There is a Strong Association between Early Preeclampsia and Congenital Heart Defects: A Large Population-Based, Retrospective Study

2020 ◽  
pp. 1-8
Author(s):  
Jie Liu ◽  
Guanglin Zhao ◽  
Jiansheng Xie ◽  
Shuhua Wu ◽  
Bohong Li ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Congenital Heart Defects ◽  
Early Onset ◽  
Congenital Heart ◽  
Septal Defect ◽  
Heart Defects ◽  
Strong Association ◽  
Large Population ◽  
Population Based ◽  
And Child Health

<b><i>Objective:</i></b> The aim of this study was to determine the prevalence of congenital heart defects and examine their association with preeclampsia (PE). <b><i>Methods:</i></b> A clinical-based, retrospective study was conducted in Shenzhen between 2004 and 2017. Data were collected from Shenzhen Maternal and Child Health Hospital Medical Record Database. This study included all infants who were born at the hospital with or without heart defects and their mothers (<i>N</i> = 177,434 newborns). Data processing and analysis were performed by SPSS23.0 (Chicago, IL, USA). <b><i>Results:</i></b> 6,852 women (3.9%) were diagnosed as PE and 1,289 newborns (7.30 per 1,000) have congenital heart disease (CHD). Prevalence of CHD in newborns of women with PE is 15.8 per 1,000 significantly higher than the overall prevalence (7.30 per 1,000). CHD in newborns has strong association with PE, especially early-onset PE (adjusted OR 3.29 and 95% CI 2.15–5.03) and severe PE (adjusted OR 2.75 and 95% CI 2.13–3.56). Among those with CHD, infants of preeclamptic women had higher prevalence of tetralogy of Fallot (43.78 vs. 28.14 per 100,000), atrial septal defect (335.67 vs. 53.93 per 100,000), ventricular dysplasia (102.16 vs. 89.69 per 100,000), and ventricular septal defect (525.39 vs. 212.22 per 100,000) than pregnant women with non-PE. <b><i>Conclusion:</i></b> PE, especially early-onset PE and severe PE, is strongly associated with offspring CHD. Our results help advance the current understanding of the association between PE and offspring CHD. So preventing PE and reducing PE may have a beneficial effect on the offspring CHD.

scholarly journals Congenital heart defects in dogs: A retrospective study of 301 dogs

2017 ◽  
Vol 73 (10) ◽  
pp. 651-656
Author(s):  
Magdalena Garncarz ◽  
Marta Parzeniecka-Jaworska ◽  
Olga Szaluś-Jordanow
Keyword(s):  
Retrospective Study ◽  
Congenital Heart Defects ◽  
Medical Records ◽  
Congenital Heart ◽  
Septal Defect ◽  
Early Recognition ◽  
Heart Defects ◽  
Ductus Arteriosus ◽  
Subaortic Stenosis ◽  
Patent Ductus

The aim of the study was to assess the frequency of congenital heart defects in a population of dogs in Poland and to determine which breeds were affected by particular defects. A retrospective study of the medical records of cardiologically examined dogs revealed 301 cases of echocardiographically confirmed congenital heart defects. Dogs with congenital heart defects made up 2.7% of the dogs that underwent a cardiologic examination. The age at diagnosis ranged from 2 weeks to 190 months. Mixed breeds (33 dogs, 11%), Bull Terriers (31, 10%), Boxers (28, 9%), German Shepherds (17, 6%), Yorkshire Terriers (17, 6%), and French Bulldogs (16, 5%) were the most frequently affected breeds. Subaortic stenosis (120 cases, 33.9%), pulmonic stenosis (64, 18.1%), patent ductus arteriosus (59, 16.7%), mitral valve dysplasia (56, 15.8%), ventricular septal defect (24, 6.8%) and tricuspid valve dysplasia (17, 4.8%) were the most frequent congenital heart defects recognized in this study. Isolated congenital heart disease occurred in 258 dogs (86%), while multiple heart defects were noted in 43 dogs (14%). Most (60%) congenital heart defects were recognized in dogs older than 1 year. Early recognition of congenital heart defects is important for better patient care. Collecting information on the frequency of congenital heart defects in particular breeds will be useful in educating breeders and thus in improving the overall health of the breed.

