Vascular Density of the Anterior Segment of the Eye Determined by Optical Coherence Tomography Angiography and Slit-Lamp Photography

2020 ◽  
Vol 63 (6) ◽  
pp. 572-579
Author(s):  
Nina Teresa Aicher ◽  
Katsuya Nagahori ◽  
Makoto Inoue ◽  
Yuji Itoh ◽  
Akito Hirakata
Keyword(s):  
Optical Coherence Tomography ◽  
Cataract Surgery ◽  
Optical Coherence Tomography Angiography ◽  
Anterior Segment ◽  
Vascular Density ◽  
Optical Coherence ◽  
Slit Lamp ◽  
Swept Source ◽  
Vascular Flow ◽  
Imagej Software

<b><i>Objective:</i></b> To determine the vascular density of the anterior segment (AS) of the eye from optical coherence tomography angiography (OCTA) images and slit-lamp photographs. <b><i>Methods:</i></b> A swept-source OCTA (Plex Elite 9000; Carl Zeiss) device modified with a +10-diopter lens was used to record the vasculature of the AS. Twenty eyes, including 4 eyes of 4 healthy subjects and 16 eyes of 12 patients scheduled for cataract surgery or combined vitrectomy and cataract surgery, were studied. The slit-lamp photographs of the AS were acquired concurrently with the AS-OCTA images. The vascular density was measured preoperatively and postoperatively in the nasal, temporal, superior, and inferior quadrants after binarization with ImageJ software. <b><i>Results:</i></b> Acceptable AS-OCTA images were obtained of 65% (superior), 80% (nasal), 70% (inferior), and 80% (temporal) of the eyes. The percentage of acceptable images was significantly lower in the superior quadrant among the AS-OCTA images than among the AS photographs (100%; <i>p</i> = 0.004). The vascular density determined by AS-OCTA was higher than that determined in the AS photographs in all quadrants (<i>p</i> = 0.011 to &#x3c;0.001). The AS-OCTA B-mode images showed that vascular flow was identified mainly between the conjunctiva and sclera but not in the ciliary body. The vascular density increased significantly after cataract surgery in the superior quadrant, which was significantly correlated with the location of the surgical incision (<i>p</i> = 0.03). <b><i>Conclusion:</i></b> AS-OCTA can obtain images with higher vascular density of the conjunctiva and sclera than slit-lamp photographs, and AS-OCTA images can show a postoperative increase in vascular density.

Role of anterior segment optical coherence tomography angiography in assessing limbal vasculature in acute chemical injury of the eye

2021 ◽  
pp. bjophthalmol-2021-318847
Author(s):  
Marcus Ang ◽  
Valencia Foo ◽  
Mengyuan Ke ◽  
Bingyao Tan ◽  
Louis Tong ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Optical Coherence Tomography Angiography ◽  
Rapid Assessment ◽  
Anterior Segment ◽  
Vessel Density ◽  
Optical Coherence ◽  
Slit Lamp ◽  
Swept Source ◽  
Chemical Injury

PurposeTo study the role of two anterior segment optical coherence tomography angiography (AS-OCTA) systems in eyes with acute chemical injury.MethodsProspective study in subjects with unilateral chemical injuries. Sequential slit-lamp assessment with spectral domain (SD) (AngioVue, Optovue, USA) and swept source (SS) (Plex Elite, Zeiss, Carl Zeiss Meditec, Dublin, California, USA) AS-OCTA was performed in both eyes within 24–48 hours of injury. Subjects were managed with a standard clinical protocol and followed-up for 3 months. We assessed limbal disruption (loss of normal limbal vessel architecture), limbal vessel density measurements and agreement (kappa coefficient, κ) between masked assessors of limbal disruption based on AS-OCTA scans and slit-lamp assessment.ResultsTen subjects with median age 31 (25–33) years, 20% women, 60% suffered alkali injuries (Roper-Hall grade 1.5±0.7, Dua grade 2.3±1.2) at presentation. Mean limbal vessel density was lower in quadrants of affected eyes compared with controls detected by SD AS-OCTA (9.4%±2.0% vs 15.5%±1.8%, p<0.001) and SS AS-OCTA (8.8%±2.5% vs 13.9%±1.3%, p=0.01). There was substantial agreement when assessing limbal disruption on AS-OCTA (κ=0.7) compared with slit-lamp evaluation (κ=0.4). Overall, we found good agreement between SD and SS AS-OCTA systems in assessing limbal vessel density in eyes with chemical injury at presentation (mean paired difference: −1.08, 95% CI −3.2 to 0.5; p=0.189).ConclusionsIn this pilot study, AS-OCTA provided objective, non-contact, rapid assessment of limbal vasculature involvement in eyes with acute chemical injury. Further studies are required to establish the role of AS-OCTA in determining the prognosis of eyes with chemical injury.

