scholarly journals Bilateral XEN Gel Stent Implantation in Juvenile-Onset Open-Angle Glaucoma

2020 ◽  
Vol 11 (2) ◽  
pp. 336-341
Author(s):  
Emma Klug ◽  
David Solá-Del Valle
Keyword(s):  
Open Angle Glaucoma ◽  
Invasive Procedure ◽  
Open Angle ◽  
Minimally Invasive Procedure ◽  
Successful Management ◽  
Glaucoma Medication ◽  
Effective Treatment Option ◽  
Juvenile Onset ◽  
Current Case ◽  
Xen Gel Stent

The purpose of the current case is to report the successful management of juvenile-onset open-angle glaucoma with bilateral XEN Gel Stent (Allegran Inc., Irvine, CA) implantation in a patient first diagnosed during pregnancy with co-existing dysautonomia. Treatment with the XEN Gel Stent provided dramatic reductions in intraocular pressure (IOP), and glaucoma medications sustained up to 23 months postoperatively. The success of this case may suggest that this minimally invasive procedure could be an effective treatment option for younger patients who require substantial reductions in IOP and glaucoma medication burden.

scholarly journals Mutations in the CYP1B1 gene may contribute to juvenile-onset open-angle glaucoma

Eye ◽  
2012 ◽  
Vol 26 (10) ◽  
pp. 1369-1377 ◽  
Author(s):  
C-C Su ◽  
Y-F Liu ◽  
S-Y Li ◽  
J-J Yang ◽  
Y-C Yen
Keyword(s):  
Open Angle Glaucoma ◽  
Open Angle ◽  
Juvenile Onset ◽  
Cyp1b1 Gene

scholarly journals XEN Gel Stent in the management of primary open-angle glaucoma

2020 ◽  
Vol 141 (1) ◽  
pp. 65-76
Author(s):  
Michał Post ◽  
Wojciech Lubiński ◽  
Dominik Śliwiak ◽  
Karolina Podborączyńska-Jodko ◽  
Maciej Mularczyk
Keyword(s):  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Open Angle ◽  
Xen Gel Stent

XEN implant in primary and secondary open-angle glaucoma: A 12-month retrospective study

2019 ◽  
Vol 30 (5) ◽  
pp. 1034-1041 ◽  
Author(s):  
Ana Ibáñez-Muñoz ◽  
Víctor Santiago Soto-Biforcos ◽  
Leticia Rodríguez-Vicente ◽  
Irune Ortega-Renedo ◽  
María Chacón-González ◽  
...  
Keyword(s):  
Intraocular Pressure ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Pressure Control ◽  
Pressure Reduction ◽  
Open Angle ◽  
Xen Gel Stent ◽  
Intraocular Pressure Reduction ◽  
Study Population ◽  
Xen Implant

Purpose: The aim of this study was to compare the efficacy and safety of the XEN45 gel stent implant in patients with primary open-angle glaucoma or secondary open-angle glaucoma. Patients and methods: This is a retrospective, single-center, and comparative study conducted in consecutive primary open-angle glaucoma or secondary open-angle glaucoma patients, who underwent a XEN45 implant, alone or in combination with phacoemulsification. The primary end point was the intraocular pressure at the end of the follow-up period. Complete success was defined as an intraocular pressure reduction of ⩾20% from baseline to month 12 without antiglaucoma treatment. Results: Of the 69 patients (74 eyes) who were screened, 68 patients (73 eyes) were included in this study. In the overall study population, XEN gel stent significantly reduced intraocular pressure from 22.3 (21.0–23.5) mmHg at baseline to 15.3 (14.3–16.3) mmHg, p < 0.0001. As compared to baseline, mean intraocular pressure reduction was –7.3 (−9.7 to −5.0) and –6.6 (−8.4 to −4.8) mmHg in the primary open-angle glaucoma and secondary open-angle glaucoma groups, respectively, p = 0.6357. At month 12, 53 (72.6%) eyes were classified as success. The mean number of antiglaucoma medications was significantly reduced in both groups ( p < 0.0001, each). Complications included anterior chamber flattening (one eye), XEN implant extrusion (four eyes), one of whom had an endophthalmitis that required vitrectomy, and one eye underwent a trabeculectomy due to inadequate intraocular pressure control. Conclusion: XEN gel stent, either alone or in combination with phacoemulsification, provided a significant reduction in both intraocular pressure and medical antiglaucoma treatment, but with some safety concerns, in a cohort of patients with open-angle glaucoma (primary or secondary).

