scholarly journals The Cumulative Exposure to High-Sensitivity C-Reactive Protein Predicts the Risk of Chronic Kidney Diseases

2019 ◽  
Vol 45 (1) ◽  
pp. 84-94
Author(s):  
Jingli Gao ◽  
Aitian Wang ◽  
Xiaolan Li ◽  
Junjuan Li ◽  
Hualing Zhao ◽  
...  
Keyword(s):  
Kidney Diseases ◽  
High Sensitivity ◽  
Cox Proportional Hazards ◽  
Exposed Group ◽  
Cumulative Exposure ◽  
C Reactive Protein ◽  
Chronic Kidney Diseases ◽  
Reactive Protein ◽  
Increased Risk ◽  
Hs Crp

Background and Objectives: This study was to characterize the association of cumulative exposure to increased high-sensitivity C-reactive protein (hs-CRP) with chronic kidney diseases (CKD). Methods: We included 35,194 participants with hs-CRP measured at three examinations in 2006, 2008, 2010. Participants were classified into nonexposed group (hs-CRP <3.0 mg/L in all 3 examinations), 1-exposed group (hs-CRP ≥3.0 mg/L in 1 of the 3 examinations), 2-exposed group (hs-CRP ≥3.0 mg/L in 2 of the 3 examinations), and 3-exposed group (hs-CRP ≥3.0 mg/L in 3 examinations). Cox proportional hazards models were used to assess the association of cumulative hs-CRP with incident CKD. CKD includes an estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m2 or urinary protein positive. Results: The study showed the risk of CKD as the number of years of exposure to hs-CRP increases. Participants in 3-exposed group had significantly increased CKD risk with hazard ratio (HR) (95% confidence interval, CI) of 1.70 (1.49–1.93), in comparison with 1.47 (1.34–1.62) for participants in the 2-exposed group, and 1.08 (1.00–1.16) for those in the 1-exposed group (p < 0.01); meanwhile, the similar and significant associations were also observed for eGFR <60 mL/min/1.73 m2, proteinuria positive, in participants of the 3-exposed group in comparison with the nonexposed group, with respective HRs (95% CI) of 1.27 (1.01–1.58) and 2.27 (1.87–2.76). Conclusions: Cumulative exposure to hs-CRP was associated with a subsequent increased risk of CKD and was of great value to risk prediction.

P3645Prognosis in relation to high-sensitivity C-reactive protein levels in patients with non-obstructive coronary artery disease

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
H W Zhang ◽  
Y X Cao ◽  
J L Jin ◽  
Y L Guo ◽  
Y Gao ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Obstructive Coronary Artery Disease ◽  
High Sensitivity ◽  
C Reactive Protein ◽  
Development Fund ◽  
Reactive Protein ◽  
Increased Risk ◽  
Hs Crp ◽  
Artery Disease

Abstract Background It has been reported that coronary artery disease (CAD) is characterized by inflammation and non-obstructive CAD (NOCAD) increases the risk of cardiovascular events (CVEs) compared with ones with normal or near-normal coronary arteries (NNCA), even is similar to obstructive CAD (OCAD). We hypothesized that elevated high-sensitivity C-reactive protein (hs-CRP) may be linked to CVEs in those patients with NOCAD. Purpose To investigate the predictive role of hs-CRP in patients with NOCAD. Methods Of 7,746 consecutive patients with angina-like chest pain admissions, 4,662 eligible patients were enrolled who received coronary artery angiography (CAG) and followed up for the CVEs comprising all-cause mortality, myocardial infarction, stroke and late revascularization. According to the results of CAG, the patients were classified as NNCA group (<20% stenosis, n=698, 15.0%), NOCAD group (20–49% stenosis, n=639, 14.3%), and OCAD group (≥50% stenosis, n=3325, 70.7%). They were further subdivided into 3 groups according to baseline hs-CRP levels (<1, 1–3 and >3 mg/L). Proportional hazards models were used to assess the risk of CVEs in all patients enrolled. Results A total of 338 patients (7.3%) experienced CVEs during an average of 13403 person-years follow-up. Patients with NOCAD and OCAD had higher rates of CVEs compared to those with NNCA (p<0.05, respectively). In Cox's models after adjustment of confounders, the risk of CVEs elevated with the increasing degrees of CAD with hazard ratio of 2.01 [95% confidence interval (95% CI): 1.07–3.79, p=0.03] for patients with NOCAD and 2.81 (95% CI: 1.60–4.93, p<0.001) for patients with OCAD compared with the NNCA group. Moreover, elevated hs-CRP levels were associated with the severity of coronary lesions and an elevated increased risk of CVEs in patients with NOCAD and OCAD compared those with NNCA (p<0.05, respectively). Conclusions Patients with NOCAD had indeed worse outcomes and hs-CRP levels were positively in relation to the CVEs in those with NOCAD, which may help to the risk assessment in ones with NOCAD. Acknowledgement/Funding This study was partly supported by Capital Health Development Fund (201614035) and CAMS Innovation Fund for Medical Sciences (2016-I2M-1-011) awarded