Impact of Cataract Surgery on Filtering Bleb Morphology Identified Via Swept-source 3-dimensional Anterior Segment Optical Coherence Tomography

2019 ◽  
Vol 28 (5) ◽  
pp. 433-439
Author(s):  
Akiko Narita ◽  
Yuki Morizane ◽  
Tomoe Miyake ◽  
Kae Sugihara ◽  
Tomoko Ishikawa ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Cataract Surgery ◽  
Anterior Segment ◽  
Optical Coherence ◽  
Swept Source ◽  
3 Dimensional ◽  
Filtering Bleb

scholarly journals Assessment of anterior chamber configuration changes after phacoemulsification with swept-source optical coherence tomography

2019 ◽  
Author(s):  
Man Hu ◽  
Qian Zheng ◽  
Zhangliang Li ◽  
Pingjun Chang ◽  
Yun-e Zhao
Keyword(s):  
Optical Coherence Tomography ◽  
Cataract Surgery ◽  
Anterior Chamber ◽  
Anterior Segment ◽  
Anterior Chamber Depth ◽  
Optical Coherence ◽  
Swept Source ◽  
Narrow Angle ◽  
Age Related ◽  
Shallow Anterior Chamber

Abstract Background To assess the changes of anterior chamber angle in patients with shallow anterior chamber and normal anterior chamber after phacoemulsification and intraocular lens implantation (IOL) using anterior segment swept-source optical coherence tomography (AS-SS-OCT). Methods This was a prospective case control study; 60 eyes of 60 patients who underwent cataract surgery. Based on anterior chamber depth (ACD) and gonioscopy findings, the eyes were classified into two groups, shallow anterior chamber group (30 eyes) and normal anterior chamber group (30 eyes). AS-SS-OCT was used to measure ACD and angle parameters angle opening distance (AOD), angle recess area (ARA), trabecular iris space area(TISA), and trabecular iris angle (TIA). Serial changes in each group were measured before and 3 months after phacoemulsification and IOL, and the differences between the two groups were compared. Results All angle parameters including ACD, AOD, ARA, TISA, and TIA in both groups at 3 months after cataract surgery were significantly different from the preoperative values (p<0.01). In addition, we found significant differences of all angle parameters between groups of shallow anterior chamber (SAC) and normal anterior chamber (NAC) (All P< 0.05). Besides, the TISA750 in superior quadrant and anterior chamber volume (ACV) were significantly smaller in the group of SAC than those in the group of NAC (P = 0.041 and 0.002, respectively). Conclusions The parameters of anterior chamber increased significantly in both two groups but not increase to the same extent 3 months after phacoemulsification. Iris thickening may also be one of the narrow angle factors,not just age-related lens thickening.

Anterior segment optical coherence tomography angiography for iris vasculature in pigmented eyes

2020 ◽  
pp. bjophthalmol-2020-316930
Author(s):  
Marcus Ang ◽  
Kavya Devarajan ◽  
Anna CS Tan ◽  
Mengyuan Ke ◽  
Bingyao Tan ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Optical Coherence Tomography Angiography ◽  
Anterior Segment ◽  
Mean Difference ◽  
Vessel Density ◽  
Optical Coherence ◽  
Swept Source ◽  
Density Measurements ◽  
Stage 1 ◽  
Swept Source Octa

