scholarly journals Serotonin Syndrome Developing Immediately after the Initiation of Low-Dose Methadone Therapy: A Case Report

2020 ◽  
Vol 13 (1) ◽  
pp. 281-284 ◽  
Author(s):  
Masayoshi Kumai ◽  
Yosuke Maeda ◽  
Mototsugu Miura ◽  
Kenkichi Tsuruga ◽  
Takehiro Yamada ◽  
...  
Keyword(s):  
Case Report ◽  
Sustained Release ◽  
Desmoid Tumor ◽  
Serotonin Syndrome ◽  
Low Dose ◽  
Sustained Release Tablets ◽  
Excessive Perspiration

We present a case in which serotonin syndrome developed immediately after the initiation of low-dose methadone following an increase in oxycodone dose and the initiation of duloxetine. The symptoms of serotonin syndrome were alleviated and later disappeared upon cessation of methadone alone. The case was a 47-year-old woman with a desmoid tumor. The administration of duloxetine (20 mg/day) was initiated while the patient took oxycodone sustained-release tablets (40 mg/day). The following day, excessive perspiration, chills, and tremors appeared after the initiation of 15 mg/day methadone. Discontinuation of methadone led to an alleviation of the symptoms which completely disappeared 3 days later. The results suggest that low-dose methadone can trigger serotonin syndrome as early as after the first dose. Thus, it is important to be aware of the risks and to immediately take action if symptoms appear.

Resting Tremor during Low-dose Tricyclic Antidepressant Treatment - A case report -

2007 ◽  
Vol 20 (1) ◽  
pp. 71
Author(s):  
Young Bok Lee ◽  
Jong Taek Park ◽  
Ja Youn Jeon ◽  
Kwang Ho Lee
Keyword(s):  
Case Report ◽  
Low Dose ◽  
Antidepressant Treatment ◽  
Tricyclic Antidepressant ◽  
Resting Tremor

Desmoid tumor following dorsal laminectomy: case report

2016 ◽  
Vol 1 (11) ◽  
Author(s):  
R. Rispoli ◽  
A. Di Chirico ◽  
E. Tinella ◽  
A. Peciarolo ◽  
S. Ascani ◽  
...  
Keyword(s):  
Case Report ◽  
Desmoid Tumor ◽  
Dorsal Laminectomy

Serotonin Syndrome: A Case Report.

2016 ◽  
Vol 12 (01) ◽  
pp. 58-61
Author(s):  
Nantawan Tinroongroj ◽  
Apichard Sukonthasarn
Keyword(s):  
Case Report ◽  
Serotonin Syndrome

Formulation and Evaluation of Sustained Release Dosage Forms of Norfloxacin

2018 ◽  
Vol 11 (6) ◽  
pp. 4331-4337
Author(s):  
C Suja ◽  
Sismy C
Keyword(s):  
Sustained Release ◽  
Guar Gum ◽  
In Vitro Release ◽  
Angle Of Repose ◽  
Prolonged Release ◽  
Weight Variation ◽  
Sustained Release Tablets ◽  
Release Study ◽  
Vitro Release

The goal of this study was to formulate and evaluate norfloxacin sustained release tablets. Norfloxacin sustained release tablets were prepared by wet granulation method using two polymers such as HPMC K 100 M (hydrophilic polymer) and guar gum (natural polymer) and with three polymer ratios (0.5, 1.0 and 1.5). The prepared granules were evaluated to preformulation studies such as angle of repose, bulk density, tapped density, bulkiness, compressibility index and Hauser’s ratio. All the parameters shows that the granules having good flow properties. Then the formulated tablets were taken to evaluation studies such as hardness, weight variation, friability, drug content and thickness. All the parameters were within the acceptable limits. IR spectral analysis showed that there was no interaction between the drug and polymers. The in vitro release study was performed in phosphate buffer pH 7.4 at 293 nm. The in vitro release study showed that if the polymer ratio is increased, then the release of the drug is prolonged. HPMC K 100M shows a prolonged release when compared to guar gum.

