scholarly journals Development of a Vaping Machine for the Sampling of THC and CBD Aerosols Generated by Two Portable Dry Herb Cannabis Vaporisers

2020 ◽  
Vol 3 (1) ◽  
pp. 84-94 ◽  
Author(s):  
Laura Carrara ◽  
Christian Giroud ◽  
Nicolas Concha-Lozano
Keyword(s):  
Cannabis Sativa ◽  
Therapeutic Potential ◽  
Electronic Cigarettes ◽  
Immediate Release ◽  
Self Medication ◽  
Extraction Coefficient ◽  
Adverse Health Effects ◽  
The Common ◽  
Recreational Use ◽  
Kinetics Of

Cannabis sativa is known for its recreational use, but also for its therapeutic potential. There has been wide discussion over the use of cannabis for medical purposes in recent years, especially because a consensus has not been reached regarding its risk/benefit balance. Among the more common modes of administration, vaping with a vaporiser is most frequently used for self-medication. Vaping seems to be a better alternative to preventing adverse health effects due to toxic compounds produced during combustion when cannabis is smoked. However, the delivery kinetics and efficiency of most portable vaporisers are not fully characterised with an appropriate vaping regime. This determination requires a specific vaping machine operating under realistic puffing conditions. In this study, a vaping machine was conceived to fit with the common uses of portable vaporisers that requires conditions different from those used for electronic cigarettes. The experimental setup in this study was optimised to sample aerosolised cannabinoids. The delivery kinetics, efficiency, and decarboxylation yields of two commercially available vaporisers (DaVinci® and Mighty Medic®) were evaluated for delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD). Among all tested sampling supports, the glass fibre filter is the most efficient medium to collect mixed THC and CBD aerosols. From the delivery kinetics of cannabinoids, a single-parameter model was used to calculate the extraction coefficient of each vaporiser. The results show that the Mighty Medic® vaporiser had a higher extraction coefficient (0.39) and a more immediate release of cannabinoids than the DaVinci® vaporiser (0.16), which had a gradual and slower rate of vaporisation. This parameter could be a quantitative input in pharmacokinetic models of administration of volatile compounds using vaporisers and a useful tool for the comparison of vaporisers.

Critical Review on the Chemical Aspects of Cannabidiol (CBD) and Harmonization of Computational Bioactivity Data

2020 ◽  
Vol 28 (2) ◽  
pp. 213-237 ◽  
Author(s):  
Andrea Mastinu ◽  
Giovanni Ribaudo ◽  
Alberto Ongaro ◽  
Sara Anna Bonini ◽  
Maurizio Memo ◽  
...  
Keyword(s):  
In Silico ◽  
Cannabis Sativa ◽  
Therapeutic Potential ◽  
The Novel ◽  
In Silico Studies ◽  
Computational Data ◽  
Synthetic Approaches ◽  
Analytical Approaches ◽  
Yield Sensitivity ◽  
Therapeutic Profile

: Cannabidiol (CBD) is a non-psychotropic phytocannabinoid which represents one of the constituents of the “phytocomplex” of Cannabis sativa. This natural compound is attracting growing interest since when CBD-based remedies and commercial products were marketed. This review aims to exhaustively address the extractive and analytical approaches that have been developed for the isolation and quantification of CBD. Recent updates on cutting-edge technologies were critically examined in terms of yield, sensitivity, flexibility and performances in general, and are reviewed alongside original representative results. As an add-on to currently available contributions in the literature, the evolution of the novel, efficient synthetic approaches for the preparation of CBD, a procedure which is appealing for the pharmaceutical industry, is also discussed. Moreover, with the increasing interest on the therapeutic potential of CBD and the limited understanding of the undergoing biochemical pathways, the reader will be updated about recent in silico studies on the molecular interactions of CBD towards several different targets attempting to fill this gap. Computational data retrieved from the literature have been integrated with novel in silico experiments, critically discussed to provide a comprehensive and updated overview on the undebatable potential of CBD and its therapeutic profile.

