scholarly journals Cardiovascular Risk in Polycythemia Vera: Thrombotic Risk and Survival: Can Cytoreductive Therapy Be Useful in Patients with Low-Risk Polycythemia Vera with Cardiovascular Risk Factors?

2020 ◽  
Vol 43 (10) ◽  
pp. 526-530
Author(s):  
Salvatrice Mancuso ◽  
Marco Santoro ◽  
Vincenzo Accurso ◽  
Giuseppe Agliastro ◽  
Simona Raso ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Polycythemia Vera ◽  
Low Risk ◽  
Thrombotic Risk

scholarly journals CARDIOVASCULAR RISK IN ESSENTIAL THROMBOCYTHEMIA AND POLYCYTHEMIA VERA: THROMBOTIC RISK AND SURVIVAL

2020 ◽  
Vol 12 (1) ◽  
pp. e2020008
Author(s):  
Vincenzo Accurso ◽  
Marco Santoro ◽  
Salvatrice Mancuso ◽  
Angelo Davide Contrino ◽  
Paolo Casimio ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Cigarette Smoking ◽  
Cardiovascular Risk Factors ◽  
Polycythemia Vera ◽  
Essential Thrombocythemia ◽  
Thrombotic Event ◽  
Bleeding Events ◽  
Thrombotic Risk ◽  
The Impact

Abstract Thromboembolic and bleeding events pose a severe risk for patients with Polycythemia Vera (PV) and Essential Thrombocythemia (ET). Many factors can contribute to determine the thrombotic event, including the interaction between platelets, leukocytes and endothelium alterations. Moreover, a very important role can be played by cardiovascular risk factors (CV.R) such as cigarette smoking habits, hypertension, diabetes, obesity and dyslipidemia. In this study we evaluated the impact that CV.R plays on thrombotic risk and survival in patients with PV and ET.

scholarly journals No Impact of the Increased Number of Cardiovascular Risk Factors on Thrombosis and Survival in Polycythemia Vera

2021 ◽  
pp. 1-3
Author(s):  
Ivan Krečak ◽  
Martina Morić Perić ◽  
Ivan Zekanović ◽  
Hrvoje Holik ◽  
Božena Coha ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Polycythemia Vera

scholarly journals Cardiovascular Risk Factors and Diabetes in Medical Students: Observational Study, Experience in Colombia

2018 ◽  
Vol 6 (2) ◽  
pp. 61-65 ◽  
Author(s):  
Diego Mauricio Bados Enriquez ◽  
Karoll Vanessa Ladino Oyola ◽  
Juan Esteban Yucuma Ruiz
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Cardiovascular Disease ◽  
Cardiovascular Risk ◽  
Medical Students ◽  
Cardiovascular Risk Factors ◽  
Risk Score ◽  
Low Risk ◽  
Early Interventions ◽  
Moderate Risk

Background: Cardiovascular Disease is a leading cause of preventable death. Cardiovascular risk factors’ identification is the cornerstone for effective and early interventions decreasing the frequency of acute health-threatening events. Since adolescence and youth are very vulnerable stages to develop risky habits, we decided to run this study in the Multidisciplinary Universitary Camp for Research and Service. Methods: A descriptive cross-sectional study was performed in the Multidisciplinary Universitary Camp for Research and Service in which 450 medical students from Colombia were assessed. After a probabilistic random simple sampling (n=50), we applied the World Health Organization test and Finnish Risk Score to calculate Cardiovascular and Diabetes Mellitus risk, respectively. We characterized the population by sociodemographic variables and anthropometric measurements. Results: The study shows that from 18 participating universities (n=50), the mean age of the participants was 21.14 years (SD 7.3) of whom 40% were male and 60% were female. Overall, 92% have a low risk of cardiovascular disease, 6% are at moderate risk and 2% are at high risk. 92% have low risk of diabetes mellitus and 8% are at moderate risk of having diabetes mellitus in the long term. Conclusion: The early identification of and intervention on risk factors could decrease significantly the onset of acute health-threatening cardiovascular pathologies. As medical students, adolescents and young adults are at risk of developing unhealthy habits which increase the incidence of cardiovascular disorders. The use of anthropometric measures and validated risk score scales is an appropriate way to get evidence for starting early interventions.

