Artemisia Pollen Extracts Exposed to Diesel Exhaust Enhance Airway Inflammation and Immunological Imbalance in Asthmatic Mice Model

2020 ◽  
Vol 181 (5) ◽  
pp. 342-352
Author(s):  
Ying Chen ◽  
Li Han ◽  
Yan Zhou ◽  
Ling Yang ◽  
Yin-Shi Guo
Keyword(s):  
Airway Inflammation ◽  
Diesel Exhaust ◽  
Mice Model ◽  
Artemisia Pollen

scholarly journals Diesel Exhaust Particles Enhance Antigen-induced Airway Inflammation and Local Cytokine Expression in Mice

1997 ◽  
Vol 156 (1) ◽  
pp. 36-42 ◽  
Author(s):  
HIROHISA TAKANO ◽  
TOSHIKAZU YOSHIKAWA ◽  
TAKAMICHI ICHINOSE ◽  
YUICHI MIYABARA ◽  
KOICHI IMAOKA ◽  
...  
Keyword(s):  
Airway Inflammation ◽  
Diesel Exhaust ◽  
Cytokine Expression ◽  
Diesel Exhaust Particles ◽  
Exhaust Particles ◽  
Local Cytokine

scholarly journals Pulmonary exposure to diesel exhaust particles induces airway inflammation and cytokine expression in NC/Nga mice

2005 ◽  
Vol 79 (10) ◽  
pp. 595-599 ◽  
Author(s):  
Ken-ichiro Inoue ◽  
Hirohisa Takano ◽  
Rie Yanagisawa ◽  
Takamichi Ichinose ◽  
Akinori Shimada ◽  
...  
Keyword(s):  
Airway Inflammation ◽  
Diesel Exhaust ◽  
Cytokine Expression ◽  
Diesel Exhaust Particles ◽  
Pulmonary Exposure ◽  
Exhaust Particles

Diesel Exhaust Enhances Allergic Airway Inflammation and Hyperresponsiveness in Mice

1998 ◽  
Vol 157 (4) ◽  
pp. 1138-1144 ◽  
Author(s):  
YUICHI MIYABARA ◽  
HIROHISA TAKANO ◽  
TAKAMICHI ICHINOSE ◽  
HEUNG-BIN LIM ◽  
MASARU SAGAI
Keyword(s):  
Airway Inflammation ◽  
Diesel Exhaust ◽  
Allergic Airway Inflammation

Diesel exhaust particles and airway inflammation

2012 ◽  
Vol 18 (2) ◽  
pp. 144-150 ◽  
Author(s):  
Andrew J. Ghio ◽  
Candice B. Smith ◽  
Michael C. Madden
Keyword(s):  
Airway Inflammation ◽  
Diesel Exhaust ◽  
Diesel Exhaust Particles ◽  
Exhaust Particles

scholarly journals Effects of caffeoylxanthiazonoside on airway inflammation in an allergic asthma mice model

2021 ◽  
Vol 18 (4) ◽  
pp. 761-766
Author(s):  
Qian Wu ◽  
Hui Wang ◽  
Xiaowen Che ◽  
Wei Wang
Keyword(s):  
Protein Expression ◽  
Western Blot ◽  
Airway Inflammation ◽  
Allergic Asthma ◽  
Inflammatory Cells ◽  
Lavage Fluid ◽  
The Body ◽  
Enzyme Linked Immunosorbent Assay ◽  
Mice Model ◽  
Ifn Γ

Purpose: To investigate the inhibitory effects of caffeoylxanthiazonoside (CYT) on airway inflammation in mice and its mechanism of action. Methods: An allergic asthma mice model was established by intraperitoneal injection and aerosol nebulization with ovalbumin (OVA). After treatment with CYT, the blood and bronchoalveolar lavage fluid (BALF) were collected from the mice. The leukocytes were classified and counted with Giemsa solution. Enzyme-linked immunosorbent assay (ELISA) was used to determine the serum levels of IgE, and IL-4, IL-5, IL-13 and IFN-γ in the BALF of mice. Lung tissues were obtained from the mice and MUC5AC protein expression was measured by western blot. Results: CYT significantly decreased the serum level of IgE in asthmatic mice. Inflammatory cells in BALF of mice were markedly reduced (p < 0.05) by CYT treatment at varying doses (10, 20, and 40 mg/kg). Treatment with CYT also significantly suppressed the cytokines of IL-4, IL-5 and IL-13 and increased the IFN-γ in the BLAF of OVA-induced allergic asthma mice (p < 0.05). Western blot results indicate that CYT treatment significantly decreased the expression of MUC5AC protein in the lung tissues of asthmatic mice. In addition, no significant effects on the body weight of the mice were found after CYT treatment. Conclusion: Caffeoylxanthiazonoside inhibits airway inflammation in allergic asthma mice by altering Th1/Th2 via re-balancing of related cytokines and downregulation of lung MUC5AC protein expression. Therefore, this compound can potentially be developed for the therapeutic management of inflammation in allergic asthma.

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