scholarly journals Role of PD-L1 Expression during the Progression of Submucosal Gastric Cancer

Oncology ◽  
2020 ◽  
Vol 99 (1) ◽  
pp. 15-22
Author(s):  
Yasunari Ubukata ◽  
Kyoichi Ogata ◽  
Makoto Sohda ◽  
Takehiko Yokobori ◽  
Yuki Shimoda ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Vascular Invasion ◽  
Early Stage ◽  
Tumor Diameter ◽  
Muscularis Mucosa ◽  
Cell Nuclei ◽  
Invasive Front ◽  
Depth Of Penetration ◽  
Submucosal Gastric Cancer

<b><i>Introduction:</i></b> Programmed death-ligand 1 (PD-L1) expression is a prognostic marker for gastric cancer that correlates with tumor diameter and depth of penetration. But the role of PD-L1 and mechanism(s) employed in the initial phase of invasion in early gastric cancer is yet to be understood. <b><i>Objective:</i></b> This study aims to elucidate the role of PD-L1 during the progression of gastric cancer, specifically invading the submucosa beyond the lamina muscularis mucosa. <b><i>Methods:</i></b> Using 107 patients with pathological submucosal gastric cancer, we determined the expression of PD-L1 based on the staining of the cell membrane or cytoplasm of tumor cells in the central and invasive front of the tumor. Samples were categorized into 3 groups based on the intensity of PD-L1 expression. CD8<sup>+</sup> lymphocytes expressing PD-1 and CD163<sup>+</sup> macrophages were used to determine the number of cell nuclei at the invasive front, similar to PD-L1. CMTM6 levels were determined and used to stratify samples into 3 groups. <b><i>Results:</i></b> PD-L1 expression was higher in the invasive front (26.2%) than in the central portion of the tumors (7.4%; <i>p</i> &#x3c; 0.001). Moreover, lymphatic and vascular invasion were more frequently observed in samples with high levels of PD-L1 (lymphatic invasion: 60.7 vs. 35.4%, <i>p</i> = 0.0026, and vascular invasion: 39.3 vs. 16.5%, <i>p</i> = 0.0018). There was no correlation between PD-L1 expression and the levels of PD-1, CD8, CD163, and CMTM6. <b><i>Conclusions:</i></b> PD-L1-expressing cancer cells at the invasive front of gastric cancer influence the initial stages of tumor invasion and lymphovascular permeation in early-stage gastric cancers. Immune checkpoint signaling may be the driving force in the invasive front during the invasion of the submucosa beyond the lamina muscularis mucosa.

Regulation of gastric carcinoma development in gastric adenoma/dysplasia by crebzf inhibition via miRNA-421.

2020 ◽  
Vol 38 (4_suppl) ◽  
pp. 410-410 ◽  
Author(s):  
Yu Jin Kim ◽  
Won Shik Kim ◽  
Sang Woo Kim ◽  
Woon Yong Jung
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
Early Stage ◽  
Gastric Adenoma ◽  
Gastric Cancer Cells ◽  
Gastric Cancer Cell Lines ◽  
And Migration ◽  
Gastric Cancer Patients ◽  
And Function

410 Background: In our previous study, we identified three miRNAs (hsa-miR-421, hsa-miR-29b-1-5p, and hsa-miR-27b-5p) with two mRNAs (FBXO11 and CREBZF) that might play an important role in the development of gastric adenocarcinoma (GAC) from premalignant adenomas. However, the expression and function of these miRNAs have not been not well characterized. Methods: We investigated the roles of CREBZF and miRNAs as potential biomarkers for the progression of gastric cancer (GC) in low-/high-grade dysplasia and early gastric cancer patients using immunohistochemical staining and miRNA in situ hybridization. Considering that targets can modulate in GC, we analyzed the CREBZF expression in gastric cancer cell lines by RT-PCR and western blot analysis. Results: We observed lower expression of CREBZF with increasing miRNAs in the MKN-74 gastric cancer cells compared to that in SNU-NCC-19. Next, the role of CREBZF in MKN-74 gastric cancer cells was investigated via cell viability and migration assays by miRNA/anti-miRNA modulation. Furthermore, we found that hsa-miR-421/hsa-miR-29b-1-5p target CREBZF and might play an important role in the migration of MKN-74 cells. Conclusions: This study suggests that increased CREBZF by hsa-miR-421/hsa-miR-29b-1-5p inhibition may be important to prevent the progression of gastric cancer in its early stage.

scholarly journals The role of perioperative radiotherapy in gastric cancer

2012 ◽  
Vol 6 (2) ◽  
pp. 23 ◽  
Author(s):  
Thales Paulo Batista ◽  
Lucas Marque De Mendonça ◽  
Ana Luiza Fassizoli-Fonte
Keyword(s):  
Gastric Cancer ◽  
Therapeutic Strategy ◽  
Multimodal Therapy ◽  
Early Stage ◽  
Locally Advanced ◽  
Early Stage Disease ◽  
Stage Disease ◽  
Locally Advanced Tumors ◽  
Related Mortality

Gastric cancer is one of the most common neoplasms and a main cause of cancer-related mortality worldwide. Surgery remains the mainstay for cure and is considered for all patients with potentially curable disease. However, despite the fact that surgery alone usually leads to favorable outcomes in early stage disease, late diagnosis usually means a poor prognosis. In these settings, multimodal therapy has become the established treatment for locally advanced tumors, while the high risk of locoregional relapse has favored the inclusion of radiotherapy in the comprehensive therapeutic strategy. We provide a critical, non-systematic review of gastric cancer and discuss the role of perioperative radiation therapy in its treatment.

