scholarly journals Brain Imaging Signs and Health-Related Quality of Life after Acute Ischemic Stroke: Analysis of ENCHANTED Alteplase Dose Arm

2020 ◽  
Vol 49 (4) ◽  
pp. 427-436 ◽  
Author(s):  
Xiaoying Chen ◽  
Candice Delcourt ◽  
Lingli Sun ◽  
Zien Zhou ◽  
Sohei Yoshimura ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Brain Imaging ◽  
Performance Model ◽  
Health Related Quality ◽  
Quality Of Life Scale ◽  
Related Quality ◽  
Health Related

Background and Purpose: The influence of specific brain lesions on health-related quality of life (HRQoL) after acute ischemic stroke (AIS) is uncertain. We aimed to identify imaging predictors of poor HRQoL in alteplase-treated participants of the alteplase dose arm of the Enhanced Control of Hypertension and Thrombolysis Stroke Study (ENCHANTED). Methods: ENCHANTED was an international trial of low- versus standard-dose intravenous alteplase in AIS patients, with functional outcome (modified Rankin scale [mRS]) and HRQoL on the 5-dimension European Quality of Life Scale (EQ-5D) assessed at 90 days post-randomization. Brain images were analyzed centrally by trained assessors. Multivariable logistic regression was undertaken in the study population randomly divided (2:1) into training (development) and validation (performance) groups, with age (per 10-year increase), ethnicity, baseline National Institutes of Health Stroke Scale (NIHSS) score, diabetes mellitus, premorbid function (mRS score 0 or 1), and proxy respondent, forced into all models. Data are presented with odds ratios (ORs) and 95% confidence intervals (CIs). Results: Eight prediction models were developed and validated in 2,526 AIS patients (median age 67.5 years; 38.4% female; 61.7% Asian) with complete brain imaging and 90-day EQ-5D utility score data. The best performance model included acute ischemic changes in the right (OR 1.69, 95% CI: 1.24–2.29) and deep (OR 1.50, 95% CI: 1.03–2.19) middle cerebral artery (MCA) regions. Several background features of brain frailty – atrophy, white matter change, and old infarcts – were significantly associated with adverse physical but not emotional HRQoL domains. Conclusions: In thrombolysed AIS patients, right-sided and deep ischemia within the MCA territory predict poor overall HRQoL, whilst features of old cerebral ischemia are associated with reduced physical HRQoL.

scholarly journals Enlarged perivascular spaces are associated with health-related quality of life in patients with acute ischemic stroke

2017 ◽  
Vol 23 (12) ◽  
pp. 973-979 ◽  
Author(s):  
Yan Liang ◽  
Min Deng ◽  
Yang-Kun Chen ◽  
Vincent Mok ◽  
De-Feng Wang ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Perivascular Spaces ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related

scholarly journals Quality of life in patients with chronic wounds: magnitude of changes and predictive factors

2017 ◽  
Vol 51 (0) ◽  
Author(s):  
Vera Lúcia Conceição de Gouveia Santos ◽  
Alcicléa dos Santos Oliveira ◽  
Ana Flávia dos Santos Amaral ◽  
Erika Tihemi Nishi ◽  
Jaqueline Betteloni Junqueira ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Chronic Wounds ◽  
Religious Practice ◽  
Health Related Quality ◽  
Outpatient Services ◽  
Global Assessment Scale ◽  
Quality Of Life Scale ◽  
Related Quality ◽  
Health Related

Abstract OBJECTIVE To assess health-related quality of life, its predictors and magnitude of changes in health-related quality of life in patients with chronic wounds receiving specialized outpatient treatment. METHOD Secondary, retrospective, descriptive, quantitative study with patients with chronic wounds from two specialized outpatient services in Brazil assessed through Ferrans & Powers Quality of Life Index-Wound Version, Visual Analog Pain Scale, Global Assessment Scale, Pressure Ulcer Scale for Healing, sociodemographic and clinical questionnaires at baseline and after 60 days of treatment. Data were analyzed by ANOVA, Spearman Coefficient, Mann-Whitney test and multivariate logistic regression. RESULTS Twenty-seven patients participated in the study. The overall health-related quality of life scale, health and functioning subscale and socioeconomic subscale scores increased after 60 days of treatment compared to baseline. Pain reduction was a predictor of changes in overall health-related quality of life score as well as religious practice in the family subscale. 92.6% patients perceived moderate to extensive changes in health-related quality of life. CONCLUSION there was improvement of health-related quality of life for the sample studied in the period; pain and religious practice have emerged as predictors of changes in health-related quality of life.