Risk Factors for Thrombosis Vary According to Age in Patients with Essential Thrombocythemia: a Retrospective Analysis of 1090 Patients from the “Gruppo Laziale SMPC Ph Negative “,

Blood ◽  
2011 ◽  
Vol 118 (21) ◽  
pp. 3854-3854
Author(s):  
Marco Montanaro ◽  
Roberto Latagliata ◽  
Michele Cedrone ◽  
Nicoletta Villivà ◽  
Raffaele Porrini ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Thrombotic Event ◽  
Age Groups ◽  
Thrombotic Risk ◽  
Mutational Status ◽  
Group A ◽  
Group B

Abstract Abstract 3854 Increasing age is a well-recognised risk factor for thrombotic events in patients with Essential Thrombocythemia (ET): however, few data exist on the role of other clinical and biological features in different age groups. To address this issue, we analysed retrospectively 1090 ET patients (M/F 403/687, median age 63 years, IR 17 – 96) diagnosed at 11 Hematological Institutions in the Lazio region from 1980 to 2010 and with a median period of follow-up of 84 months (IR 1 – 371). Based on the commonly adopted age threshold, 480 patients (44 %) were < 60 years (Group A) and 610 (56 %) were ≥ 60 years (Group B). Clinical and biological features as well as cardiovascular risk factors analyzed for the impact on the thrombotic risk in the two age groups are reported in the Table.Group A < 60 yearsGroup B ≥ 60 yearsPutative risk factorsRisk ratio (95% CI)P valueRisk ratio (95% CI)P valueM/F167/3132.68 (1.03–6.94)0.0029236/3741.12 (0.17–2.59)0.73WBC median (range) x 109/l8.9 (4.29–22.35)0.387 (0.149–1,004)0.06458.9 (1.2–57.7)0.79 (0.41–1.47)0.445PLTS median (range) x 109/l837 (451–3582)0.37 (0.258–1.70)0.66802 (450–3104)0.52 (0.28–0.99)0.0052Hb median, g/dL (range)14.1 (6.0–18.4)0.86 (0.33–2.24)0.76914.0 (7.0–17.8)0.87 (0.45–1.67)0.674*JAK-2 mutational status: wild type/mutated (%)53.2/46.81.57 (0.50–4.87)0.4434.1/65.90.498 (0.17–1.48)0.209Previous thrombotic events: n° (%)· All events72 (15)2.18 (0.59–7.96)0.12149 (24.4)3.01 (1.38–6.57)0.0004· within 24 months from diagnosis48 (10)1.43 (0.19–10.4)0.7464 (10.5)0.506 (0.18–1.39)0.189· within 60 months from diagnosis60 (12.5)NA0.5191 (14.9)0.323 (0.11–0.95)0.023Cardiovascular risk factors: Y/N %○ Arterial hypertension41.7/58.31.68(0.64–4.36)0.2880.7/19.30.96 (0.36–2.57)0.935○ Diabetes10.2/89.81.11 (0.23–5.15)0.8925.0/75.01.09 (0.38–3.11)0.86○ Smoking attitude45.6/54.42.78 (1.01–7.65)0.06758.3/41.71.04 (0.35–3.09)0.94○ Hyperlipidemia31.0/69.03.11(0.917–10.592)0.03951.6/48.42.31 (0.70–7.55)0.203 In Group A, 39 patients (8.1%) had at least one thrombotic event during follow-up; there were 20 (51.3%) arterial thrombosis and 19 (48.7%) venous thrombosis. In Group B, 63 patients (10.3%) had at least one thrombotic event during follow-up; there were 38 (69.4%) arterial thromboses and 25 (39.6%) venous thromboses. In group A univariate analysis for thrombosis-free survival performed by Kaplan-Meier method, disclosed a significant impact of male gender (p=0.0029, CI 1.03–6.94, HR 2.68), > 2 cardiovascular risk factors (p=0.0002, CI 1.87 – 190, HR 18.94) and isolated hyperlipidemia (p=0.039, CI 0.917 – 10.59, HR 3.11), while previous thrombotic events had no significant impact (p=0.27). By contrast, the presence of a previous thrombotic event was the only feature with a significant impact on thrombotic risk in Group B (p=0.0004, CI 1.38 – 6.55, HR 3.01). WBC and PLTS values at different cut-off levels as well as JAK-2 mutational status did not have any impact on thrombosis in either age groups. However, in group B, we observed a trend (p=0.052, CI 0.28–0.99, HR 0.52) towards a protective effect of higher PLTS values (> 800 × 109/l). In conclusion, our data seem to reinforce the need of a different thrombotic risk assessment in distinct age groups: in particular, younger patients could benefit from early recognition and treatment of well-known cardiovascular risk factors. Disclosures: No relevant conflicts of interest to declare.

