Clinicopathological Relevance and Prognostic Value of Androgen Receptor in Mammary Paget’s Disease with Underlying Invasive Ductal Carcinoma

2020 ◽  
Vol 43 (7-8) ◽  
pp. 346-353
Author(s):  
Menglu Zhang ◽  
Xiangzhi Meng ◽  
Changyuan Guo ◽  
Jiaqi Liu ◽  
Zeyu Xing ◽  
...  
Keyword(s):  
Androgen Receptor ◽  
Invasive Ductal Carcinoma ◽  
Prognostic Value ◽  
Ductal Carcinoma ◽  
Paget’S Disease ◽  
Paget's Disease ◽  
Mammary Paget’S Disease

scholarly journals Pathological Complete Response following Neoadjuvant Chemotherapy in Invasive Ductal Carcinoma with Mammary Paget’s Disease: A Case Report

2021 ◽  
pp. 1242-1247
Author(s):  
Wataru Goto ◽  
Shinichiro Kashiwagi ◽  
Yuko Kawano ◽  
Asuka Komoda ◽  
Sae Ishihara ◽  
...  
Keyword(s):  
Neoadjuvant Chemotherapy ◽  
Invasive Ductal Carcinoma ◽  
Ductal Carcinoma ◽  
Histopathological Examination ◽  
Paget’S Disease ◽  
Complete Response ◽  
Breast Conserving Surgery ◽  
Punch Biopsy ◽  
Paget's Disease ◽  
Mammary Paget’S Disease

Mammary Paget’s disease is a rare malignancy. Mastectomy or breast-conserving surgery has been considered as the standard treatment, while there have been few reports of neoadjuvant chemotherapy (NAC). A 53-year-old woman with erythema and skin ulceration of the left breast was admitted to our institution. Breast examinations revealed left invasive ductal carcinoma (cT1bN0M0, cStage I), and a punch biopsy of the left mammary erythema indicated Paget’s disease (cTisN0M0, cStage0). The patient received NAC because of multiple lesions. Consequently, the breast tumor clinically disappeared, and the erythema improved. These outcomes made it easier to perform surgery (left mastectomy and sentinel node biopsy). Histopathological examination revealed no residual cancer cells in either the mammary gland or breast skin, and no metastasis was found in the sentinel lymph node. Therefore, NAC may be a useful treatment for mammary Paget’s disease.

Mammary Paget’s Disease of the Male Breast: A Rare Case With an Unusual Immunohistochemical Profile

2019 ◽  
Vol 28 (2) ◽  
pp. 210-215 ◽  
Author(s):  
Samantha A. Moore ◽  
Hollis M. Notgrass ◽  
Travis W. Vandergriff ◽  
Sunati Sahoo
Keyword(s):  
Estrogen Receptor ◽  
Progesterone Receptor ◽  
Ductal Carcinoma In Situ ◽  
Carcinoma In Situ ◽  
Ductal Carcinoma ◽  
Paget’S Disease ◽  
Paget's Disease ◽  
Disease Evolution ◽  
Mammary Paget’S Disease

Mammary Paget’s disease is rare and comprises about 0.62% of all breast cancer cases, only 1.65% of which occur in male patients. This case report involves a 76-year-old man who presented to his primary care physician with an itching, scaly, unilateral lesion involving the nipple skin. He underwent wide local excision of the lesion for a diagnosis of Bowen’s disease (squamous cell carcinoma in situ). Histologic examination of the specimen revealed mammary Paget’s disease with ductal carcinoma in situ in the underlying breast tissue. A panel of immunohistochemical stains revealed the Paget cells to be positive for cytokeratin 7, MUC1, GATA3, and androgen receptor and negative for cytokeratins 5/6, p63, SOX10, and MART-1/Melan-A. Paget cells were also negative for estrogen receptor and progesterone receptor, and positive for HER2/neu. However, the underlying ductal carcinoma in situ was positive for both estrogen receptor and progesterone receptor and negative for HER2/neu. This discordance, supported by the current literature, suggests an alternative etiology for Paget’s disease in certain cases that cannot be explained by the well-established epidermotropic and transformative theories of Paget’s disease evolution.

