scholarly journals Paraneoplastic Limbic Encephalitis Associated with Anti-CV2/CRMP5 Antibodies Secondary to Thymoma in an Adolescent

2020 ◽  
Vol 12 (1) ◽  
pp. 50-55 ◽  
Author(s):  
Ismail Ibrahim Ismail ◽  
John K. John ◽  
Mohamed Ibrahim ◽  
Jasem Yousef  Al-Hashel
Keyword(s):  
Male Patient ◽  
Limbic Encephalitis ◽  
Clinical Manifestations ◽  
Neurological Manifestation ◽  
Paraneoplastic Neurological Syndromes ◽  
Paraneoplastic Limbic Encephalitis ◽  
Onconeuronal Antibodies

Paraneoplastic neurological syndromes (PNS) associated with anti-CV2/CRMP5 antibodies are rare in the literature. Various clinical manifestations can occur including paraneoplastic limbic encephalitis (PLE). Thymoma is one of the rare causes that can be associated with this syndrome. It has not been reported in the literature in children or adolescents to the best of our knowledge. We report a case of PLE in a 19-year-old male patient secondary to thymoma that was diagnosed after 5 years of onset. Anti-CV2/CRMP5 antibodies were positive in the serum and became negative after thymectomy. Diagnosis of PNS should be evoked in cases with atypical neurological manifestation and can be confirmed by the presence of onconeuronal antibodies. We report the first pediatric PLE secondary to thymoma associated with anti-CV2/CRMP5 antibodies.

Paraneoplastic Limbic Encephalitis Secondary To Mixed Non-Seminomatous Germ Cell Tumours

2020 ◽  
Vol 154 (Supplement_1) ◽  
pp. S55-S56
Author(s):  
A Ullah ◽  
S Heneidi ◽  
P Biddinger ◽  
N Patel ◽  
C Wehrle ◽  
...  
Keyword(s):  
Germ Cell ◽  
Limbic Encephalitis ◽  
Germ Cell Tumors ◽  
Testicular Tumor ◽  
Primary Malignancy ◽  
Rare Presentation ◽  
Paraneoplastic Limbic Encephalitis ◽  
Nonseminomatous Germ Cell Tumor ◽  
Aortic Lymph Node ◽  
Alteration Of Consciousness

Abstract Casestudy: Testicular tumors account for 1–2% of all tumors in men, with 95% of these being germ cell tumors. The main risk factor for the development of testicular cancer is cryptorchidism. Paraneoplastic limbic encephalitis is a rare sequela of testicular tumor associated with anti-Ma2 and KLH11 antibodies. The most effective treatment for paraneoplastic limbic encephalitis is treatment of the primary malignancy. We present a 41-year-old male that presented to the emergency department with two weeks of episodic alteration of consciousness and memory disturbances. Negative neurologic evaluation and imaging led to concern for a paraneoplastic process from a distant malignancy. CT imaging revealed an enlarged, necrotic para-aortic lymph node and subsequent ultrasound demonstrated a right sided testicular mass. Right radical orchiectomy was performed. Microscopically, the mass consisted of mixed respiratory epithelium, gastrointestinal glands and squamous epithelium with keratinization consistent with a post-pubertal testicular teratoma with associated in-situ germ cell neoplasia. Resection of the para-aortic mass revealed large anaplastic cells with epithelioid features, nuclear pleomorphism and frequent mitoses. Immunostaining was positive for Pan-Keratin and OCT4, consistent with poorly differentiated embryonal carcinoma. Resection of the primary and metastatic disease, as well as treatment with corticosteroids resulted in resolution of the encephalitis. This presentation of severe neurological disturbances in the setting of a metastatic mixed nonseminomatous germ cell tumor represents a rare presentation of paraneoplastic limbic encephalitis.