Exploring the Chemistry and Therapeutic Potential of Triazoles: A Comprehensive Literature Review

2019 ◽  
Vol 19 (16) ◽  
pp. 1298-1368 ◽  
Author(s):  
Ankit Jain ◽  
Poonam Piplani
Keyword(s):  
Oxidative Stress ◽  
Drug Discovery ◽  
Literature Review ◽  
Structural Modification ◽  
Therapeutic Potential ◽  
Pharmacological Properties ◽  
Pharmacological Activities ◽  
Triazole Derivatives ◽  
Comprehensive Literature Review ◽  
The Common

: Triazole is a valuable platform in medicinal chemistry, possessing assorted pharmacological properties, which could play a major role in the common mechanisms associated with various disorders like cancer, infections, inflammation, convulsions, oxidative stress and neurodegeneration. Structural modification of this scaffold could be helpful in the generation of new therapeutically useful agents. Although research endeavors are moving towards the growth of synthetic analogs of triazole, there is still a lot of scope to achieve drug discovery break-through in this area. Upcoming therapeutic prospective of this moiety has captured the attention of medicinal chemists to synthesize novel triazole derivatives. The authors amalgamated the chemistry, synthetic strategies and detailed pharmacological activities of the triazole nucleus in the present review. Information regarding the marketed triazole derivatives has also been incorporated. The objective of the review is to provide insights to designing and synthesizing novel triazole derivatives with advanced and unexplored pharmacological implications.

scholarly journals Non-Cannabinoid Metabolites of Cannabis sativa L. with Therapeutic Potential

Plants ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 400
Author(s):  
Henry Lowe ◽  
Blair Steele ◽  
Joseph Bryant ◽  
Ngeh Toyang ◽  
Wilfred Ngwa
Keyword(s):  
Secondary Metabolites ◽  
Cannabis Sativa ◽  
Therapeutic Potential ◽  
Physiological Activity ◽  
Economic Value ◽  
Therapeutic Window ◽  
Future Directions ◽  
Medicinal Properties ◽  
The Many ◽  
Human Viruses

The cannabis plant (Cannabis sativa L.) produces an estimated 545 chemical compounds of different biogenetic classes. In addition to economic value, many of these phytochemicals have medicinal and physiological activity. The plant is most popularly known for its two most-prominent and most-studied secondary metabolites—Δ9-tetrahydrocannabinol (Δ9-THC) and cannabidiol (CBD). Both Δ9-THC and CBD have a wide therapeutic window across many ailments and form part of a class of secondary metabolites called cannabinoids—of which approximately over 104 exist. This review will focus on non-cannabinoid metabolites of Cannabis sativa that also have therapeutic potential, some of which share medicinal properties similar to those of cannabinoids. The most notable of these non-cannabinoid phytochemicals are flavonoids and terpenes. We will also discuss future directions in cannabis research and development of cannabis-based pharmaceuticals. Caflanone, a flavonoid molecule with selective activity against the human viruses including the coronavirus OC43 (HCov-OC43) that is responsible for COVID-19, and certain cancers, is one of the most promising non-cannabinoid molecules that is being advanced into clinical trials. As validated by thousands of years of the use of cannabis for medicinal purposes, vast anecdotal evidence abounds on the medicinal benefits of the plant. These benefits are attributed to the many phytochemicals in this plant, including non-cannabinoids. The most promising non-cannabinoids with potential to alleviate global disease burdens are discussed.

scholarly journals Phytochemical Benefits of Agroresidues as Alternative Nutritive Dietary Resource for Pig and Poultry Farming

2018 ◽  
Vol 2018 ◽  
pp. 1-15 ◽  
Author(s):  
Matthew Achilonu ◽  
Karabo Shale ◽  
Georgina Arthur ◽  
Kuben Naidoo ◽  
Michael Mbatha
Keyword(s):  
Animal Feed ◽  
Therapeutic Potential ◽  
Sustainable Growth ◽  
World Population ◽  
Animal Products ◽  
Feed Resources ◽  
Livestock Feed ◽  
The Common ◽  
Bioactive Phytochemicals ◽  
Unconventional Feed

