Allergische Rhinitis: Zugang zu Allergen-Immuntherapie erleichtert

2020 ◽  
Vol 8 (3) ◽  
pp. 107-108
Author(s):  
Vera Mahler
Keyword(s):  
Allergic Rhinitis ◽  
Real World ◽  
Simple Algorithm ◽  
Allergische Rhinitis ◽  
Assessment Development ◽  
Randomized Controlled ◽  
Real World Evidence ◽  
Increasing Trend ◽  
Chamber Studies ◽  
Selection Of

The selection of pharmacotherapy for patients with allergic rhinitis aims to control the disease and depends on many factors. Grading of Recommendations Assessment, Development and Evaluation (GRADE) guidelines have considerably improved the treatment of allergic rhinitis. However, there is an increasing trend toward use of real-world evidence to inform clinical practice, especially because randomized controlled trials are often limited with regard to the applicability of results. The Contre les Maladies Chroniques pour un Vieillissement Actif (MACVIA) algorithm has proposed an allergic rhinitis treatment by a consensus group. This simple algorithm can be used to step up or step down allergic rhinitis treatment. Next-generation guidelines for the pharmacologic treatment of allergic rhinitis were developed by using existing GRADE-based guidelines for the disease, real-world evidence provided by mobile technology, and additive studies (allergen chamber studies) to refine the MACVIA algorithm.

Real‐world evidence of subcutaneous allergoid immunotherapy in house dust mite‐induced allergic rhinitis and asthma

Allergy ◽  
2020 ◽  
Vol 75 (8) ◽  
pp. 2050-2058 ◽  
Author(s):  
Marek Jutel ◽  
Bernd Brüggenjürgen ◽  
Hartmut Richter ◽  
Christian Vogelberg
Keyword(s):  
Allergic Rhinitis ◽  
House Dust ◽  
House Dust Mite ◽  
Real World ◽  
Real World Evidence ◽  
Dust Mite

scholarly journals Randomized Controlled Trials Versus Real World Evidence: Neither Magic Nor Myth

2020 ◽  
Author(s):  
Hans‐Georg Eichler ◽  
Francesco Pignatti ◽  
Brigitte Schwarzer‐Daum ◽  
Ana Hidalgo‐Simon ◽  
Irmgard Eichler ◽  
...  
Keyword(s):  
Randomized Controlled Trials ◽  
Real World ◽  
Controlled Trials ◽  
Randomized Controlled ◽  
Real World Evidence

scholarly journals The Expanding Role of Real-World Evidence Trials in Health Care Decision Making

2019 ◽  
Vol 14 (1) ◽  
pp. 174-179 ◽  
Author(s):  
David C. Klonoff
Keyword(s):  
Real World ◽  
Clinical Evidence ◽  
Real World Data ◽  
Medical Products ◽  
Advantages And Disadvantages ◽  
Randomized Controlled ◽  
Real World Evidence ◽  
Care Decision

Real-world evidence (RWE) is the clinical evidence about benefits or risks of medical products derived from analyzing real world data (RWD), which are data collected through routine clinical practice. This article discusses the advantages and disadvantages of RWE studies, how these studies differ from randomized controlled trials (RCTs), how to overcome barriers to current skepticism about RWE, how FDA is using RWE, how to improve the quality of RWE, and finally the future of RWE trials.

scholarly journals PCV2 Characterizing Patients Treated with Macitentan: Real-World Evidence and a Randomized Controlled Trial Cohort

2020 ◽  
Vol 23 ◽  
pp. S486
Author(s):  
N. Kim ◽  
K.M. Chin ◽  
V.V. McLaughlin ◽  
C. Zhao ◽  
M. Flynn ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Real World ◽  
Controlled Trial ◽  
Randomized Controlled ◽  
Real World Evidence

scholarly journals Role of real-world evidence in informing cancer care: lessons from colorectal cancer

2019 ◽  
Vol 26 (1) ◽  
Author(s):  
A. Batra ◽  
W. Y. Cheung
Keyword(s):  
Colorectal Cancer ◽  
Real World ◽  
Cancer Care ◽  
Clinical Care ◽  
Real World Data ◽  
Cancer Management ◽  
Randomized Controlled ◽  
Real World Evidence ◽  
Research Questions

The term “real-world evidence” (rwe) describes the analysis of data that are collected beyond the context of clinical trials. The use and application of rwe have become increasingly common and relevant, especially in oncology, because there is growing recognition that randomized controlled trials (rcts) might not be sufficiently representative of the entire patient population that is affected by cancer, and that specific clinical research questions might be best addressed by real-world data. In this brief review, our main aim is to highlight the role of rwe in informing cancer care, particularly focusing on specific examples from colorectal cancer. Our hope is to illustrate the ways in which rwe can complement rcts in improving the understanding of cancer management and how rwe can facilitate cancer treatment decisions for real-world patients encountered in routine clinical care.

scholarly journals Role of real-world evidence studies in cardiology

2021 ◽  
Vol 26 (3S) ◽  
pp. 4636
Author(s):  
T. V. Pavlova
Keyword(s):  
Real World ◽  
Observational Studies ◽  
Safety Data ◽  
Randomized Controlled ◽  
Medication Effects ◽  
Real World Evidence ◽  
Methodological Problems ◽  
Based Medicine

The introduction of evidence-based medicine into practical healthcare provides physicians with the opportunity to use treatment approaches, which have been proven to be effective in randomized controlled trials. In this case, it is necessary to consider using the medication in a particular patient in accordance with the design of clinical trials and strictly follow the instructions. Drugs should be critically selected with focus on quality of available efficacy and safety data obtained in the population closest to a patient. In addition, clinicians should regularly review the available data with particular regard to its quality. The advantages, disadvantages, limitations and methodological problems of observational studies should be carefully considered during the interpretation of results. At the same time, the compliance of the results of real-world evidence studies with registration trial data indicates a high reproducibility of medication effects.

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