PurposeTo compare anterior segment optical coherence tomography angiography (AS-OCTA) systems in delineating normal iris vessels and iris neovascularisation (NVI) in eyes with pigmented irides.MethodsProspective study from January 2019 to June 2019 of 10 consecutive patients with normal pigmented iris, had AS-OCTA scans with a described illumination technique, before using the same protocol in five eyes with NVI (clinical stages 1–3). All scans were sequentially performed using a spectral-domain OCTA (SD-OCTA), and a swept-source OCTA (SS-OCTA, Plex Elite 9000). Images were graded by two masked observers for visibility, artefacts and NVI characteristics. The main outcome measure was iris vessel density measurements comparing SS-OCTA and SD-OCTA systems.ResultsThe median age of subjects was 28 (20–35) years, and 50% were female. The paired mean difference of iris vessel density measurements was 11.7 (95% CI 14.7 to 8.1; p=0.002), SS-OCTA detecting more vessels than SD-OCTA. The inter-rater reliability for artefact score (κ=0.799, p<0.001) and visibility score (κ=0.722; p<0.001) were substantial. Both AS-OCTA systems were able to detect NVI vessels with a fair agreement (κ=0.588), with clearer NVI characteristics in stage 1/2 compared to stage 3 NVI (mean difference NVI score: 2.7±0.4, p=0.009).ConclusionThe SS-OCTA was better able to delineate iris vessels in normal pigmented irides compared to SD-OCTA. Both AS-OCTA systems identified NVI characteristics based on its atypical configuration or location, but further improvements are needed to allow for more accurate objective, serial quantification for clinical use.

scholarly journals A Novel Automatic Method to Estimate Visual Acuity and Analyze the Retinal Vasculature in Retinal Vein Occlusion Using Swept Source Optical Coherence Tomography Angiography

2019 ◽  
Vol 8 (10) ◽  
pp. 1515 ◽  
Author(s):  
Díez-Sotelo ◽  
Díaz ◽  
Abraldes ◽  
Gómez-Ulla ◽  
Penedo ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Visual Acuity ◽  
Optical Coherence Tomography Angiography ◽  
Foveal Avascular Zone ◽  
Depth Information ◽  
Vascular Density ◽  
Optical Coherence ◽  
Automatic Method ◽  
Correlation Index ◽  
Swept Source

The assessment of vascular biomarkers and their correlation with visual acuity is one of the most important issues in the diagnosis and follow-up of retinal vein occlusions (RVOs). The high workloads of clinical practice make it necessary to have a fast, objective, and automatic method to analyze image features and correlate them with visual function. The aim of this study is to propose a fully automatic system which is capable of estimating visual acuity (VA) in RVO eyes, based only on information obtained from macular optical coherence tomography angiography (OCTA) images. We also propose an automatic methodology to rapidly measure the foveal avascular zone (FAZ) area and the vascular density (VD) in the superficial and deep capillary plexuses in swept-source OCTA images centered on the fovea. The proposed methodology is validated using a representative sample of 133 visits of 50 RVO patients. Our methodology estimates VA with very high precision and is even more accurate when we integrate depth information, providing a high correlation index of 0.869 with the real VA, which outperforms the correlation index of 0.855 obtained when estimating VA from the data obtained by the semiautomatic existing method. In conclusion, the proposed method is the first computational system able to estimate VA in RVO, with the additional benefits of being automatic, less time-consuming, objective and more accurate. Furthermore, the proposed method is able to integrate depth information, a feature which is lacking in the existing method.

scholarly journals Optical Coherence Tomography Angiography following Scleral Buckling Surgery

2021 ◽  
Vol 13 (1) ◽  
pp. 165-170
Author(s):  
Punita Kumari Sodhi ◽  
Anu Sharma ◽  
Nasiq Hasan
Keyword(s):  
Optical Coherence Tomography ◽  
Optical Coherence Tomography Angiography ◽  
Scleral Buckling ◽  
Vascular Density ◽  
Optical Coherence ◽  
Swept Source ◽  
Fellow Eye ◽  
Post Surgery ◽  
Capillary Plexus ◽  
Superficial Capillary Plexus

