scholarly journals Tattoo-Associated Basal Cell Carcinoma: Coincident or Coincidence

2020 ◽  
Vol 5 (2) ◽  
pp. 1-8
Author(s):  
Philip R. Cohen ◽  
Christof P. Erickson ◽  
Nathan S. Uebelhoer ◽  
Antoanella Calame
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
The Other ◽  
Medical Complications ◽  
Supporting Evidence ◽  
The Sun ◽  
Native State ◽  
Exposed Skin ◽  
Left Scapula

Tattoos may be associated with medical complications including, albeit rarely, skin cancer. The features of a 46-year-old man who developed a basal cell carcinoma within a tattoo on his left scapula are described and the characteristics of the other 13 patients (7 men and 6 women) with tattoo-associated basal cell carcinoma are reviewed. The tumor usually occurs on the sun-exposed skin of individuals aged 60 years and older whose tattoo has often been present for 20 years or more. The pathogenesis of a basal cell carcinoma developing within a tattoo may merely be a coincidence. However, there is supporting evidence that the tattoo and the subsequent basal cell carcinoma may be coincident events whereby either tattoo injection-associated trauma or the tattoo pigments and dyes (in their native state or after ultraviolet radiation alteration) or both have a carcinogenic impact on the development of the basal cell carcinoma at that location.

scholarly journals Basal Cell Carcinoma on the Sole: An Easily Missed Cancer

2016 ◽  
Vol 8 (3) ◽  
pp. 283-286 ◽  
Author(s):  
Natalie L. Hone ◽  
Radhika Grandhi ◽  
Adam A. Ingraffea
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Significant Risk ◽  
Significant Risk Factor ◽  
The Sun ◽  
Common Skin ◽  
Ultraviolet Ray ◽  
Solar Ultraviolet ◽  
Sole Of The Foot

Basal cell carcinoma (BCC) is the most common skin cancer, and solar ultraviolet ray exposure is the most significant risk factor for its development. The plantar foot is infrequently exposed to the sun, thus the presence of BCC on the sole is rare. We report a case of BCC on the sole of the foot and its treatment in the hope to facilitate its detection.

CD10, TDAG51, CK20, AR, INSM1, and Nestin Expression in the Differential Diagnosis of Trichoblastoma and Basal Cell Carcinoma

2018 ◽  
Vol 27 (1) ◽  
pp. 19-27 ◽  
Author(s):  
Cem Leblebici ◽  
Buket Bambul Sığırcı ◽  
Canan Kelten Talu ◽  
Sevim Baykal Koca ◽  
Gülben Erdem Huq
Keyword(s):  
Differential Diagnosis ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
The Other ◽  
Cytokeratin 20 ◽  
Nestin Expression ◽  
The Difference ◽  
Nevus Sebaceous ◽  
Sensitive Marker

Background. Trichoblastoma (TB) and basal cell carcinoma (BCC) are 2 different neoplasms composed of basaloid cells and have overlapping histopathological features. We compared the immunoexpression of CD10, T-cell death-associated gene 51 (TDAG51), cytokeratin 20 (CK20), androgen receptor (AR), insulinoma-associated protein 1 (INSM1), and nestin for the differential diagnosis of these tumors. Materials and Methods. We assessed a total of 27 BCC and 27 TB cases, including 4 TB lesions in nevus sebaceous and 3 malignant TB lesions for CD10, TDAG51, CK20, AR, INSM1, and nestin expression. Results. Staining for CK20, TDAG51, INSM1, and stromal CD10 was significantly more common in TB cases than in BCC cases ( P < .001). Epithelial CD10 and AR staining was significantly more common in BCC cases than in TB cases ( P < .001). The difference between the groups for nestin staining was not significant ( P > .05). Stromal CD10 staining was the most sensitive marker (96.3%) and INSM1 the least sensitive (55.6%) marker for TB. TDAG51 showed 100% specificity for TB. A larger number of CK20 positive cells was found in the cases associated with nevus sebaceous than in the other TBs. Conclusion. All the selected markers except nestin were useful for the differential diagnosis between TB and BCC. CD10 and TDAG51 were more useful than the other markers. The use of CK20 could be preferred in nevus sebaceous lesions. INSM1 was less effective in highlighting Merkel cells within the lesion than CK20.

