma (AIDS-NHL). However, whether EBV has a pathogenetic role in these tumors or is a passenger virus has not been conclusively demonstrated. One element to distinguish between these two possibilities is to determine whether EBV infection has preceded and, thus, possibly contributed to clonal expansion, or whether infection has occurred after clonal expansion and thus is unlikely to contribute to pathogenesis. Toward this end we analyzed the structure of the heterogeneous genomic termini of EBV as markers of clonal infection in a panel of eBL (11 cases), sBL (9 cases), and AIDS-NHL (10 cases) biopsies. We show that EBV termini are uniformly clonal in sBL, eBL, and AIDS-NHL, strongly suggesting that EBV infection has preceded and, thus, most likely contributed to clonal expansion in these malignancies.

scholarly journals Establishment of two Epstein-Barr virus negative Burkitt cell lines from a patient with AIDS and B-cell lymphoma

Blood ◽  
1988 ◽  
Vol 72 (4) ◽  
pp. 1255-1260 ◽  
Author(s):  
A Ganser ◽  
C Carlo-Stella ◽  
CR Bartram ◽  
T Boehm ◽  
G Heil ◽  
...  
Keyword(s):  
B Cell ◽  
Cell Lines ◽  
Epstein Barr Virus ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Cell Receptor ◽  
Immunoglobulin Gene ◽  
Barr Virus ◽  
Epstein Barr ◽  
Immunodeficiency Syndrome

Abstract To analyze the pathogenesis of B-cell lymphomas in patients with acquired immunodeficiency syndrome (AIDS), we studied two cell lines, Es I and Es III, established from one such lymphoma for the presence of sequences of the Epstein-Barr virus (EBV) and the human immunodeficiency virus [HIV; lymphadenopathy-associated virus (LAV/HTLV- III)] as well as for the presence of cytogenetic abnormalities and monoclonal rearrangements of immunoglobulin and T-cell receptor genes. Both cell lines expressed the same IgM, kappa phenotype as the original lymphoma. The karyotype of Es I was 46, XY, t(8;14), 2 p+, inv (6p), 17p-, and the cells of Es III had an additional i(7q). Immunoglobulin gene studies demonstrated the identical monoclonal rearrangements in both cell lines. Neither EBV nor HIV sequences were detectable in the malignant B cells at the genomic level, leading to the conclusion that mechanisms other than transformation by EBV or HIV may have contributed to the B-cell lymphoma in this patient and possibly also to the generally increased frequency in patients with AIDS.

Acquired myospherulosis secondary to gluteal augmentation on fine needle aspiration cytology: A diagnostic challenge

2017 ◽  
Vol 46 (5) ◽  
pp. 438-442
Author(s):  
Susan Alperstein ◽  
Thomas Dilcher ◽  
Kartik Viswanathan ◽  
Rema A. Rao ◽  
Momin T. Siddiqui ◽  
...  
Keyword(s):  
Fine Needle Aspiration ◽  
Fine Needle Aspiration Cytology ◽  
Needle Aspiration ◽  
Diagnostic Challenge ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
Gluteal Augmentation ◽  
Needle Aspiration Cytology
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