scholarly journals Left Ventricular Noncompaction Is More Prevalent in Ventricular Septal Defect Than Other Congenital Heart Defects: A Morphological Study

2020 ◽  
Vol 7 (4) ◽  
pp. 39
Author(s):  
Laís Costa Marques ◽  
Gabriel Romero Liguori ◽  
Ana Carolina Amarante Amarante Souza ◽  
Vera Demarchi Aiello
Keyword(s):  
Ventricular Septal Defect ◽  
Congenital Heart Defects ◽  
Morphological Study ◽  
Congenital Heart ◽  
Septal Defect ◽  
Heart Defects ◽  
Atrioventricular Septal Defect ◽  
Left Ventricular ◽  
Left Ventricular Noncompaction ◽  
Ventricular Noncompaction

Left ventricular noncompaction (LVNC) is a condition characterized by prominent ventricular trabeculae and deep intertrabecular recesses and has been described as a possible substrate for arrhythmias, thromboembolism, and heart failure. Herein, we explored the prevalence of LVNC morphology among hearts with congenital heart defects (CHD). We examined 259 postnatal hearts with one of the following CHD: isolated ventricular septal defect (VSD); isolated atrial septal defect (ASD); atrioventricular septal defect (AVSD); transposition of the great arteries (TGA); isomerism of the atrial appendages (ISOM); Ebstein’s malformation (EB); Tetralogy of Fallot (TF). Eleven hearts from children who died of non-cardiovascular causes were used as controls. The thickness of the compacted and non-compacted left ventricular myocardial wall was determined and the specimens classified as presenting or not LVNC morphology according to three criteria, as proposed by Chin, Jenni, and Petersen. Normal hearts did not present LVNC, but the CHD group presented different percentages of LVNC in at least one diagnostic criterium. The prevalence of LVNC was respectively, according to Chin’s, Jenni´s and Petersen´s methods: for VSD—54.2%, 35.4%, and 12.5%; ASD—8.3%, 8.3%, and 8.3%; AVSD—2.9%, 2.9%, and 0.0%; TGA—22.6%, 17%, and 5.7%; ISOM—7.1%, 7.1%, and 7.1%; EB—28.6%, 9.5%, and 0.0%; TF—5.9%. 2.9%, and 2.9%. VSD hearts showed a significantly greater risk of presenting LVNC when compared to controls (Chin and Jenni criteria). No other CHD presented similar risk. Current results show some agreement with previous studies, such as LVNC morphology being more prevalent in VSDs. Nonetheless, this is a morphological study and cannot be correlated with symptoms or severity of the CHD.

Congenital heart defects in cats: a retrospective study of 162 cats (1996–2013)

2015 ◽  
Vol 17 ◽  
pp. S215-S219 ◽  
Author(s):  
Anna Tidholm ◽  
Ingrid Ljungvall ◽  
Jenny Michal ◽  
Jens Häggström ◽  
Katja Höglund
Keyword(s):  
Retrospective Study ◽  
Congenital Heart Defects ◽  
Congenital Heart ◽  
Heart Defects

scholarly journals Nausea during Pregnancy and Congenital Heart Defects: A Population-based Case-Control Study

1999 ◽  
Vol 149 (8) ◽  
pp. 717-725 ◽  
Author(s):  
R. S. Boneva ◽  
C. A. Moore ◽  
L. Botto ◽  
L.-Y. Wong ◽  
J. David Erickson
Keyword(s):  
Congenital Heart Defects ◽  
Congenital Heart ◽  
Case Control Study ◽  
Heart Defects ◽  
Population Based ◽  
Case Control ◽  
Control Study

The Contribution of Chromosomal Abnormalities to Congenital Heart Defects: A Population-Based Study

2011 ◽  
Vol 32 (8) ◽  
pp. 1147-1157 ◽  
Author(s):  
Robert J. Hartman ◽  
Sonja A. Rasmussen ◽  
Lorenzo D. Botto ◽  
Tiffany Riehle-Colarusso ◽  
Christa L. Martin ◽  
...  
Keyword(s):  
Congenital Heart Defects ◽  
Congenital Heart ◽  
Chromosomal Abnormalities ◽  
Heart Defects ◽  
Population Based ◽  
Population Based Study
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