Susceptibility to Basal Cell Carcinoma is Associated with High Dermal Mast Cell Prevalence in Non–sun-exposed Skin for an Australian Population¶

2003 ◽  
Vol 78 (6) ◽  
pp. 633 ◽  
Author(s):  
Michele A. Grimbaldeston ◽  
Adele Green ◽  
Steven Darlington ◽  
Bryan O. Robertson ◽  
Gillian Marshman ◽  
...  
Keyword(s):  
Mast Cell ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Australian Population ◽  
Exposed Skin

scholarly journals Micronodular basal cell carcinoma of the scrotum: a case report and review of the literature

2021 ◽  
Vol 15 (1) ◽  
Author(s):  
Mohammad Younes ◽  
Lamia Kouba ◽  
Hanaa Almsokar ◽  
Ayham Badran
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Excisional Biopsy ◽  
Histological Subtypes ◽  
Main Risk Factor ◽  
Case Presentation ◽  
Exposed Skin ◽  
First Case ◽  
Ultraviolet Radiation Exposure

Abstract Introduction Basal cell carcinoma is the most common nonmelanotic skin cancer. It has variable clinical and histological subtypes that vary in their aggressiveness and liability to recurrence and metastasis. Chronic ultraviolet radiation exposure is considered to be the main risk factor for developing basal cell carcinoma; therefore, it typically arises on sun-exposed skin, mainly the head and neck. Case presentation We present the case of a 55-year-old Caucasian male who presented with a lesion on the scrotum for 2 years. The lesion was clinically presumed benign and initially treated with curettage. Microscopic examination revealed an incompletely resected micronodular basal cell carcinoma with sebaceous differentiation. Therefore, a second excisional biopsy was performed to completely excise the incidentally discovered malignant tumor. Conclusion We report the first case of micronodular basal cell carcinoma arising on the scrotum. The goal of our article is to draw clinicians’ attention to the possible involvement of unexposed skin with basal cell carcinoma, and we highlight the importance of accurate diagnosis and prompt treatment due to the aggressive nature of micronodular basal cell carcinoma.

scholarly journals Basal Cell Carcinoma: What’s New Under the Sun

2010 ◽  
Vol 86 (3) ◽  
pp. 481-491 ◽  
Author(s):  
Clio Dessinioti ◽  
Christina Antoniou ◽  
Andreas Katsambas ◽  
Alexander J. Stratigos
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
The Sun

UV-specific p53 and PTCH mutations in sporadic basal cell carcinoma of sun-exposed skin

2001 ◽  
Vol 44 (2) ◽  
pp. 293-297 ◽  
Author(s):  
Dsire Ratner ◽  
Monica Peacocke ◽  
Hong Zhang ◽  
Xiao Li Ping a ◽  
Hui C. Tsou
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Exposed Skin

scholarly journals Infiltrating basal cell carcinoma: a stellate peri-tumor dermatoscopy pattern as a clue to diagnosis

2015 ◽  
pp. 21-26
Author(s):  
John H. Pyne ◽  
Paul Fishburn ◽  
Anthony Dicker ◽  
Michael David
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Skin Surface ◽  
Kappa Coefficient ◽  
The Other ◽  
Histopathologic Examination ◽  
Tumor Depth ◽  
Tumor Mass ◽  
Shaped Pattern