scholarly journals Structural Validity of a 14-Item Abridged Version of the Menopause Cervantes Health-Related-Quality-Of-Life Scale

2013 ◽  
Vol 16 (7) ◽  
pp. A338 ◽  
Author(s):  
P. Coronado ◽  
R. Sánchez-Borrego ◽  
S. Palacios ◽  
M.A. Ruiz ◽  
J. Rejas
Keyword(s):  
Quality Of Life ◽  
Health Related Quality ◽  
Structural Validity ◽  
Quality Of Life Scale ◽  
Life Scale ◽  
Related Quality ◽  
Health Related

scholarly journals Determinants of Health-related Quality of Life in Recently Detoxified Patients With Severe Alcohol Use Disorder

2021 ◽  
Author(s):  
Najlaa Lahbairi ◽  
Alice Laniepce ◽  
Shailendra Segobin ◽  
Nicolas Cabé ◽  
Céline Boudehent ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Alcohol Use ◽  
Sleep Quality ◽  
Alcohol Use Disorder ◽  
Treatment Success ◽  
Health Related Quality ◽  
Quality Of Life Scale ◽  
Related Quality ◽  
Health Related

Abstract Background. Health-related quality of life (HRQoL) is an important clinical outcome in Alcohol Use Disorder (AUD) and is considered as a relevant indicator of treatment success. While a better understanding of the factors affecting HRQoL would enable to adjust patients’ care to favour treatment outcome, the determinants of HRQoL in AUD remain unclear. This study aims at describing HRQoL in AUD patients and at identifying its best predictors. Methods. We included 53 recently detoxified patients with severe AUD (sAUD) and 38 healthy controls (HC). They underwent a cognitive assessment and filled in questionnaires concerning socio-demographics, alcohol history, sleep quality, depression, anxiety and impulsivity. Additionally, a HRQoL questionnaire especially designed for AUD patients (Alcohol Quality of Life Scale; AQoLS) was used.Results. sAUD patients reported that alcohol affects their HRQoL mainly in the “negative emotions”, “control”, “relationships”, and “sleep” domains. Compared to HC, they were impaired on episodic memory, working memory, executive functions, and processing speed tasks. They also reported lower sleep quality, higher depression, anxiety and impulsivity. No association was found between AQoLS total score and socio-demographics, cognitive performance, or sleep quality in patients. We found a significant correlation between HRQoL and depression/anxiety as well as impulsivity. Anxiety and impulsivity were indeed the only significant predictors of HRQoL, explaining 47.7% of the variance. Conclusions. Anxiety and impulsivity are crucial determinants of HRQoL in recently detoxified sAUD patients. Since anxiety and impulsivity are frequent issues in addiction and especially in AUD, they should be particularly considered by clinicians to favour treatment outcomes.

Long-Term Health-Related Quality of Life in Survivors of Congenital Diaphragmatic Hernia

2020 ◽  
Vol 30 (03) ◽  
pp. 273-278
Author(s):  
Gabrielle Derraugh ◽  
Suyin A. Lum Min ◽  
Richard Keijzer
Keyword(s):  
Quality Of Life ◽  
General Population ◽  
Congenital Diaphragmatic Hernia ◽  
Diaphragmatic Hernia ◽  
Health Related Quality ◽  
Quality Of Life Scale ◽  
Related Quality ◽  
Health Related ◽  
Poor Outcomes

AbstractThe health-related quality of life (HRQoL) of survivors of congenital diaphragmatic hernia (CDH) is presently unknown. Literature prior to 2015 suggests that CDH survivors have worse HRQoL compared with the general population. However, due to changes in the diagnosis, management, and follow-up of CDH patients, this may no longer be true. The objective of this review was to determine what recent literature suggests regarding the HRQoL of CDH survivors. We reviewed all studies published between April 9, 2015, and April 6, 2020, that described the HRQoL of CDH survivors. Studies were identified using PubMed, and the references of the identified papers were searched for additional studies eligible for inclusion. Seven studies describing HRQoL in CDH survivors using validated measures of HRQoL for children, PedsQL (Pediatric Quality of Life Inventory), KIDSCREEN-52, and Comprehensive Quality of Life Scale – School Version were examined. The findings were disparate. One study suggested that CDH survivors had better than average HRQoL scores, three studies found patients and controls had equivalent scores, and two studies reported poor outcomes for CDH patients. The final study found no effect of disease severity on HRQoL, as determined by prenatal ultrasound. Evidence published between 2015 and 2020 suggests that CDH patients have an HRQoL equivalent to the general population.

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