A tRial Evaluating Mid Cut-Off Value Membrane Clearance of Albumin and Light Chains in HemoDialysis Patients: A Safety Device Study

2020 ◽  
Vol 49 (4) ◽  
pp. 468-478 ◽  
Author(s):  
Rathika Krishnasamy ◽  
Carmel M. Hawley ◽  
Meg J. Jardine ◽  
Matthew A. Roberts ◽  
Yeoungjee Cho ◽  
...  
Keyword(s):  
Quality Of Life ◽  
New Zealand ◽  
Serum Albumin ◽  
Hemodialysis Patients ◽  
Significant Loss ◽  
Light Chains ◽  
High Flux ◽  
Restless Legs ◽  
Clinical Trials Registry

Background: A new class of dialysis membrane, the mid cut-off (MCO) dialyzer, has been developed to improve the clearance of uremic toxins in hemodialysis (HD). The a tRial Evaluating Mid cut-Off Value membrane clearance of Albumin and Light chains in HemoDialysis patients (REMOVAL-HD) study aimed to determine if regular use of MCO dialyzer was safe and specifically did not result in a significant loss of albumin. Methods: This investigator initiated, crossover, longitudinal, device study was conducted across 9 centers in Australia and New Zealand (n = 89). Participants had a 4-week wash-in with high-flux HD, followed by 24-week intervention with MCO HD and a subsequent 4-week wash-out with high-flux HD. The primary outcome was change in serum albumin between weeks 4 and 28. Secondary outcomes included trends in serum albumin, changes in kappa- and lambda-free light chains (FLC), 6-min walk test (6MWT), malnutrition inflammation score (MIS), restless legs score and quality of life. Results: Participants had a mean age of 66 ± 14 years, 62% were men, 45% were anuric, and 51% had ­diabetes. There was no reduction in serum albumin following treatment with MCO HD (mean reduction –0.7 g/L, 95% CI –1.5 to 0.1). A sustained, unexplained reduction in serum albumin (>25%) was not observed in any participant. A reduction in FLC was observed 2 weeks into MCO HD (lambda-FLC: Δ –9.1 mg/L, 95% CI –14.4 to –3.7; kappa-FLC: Δ –5.7 mg/L, 95% CI –9.8 to –1.6) and was sustained for the rest of the study intervention. Both FLC increased after the cessation of MCO use. There was no improvement in restless legs symptoms, quality of life, 6MWT or MIS scores. Conclusions: Regular HD using the MCO dialyzer did not result in a significant fall in serum albumin. There were no effects on quality of life, functional status or nutrition. Trial Registration: Australian New Zealand Clinical Trials Registry Number (ANZCTRN) 12616000804482.

Can Dialysis Modality Influence Quality of Life in Chronic Hemodialysis Patients? Low-Flux Hemodialysis versus High-Flux Hemodiafiltration: A Cross-Over Study

Renal Failure ◽  
2012 ◽  
Vol 35 (2) ◽  
pp. 216-221 ◽  
Author(s):  
Konstantia Kantartzi ◽  
Stelios Panagoutsos ◽  
Efthemia Mourvati ◽  
Athanasios Roumeliotis ◽  
Konstantinos Leivaditis ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Hemodialysis Patients ◽  
Chronic Hemodialysis ◽  
High Flux ◽  
Dialysis Modality

Effect of High-Flux Hemodialysis on Quality of Life and Neuropsychological Function in Chronic Hemodialysis Patients

1992 ◽  
Vol 12 (6) ◽  
pp. 412-418 ◽  
Author(s):  
David N. Churchill ◽  
Daniel R. Bird ◽  
Wayne Taylor ◽  
Mary Louise Beecroft ◽  
Joanne Gorman ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Hemodialysis Patients ◽  
Chronic Hemodialysis ◽  
High Flux ◽  
Neuropsychological Function

Restless legs syndrome in hemodialysis patients: association with depression and quality of life

2010 ◽  
Vol 15 (3) ◽  
pp. 311-315 ◽  
Author(s):  
Deniz Tuncel ◽  
Fatma Özlem Orhan ◽  
Hayriye Sayarlioglu ◽  
Ismet Onder Isık ◽  
Uygar Utku ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Restless Legs Syndrome ◽  
Hemodialysis Patients ◽  
Restless Legs

scholarly journals Comparison the effect of high flux and low flux dialyzer on quality of life in hemodialysis patients; a clinical trial

2018 ◽  
Vol 8 (2) ◽  
pp. 98-105 ◽  
Author(s):  
Khodayar Oshvandi ◽  
Mehri Safari ◽  
Mahmood Gholyaf ◽  
Abbas Moghim-Beygi ◽  
Farshid Shamsaei ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Clinical Trial ◽  
Life Quality ◽  
Public Health Problem ◽  
Hemodialysis Patients ◽  
Life Questionnaire ◽  
High Flux ◽  
Dialysis Adequacy ◽  
Mortality And Morbidity

Introduction: End-stage renal disease (ESRD) is a worldwide public health problem. ESRD reduces health-related quality of life. Quality of life is an important determinant in the mortality and morbidity of hemodialysis patients. However, several studies have suggested that high flux dialyzers increase dialysis adequacy and reduce mortality and morbidity in these patients. Objectives: This study aimed to investigate the effects of high flux and low flux dialyzers on the quality of life in hemodialysis patients. Patients and Methods: In this clinical trial, 93 patients who met the inclusion criteria were randomly assigned to two groups of high flux and low flux dialyzers. Before intervention, both groups filled demographic and quality of life questionnaires. They were undergone dialysis with two dialyzers (one group by high flux and another by low flux) three times a week for 6 weeks. Then quality of life questionnaire was filled by both groups once again. Results: The overall quality of life score was not significantly different in both groups before intervention (P=0.121). After intervention, however, high flux group attained a significantly higher mean score (54 ± 10.4) than low flux group (43.89 ± 11.64) (P<0.001). Conclusion: According to the results of this study, the use of high flux dialyzers can be a useful method to increase the quality of life in hemodialysis patients.

Restless legs syndrome in hemodialysis patients: health-related quality of life and laboratory data analysis

2006 ◽  
Vol 66 (12) ◽  
pp. 440-446 ◽  
Author(s):  
A. Kawauchi ◽  
Y. Inoue ◽  
T. Hashimoto ◽  
N. Tachibana ◽  
S. Shirakawa ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Data Analysis ◽  
Restless Legs Syndrome ◽  
Laboratory Data ◽  
Hemodialysis Patients ◽  
Health Related Quality ◽  
Restless Legs ◽  
Related Quality ◽  
Health Related
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