scholarly journals Cerebral Impaludation – An Ignoble Procedure between Two Nobel Prizes: Frontal Lobe Lesions before the Introduction of Leucotomy

2020 ◽  
Vol 98 (3) ◽  
pp. 150-159
Author(s):  
Patric Blomstedt
Keyword(s):  
Frontal Lobe ◽  
Nobel Prizes ◽  
Frontal Lobe Lesions

Susceptibility to Memory Interference Effects following Frontal Lobe Damage: Findings from Tests of Paired-Associate Learning

1995 ◽  
Vol 7 (2) ◽  
pp. 144-152 ◽  
Author(s):  
Arthur P. Shimamura ◽  
Paul J. Jurica ◽  
Jennifer A. Mangels ◽  
Felick B. Gershberg ◽  
Robert T. Knight
Keyword(s):  
Frontal Lobe ◽  
Paired Associate ◽  
Memory Function ◽  
Paired Associate Learning ◽  
Interference Effects ◽  
Associate Learning ◽  
Memory Interference ◽  
Frontal Lobe Lesions ◽  
List Learning ◽  
Different Response

Patients with frontal lobe lesions were adminstered tests of paired-associate learning in which cue and response words are manipulated to increase interference across two study lists. In one test of paired-associate learning (AB-AC test), cue words used in one list are repeated in a second list but are associated with different response words (e.g., LION-HUNTER, LION-CIRCUS). In another test (AB-ABr test), words used in one list are repeated in a second list but are rearranged to form new pairs. Compared to control subjects, patients with frontal lobe lesions exhibited disproportionate impairment of second-list learning as a result of interference effects. In particular, patients exhibited the poorest performance during the initial trial of the second list, a trial in which interference effects from the first list would be most apparent. These findings suggest that the on-line control of irrelevant or competing memory associations is disrupted following frontal lobe lesions. This disruption may be indicative of an impaired gating or filtering mechanism that affects not only memory function but other cognitive function as well.

Inaccurate prediction of retrieval in a face matrix learning task after right frontal lobe lesions.

1999 ◽  
Vol 13 (2) ◽  
pp. 298-305 ◽  
Author(s):  
Juhani Vilkki ◽  
Outi Surma-aho ◽  
Antti Servo
Keyword(s):  
Frontal Lobe ◽  
Learning Task ◽  
Frontal Lobe Lesions

Residual impairment in handgrip strength after unilateral frontal-lobe lesions

1988 ◽  
Vol 26 (4) ◽  
pp. 555-564 ◽  
Author(s):  
G. Leonard ◽  
L. Jones ◽  
B. Milner
Keyword(s):  
Frontal Lobe ◽  
Handgrip Strength ◽  
Frontal Lobe Lesions

scholarly journals Bilateral frontal lobe lesions

QJM ◽  
2001 ◽  
Vol 94 (8) ◽  
pp. 449-449 ◽  
Author(s):  
A.L. Manoj
Keyword(s):  
Frontal Lobe ◽  
Frontal Lobe Lesions

Verbal and design fluency in patients with frontal lobe lesions

2001 ◽  
Vol 7 (5) ◽  
pp. 586-596 ◽  
Author(s):  
JULIANA V. BALDO ◽  
ARTHUR P. SHIMAMURA ◽  
DEAN C. DELIS ◽  
JOEL KRAMER ◽  
EDITH KAPLAN
Keyword(s):  
Frontal Cortex ◽  
Frontal Lobe ◽  
Verbal Fluency ◽  
Right Hemisphere ◽  
Verbal Fluency Task ◽  
Frontal Lobe Lesions ◽  
Design Fluency ◽  
The Right ◽  
Frontal Lesions ◽  
Fluency Task

The ability to generate items belonging to categories in verbal fluency tasks has been attributed to frontal cortex. Nonverbal fluency (e.g., design fluency) has been assessed separately and found to rely on the right hemisphere or right frontal cortex. The current study assessed both verbal and nonverbal fluency in a single group of patients with focal, frontal lobe lesions and age- and education-matched control participants. In the verbal fluency task, participants generated items belonging to both letter cues (F, A, and S) and category cues (animals and boys' names). In the design fluency task, participants generated novel designs by connecting dot arrays with 4 straight lines. A switching condition was included in both verbal and design fluency tasks and required participants to switch back and forth between different sets (e.g., between naming fruits and furniture). As a group, patients with frontal lobe lesions were impaired, compared to control participants, on both verbal and design fluency tasks. Patients with left frontal lesions performed worse than patients with right frontal lesions on the verbal fluency task, but the 2 groups performed comparably on the design fluency task. Both patients and control participants were impacted similarly by the switching conditions. These results suggest that verbal fluency is more dependent on left frontal cortex, while nonverbal fluency tasks, such as design fluency, recruit both right and left frontal processes. (JINS, 2001, 7, 586–596.)

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