Endoscopic Lung Volume Reduction in COPD: The Impact of Coil Implantation on Patients’ Physical Activity

Respiration ◽  
2019 ◽  
Vol 99 (2) ◽  
pp. 177-180
Author(s):  
Leonie Biener ◽  
Dirk Skowasch ◽  
Sophia Hollmann ◽  
Tina Schreiber ◽  
Georg Nickenig ◽  
...  
Respiration ◽  
2021 ◽  
pp. 1-8
Author(s):  
Karin Sanders ◽  
Karin Klooster ◽  
Lowie E.G.W. Vanfleteren ◽  
Guy Plasqui ◽  
Anne-Marie Dingemans ◽  
...  

<b><i>Background:</i></b> Hypermetabolism and muscle wasting frequently occur in patients with severe emphysema. Improving respiratory mechanics by bronchoscopic lung volume reduction (BLVR) might contribute to muscle maintenance by decreasing energy requirements and alleviating eating-related dyspnoea. <b><i>Objective:</i></b> The goal was to assess the impact of BLVR on energy balance regulation. <b><i>Design:</i></b> Twenty emphysematous subjects participated in a controlled clinical experiment before and 6 months after BLVR. Energy requirements were assessed: basal metabolic rate (BMR) by ventilated hood, total daily energy expenditure (TDEE) by doubly labelled water, whole body fat-free mass (FFM) by deuterium dilution, and physical activity by accelerometry. Oxygen saturation, breathing rate, and heart rate were monitored before, during, and after a standardized meal via pulse oximetry and dyspnoea was rated. <b><i>Results:</i></b> Sixteen patients completed follow-up, and among those, 10 patients exceeded the minimal clinically important difference of residual volume (RV) reduction. RV was reduced with median (range) 1,285 mL (−2,430, −540). Before BLVR, 90% of patients was FFM-depleted despite a normal BMI (24.3 ± 4.3 kg/m<sup>2</sup>). BMR was elevated by 130%. TDEE/BMR was 1.4 ± 0.2 despite a very low median (range) daily step count of 2,188 (739, 7,110). Following BLVR, the components of energy metabolism did not change significantly after intervention compared to before intervention, but BLVR treatment decreased meal-related dyspnoea (4.1 vs. 1.7, <i>p</i> = 0.019). <b><i>Conclusions:</i></b> Impaired respiratory mechanics in hyperinflated emphysematous patients did not explain hypermetabolism. <b><i>Clinical Trial Registry Number:</i></b> NCT02500004 at www.clinicaltrial.gov.


CHEST Journal ◽  
1999 ◽  
Vol 116 (3) ◽  
pp. 693-696 ◽  
Author(s):  
Peter Mazolewski ◽  
J.F. Turner ◽  
Mindy Baker ◽  
Terry Kurtz ◽  
Alex G. Little

2012 ◽  
Vol 40 (6) ◽  
pp. 1566-1567 ◽  
Author(s):  
Jorine E. Hartman ◽  
H. Marike Boezen ◽  
Sanne Heintzbergen ◽  
Mathieu H.G. de Greef ◽  
Karin Klooster ◽  
...  

Author(s):  
Lea Schotten ◽  
Filiz Oezkan ◽  
Birte Schwarz ◽  
Jane Winantea ◽  
Christian Taube ◽  
...  

Pneumologie ◽  
2017 ◽  
Vol 71 (S 01) ◽  
pp. S1-S125
Author(s):  
C Pizarro ◽  
S Hollmann ◽  
I Tuleta ◽  
G Nickenig ◽  
D Skowasch

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