The Relationship of Pathological Datas of Gastric Cancer Patients after Radical Gastrectomy with Radiotherapy

2013 ◽  
Vol 641-642 ◽  
pp. 828-833
Author(s):  
Ju Dong Luo ◽  
Xu Jing Lu ◽  
Ling Chen ◽  
Yan Ma ◽  
Ying Ze Kong ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Patients ◽  
Vascular Invasion ◽  
Lymphatic Vessel ◽  
Univariate Analysis ◽  
Lymphatic Vessel Invasion ◽  
Related Factor ◽  
Tumor Diameter ◽  
Vessel Invasion ◽  
Gastric Cancer Patients

Mdthod :110 gastric cancer patients were selected from Feb 2004 to Jan 2006, who had complete pathological data and were underwent radical resection. All patients were diagnosed by endoscopy, preoperative histologic diagnosis and exclusion from distant metastasis, using D1 or D2 lymph node dissection, postoperative pathology confirmed stump negative. Univariate analysis was applied on the pathologic information and multivariate analysis was applied based on the univariate analysis. Result :(1)Univariate analysis showed that tumor diameter、histology、vascular invasion、lymphatic vessel invasion and neural invasion were correlated with T/N classification.Multivariate analysis showed that vascular invasion and lymphatic vessel invasion were correlated with T classification and lymphatic vessel invasion was associated with N classification. (2) For T and N stages, lymphatic vessel invasion was strongly related factor. Conclusion: For T and N stages,, lymphatic vessel invasion was strongly relevant factor. For patients with confirmed lymphatic vessel invasion, postoperative adjuvant radiotherapy is suggested.

scholarly journals Down-Regulation of Submucosal Claudin-18 at the Invasive Front is Associated With Proliferative Potential of Submucosal Gastric Cancer

2011 ◽  
Vol 140 (5) ◽  
pp. S-344
Author(s):  
Takuya Okugawa ◽  
Tadayuki Oshima ◽  
Tsuyoshi Morita ◽  
Jun Sakurai ◽  
Junji Tanaka ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Proliferative Potential ◽  
Invasive Front ◽  
Down Regulation ◽  
Submucosal Gastric Cancer

scholarly journals Can the Neutrophil to Lymphocyte Ratio Be Used to Determine Gastric Cancer Treatment Outcomes? A Systematic Review and Meta-Analysis

2016 ◽  
Vol 2016 ◽  
pp. 1-10 ◽  
Author(s):  
Jingxu Sun ◽  
Xiaowan Chen ◽  
Peng Gao ◽  
Yongxi Song ◽  
Xuanzhang Huang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Early Stage ◽  
Disease Free Survival ◽  
Neutrophil To Lymphocyte Ratio ◽  
Prognostic Role ◽  
Free Survival ◽  
Stage Iv Gastric Cancer ◽  
Lymphocyte Ratio ◽  
Poor Outcome

The prognostic role of neutrophil to lymphocyte ratio (NLR) in gastric cancer remains controversial. We aimed to quantify the prognostic role of peripheral blood NLR in gastric cancer. A literature search was conducted in PubMed, EMBASE, and Cochrane databases. The results for overall survival (OS) and progression-free survival (PFS)/disease-free survival (DFS) are expressed as hazard ratios (HRs) with 95% confidence intervals (CIs). 19 studies with 5431 patients were eligible for final analysis. Elevated NLRs were associated with a significantly poor outcome for OS (HR = 1.98; 95% CI: 1.75–2.24,p<0.001) and PFS (HR = 1.58; 95% CI: 1.32–1.88,p<0.001) compared with patients who had normal NLRs. The NLR was higher for patients with late-stage compared with early-stage gastric cancer (OR = 2.76; 95% CI: 1.36–5.61,p=0.005). NLR lost its predictive role for patients with stage IV gastric cancer who received palliative surgery (HR = 1.73; 95% CI: 0.85–3.54,p=0.13). Our results also indicated that prognoses might be influenced by the NLR cutoff values. In conclusion, elevated pretreatment NLRs are associated with poor outcome for patients with gastric cancer. The ability to use the NLR to evaluate the status of patients may be used in the future for personalized cancer care.

scholarly journals The role of perioperative radiotherapy in gastric cancer

2012 ◽  
pp. e23
Author(s):  
Thales Paulo Batista ◽  
Lucas Marque De Mendonça ◽  
Ana Luiza Fassizoli-Fonte
Keyword(s):  
Gastric Cancer ◽  
Therapeutic Strategy ◽  
Multimodal Therapy ◽  
Early Stage ◽  
Locally Advanced ◽  
Early Stage Disease ◽  
Stage Disease ◽  
Locally Advanced Tumors ◽  
Related Mortality

Gastric cancer is one of the most common neoplasms and a main cause of cancer-related mortality worldwide. Surgery remains the mainstay for cure and is considered for all patients with potentially curable disease. However, despite the fact that surgery alone usually leads to favorable outcomes in early stage disease, late diagnosis usually means a poor prognosis. In these settings, multimodal therapy has become the established treatment for locally advanced tumors, while the high risk of locoregional relapse has favored the inclusion of radiotherapy in the comprehensive therapeutic strategy. We provide a critical, non-systematic review of gastric cancer and discuss the role of perioperative radiation therapy in its treatment.

The role of cbl family of ubiquitin ligases in gastric cancer exosome-induced apoptosis of Jurkat T cells

2009 ◽  
pp. 1-8
Author(s):  
Jing-Lei Qu ◽  
Xiu-Juan Qu ◽  
Ming-Fang Zhao ◽  
Yue-E Teng ◽  
Ye Zhang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
T Cells ◽  
Ubiquitin Ligases ◽  
Jurkat T Cells ◽  
Induced Apoptosis
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