Enoxaparin-induced Wunderlich syndrome in a young patient with anti-GAD 65-associated opsoclonus and limbic encephalitis: a rare complication in a rare disease

2021 ◽  
Vol 14 (10) ◽  
pp. e244916
Author(s):  
Saranya B Gomathy ◽  
Animesh Das ◽  
Awadh Kishor Pandit ◽  
Achal Kumar Srivastava
Keyword(s):  
Rare Disease ◽  
Young Patient ◽  
Clinical Condition ◽  
Limbic Encephalitis ◽  
Rare Complication ◽  
Clinical Manifestations ◽  
Autoimmune Encephalitis ◽  
Rare Condition ◽  
Gad 65 ◽  
Good Improvement

Wunderlich syndrome is a rare condition characterised by acute spontaneous non-traumatic renal haemorrhage into the subcapsular and perirenal spaces. Our case of anti-GAD65-associated autoimmune encephalitis (AE), aged 30 years, developed this complication following use of enoxaparin and was managed by selective glue embolisation of subsegmental branches of right renal cortical arteries. Our case had opsoclonus as one of the clinical manifestations, which has till now been described in only two patients of this AE. This patient received all forms of induction therapies (steroids, plasmapheresis, intravenous immunoglobulin and rituximab) following which she had good improvement in her clinical condition. The good response to immunotherapy is also a point of discussion as this has been rarely associated with anti-GAD65 AE.

Paraneoplastic Limbic Encephalitis Secondary to SCLC on 18F-FDG PET/CT

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Alinne Fernanda Amaral Verçosa ◽  
Isabella Araújo Mota ◽  
Maria Eduarda Duarte de Mello Flamini ◽  
Rodrigo de Carvalho Flamini
Keyword(s):  
Fdg Pet ◽  
Limbic Encephalitis ◽  
Paraneoplastic Limbic Encephalitis ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct

NEUROLOGICAL MANIFESTATION IN A MALE PATIENT WITH SYSTEMIC LUPUS ERYTHEMATOSUS - A CASE REPORT

2021 ◽  
Author(s):  
Bárbara Mariana dos Santos Silva ◽  
Gabriela de Lira Pessoa Mota ◽  
Marina Souto da Cunha Brendel Braga ◽  
Guilherme e Silva Alves ◽  
Laísa Nascimento Diniz Teixeira ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Case Report ◽  
Male Patient ◽  
Lupus Erythematosus ◽  
Neurological Manifestation ◽  
Systemic Lupus

Paraneoplastic limbic encephalitis: a challenging diagnosis

2019 ◽  
Vol 6 (2) ◽  
Author(s):  
Silvia Storer ◽  
Annalisa Mone ◽  
Marco Barillari ◽  
Giancarlo Mansueto
Keyword(s):  
Limbic Encephalitis ◽  
Paraneoplastic Limbic Encephalitis

A Case of Paraneoplastic Limbic Encephalitis Associated with Primary Adenocarcinoma of Lung

2007 ◽  
Vol 63 (4) ◽  
pp. 382
Author(s):  
Hyun Jong Shin ◽  
Hyun Soo Kim ◽  
Keum Nam Lim ◽  
U Seok Noh ◽  
Jung Hye Choi ◽  
...  
Keyword(s):  
Limbic Encephalitis ◽  
Primary Adenocarcinoma ◽  
Paraneoplastic Limbic Encephalitis ◽  
Adenocarcinoma Of Lung

scholarly journals Paraneoplastic Limbic Encephalitis

2005 ◽  
Vol 53 (2) ◽  
pp. 106-108 ◽  
Author(s):  
J.M.S. Pearce
Keyword(s):  
Limbic Encephalitis ◽  
Paraneoplastic Limbic Encephalitis

scholarly journals Paraneoplastic limbic encephalitis associated with testicular mixed germ cell tumor

2018 ◽  
Vol 2018 ◽  
Author(s):  
Dana Almedallah ◽  
Gada Alsaffar ◽  
Ghadeer Al-Shabeeb ◽  
Aalaa Baarmah ◽  
Eman Nassim
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumor ◽  
Limbic Encephalitis ◽  
Cell Tumor ◽  
Paraneoplastic Limbic Encephalitis ◽  
Mixed Germ Cell Tumor
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