Prescriptive Reference Standards of Third-Trimester Cerebroplacental Ratio and Its Physiological Determinants

2020 ◽  
Vol 47 (10) ◽  
pp. 757-764
Author(s):  
Marta Rial-Crestelo ◽  
Laura Garcia-Otero ◽  
Annalisa Cancemi ◽  
Mariella Giannone ◽  
Elena Escazzocchio ◽  
...  

<b><i>Objective:</i></b> To construct valid reference standards reflecting optimal cerebroplacental ratio and to explore its physiological determinants. <b><i>Methods:</i></b> A cohort of 391 low-risk pregnancies of singleton pregnancies of nonmalformed fetuses without maternal medical conditions and with normal perinatal outcomes was created. Doppler measurements of the middle cerebral artery and umbilical artery were performed at 24–42 weeks. Reference standards were produced, and the influence of physiological determinants was explored by nonparametric quantile regression. The derived standards were validated in a cohort of 200 low-risk pregnancies. <b><i>Results:</i></b> Maternal body mass index was significantly associated with the 5th centile of the cerebroplacental ratio. For each additional unit of body mass index, the 5th centile was on average 0.014 lower. The derived 5th, 10th, and 50th centiles selected in the validation cohort were 5, 9.5, and 51% of the measurements. <b><i>Conclusions:</i></b> This study provides methodologically sound prescriptive standards and suggests that maternal body mass index is a determinant of a cutoff commonly used for decision-making.

2008 ◽  
Vol 87 (2) ◽  
pp. 163-170 ◽  
Author(s):  
Horace Roman ◽  
Francois Goffinet ◽  
Tara F. Hulsey ◽  
Roger Newman ◽  
Pierre Yves Robillard ◽  
...  

2020 ◽  
Vol 80 (05) ◽  
pp. 508-517
Author(s):  
Kathrin Noever ◽  
Julia Schubert ◽  
Edith Reuschel ◽  
Nina Timmesfeld ◽  
Birgit Arabin

Abstract Introduction Maternal obesity and excessive gestational weight gain (GWG) affect the outcomes of women and their offspring. Our aim was to evaluate population-based data from Germany. Material and Methods Data from 583 633/791 514 mother-child pairs obtained from the perinatal database in Hesse for the period from 2000 to 2015 were used after excluding incomplete or non-plausible datasets. Early-stage pregnancy maternal body mass index (BMI) and GWG were evaluated. Significant outcome changes were calculated using linear or logistic regression models. Results The mean maternal age increased from 29.9 to 31.28 years; GWG increased from 445.1 to 457.2 g/week (p < 0.01). Similarly, rates for both overweight and obesity rose from 31.5 to 37.5% (p < 0.001). Cesarean section rates rose from 22.8 to 33.2% (p < 0.001) and rates of postpartum hemorrhage increased from 0.6 to 1% (p < 0.001). There was no significant change in the rates for stillbirth or perinatal mortality (p = 0.92 and p = 0.53 respectively), but there was an increase in the rates of admissions to neonatal intensive care units from 7.8 to 9.5% (p < 0.0001). The percentage of newborns with an Apgar score of < 7 at 5 minutes increased from 1 to 1.1% (p < 0.01) and the rate of neonates with an umbilical artery pH of < 7.1 rose from 1.7 to 2.4% (p < 0.01). Conclusions In just 15 years, pre-pregnancy BMI and GWG rates of women with singleton pregnancies have increased, and this increase has been accompanied by a significant rise in the rate of cesarean sections and a significant worsening of short-term maternal and neonatal outcomes. It is time to discuss the risks and the short-term and more worrying long-term consequences for mothers and their offspring and the future impact on our healthcare system.


2013 ◽  
Vol 31 (03) ◽  
pp. 249-256 ◽  
Author(s):  
Camelia Guild ◽  
Yvonne Cheng ◽  
Aaron Caughey ◽  
Donna Halloran ◽  
Nicole Marshall

BMJ Open ◽  
2017 ◽  
Vol 7 (10) ◽  
pp. e015258 ◽  
Author(s):  
Angela Vinturache ◽  
Aoife McKeating ◽  
Niamh Daly ◽  
Sharon Sheehan ◽  
Michael Turner

ObjectiveTo estimate the association between maternal body mass index (BMI) and risk of spontaneous preterm delivery (sPTD) and elective preterm delivery (ePTD) in singleton and multiple pregnancies.DesignRetrospective cohort study.SettingElectronic records of all deliveries from 2009 through 2013 in a tertiary university hospital were abstracted for demographic and obstetrical information.ParticipantsA total of 38 528 deliveries were included. Participants with missing data were excluded from the study. BMI was calculated from the measurement of height and weight at the first prenatal visit and categorised. Sonographic confirmation of gestational age was standard.Outcome measuresPrimary outcomes, sPTD and ePTD in singleton and multiple pregnancies, were evaluated by multinomial logistic regression analyses, stratified by parity, controlling for confounding variables.ResultsOverall rate of PTD was 5.9%, from which 2.7% were sPTD and 3.2% ePTD. The rate of PTD was 50.4% in multiple pregnancies and 5.0% in singleton pregnancies. The risk of sPTD was increased in obese nulliparas (adjusted OR (aOR) 2.8, 95% CI 1.7 to 4.4) and underweight multiparas (aOR 2.2, 95% CI 1.3 to 3.8). The risk of ePTD was increased in underweight nulliparas (aOR 1.8; 95% CI 1.04 to 3.4) and severely obese multiparas (aOR 1.4, 95% CI 1.02 to 3.8).Severe obesity increased the risk of both sPTD (aOR 1.4; 95% CI 1.01 to 2.1) and ePTD (aOR 1.4; 95% CI 1.1 to 1.8) in singleton pregnancies. Obesity did not influence the rate of either sPTD or ePTD in multiple pregnancies.ConclusionMaternal obesity is an independent risk factor for PTD in singleton pregnancies but not in multiple pregnancies. Obesity and nulliparity increase the risk of sPTD, whereas obesity and multiparity increase the risk of ePTD.


2009 ◽  
Vol 29 (3) ◽  
pp. 147
Author(s):  
H. Roman ◽  
F. Goffinet ◽  
T. F. Hulsey ◽  
R. Newman ◽  
P. Y. Robillard ◽  
...  

2019 ◽  
Vol 220 (1) ◽  
pp. S257
Author(s):  
Shelly Soni ◽  
Matthew J. Blitz ◽  
Lakha Prasannan ◽  
Meir Greenberg ◽  
Michael Qiu ◽  
...  

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