Introduction: The retinal changes following scleral buckling surgery (SBS) for rhegmatogenous retinal detachment (RRD) have been rarely evaluated with optical coherence tomography angiography (OCTA). Methods: A 40 years old male presented with subtotal RD involving the macula and had best corrected visual acuity of logmar 2.3 in the affected right eye. Five months after applying 120 degree scleral buckle, swept source optical coherence tomography (SSOCT) and swept source optical coherence tomography angiography (SS-OCTA) were done.   Result: At five months post-surgery, despite a settled retina in the operated eye, the patient had  vision of logmar 1 and thin retinal nerve fibre layer (115 micrometer). The SSOCT showed  inner segment-outer segment (IS-OS) junction disruption, thinned retinal pigment epithelium, central macular thickness of 275 micrometer and subfoveal choroidal thickness of 222 micrometer. A 3x3 mm macular OCTA scan showed a normal foveal avascular zone along with higher values for vascular density in superficial capillary plexus in all quadrants except temporal quadrant in operated eye as compared to fellow eye.  Conclusion: The SBS with 120 degree buckle did not lead to a reduced vascular density in superficial capillary plexus in the operated eye with respect to fellow eye. 

scholarly journals Macular Vascular Flow Area and Vascular Density in Healthy Population Using Optical Coherence Tomography Angiography

2016 ◽  
Vol 57 (15) ◽  
pp. 6713 ◽  
Author(s):  
Rodrigo Abreu-Gonzalez ◽  
Raqeul Diaz-Rodriguez ◽  
Gloria Rubio-Rodriguez ◽  
Maria A. Gil-Hernandez ◽  
Pedro Abreu-Reyes
Keyword(s):  
Optical Coherence Tomography ◽  
Optical Coherence Tomography Angiography ◽  
Vascular Density ◽  
Healthy Population ◽  
Optical Coherence ◽  
Flow Area ◽  
Vascular Flow

Swept-source optical coherence tomography angiography in serpiginous choroiditis

2017 ◽  
Vol 102 (7) ◽  
pp. 991-995 ◽  
Author(s):  
Daniela Montorio ◽  
Chiara Giuffrè ◽  
Elisabetta Miserocchi ◽  
Giulio Modorati ◽  
Riccardo Sacconi ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Optical Coherence Tomography Angiography ◽  
Fundus Autofluorescence ◽  
Vessel Density ◽  
Vascular Density ◽  
Optical Coherence ◽  
Swept Source ◽  
Inflammatory Lesions ◽  
Choroidal Vessel ◽  
Outer Border

Background/AimsTo analyse choroidal vascular density of affected and non-affected areas in active and inactive serpiginouschoroiditis (SC) by means of optical coherence tomography angiography (OCT-A).MethodsIn this cross-sectional and observational study, 22 eyes of 11 patients diagnosed with SC were included. All patients underwent blue-light fundus autofluorescence (spectralis Heidelberg retinalangiography+OCT) and swept-source OCT-A (AngioPlex Elite 9000 SS-OCT, Carl Zeiss Meditech) to analyse qualitative features and choroidal vessel density of areas considered affected, and the inner and the outer border of the lesions. Unaffected areas of otherwise healthy retina have also been studied.ResultsAll inactive inflammatory lesions were characterised by atrophy of choriocapillaris with an impairment of its detectable flow and greater visibility of choroidal vessels. On the other hand, all active inflammatory lesions showed an area of complete absence of decorrelation signal. The pathological border was characterised by a statistically significant lower choroidal vessel density compared with both the outer border and the unaffected area (0.650±0.113 vs 0.698±0.112, (p<0.001)). Although not statistically significant, vessel density of the outer border of inactive lesions was lower than vessel density of unaffected areas (0.650±0.113 vs 0.698±0.112, p=0.441). Active inflammatory lesions showed an area of complete absence of decorrelation signal at the level of the choriocapillaris and whole choroid.ConclusionOCT-A represents a new imaging technique that provides useful information about the leading changes of choroidal vascular network in active and inactive lesions of SC.

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