The growing world population is challenging the animal products supply system, particularly in developing countries, where demand for meat and milk in 2050 is estimated to increase to 109% and 116%, respectively, amidst deteriorating livestock feed sources. Globally, adequate production and availability of animal feed products to subsistence farmers has been declining due to factors such as global warming, growth in population, and low economic growth. This paper seeks to examine the existing scientific literature on the utilization of some unconventional feed resources, to abate the challenge of feed deficit and thus improve animal nutrition. The use of fruit waste and agricultural farm residues affords alternative, nutritive livestock dietary supplements; it has been proven they contain a spectrum of vital bioactive phytochemicals essential for sustainable growth and development of animals. The biochemical composition of the plant wastes and residues include carbohydrates, proteins, nucleic acids, and fatty acids, while the common bioactive phytochemicals are polyphenols, alkaloids, carotenoids, and flavonoids, along with tannins, terpenes, and saponins, which play vital roles in reducing disease-causing agents, such as bacteria, viruses, and free radical-associated diseases. The phytochemicals exhibit antioxidant, antimicrobial, antifungal, and anti-inflammatory, as well as anti-parasitic and antiprotozoal properties. However, it is important to guard against antinutritive and toxicity levels in animal feed products. The paper concludes that agroresidues’/wastes’ nutritive and therapeutic potential could serve as alternative livestock feed resource, while also acting as additional job and income generator for communities.

scholarly journals Insights into the Control of Drug Release from Complex Immediate Release Formulations

Pharmaceutics ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 933
Author(s):  
Runqiao Dong ◽  
James C. DiNunzio ◽  
Brian P. Regler ◽  
Walter Wasylaschuk ◽  
Adam Socia ◽  
...  
Keyword(s):  
Drug Release ◽  
Immediate Release ◽  
Liquid Penetration ◽  
Central Importance ◽  
Water Penetration ◽  
Release Process ◽  
Terahertz Pulsed Imaging ◽  
And Control ◽  
Kinetics Of ◽  
Spray Dried

The kinetics of water transport into tablets, and how it can be controlled by the formulation as well as the tablet microstructure, are of central importance in order to design and control the dissolution and drug release process, especially for immediate release tablets. This research employed terahertz pulsed imaging to measure the process of water penetrating through tablets using a flow cell. Tablets were prepared over a range of porosity between 10% to 20%. The formulations consist of two drugs (MK-8408: ruzasvir as a spray dried intermediate, and MK-3682: uprifosbuvir as a crystalline drug substance) and NaCl (0% to 20%) at varying levels of concentrations as well as other excipients. A power-law model is found to fit the liquid penetration exceptionally well (average R2>0.995). For each formulation, the rate of water penetration, extent of swelling and the USP dissolution rate were compared. A factorial analysis then revealed that the tablet porosity was the dominating factor for both liquid penetration and dissolution. NaCl more significantly influenced liquid penetration due to osmotic driving force as well as gelling suppression, but there appears to be little difference when NaCl loading in the formulation increases from 5% to 10%. The level of spray dried intermediate was observed to further limit the release of API in dissolution.

Kinetics of hypso anhydrites dissolution in water. Experimental studies

2019 ◽  
pp. 93-96
Author(s):  
A. L. Lebedev ◽  
I. V. Avilina
Keyword(s):  
Experimental Data ◽  
Experimental Study ◽  
Riccati Equation ◽  
Balance Equation ◽  
Experimental Studies ◽  
Common Ion ◽  
The Common ◽  
Common Ion Effect ◽  
Kinetics Of Dissolution ◽  
Kinetics Of

Experimental study of kinetics of dissolution of hypso anhydrites at 25 ᵒC made it possible to formulate model of the process in the form of a balance equation for the kinetics of dissolution of gypsum, anhydrite (first and second orders, respectively) and kinetics of precipitation of gypsum (second order). The processing of the experimental data were carried out on the basis of the solution of the Riccati equation. When taking into account the common-ion effect on the solubility of gypsum and anhydrite, the calculated values turned out to be more comparable with the experimental ones.

scholarly journals Yield, Characterization, and Possible Exploitation of Cannabis Sativa L. Roots Grown under Aeroponics Cultivation

Molecules ◽  
2021 ◽  
Vol 26 (16) ◽  
pp. 4889
Author(s):  
Fabio Ferrini ◽  
Daniele Fraternale ◽  
Sabrina Donati Donati Zeppa ◽  
Giancarlo Verardo ◽  
Andrea Gorassini ◽  
...  
Keyword(s):  
Cannabis Sativa ◽  
Therapeutic Potential ◽  
Total Content ◽  
Bioactive Molecules ◽  
Bioactive Metabolites ◽  
Cultivated Plants ◽  
Root Extracts ◽  
Cultivation Technique ◽  
Long Time ◽  
Health Promoting