scholarly journals Troponin T but not C reactive protein is associated with future surgery for aortic stenosis: a population-based nested case-referent study

Open Heart ◽  
2020 ◽  
Vol 7 (2) ◽  
pp. e001325
Author(s):  
Anders Holmgren ◽  
Johan Ljungberg ◽  
Johan Hultdin ◽  
Bengt Johansson ◽  
Ingvar A Bergdahl ◽  
...  
Keyword(s):  
Aortic Stenosis ◽  
Troponin T ◽  
High Sensitivity ◽  
C Reactive Protein ◽  
Myocardial Mass ◽  
Time To Surgery ◽  
Reactive Protein ◽  
Potential Biomarker ◽  
Increased Risk ◽  
Hs Crp

AimsHigh-sensitivity troponin T (hs-TnT) and high-sensitivity C reactive protein (hs-CRP) may convey prognostic information in patients with aortic stenosis (AS). This study evaluated if hs-TnT and hs-CRP associate with myocardial mass, and risk of future surgery for AS.MethodsIn total, 336 patients (48% women) with surgery for AS with previous participation in large population surveys were identified. Preoperatively, myocardial mass and the presence of coronary artery disease (CAD) were assessed. Two matched referents were allocated for each case, and hs-TnT and hs-CRP were determined in stored plasma from the baseline survey. Conditional logistic regression analysis was used to estimate the risk (OR (95% CI)) related to one (natural logarithm) SD increase in hs-TnT and hs-CRP. Kaplan-Mayer and Cox regression analyses were used to evaluate time to surgery.ResultsMedian age (IQR) was 59.8 (10.3) years at survey, and median time between survey and surgery was 10.9 (9.3) years. Hs-TnT was independently associated with surgery for AS (1.24 (1.06–1.44)) irrespective of CAD, whereas Hs-CRP was not (1.05 (0.90–1.22)). Elevated hs-TnT levels at survey associated with shorter time to surgery (p<0.001), and with increased myocardial mass (p=0.002). Hs-CRP did not associate with time to surgery or with myocardial mass.ConclusionsHs-TnT—but not hs-CRP—was associated with increased risk of—and shorter time to—future surgery for AS. Hs-TnT associated with myocardial mass at surgery which indicates that hs-TnT could be a potential biomarker for determining intervention.

scholarly journals HUBUNGAN ANTARA WHR DENGAN KADAR Hs-CRP SERUM PADA MAHASISWA OBES DAN TIDAK OBES DI FAKULTAS KEDOKTERAN UNIVERSITAS SAM RATULANGI MANADO

2013 ◽  
Vol 1 (1) ◽  
Author(s):  
Ezra Toreh ◽  
Shirley E. S. Kawengian ◽  
Alexander S. L. Bolang
Keyword(s):  
Statistical Analysis ◽  
High Sensitivity ◽  
Medical Faculty ◽  
C Reactive Protein ◽  
Cross Sectional ◽  
Waist To Hip Ratio ◽  
Reactive Protein ◽  
Increased Risk ◽  
Hs Crp ◽  
Spearman Test