The prevalence of cardiovascular risk factors among centenarians is low: risk factors in centenarians

2006 ◽  
Vol 13 (6) ◽  
pp. 993-995 ◽  
Author(s):  
Jolanta Życzkowska ◽  
Alicja Klich-Rαczka ◽  
Barbara Wizner ◽  
Maągorzata Mossakowska ◽  
Katarzyna Wieczorowska-Tobis ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Low Risk

scholarly journals The Essential Thrombocythemia, Thrombotic Risk Stratification, and Cardiovascular Risk Factors

2020 ◽  
Vol 2020 ◽  
pp. 1-5
Author(s):  
Salvatrice Mancuso ◽  
Vincenzo Accurso ◽  
Marco Santoro ◽  
Simona Raso ◽  
Angelo Davide Contrino ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Essential Thrombocythemia ◽  
Scoring Systems ◽  
Risk Groups ◽  
Risk Scores ◽  
Driver Mutations ◽  
Thrombotic Risk ◽  
The Impact

Essential thrombocythemia is a rare hematological malignancy with good overall survival, but moderate to high risk of developing arterial or venous thrombosis lifelong. Different thrombotic risk scores for patients with essential thrombocythemia have been proposed, but only one of them (the IPSET-t scoring system) takes into account the classical cardiovascular risk factors as one of the scoring items. Currently, in clinical practice, the presence of cardiovascular risk factors in patients with diagnosis of ET rarely determines the decision to initiate cytoreductive therapies. In our study, we compared different risk models to estimate the thrombotic risk of 233 ET patients and the role of specific driver mutations and evaluated the impact that conventional cardiovascular risk factors (hypertension, cigarette smoking, diabetes, obesity, and dyslipidaemia) have on thrombotic risk in patients with ET. Perspective studies conducted on a polycentric large cohort of patients should be conducted to estimate the impact of cardiovascular risk factors in determining thrombosis in ET patients, evaluating the opportunity of initiating a cytoreductive therapy in patients with cardiovascular risk factors, even if classified into low to moderate risk groups according to other scoring systems.

scholarly journals Relationship between cardiovascular risk factors and coronary calcification in a middle-aged Dutch population: the Imalife study

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
C Xia ◽  
M Vonder ◽  
G Sidorenkov ◽  
M Den Dekker ◽  
M Oudkerk ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Coronary Artery ◽  
Cardiovascular Risk Factors ◽  
Coronary Artery Calcium ◽  
Coronary Calcification ◽  
Low Risk ◽  
Funding Source ◽  
Middle Aged ◽  
Score Risk