scholarly journals A novel Asp380Ala mutation in the GLC1A/myocilin gene in a family with juvenile onset primary open angle glaucoma.

1998 ◽  
Vol 35 (11) ◽  
pp. 957-960 ◽  
Author(s):  
A M Kennan ◽  
F C Mansergh ◽  
J H Fingert ◽  
T Clark ◽  
C Ayuso ◽  
...  
Keyword(s):  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Open Angle ◽  
Juvenile Onset

scholarly journals New mutation in the myocilin gene segregates with juvenile-onset open-angle glaucoma in a Brazilian family

Gene ◽  
2013 ◽  
Vol 523 (1) ◽  
pp. 50-57 ◽  
Author(s):  
Carolina Ayumi Braghini ◽  
Izabella Agostinho Pena Neshich ◽  
Goran Neshich ◽  
Fernanda Caroline Soardi ◽  
Maricilda Palandi de Mello ◽  
...  
Keyword(s):  
Open Angle Glaucoma ◽  
Open Angle ◽  
Juvenile Onset ◽  
New Mutation

Extent of asymmetry and unilaterality among juvenile onset primary open angle glaucoma patients

2011 ◽  
Vol 39 (7) ◽  
pp. 633-638 ◽  
Author(s):  
Viney Gupta ◽  
Shikha Gupta ◽  
Munish Dhawan ◽  
Ajay Sharma ◽  
Kulwant S Kapoor ◽  
...  
Keyword(s):  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Open Angle ◽  
Juvenile Onset

scholarly journals Evaluation of Outflow StructuresIn Vivoafter the Phacocanaloplasty

2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Daiva Paulaviciute-Baikstiene ◽  
Renata Vaiciuliene ◽  
Vytautas Jasinskas ◽  
Ingrida Januleviciene
Keyword(s):  
Optical Coherence Tomography ◽  
Visual Acuity ◽  
Intraocular Pressure ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Anterior Segment ◽  
Open Angle ◽  
Glaucoma Medication ◽  
Postoperative Visual Acuity

Purpose. To evaluate thein vivochanges in Schlemm’s canal (SC) and the trabecular meshwork (TM) in patients with primary open-angle glaucoma (POAG) after phacocanaloplasty using anterior segment optical coherence tomography (AS-OCT).Methods. Ten eyes of nine patients with POAG (6 men and 3 women) who underwent phacocanaloplasty. Preoperative and postoperative visual acuity (VA), intraocular pressure (IOP), and use of glaucoma medications were evaluated. The main outcome measures were the area of SC and TM thickness assessed using AS-OCT before and 12 months after surgery.Results. We found statistically significant reduction in IOP (from 26.4 (8.6) mmHg to 12.9 (2.5) (p<0.05) mmHg), increase in VA from 0.7 (0.4) to 0.9 (0.2), and decrease in glaucoma medication from 2.6 (1.2) to 1.1 (1.3) at 12 months postoperatively. There was a significant increase in the SC area (3081.7 (842.8) μm2versus 5098.8 (1190.5) μm2,p<0.001) and a decrease in mean TM thickness (91.2 (18.6) μm versus 81.3 (15.1) μm,p=0.001) after surgery. We found negative correlations between SC area and IOP before surgery (r=-0.67,p=0.03) and also between SC area before and IOP reduction 12 months after the phacocanaloplasty (r=-0.80,p=0.005).Conclusions. Our results showed statistically significant dilation of SC area and reduction of TM thickness after phacocanaloplasty in POAG patients. The degree of SC expansion was related to the IOP decrease.

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