Abstract: Central obesity is recognized as a major factor that associated with increased risk for some chronic diseases. Waist to hip ratio described the increase in visceral adipose tissue and subcutaneous fat on waist circumference and hip circumference.C-reactive protein is the detection of cardiovascular disease risk in conventional but not sensitive enough to detect cardiovascular risk so  beused the new method is of high sensitivity C-reactive protein.The research have purpose to know the difference and relationship of waist to hip ratio and high sensitivity c-reactive protein level between obese and non-obese students at Medical Faculty of Sam Ratulangi University Manado. This research was an observational analytic cross-sectional approach. The results of statistical analysis using the Mann-Whitney U test revealed that there were significant differences (p = 0.000 <0.05) both WHR and hs-CRP level in both groups of students are. Conclusion: The results of statistical analysis using the Spearman test showed that there is a positive very weak relationship (r = 0309) and significant (p = 0017 <0.05) between the values ​​of WHR with hs-CRP level in obese and non-obese students at Medical Faculty of Sam Ratulangi University Manado. Key Words: WHR, hs-CRP     Abstrak: Obesitas sentral diakui sebagai factor utama yang dikaitkan dengan peningkatan resiko untuk beberapa penyakit kronis. Waist to hip ratio (WHR) menggambarkan peningkatan jaringan adiposa visceral dan lemak subkutan pada lingkar pinggang dan lingkar pinggul. C-reactive protein (CRP) merupakan deteksi risiko penyakit kardiovaskular tapi secara konvensional tidak cukup sensitif untuk mendeteksi risiko kardiovaskular sehingga digunakan metode baru yaitu high sensitivity C-reactive protein (hsCRP). Penelitian bertujuan untuk mengetahui perbedaan dan hubungan waist to hip ratio (WHR) dengan kadar high sensitivity c-reactive protein (hs-CRP) serum pada mahasiswa obes dan tidak-obes di Fakultas Kedokteran Universitas Sam Ratulangi Manado. Penelitian ini bersifat observasional analitik dengan menggunakan pendekatan cross-sectional. Hasil analisis statistic dengan menggunakan uji Mann-Whitney U menunjukan terdapat perbedaan yang bermakna (p=0.000<0.05) baik WHR maupun kadar hs-CRP serum pada kedua kelompok mahasiswa tersebut. Simpulan: Hasil analisis statistic dengan mengguna-kan uji Spearman menunjukan bahwa terdapat hubungan yang positif sangat lemah (r=0.309) dan bermakna (p=0.017<0.05) antara nilai WHR dengan kadar hs-CRP serum mahasiswa obes dan tidak-obes pada Fakultas Kedokteran Universitas Sam Ratulangi Manado. Kata Kunci: WHR, hs-CRP

scholarly journals Coronary tortuosity is associated with an elevated high-sensitivity C-reactive protein concentration and increased risk of ischemic stroke in hypertensive patients

2018 ◽  
Vol 46 (4) ◽  
pp. 1579-1584 ◽  
Author(s):  
Yang Li ◽  
Abdul Qadir Nawabi ◽  
Yi Feng ◽  
Genshan Ma ◽  
Jiayi Tong ◽  
...  
Keyword(s):  
Cerebrovascular Accident ◽  
High Sensitivity ◽  
Lacunar Infarction ◽  
C Reactive Protein ◽  
Hypertensive Patients ◽  
Reactive Protein ◽  
Increased Risk ◽  
Hs Crp ◽  
Coronary Tortuosity ◽  
N 93

Objective The clinical implication of coronary tortuosity is unclear. The present study was conducted to determine the relationships between coronary tortuosity and the high-sensitivity C-reactive protein (hs-CRP) concentration and between coronary tortuosity and cerebrovascular accident in hypertensive patients without coronary artery disease. Methods In total, 236 patients with normal coronary angiography findings were categorized into 3 different groups: control participants (n = 58), who had neither hypertension nor coronary tortuosity; patients with hypertension but no coronary tortuosity (H-NCT group, n = 93); and patients with both hypertension and coronary tortuosity (H-CT group, n = 85). The hs-CRP concentration was measured in every patient, and 168 hypertensive patients were followed up for at least 2 years to check for the development of cerebrovascular accident. Results The hs-CRP concentration was significantly higher in the H-CT group than in the control and H-NCT groups (4.33 ± 3.15 vs. 1.52 ± 1.31 and 2.31 ± 2.09 mg/L, respectively). The incidence of lacunar infarction was higher in the H-CT than H-NCT group during the follow-up. Conclusions Hypertensive patients with coronary tortuosity have a higher serum hs-CRP level concentration and have a higher incidence of lacunar infarction than hypertensive patients without coronary tortuosity.

