The Mammary Gland as an Integral Component of the Common Mucosal Immune System

2020 ◽  
pp. 27-37 ◽  
Author(s):  
Jiri Mestecky
Keyword(s):  
Mammary Gland ◽  
Immune System ◽  
Mucosal Immune System ◽  
Integral Component ◽  
The Common

The common mucosal immune system in the human genital tract and mammary gland

1989 ◽  
Vol 15 ◽  
pp. 30
Author(s):  
J Mestecky ◽  
W.H Kutteh ◽  
I Ladjeva ◽  
J.H Peterman
Keyword(s):  
Mammary Gland ◽  
Immune System ◽  
Genital Tract ◽  
Mucosal Immune System ◽  
The Common

NALT M cells are important for immune induction for the common mucosal immune system

2017 ◽  
Vol 29 (10) ◽  
pp. 471-478 ◽  
Author(s):  
Yasuhiro Date ◽  
Masashi Ebisawa ◽  
Shinji Fukuda ◽  
Hideaki Shima ◽  
Yuuki Obata ◽  
...  
Keyword(s):  
Immune System ◽  
Mucosal Immune System ◽  
M Cells ◽  
The Common

scholarly journals Modified Immunogenicity of a Mucosally Administered Antigen

2001 ◽  
Vol 8 (3) ◽  
pp. 540-544 ◽  
Author(s):  
Richard L. Gregory
Keyword(s):  
Immune System ◽  
Immunoglobulin A ◽  
Human Saliva ◽  
Mucosal Immune System ◽  
Antigenic Determinants ◽  
Enzyme Linked Immunosorbent Assay ◽  
Igg Antibodies ◽  
Serum Samples ◽  
Naturally Occurring ◽  
The Common

ABSTRACT Streptococcus mutans is present in the saliva of most individuals and is modified by salivary components bound to the cells. These saliva-bound S. mutans are swallowed, exposed to high levels of acidity in the stomach, and presented to the common mucosal immune system. Much effort has been directed to identifying the specific S. mutans antigens that the mucosal immune responses are directed against. However, little is known about the host-altered antigenic determinants that the mucosal immune system recognizes. The immunogenicity of gastrically intubated untreatedS. mutans cells, cells coated with whole human saliva, cells treated with HCl (pH 2.0), and saliva-coated and acid-treated cells in mice was investigated. Saliva and serum samples were assayed by enzyme linked immunosorbent assay for immunoglobulin A (IgA) and IgG antibodies, respectively, against the untreated or treated S. mutans cells. In general, the levels of salivary IgA and serum IgG antibodies to the antigen against which the mice were immunized were significantly higher (P ≤ 0.05). In addition, human saliva and serum samples from 12 subjects were assayed for naturally occurring antibody against the untreated or treated S. mutans cells. In every case, significantly higher reactivity was directed against the saliva-coated and acid-treated cells followed by the saliva-coated S. mutans. These results provide evidence for the altered immunogenicity of swallowed S. mutans in humans by coating native S. mutans antigens with salivary components and/or denaturing surface S. mutans antigens in the acidic environment of the stomach, which would lead to an immune response to modified S. mutans determinants and not to native S. mutans antigens.

Immunophysiology of the gut: a research frontier for integrative studies of the common mucosal immune system

1993 ◽  
Vol 265 (4) ◽  
pp. G599-G610 ◽  
Author(s):  
G. A. Castro ◽  
C. J. Arntzen
Keyword(s):  
Immune System ◽  
Vaccine Development ◽  
Mucosal Immune System ◽  
Health Maintenance ◽  
The Past ◽  
Integrative Studies ◽  
Central Nervous Systems ◽  
The Common ◽  
New Research ◽  
Induced Changes

This review highlights work that, within the past decade, transformed mucosal immunophysiology from a hypothetical concept to a fully recognized interdiscipline. The regulation of epithelial and smooth muscle functions by the mucosal immune system represents an exquisitely sensitive adaptation to local antigenic challenge. Furthermore, immunologic cells communicate with nerves via paracrine secretions to rapidly transduce antigenic signals into panmucosal changes in function. These local immunocyte-nerve interactions are modulated by the autonomic and central nervous systems. Because of the common mucosal immune system, antigen-induced changes similar to those occurring in the intestine and colon are predicted to occur in mucosa of all hollow organs. The drawing together of fields as diverse as medicine and agriculture underscores the scope of areas encompassed by immunophysiology. Newly acquired knowledge has positioned the field to advance rapidly in both basic and applied directions. Forces that will remodel the field in the next decade will be derived from public concerns about human health maintenance and the explosive and novel use of new research tools stemming from molecular biology. These forces will draw on and advance our knowledge in areas as diverse as vaccine development and prevention of allergic reactions to foods, bioengineered foods in particular.

Compartmentalization within the Common Mucosal Immune System

1995 ◽  
pp. 97-101 ◽  
Author(s):  
Zina Moldoveanu ◽  
Michael W. Russell ◽  
Hong Yin Wu ◽  
Wen-Qiang Huang ◽  
Richard W. Compans ◽  
...  
Keyword(s):  
Immune System ◽  
Mucosal Immune System ◽  
The Common
Sign in / Sign up

Export Citation Format

Share Document