scholarly journals Prevalence of and risk factors for diabetic retinopathy and diabetic macular edema in patients with early and late onset diabetes mellitus

2020 ◽  
Author(s):  
Yu Wang ◽  
Zhong Lin ◽  
Gang Zhai ◽  
xiaoxia ding ◽  
liang wen ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Diabetic Retinopathy ◽  
Macular Edema ◽  
Diabetic Macular Edema ◽  
Late Onset ◽  
Onset Diabetes

Systemic and Genetic Risk Factors in Diabetic Retinopathy and Diabetic Macular Edema

2018 ◽  
pp. 102-107
Keyword(s):  
Risk Factors ◽  
Diabetic Retinopathy ◽  
Macular Edema ◽  
Diabetic Macular Edema ◽  
Systemic Risk ◽  
Genetic Effect ◽  
Current Treatment ◽  
Genetic Studies ◽  
Patient Subgroups ◽  
Systemic Risk Factors

Diabetic retinopathy (DR) is an increasingly common health problem in our country as it is all over the world. DR is a leading cause of loss of vision patients at a productive age. Current treatment of diabetic macular edema (DME) is distressing, expensive, and not suitable for some patient subgroups. For this reason, the development and progression of DR and DME are affected by many systemic risk factors. It is important to increase the understanding of these responsible risk factors and develop preventive strategies. However, the presence of systemic risk factors is inadequate to predict the progression of the disease on an individual basis. It indicates the presence of a genetic effect. In this review, we have summarized the known systemic risk factors as well as the genetic basis of the disease under the light of genetic studies.

scholarly journals Intraocular Risk Factors in the Primary Formation of Diabetic Macular Edema in Patients with Diabetes Mellitus Type II

2019 ◽  
Vol 16 (1) ◽  
pp. 63-69
Author(s):  
M. V. Pshenichnov ◽  
O. V. Kolenko ◽  
E. L. Sorokin ◽  
Yu. E. Pashentcev
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Macular Edema ◽  
Diabetic Macular Edema ◽  
Comparison Group ◽  
Mean Value ◽  
Main Group ◽  
Type Ii ◽  
Diabetes Mellitus Type Ii ◽  
The Mean

Purpose. Revealing of the intraocular risk factors in the diabetic macular edema (ME) formatis in diabetes mellitus type II (DM2). Patients and methods. A 3.5-year research of 80 patients (160 eyes) with DM2 without signs of ME at the beginning of the research was performed. The main group consisted of 46 patients with ME symptoms on one or both eyes during the research period, the comparison group included 34 patients without ME symptoms to the end of the research. The initial ocular characteristics were retrospectively compared in groups.Results. The mean value of the axial lengths (AL) in the eyes of the main group was 23.12 ± 0.75 mm compared to 23.82 ± 0.62 mm in the comparison group (significant difference, p < 0.01). AL was less than 23.5 mm in 66 % eyes in the main group and only in 22 % of the eyes in the comparison group (p < 0.01). The mean value of the initial macular retina volume in the main group was significantly higher than in the comparison group — 7.51 ± 0.22 mm3 and 7.21 ± 0.12 mm3, respectively (p < 0.01). Initial background diabetic retinopathy (DR) was noted in 73 % eyes in the main group, which significantly differed from the comparison group, where this index was noted only in 13 % of the eyes (p < 0.01).Conclusion. Significant ocular risk factors for the formation of ME in patients with DM2 are: the initial macular retina volume more than 7.3 mm3, the value of the AL less than 23.5 mm; the initial background DR. The use of the detected morphometric parameters of eye and retina in combination with an adequate assessment of the risk factors in human organism makes it possible to assume a high risk of the primary formation of diabetic ME in patients with DM2 with high degree of probability.

scholarly journals Urine Albumin Creatinine Ratio Among Diabetic Retinopathy Patient With And Without Diabetic Macular Edema In Moh. Hoesin Hospital Palembang

2018 ◽  
Vol 1 (1) ◽  
Author(s):  
Rina Astuti ◽  
AK Ansyori ◽  
Ramzi Amin
Keyword(s):  
Risk Factors ◽  
Diabetic Retinopathy ◽  
High Density Lipoprotein ◽  
Macular Edema ◽  
Diabetic Macular Edema ◽  
Density Lipoprotein ◽  
Creatinine Ratio ◽  
Albumin Creatinine Ratio ◽  
Urine Albumin ◽  
Urine Albumin Creatinine Ratio

Introduction: Diabetic Macular Edema is a diffuse thickening in macula which can be found in various severity of Diabetic Retinopathy. There are issue about relationship between Diabetic Macular Edema and albuminuria caused by chronic renal failure. The aim of this study is to know and compare urine albumin creatinine ratio among Diabetic Retinopathy patients with and without Diabetic Macular Edema in Moh. Hoesin Hospital. Methods: Cross sectional study with 25 sample was conducted. Diabetic Retinopathy and Diabetic Macular Edema was classified base on Early Treatment Of Diabetic Retinopathy Study (ETDRS) criteria. T-test, odd ratio and multiple logistic regretion analysis was used to analysed sociodemography characteristic (age and gender), clinical characteristic (duration of DM, hipertension, treatment, body mass indeks and antioksidan consumption), ophtalmology characteristic (visus, anterior segment anomaly and posterior segment/ severity of Diabetic Retinopathy), laboratory characteristic (HbA1c, ureum, creatinine, urine albumin creatinine ratio, and lipid profile). Result: Urine albumin creatinine ratio mean (2146.77 ± 3796.19) in Diabetic Macular Edema and (49.0 ± 45.35) in non-Diabetic Macular Edema; cutoff point 62.00 mg/dL. Odd ratio adjusted for urine albumin creatinine ratio = 18,8. In this research, risk factors which has significantly were urine albumin creatinine ratio (p=0.047) and High-Density Lipoprotein/HDL (p=0.028) with odd ratio 8.571 and 6.67 respectively. Urine albumin creatinine ratio showed significantly high Mann whitney analysis 0.02 (p<0.005). Conclusion: Urine albumin creatinine ratio in Diabetic Retinopathy with Diabetic Macular Edema was higher than without Diabetic Macular Edema. Urine albumin creatinine ratio and High Density Lipoprotein (HDL) are the two important risk factors associated with Diabetic Macular Edema.