Depression, inflammation and coronary heart disease: prognostical value of c reactive protein and depressive symptoms

2011 ◽  
Vol 26 (S2) ◽  
pp. 611-611
Author(s):  
A. Bruschi ◽  
M. Mazza ◽  
D. Harnic ◽  
P. Grandinetti ◽  
C. Battaglia ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Depressive Symptoms ◽  
Statistical Significance ◽  
High Sensitivity ◽  
C Reactive Protein ◽  
Cardiac Events ◽  
Reactive Protein ◽  
Increased Risk ◽  
Hs Crp

IntroductionThe aim of this preliminary study is to assess, in a sample of patients with Coronary Heart Disease (CHD), the specific association between depressive symptoms and systemic inflammation.MethodsSixty-One inpatients with CHD, 31 Unstable Angina and 28 Myocardial Infarction, participated in the study. The plasma levels of C Reactive Protein were measured using Dade Behring’s High Sensitivity CRP assay (hs-CRP) at T0, T30 and T90.At the same timings, they were tested by an examiner, unaware of their diagnosis, with a psychometric battery (SCL90-R, HDRS, MADRS, BDI, QlesQ).ResultsThe elevation of hs-CRP occurs during the whole observation period, with maximum significance at T90 (p = 0,031).A multivariate analysis at T0 indicates a statistical correlation between SCL90-R scores and hs-CRP levels (p = 0.02).The SCL90-R is also associated with the risk of further cardiac events (p = 0.013).Also the BDI could be useful as a prognostic factor (p = 0.026).We found a trend towards correlation between CRP values and depressive symptoms, but it never reaches statistical significance for the other scales.ConclusionsThe feelings of loss and the fear of death, related to the environmental and emotional situation of the hospitalization, may prevail in the acute phase of CHDs.Some patients may overcome this reactive depression, while others may exhibit a biological depression, related to the high level of CRP and thus to an increased risk of re-infarction and other coronary events.

scholarly journals Variability and Classification Accuracy of Serial High-Sensitivity C-Reactive Protein Measurements in Healthy Adults

2001 ◽  
Vol 47 (3) ◽  
pp. 444-450 ◽  
Author(s):  
Ira S Ockene ◽  
Charles E Matthews ◽  
Nader Rifai ◽  
Paul M Ridker ◽  
George Reed ◽  
...  
Keyword(s):  
Total Cholesterol ◽  
Classification Accuracy ◽  
High Sensitivity ◽  
Total Serum ◽  
Total Serum Cholesterol ◽  
C Reactive Protein ◽  
Relative Variation ◽  
Reactive Protein ◽  
Increased Risk ◽  
Hs Crp

Abstract Background: Increased concentrations of high-sensitivity C-reactive protein (hs-CRP), a marker of systemic inflammation, are associated with increased risk for coronary heart disease. Because of its relationship to inflammation, hs-CRP has considerable biologic variation. This study was carried out to characterize CRP variation and to compare it to another risk factor, total serum cholesterol. Methods: One hundred thirteen individuals were scheduled to have five measurements each of hs-CRP and total cholesterol carried out at quarterly intervals over a 1-year period. Variations of hs-CRP and total cholesterol were characterized, and classification accuracy was described and compared for both. Results: The relative variation was comparable for hs-CRP and total cholesterol. When classified by quartile, 63% of first and second hs-CRP measurements were in agreement; for total cholesterol it was 60%. Ninety percent of hs-CRP measurements were within one quartile of each other. This relationship was not altered by the use of log-transformed hs-CRP data. Conclusion: hs-CRP has a degree of measurement stability that is similar to that of total cholesterol.