Cannabis sativa L. has been used for a long time to obtain food, fiber, and as a medicinal and psychoactive plant. Today, the nutraceutical potential of C. sativa is being increasingly reappraised; however, C. sativa roots remain poorly studied, despite citations in the scientific literature. In this direction, we identified and quantified the presence of valuable bioactives (namely, β-sitosterol, stigmasterol, campesterol, friedelin, and epi-friedelanol) in the root extracts of C. sativa, a finding which might pave the way to the exploitation of the therapeutic potential of all parts of the C. sativa plant. To facilitate root harvesting and processing, aeroponic (AP) and aeroponic-elicited cultures (AEP) were established and compared to soil-cultivated plants (SP). Interestingly, considerably increased plant growth—particularly of the roots—and a significant increase (up to 20-fold in the case of β-sitosterol) in the total content of the aforementioned roots’ bioactive molecules were observed in AP and AEP. In conclusion, aeroponics, an easy, standardized, contaminant-free cultivation technique, facilitates the harvesting/processing of roots along with a greater production of their secondary bioactive metabolites, which could be utilized in the formulation of health-promoting and health-care products.

scholarly journals Non-Cannabinoid Metabolites of Cannabis sativa with Therapeutic Potential

2020 ◽  
Author(s):  
Henry Lowe ◽  
Blair Steele ◽  
Joseph Bryant ◽  
Ngeh Toyang ◽  
Wilfred Ngwa
Keyword(s):  
Secondary Metabolites ◽  
Cannabis Sativa ◽  
Therapeutic Potential ◽  
Physiological Activity ◽  
Economic Value ◽  
Therapeutic Window ◽  
Future Directions ◽  
Medicinal Properties ◽  
The Many ◽  
Human Viruses

The Cannabis plant (Cannabis sativa L.) produces an estimated 545 chemical compounds of different biogenetic classes. In addition to economic value, many of these phytochemicals have medicinal and physiological activity. The plant is most popularly known for its two most prominent and most studied secondary metabolites— Δ9-Tetrahydrocannabinol (Δ9-THC) and Cannabidiol (CBD). Both Δ9-THC and CBD have a wide therapeutic window across many ailments and form part of a class of secondary metabolites called cannabinoids—of which approximately over 104 exist. This review will focus on non-cannabinoid metabolites of Cannabis sativa that also have therapeutic potential, some of which share medicinal properties similar to those of cannabinoids. The most notable of these non-cannabinoid phytochemicals are flavonoids and terpenes. We will also discuss future directions in cannabis research and development of cannabis-based pharmaceuticals. Caflanone, a flavonoid molecule with selective activity against the human viruses including the coronavirus SARS-COV2, and certain cancers, is one of the most promising non-cannabinoid molecules that is being advanced into clinical trials. As validated by thousands of years of the use of cannabis for medicinal purposes, vast anecdotal evidence abounds on the medicinal benefits of the plant. These benefits are attributed to the many phytochemicals in this plant, including non-cannabinoids. The most promising non-cannabinoids with potential to alleviate global disease burdens are discussed.

Angiotensin converting enzyme in brush-border membranes of avian small intestine

1988 ◽  
Vol 135 (1) ◽  
pp. 1-8
Author(s):  
B. R. Stevens ◽  
A. Fernandez ◽  
C. del Rio Martinez
Keyword(s):  
Angiotensin Converting Enzyme ◽  
Brush Border ◽  
Physiological Role ◽  
Intestinal Epithelial ◽  
Converting Enzyme ◽  
Brush Border Membranes ◽  
Fluid Uptake ◽  
The Common ◽  
Kinetics Of ◽  
Hydrolysis Of

Angiotensin converting enzyme activity was identified in brush-border membranes purified from the small intestinal epithelium of the common grackle, Quiscalus quiscula. Angiotensin converting enzyme was enriched 20-fold in the membrane preparation, compared with intestinal epithelial cell scrapes, and was coenriched with the brush-border markers, alkaline phosphatase and aminopeptidase N. The kinetics of hydrolysis of N-[3-(2-furyl)acryloyl]-L-phenylalanylglycylglycine (FAPGG) gave a Vmax of 907 +/− 41 units g-1 and a Km of 55 +/− 6 mumol l-1. The avian intestinal angiotensin converting enzyme was inhibited by the antihypertensive drug, Ramipril, with a median inhibitory concentration (IC50) of 1 nmol l-1. In the light of previous studies on angiotensin converting enzyme in mammalian epithelia, these results may implicate a physiological role for angiotensin converting enzyme in regulating electrolyte and fluid uptake in bird small intestines.

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