Angiocentric T-cell lymphoma of the pancreas presenting as late-onset diabetes mellitus with diabetic retinopathy

2001 ◽  
Vol 32 (7) ◽  
pp. 741-745 ◽  
Author(s):  
Sanya Sukpanichnant ◽  
Tumtip Sangruchi ◽  
Plernpit Prasopchoke ◽  
Sumit Vatanavicharn ◽  
Suchai Charoenratanakul ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Diabetic Retinopathy ◽  
T Cell ◽  
Cell Lymphoma ◽  
Late Onset ◽  
T Cell Lymphoma ◽  
Onset Diabetes

scholarly journals Incidence of diabetic eye disease in accordance with duration, glycemic control, blood and ocular pressure

2017 ◽  
Vol 70 (11-12) ◽  
pp. 353-358
Author(s):  
Vladimir Canadanovic ◽  
Sandra Jovanovic ◽  
Sofija Davidovic ◽  
Ana Oros ◽  
Vladislav Dzinic ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Diabetic Retinopathy ◽  
Glycemic Control ◽  
Macular Edema ◽  
Diabetic Macular Edema ◽  
Proliferative Diabetic Retinopathy ◽  
Glycosylated Hemoglobin ◽  
Diabetic Patients ◽  
Duration Of Diabetes ◽  
Group I

Introduction. Diabetic retinopathy remains the leading cause of visual disability and blindness among professionally active adults in economically developed societies, which is of particular concern because the prevalence and incidence of diabetes mellitus is expected to increase sharply during the next decade. There are several known factors responsible for the development of diabetic retinopathy, duration of disease and blood sugar level being the most important ones. Material and Methods. Prospective study of 280 diabetic patients (diabetes mellitus type 2) divided into 3 groups according to the duration of diabetes mellitus. All diabetic patients underwent complete ophthalmological examination in artificial mydriasis and optic coherence tomography. A full medical history included patient age, the time elapsed from diabetes diagnosis, current treatment of diabetes, presence of hypertension and glycemic control assessed by glycosylated hemoglobin measurement. Results. The mean age of patients was 63.5 years (SD?6.5, range 57-70 years). Mean duration of diabetes was 7.3 years in group I, 12.4 years in group II and 17.2 years in group III. The average value of glycosylated hemoglobin was 6.58% in the group I, 7.64% in the group II and 8.29% in the third group of patients. No statistically significant difference in intraocular pressure and the level of blood pressure were found among groups. Cataract was present in 104 patients (37.1%). Complications related to diabetes among all patients included in our study were: nonproliferative diabetic retinopathy in 48.5%, proliferative diabetic retinopathy in 25.7% and diabetic macular edema in 22.5% of patients. Conclusion. The duration of diabetes is one of the most significant factors for the development of diabetic maculopathy and the progression from nonproliferative to its proliferative stage. There is significantly higher incidence of proliferative diabetic retinopathy and diabetic macular edema in patients with increased serum level of glycosylated hemoglobin. Diabetes accompanied by hypertension is related to worsening of the clinical course of diabetic eye diseases and developing diabetic macular edema and proliferative diabetic retinopathy.

scholarly journals Increased expression of Protein S in eyes with diabetic retinopathy and diabetic macular edema

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Masahiko Sugimoto ◽  
Mineo Kondo ◽  
Taro Yasuma ◽  
Corina N. D’Alessandro-Gabazza ◽  
Masaaki Toda ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Diabetic Retinopathy ◽  
Macular Edema ◽  
Enzyme Immunoassay ◽  
Diabetic Macular Edema ◽  
Plexiform Layer ◽  
Protein S ◽  
Outer Plexiform Layer ◽  
Post Mortem

AbstractProtein S (PS) is a multifunctional glycoprotein that ameliorates the detrimental effects of diabetes mellitus (DM). The aim of this study was to evaluate the distribution of PS in diabetic retinopathy (DR) and diabetic macular edema (DME). This was a study of 50 eyes with DM (37 with DME, 6 with proliferative DR, and 7 with no DR) and 19 eyes without DM. The level of PS was measured by enzyme immunoassay and was compared between eyes with or without DM, with or without DME, and with severe DME (≥ 350 μm) or mild DME (< 350 μm). We also performed immunohistopathologic evaluations of post-mortem eyes and the cystoid lesions excised during surgery. The aqueous free PS was significantly higher with DM (7.9 ± 1.2 ng/ml, P < 0.01) than without DM (6.1 ± 0.7). The aqueous free PS was significantly elevated with DME (8.2 ± 1.2, P < 0.05) compared to proliferative DR (7.0 ± 1.0) and no DR (7.0 ± 0.7). Eyes with severe DME had significantly higher aqueous free PS than mild DME (8.5 ± 1.3 vs. 7.7 ± 1.0, P < 0.05). Immunohistochemistry showed PS in the outer plexiform layer of the retina and cystoid lesion. The higher expression of PS with DR and DME suggests that PS is involved in their pathogenesis.

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