scholarly journals STUDY OF SERUM ADIPONECTIN AND HIGH SENSITIVITY C-REACTIVE PROTEIN IN DIABETIC PATIENTS

2018 ◽  
Vol 11 (7) ◽  
pp. 163
Author(s):  
Shailza Shreshtha ◽  
Preeti Sharma ◽  
Pradeep Kumar ◽  
Rachna Sharma ◽  
Shivani Gupta ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Blood Sugar ◽  
High Sensitivity ◽  
Diabetic Patients ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Markers Of Inflammation ◽  
Increased Risk ◽  
Hs Crp

Objectives: Adiponectin, a major cytokine from adipose tissue, and high sensitivity C-reactive protein (hs-CRP), well-established markers of inflammation are known to be associated with increased risk of cardiovascular disorders (CVD). Therefore the objective of our study was to evaluate the levels of these parameters and determine their correlation with glycemia to assess the cardiovascular risks in the patients with Type 2 diabetes mellitus.Methods: This study was conducted in the Department of Biochemistry, Santosh Medical College, Ghaziabad, with 25 Type 2 diabetic patients and 25 age and sex-matched controls. Ethical clearance from the institution and informed consent from the patients were taken before the study. Adiponectin was analyzed by enzyme-linked immunoadsorbent assay, and blood sugar and CRP were estimated by the kit based method.Results: Fasting blood sugar (FBS, 158.2±37.2) and hs-CRP (3.97±1.54) were significantly high, adiponectin was significantly low in the patients with diabetes compared to controls (80.52±9.72, 1.27±0.75, and 10.78±1.69, respectively, p<0.05). Adiponectin showed a negative correlation with FBS (r=−0.427) and hs-CRP (r=−0.336), but the correlation was significant only in case of FBS (p<0.05). hs-CRP positively correlated with FBS (r=0.568) and was statistically significant.Conclusion: The results of our study further support the role of adiponectin and hs-CRP as a predictive biomarker of CVD risks in the patients suffering from Type 2 diabetes.

scholarly journals Assessment of high sensitivity C-reactive protein and coronary plaque characteristics by computed tomography in patients with and without diabetes mellitus

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Hai-Ting Zhou ◽  
De-Li Zhao ◽  
Guo-Kun Wang ◽  
Tian-Zuo Wang ◽  
Hong-Wei Liang ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Computed Tomography ◽  
Coronary Artery ◽  
High Sensitivity ◽  
Coronary Plaque ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Increased Risk ◽  
Calcified Plaque ◽  
Hs Crp

Abstract Background To evaluate the coronary plaque characteristics of coronary arteries using computed tomography angiography (CTA) in order to assess the risk of coronary artery disease and the relevance of high sensitivity C reactive protein (hs-CRP) in patients with Diabetes Mellitus (DM). Methods The clinical data of 400 DM patients and 400 non-DM patients from January 2017 to December 2019 were collected, including the results of coronaryCTA. The plasma hs-CRP level of the two groups were divided into three groups: CRP ≤ 1, 1 < CRP ≤ 2, CRP > 2. The correlation of the degree of stenosis, the number of plaques, the nature of plaques and hs-CRP value between the two groups was evaluated. Results Compared with non-DM patients, the incidence of coronary artery plaques and lumen stenosis in DM patients was more higher than that in non-DM patients. DM patients were more likely to have more diseased vessels, especially diffuse vascular disease (12.00% vs 1.75%; P < 0.001). Subjects with high hs-CRP levels were more likely to have any plaque compared with individuals showing normal hs-CRP levels (p<0.01). There was no statistical significance in non calcified plaque with high level of hs-CRP, but the occurrence of plaque types in DM group was statistically significant compared with other hs-CRP levels in non DM group. Subjects with high hs-CRP were observed to be at increased risk for the presence of calcified plaque and severe narrowing in the unadjusted values. Conclusions Coronary CTA combined with hs-CRP can accurately detect the characteristics of coronary artery stenosis and plaque in DM patients, which has an important clinical value in the risk assessment of coronary heart disease in DM patients.

scholarly journals High-Sensitivity C-Reactive Protein is a Predictor of Subsequent Atrial High-Rate Episodes in Patients with Pacemakers and Preserved Ejection Fraction