scholarly journals Paget's disease of the breast in male with underlying invasive ductal carcinoma: A case report with review of literature

2021 ◽  
pp. 103035
Author(s):  
Abdulwahid M. Salih ◽  
Zuhair D. Hammood ◽  
Fahmi H. Kakamad ◽  
Snur Othman ◽  
Razhan K. Ali ◽  
...  
Keyword(s):  
Case Report ◽  
Invasive Ductal Carcinoma ◽  
Ductal Carcinoma ◽  
Paget’S Disease ◽  
Paget's Disease ◽  
Review Of Literature

Synchronous unilateral triple breast cancers composed of invasive ductal carcinoma, invasive lobular carcinoma, and Paget’s disease

Breast Cancer ◽  
2010 ◽  
Vol 21 (2) ◽  
pp. 241-245 ◽  
Author(s):  
Shunsuke Onoe ◽  
Hitoshi Tsuda ◽  
Sadako Akashi-Tanaka ◽  
Takahiro Hasebe ◽  
Eriko Iwamoto ◽  
...  
Keyword(s):  
Invasive Ductal Carcinoma ◽  
Invasive Lobular Carcinoma ◽  
Ductal Carcinoma ◽  
Lobular Carcinoma ◽  
Paget’S Disease ◽  
Paget's Disease ◽  
Breast Cancers

scholarly journals Paget’s disease of breast with an unusual presentation of involvement of overlying skin of breast: a case report

2020 ◽  
Vol 7 (12) ◽  
pp. 4231
Author(s):  
Pravin Kumar ◽  
Arpita Jindal ◽  
Bhushan Bhalgat ◽  
Phanindra Kumar Swain ◽  
Raj Govind Sharma
Keyword(s):  
Breast Cancer ◽  
Carcinoma In Situ ◽  
Ductal Carcinoma ◽  
Paget’S Disease ◽  
Paget's Disease ◽  
Rare Type ◽  
Areola Complex ◽  
Mammary Paget’S Disease ◽  
Surrounding Skin

Paget’s disease of breast is also known as Paget’s disease of the nipple & mammary Paget’s disease, involving the skin of nipple & areola. It is rare type of cancer with tumors inside the same breast which may be either ductal carcinoma in-situ or invasive breast cancer. We report a case with Paget’s disease of breast which is not only involving the nipple-areola complex but also involving surrounding skin of breast.

scholarly journals An Unusual Case of Mammary Paget’s Disease Diagnosed Using Dynamic Contrast-Enhanced MRI

2013 ◽  
Vol 2013 ◽  
pp. 1-5
Author(s):  
Eleonora Gaspari ◽  
Aurora Ricci ◽  
Valeria Liberto ◽  
Angela Lia Scarano ◽  
Maria Fornari ◽  
...  
Keyword(s):  
Unusual Case ◽  
Ductal Carcinoma ◽  
Paget’S Disease ◽  
Skin Lesions ◽  
Paget's Disease ◽  
Mri Findings ◽  
Rare Presentation ◽  
Nipple Areola Complex ◽  
Areola Complex ◽  
Mammary Paget’S Disease

Mammary Paget’s disease is a rare presentation of breast cancer. At clinical examination, it is characterized by skin lesions of the nipple-areola complex, almost always a sign of malignancy. In fact, it is often associated with an underlying mammary ductal carcinoma in situ (DCIS) or invasive carcinoma. An underlying carcinoma is also common in women with negative mammography and ultrasound (US); in these cases, magnetic resonance imaging (MRI) is a diagnostic tool useful in the detection of occult cancer. We described an unusual case of mammary Paget’s disease with underlying DCIS, in a patient without nipple-areola complex alterations and/or palpable lump. On suspicion of Paget’s disease, the patient underwent MRI examination that proved useful for an accurate diagnosis. Biopsy confirmed dynamic MRI findings.

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