Abstract Background Systematic COronary Risk Evaluation (SCORE) has been proposed to assess the 10-year risk of fatal cardiovascular diseases, with distinction between low-risk and high-risk countries. Risk modifiers are recommended to further improve risk reclassification, for example the coronary artery calcium (CAC) score. CAC scoring can significantly improve risk prediction for coronary events based on outcome studies. The impact of CAC scoring on risk classification in a middle-aged cohort from a low-risk country in comparison to SCORE is unknown. Purpose To assess presence of coronary calcification and association with cardiovascular risk factors and related SCORE risk in a middle-aged population from a low risk country. Methods Coronary calcification and classical cardiovascular risk factors were analyzed in 4,083 Dutch participants aged 45–60 years (57.9% women) without a known history of coronary artery disease in the population-based ImaLife (Imaging in Lifelines) study. Individuals underwent non-contrast cardiac CT using third generation dual-source CT. Coronary artery calcium (CAC) scores were quantified using Agatston's method. Age- and sex- specific distributions of CAC categories (0, 1–99, 100–299, ≥300) and percentiles were assessed. Distribution of CAC categories was compared to SCORE risk categories (&lt;1%, ≥1% to 5%, and ≥5%) for low risk countries. Relationship between risk factors and CAC presence was evaluated by logistic regression models. Population attributable fractions (PAFs) of classical risk factors for CAC presence were estimated to investigate potential prevention strategy. Results CAC was present in 54.5% of men and in 26.5% of women. With increasing age, an increasing percentage had a positive CAC score, from 38.1% of men and 15.2% of women at age 45–49 years, to 66.9% of men and 36.6% of women at age 55–60. Mean SCORE was 1.3% (2.0% in men, 0.7% in women). In SCORE risk &lt;1%, 32.7% of men and 17.1% of women had CAC. In men with SCORE risk ≥5% (0.1% of women), 26.9% had no CAC. Overall PAF for presence of CAC of the classical risk factors was 18.5% in men and 31.4% in women. PAF was highest for hypertension (in men 8.0%, 95% CI 4.2–11.8%; in women 13.1%, 95% CI 7.9–18.2%) followed by hypercholesterolemia and obesity. Conclusion In this middle-aged Dutch cohort, slightly over half of men and a quarter of women had any CAC. With age there was an increase in CAC presence for both sexes. Only a minor proportion of CAC presence was attributable to classical risk factors. This provides further support that CAC scoring can impact risk classification in a middle-aged population of a low-risk country. Funding Acknowledgement Type of funding source: Other. Main funding source(s): The ImaLife study is supported by an institutional research grant from Siemens Healthineers and by the Ministry of Economic Affairs and Climate Policy by means of the PPP Allowance made available by the Top Sector Life Sciences & Health to stimulate public-private partnerships.

scholarly journals IL-37 Gene and Cholesterol Metabolism: Association of Polymorphisms with the Presence of Hypercholesterolemia and Cardiovascular Risk Factors. The GEA Mexican Study

Biomolecules ◽  
2020 ◽  
Vol 10 (10) ◽  
pp. 1409
Author(s):  
Fabiola López-Bautista ◽  
Rosalinda Posadas-Sánchez ◽  
Christian Vázquez-Vázquez ◽  
José Manuel Fragoso ◽  
José Manuel Rodríguez-Pérez ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Cholesterol Metabolism ◽  
Plasma Cholesterol ◽  
Low Risk ◽  
Cholesterol Homeostasis ◽  
Reactive Protein ◽  
Confounding Variables ◽  
Visceral Abdominal Fat

Interleukin 37 (IL-37) is an anti-inflammatory cytokine involved in the regulation of cholesterol homeostasis, reducing the levels of plasma cholesterol, fatty acids, and triglycerides. The aim of the present study was to evaluate the association of the IL-37 polymorphisms with the presence of hypercholesterolemia (HC), and with cardiovascular risk factors. Nine IL-37 polymorphisms (rs2708965, rs2708962, rs6717710, rs2708961, rs2708960, rs2708958, rs2723187, rs2708947, and rs2723192) were determined by TaqMan assays in a group of 1292 individuals (514 with and 778 without hypercholesterolemia) belonging to the cohort of the GEA Mexican Study. The associations were evaluated by logistic regression, using inheritance models adjusted by confounding variables. Under codominant 1 model, the rs2708961 (OR = 0.51, p = 0.02), rs2723187 (OR = 0.35, p = 0.005), and rs2708947 (OR = 0.49, p = 0.02) polymorphisms were associated with low risk of HC. The association of the polymorphisms with cardiovascular risk factors was evaluated independently in HC and non-HC individuals. In non-HC individuals, some polymorphisms were associated with the risk of having high levels of LDL-C, glucose, and high risk of T2DM, and low risk of having high visceral abdominal fat. On the other hand, in individuals with HC five, polymorphisms were associated with high levels of C-reactive protein. The IL-37 rs2708961, rs2723187, rs2708947 polymorphisms were associated with low risk of HC, and some IL-37 polymorphisms were associated with cardiometabolic factors in both individuals with and without HC.

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