2020 ◽  
Vol 9 (11) ◽  
pp. 3677
Author(s):  
Min-Tsun Liao ◽  
Chun-Kai Chen ◽  
Ting-Tse Lin ◽  
Li-Ying Cheng ◽  
Hung-Wen Ting ◽  
...  
Keyword(s):  
Regression Analysis ◽  
Cox Regression ◽  
High Sensitivity ◽  
Cardiac Biomarkers ◽  
High Rate ◽  
C Reactive Protein ◽  
Cox Regression Analysis ◽  
Reactive Protein ◽  
Increased Risk ◽  
Hs Crp

Atrial fibrillation (AF) is associated with morbidity and mortality. Modern pacemakers can detect atrial high-rate episodes (AHREs) as a surrogate for AF. It remains controversial whether inflammation is a cause or a consequence of AF. This study investigated whether the inflammatory biomarker high-sensitivity C-reactive protein (hs-CRP) can predict subsequent AHREs. This study gathered prospective data from patients with pacemakers and a left ventricle EF ≥ 50% between 2015 and 2019. The hs-CRP and other cardiac biomarkers at baseline and device-detected AHREs, defined as atrial rate ≥ 180 bpm and duration ≥ 6 min, were determined. Cox regression analysis was used to estimate the independent predictors for AHREs. A total of 171 consecutive patients were included. During the median follow-up of 614 days, 66 patients (39%) developed subsequent AHREs. In the univariate Cox regression analysis, sick sinus syndrome (p = 0.005), prior AF (p < 0.001), mitral A velocity (p = 0.008), and hs-CRP (p = 0.013) showed significant association with the increased risk of AHREs. In the multivariate Cox regression model, hs-CRP (HR = 1.121, 95% confidence interval = 1.015–1.238, p = 0.024) retained its significance. Our results suggest that elevated hs-CRP could predict subsequent AHREs and that inflammation could play a role in AF pathogenesis in patients with preserved EF.

High-sensitivity C reactive protein and risk of cardiovascular disease in China-CVD study

2018 ◽  
Vol 73 (2) ◽  
pp. 188-192 ◽  
Author(s):  
Ying Dong ◽  
Xin Wang ◽  
Linfeng Zhang ◽  
Zuo Chen ◽  
Congyi Zheng ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Chinese Population ◽  
High Sensitivity ◽  
C Reactive Protein ◽  
Middle Aged ◽  
Reactive Protein ◽  
Net Reclassification Improvement ◽  
Increased Risk ◽  
Hs Crp

BackgroundThis study aimed to assess the association of high sensitivity C-reactive protein (hs-CRP) with cardiovascular disease (CVD) in middle-aged Chinese population.MethodsThe baseline was collected 2009–2010, and follow-up was conducted in 2016–2017. Data of hs-CRP were from baseline examination and re-examination in 2016–2017 using transmission turbidimetry with a measurement range of 0–42 000. The primary outcome was CVD including coronary heart disease events and stroke events.ResultsAmong 8688 participants free from CVD (at baseline, mean age, 50.1 years, 3897 were males), there were 189 CVD events, occurred during a median follow-up of 6.34 years (54 685 person-years at risk). From the Kaplan-Meier curve, we found that there was a progressive increase in CVD event rates by hs-CRP tertiles (log-rank test, p<0.001). Baseline hs-CRP was linearly associated with CVD (p for trend=0.015) even after adjusting for known CVD risk factors. Furthermore, the net reclassification improvement when hs-CRP was added to a model based on traditional factors was 7.85% for CVD (p=0.003). In addition, the correlation between change of hs-CRP and CVD was conducted in a subgroup (n=4778). However, we did not find the correlation between hs-CRP change and CVD (correlation coefficient: −0.003, p=0.846).ConclusionsIn the middle-aged Chinese population, hs-CRP was associated with increased risk of developing CVD. Although there was no correlation between hs-CRP change and CVD, the level of hs-CRP was higher at follow-up than baseline even among those with CVD. More attention should be given to those with higher level of hs-CRP for CVD prevention.

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