scholarly journals An Association of Varicella Zoster Virus, Facial Palsy, and Meningitis in a Young Immunocompetent Male

2020 ◽  
Vol 12 (1) ◽  
pp. 136-139
Author(s):  
Amr Ashour ◽  
Khaldun Obeidat ◽  
Bahjat Azrieh ◽  
Arwa Alsaud ◽  
Mohamed Yassin
Keyword(s):  
Varicella Zoster Virus ◽  
Facial Nerve Palsy ◽  
Secondary Infection ◽  
Neurological Deficits ◽  
Trigeminal Ganglia ◽  
Male Adult ◽  
Varicella Zoster ◽  
Meningeal Involvement ◽  
Rare Manifestation ◽  
Polymerase Chain

Varicella zoster is a secondary infection caused by the virus of chickenpox, after becoming latent in neurons of dorsal root ganglia or trigeminal ganglia. Varicella zoster virus (VZV) can be reactivated years later to produce shingles (zoster), generally in immunocompromised adults to produce neurological deficits and rash. Meningeal involvement of VZV is also reported and can be diagnosed. Herein, we report a 39-year-old immunocompetent male adult with a rare manifestation caused by VZV. The report is an association between facial nerve palsy and a polymerase chain reaction-confirmed VZV meningitis, even without the dermal typical rash. The patient eventually recovered after receiving acyclovir intravenously.

scholarly journals Quantitation of latent varicella-zoster virus DNA in human trigeminal ganglia by polymerase chain reaction.

1993 ◽  
Vol 67 (4) ◽  
pp. 2381-2384 ◽  
Author(s):  
R Mahalingam ◽  
M Wellish ◽  
D Lederer ◽  
B Forghani ◽  
R Cohrs ◽  
...  
Keyword(s):  
Polymerase Chain Reaction ◽  
Varicella Zoster Virus ◽  
Trigeminal Ganglia ◽  
Chain Reaction ◽  
Varicella Zoster ◽  
Polymerase Chain

Viable herpes simplex virus type 1 and varicella-zoster virus in the trigeminal ganglia of human cadavers

2013 ◽  
Vol 85 (5) ◽  
pp. 833-838 ◽  
Author(s):  
Hisako Saitoh ◽  
Yuko Momma ◽  
Hiroyuki Inoue ◽  
Daisuke Yajima ◽  
Hirotaro Iwase
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Varicella Zoster Virus ◽  
Virus Type ◽  
Herpes Simplex Virus Type ◽  
Trigeminal Ganglia ◽  
Varicella Zoster ◽  
Human Cadavers ◽  
Simplex Virus

scholarly journals Epigenetic Regulation of Varicella-Zoster Virus Open Reading Frames 62 and 63 in Latently Infected Human Trigeminal Ganglia

2006 ◽  
Vol 80 (10) ◽  
pp. 4921-4926 ◽  
Author(s):  
Lee Gary ◽  
Donald H. Gilden ◽  
Randall J. Cohrs
Keyword(s):  
Varicella Zoster Virus ◽  
Chromatin Immunoprecipitation ◽  
Latent Infection ◽  
Open Reading Frames ◽  
Trigeminal Ganglia ◽  
Varicella Zoster ◽  
Glycoprotein C ◽  
Latently Infected ◽  
Human Chromosome 4 ◽  
Reading Frames

ABSTRACT Open reading frames (ORFs) 21, 29, 62, 63, and 66 of varicella-zoster virus (VZV) are transcribed during latency in human ganglia. ORF 63 is the most frequently expressed gene, and ORF 62 encodes a transcriptional activator. The mechanisms regulating the expression of these genes are not well understood, although analyses of other alphaherpesviruses indicate a role for chromatin in virus gene regulation during latent infection. Using chromatin immunoprecipitation (ChIP) assays to analyze the euchromatic state of ORFs 62 and 63 compared to the centromere from human chromosome 4 (heterochromatic) and the human glyceraldehyde-3-phosphate dehydrogenase promoter (euchromatic), we show that the promoters of ORFs 62 and 63 are associated with the histone protein H3K9(Ac) and thus maintained in a euchromatic state during latency. Conversely, the promoters of ORF 36 (thymidine kinase) and ORF 14 (glycoprotein C), genes expressed during lytic but not latent infection, were not enriched in the fraction of latently infected ganglia that bound to anti-H3K9(Ac) antibody. A ChIP assay using productively infected MeWo cells revealed that VZV ORFs 62, 63, 36, and 14 are all euchromatic. Together, these data indicate that the expression of the two latency-related VZV genes, ORFs 62 and 63, is regulated epigenetically through chromatin structure.

Varicella-Zoster Virus Transcription in Human Trigeminal Ganglia

Virology ◽  
1993 ◽  
Vol 193 (1) ◽  
pp. 193-200 ◽  
Author(s):  
Jeffery L. Meier ◽  
Robert P. Holman ◽  
Kenneth D. Croen ◽  
John E. Smialek ◽  
Stephen E. Straus
Keyword(s):  
Varicella Zoster Virus ◽  
Trigeminal Ganglia ◽  
Varicella Zoster ◽  
Virus Transcription
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