Crystal Transition and Drug-excipient Compatibility of Clarithromycin in Sustained Release Tablets

2020 ◽  
Vol 16 (7) ◽  
pp. 950-959
Author(s):  
Yu Li ◽  
Xiangwen Kong ◽  
Fan Hu
Keyword(s):  
Sustained Release ◽  
Powder Diffraction ◽  
Magnesium Stearate ◽  
Influential Factor ◽  
High Concentration ◽  
Scanning Calorimetry ◽  
X Ray ◽  
Sustained Release Tablets ◽  
Crystal Transition ◽  
Excipient Compatibility

Background: Clarithromycin is widely used for infections of helicobacter pylori. Clarithromycin belongs to polymorphic drug. Crystalline state changes of clarithromycin in sustained release tablets were found. Objective: The aim of this study was to find the influential factor of the crystal transition of clarithromycin in preparation process of sustained-release tablets and to investigate the possible interactions between the clarithromycin and pharmaceutical excipients. Methods and Results: The crystal transition of active pharmaceuticals ingredients from form II to form I in portion in clarithromycin sustained release tablets were confirmed by x-ray powder diffraction. The techniques including differential scanning calorimetry and infrared spectroscopy, x-ray powder diffraction were used for assessing the compatibility between clarithromycin and several excipients as magnesium stearate, lactose, sodium carboxymethyl cellulose, polyvinyl-pyrrolidone K-30 and microcrystalline cellulose. All of these methods showed compatibilities between clarithromycin and the selected excipients. Alcohol prescription simulation was also done, which showed incompatibility between clarithromycin and concentration alcohol. Conclusion: It was confirmed that the reason for the incompatibility of clarithromycin with high concentration of alcohol was crystal transition.

Matrix Based Sustained Release Tablets of Carvedilol: Formulation and In-vitro Characterization

2018 ◽  
Vol 8 (2) ◽  
pp. 153-158
Author(s):  
Praveen Radhakrishnan ◽  
Shinu Chacko ◽  
Raman Saraswathi ◽  
Palamadai Neelakantam Krishnan
Keyword(s):  
Sustained Release ◽  
In Vitro Characterization ◽  
Sustained Release Tablets

Ayurvedic Management of Sthaulya (Obesity): A Case Report

2017 ◽  
Vol 2 (4) ◽  
Author(s):  
Nirmal P. Alodaria ◽  
S. N. Gupta ◽  
Dhaval Dholakiya ◽  
Kaushik B. Vyas
Keyword(s):  
Case Report ◽  
Male Patient ◽  
Life Style ◽  
Health Issue ◽  
Exertional Dyspnoea ◽  
Alternative Approach ◽  
Ayurvedic Treatment ◽  
Excessive Perspiration

Obesity is burning health issue for society nowadays. In Sutrasthana of Charaka Samhita, in different Adhyaya (eg. Astauninditiya, Langhanabrumhaniya, Santarpaniya) causes, symptoms and treatment of Sthaulya are described. As an alternative approach, Ayurvedic treatment may serve as promising modality. A 17 years old male patient came in P.D. Patel Ayurveda Hospital on 22th May 2017. Patients weight was 114.8 kg and BMI was 37.51 which fairly included in obesity category according to NHI guidelines. He also had some associated complaints like exertional dyspnoea, increased appetite, excessive perspiration. He was treated with Snehana (Aabhyantara and Bahya), Swedana, Vamana, Virechana, Niruha Basti, Udvartana along with oral medicines like Varunaadi Kwatha, Arogyavardhini Vati, Triphala Guggulu, and Navayasa Lauha along with prescribed dietary regimes and life style modification. He lost about 9.7 kg of weight, which was 105.1 kgs and BMI was 34.34 only in 26 days without any complications.

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