Background: Infiltrating basal cell carcinoma (BCC) has associated features that may be readily identified using dermatoscopy.  Objective: Investigate a stellate dermatoscopy pattern extending from the peripheral margin of infiltrating BCC. Methods: A total of 741 consecutive cases of BCC were assessed retrospectively using non-polarized dermatoscopy. Following histopathologic examination, cases were categorized into six different BCC subtypes. Infiltrating cases numbered 107. This stellate feature was defined as a geometric star shaped pattern extending outwards from the circumferential peripheral edge of the tumor, and identified by white lines, vessels or uneven skin surface morphology. The percentages of infiltrating subtype within the tumor mass and tumor depth were compared, with and without the stellate pattern. Results: Infiltrating BCC displayed the stellate pattern more than other BCC subtypes. Concordance between the two observers was almost perfect for white lines: Kappa coefficient of 0.87 (95% CI: 0.0.79-0.95) P<0.01 and substantial for vessels: Kappa coefficient of 0.71 95% CI: 0.59-0.84) P<0.01. Folds were only recorded in infiltrating cases (n=3). Compared to other BCC subtypes the stellate pattern had a sensitivity of 31.7% and specificity of 94.1%. A higher mean fraction of the tumor mass containing infiltrating subtype was found when comparing stellate pattern observed to stellate pattern not observed (P<0.01). No statistically significant association was found between the tumor depth with and without the stellate pattern. Conclusion: This study found a higher incidence of the stellate pattern within infiltrating BCC compared to the other BCC subtypes. As the percentage of the infiltrating subtype within the tumors increased the incidence of the stellate pattern also increased.

scholarly journals Micronodular basal cell carcinoma of the scrotum- a case report and review of the literature

2021 ◽  
Author(s):  
Mohammad Younes ◽  
Lamia Kouba ◽  
Hanaa Almsokar ◽  
Ayham Badran
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Excisional Biopsy ◽  
Histological Subtypes ◽  
Main Risk Factor ◽  
Case Presentation ◽  
Exposed Skin ◽  
First Case ◽  
Ultraviolet Radiation Exposure

Abstract Introduction: Basal cell carcinoma (BCC) is the most common non-melanotic skin cancer. It has variable clinical and histological subtypes that vary in their aggressiveness and liability to recurrence and metastasis. Chronic ultraviolet radiation exposure is considered to be the main risk factor for developing BCC; therefore it typically arises on sun-exposed skin, mainly the head and neck. Case presentation: We present the case of a 55-year-old male who presented with a lesion on the scrotum for 2 years. The lesion was clinically presumed benign and initially treated with curettage. Microscopic examination revealed an incompletely resected micronodular BCC with sebaceous differentiation. Therefore, a second excisional biopsy was performed to completely excise the incidentally-discovered malignant tumor. Conclusion: We report the first case of micronodular BCC arising on the scrotum. The goal of our article is to draw clinicians’ attention to the possible involvement of unexposed skin with BCC and we highlight the importance of accurate diagnosis and prompt treatment due the aggressive nature of micronodular BCC.

scholarly journals Risk factors for basal cell carcinoma: a case-control study

1995 ◽  
Vol 29 (1) ◽  
pp. 27-37 ◽  
Author(s):  
Marcus Maia ◽  
Nelson Guimarães Proença ◽  
José Cássio de Moraes
Keyword(s):  
Risk Factors ◽  
Logistic Regression ◽  
Regression Analysis ◽  
Risk Factor ◽  
Skin Cancer ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Odds Ratio ◽  
The Sun

A controlled trial was performed with the purpose of investigating which factors could be considered of significant risk for the development of basal cell carcinoma. A total of 259 cases of basal cell carcinoma diagnosed from July 1991 to July 1992 were compared with 518 controls matched for age and sex. All subjects in both groups were white. Protocol data were submitted to statistical analysis by the chi-square test and by multiple conditional logistic regression analysis and the following conclusions were reached: 1) light skin color (types I and II of the Fitzpatrick classification), odds ratio of 2.8; outdoor work under constant sunlight, odds ratio of 5.0; the presence of actinic lesions due to exposure to the sun, odds ratio of 4.9, are risk factors perse. 2) Type III skin in the Fitzpatrick classification only represents a risk factor when the patient reports a history of intense sunburns, but not in the absence of such a history. 3) Sunburns per se do not represent a risk factor althorig the point made in item 2 of these conclusions is valid. 4) Other suspected risk factors whose significance was not confirmed by multiple conditioned logistic regression analysis were: residence in rural areas, light eyes and blond hair color, extent of the awareness of the "sun x skin cancer" relationship, familial occurrence of skin cancer, excessive exposure to the sun, and freckles appearing in childhood.

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