Clinical Characteristics and Antifungal Susceptibility of Candida nivariensis from Vulvovaginal Candidiasis

2019 ◽  
Vol 85 (1) ◽  
pp. 88-93 ◽  
Author(s):  
Yu Shi ◽  
Yuxia Zhu ◽  
Shangrong Fan ◽  
Amerigo Vitagliano ◽  
Xiaoping Liu ◽  
...  
Keyword(s):  
Clinical Characteristics ◽  
Antifungal Susceptibility ◽  
Vulvovaginal Candidiasis ◽  
Candida Nivariensis

Antifungal susceptibility and genotypes ofCandida albicansstrains from patients with vulvovaginal candidiasis

Mycoses ◽  
2009 ◽  
Vol 52 (1) ◽  
pp. 24-28 ◽  
Author(s):  
X. P. Liu ◽  
S. R. Fan ◽  
F. Y. Bai ◽  
J. Li ◽  
Q. P. Liao
Keyword(s):  
Antifungal Susceptibility ◽  
Vulvovaginal Candidiasis

scholarly journals Clinical Characteristics and Outcomes of Rare Fungal Keratitis Caused by Verticillium dahliae

2021 ◽  
Author(s):  
Qing Huang ◽  
Wenlu Zhang ◽  
Yu Sun ◽  
Xiaofeng Li ◽  
Xiaoyu Zhang ◽  
...  
Keyword(s):  
Verticillium Dahliae ◽  
Clinical Characteristics ◽  
Corneal Ulcer ◽  
Antifungal Susceptibility ◽  
Corneal Thickness ◽  
Fungal Keratitis ◽  
Lamellar Keratoplasty ◽  
Internal Transcribed Spacer Region ◽  
In Vitro Antifungal Susceptibility

Abstract PurposeTo observe clinical characteristics and treatment outcomes of fungal keratitis cause by Verticillium dahliae. MethodsClinical data of 7 patients diagnosed as fungal keratitis cause by V. dahliae were retrospectively analyzed. The clinical manifestations, mycology, in vitro antifungal susceptibility, treatment regimens and prognoses of the patients were evaluated. ResultsAll 7 patients were farm worker, of which 5 cases were caused by plant trauma. The corneal ulcer had a round shape and a relatively limited range with the diameters mainly in the range of 2-7 mm. The stromal infiltration was mild, and had no pseudopodia, mossiness or endothelial plaques. Intact hyphaes were detected in corneal scrapings and confocal microscopy, isolates were identified by morphology and by sequencing the internal transcribed spacer region of ribosomal DNA. In vitro antifungal susceptibility testing showed that the most sensitive antifungal drug was Amphotericin B. In the 6 patients with an ulcer less than 2/3 of the corneal thickness, the ulcer healed after 18 days of antifungal treatment only in one eye. The other five patients underwent corneal ulcer debridement or conjunctival flap covering surgery. The remaining one patient with ulcer depth more than 2/3 of the corneal thickness underwent lamellar keratoplasty. ConclusionFungal keratitis caused by V. dahliae has typical signs of a mild inflammatory response, and is not sensitive to antifungal drugs. It is recommended that patients undergo corneal ulcer debridement as soon as possible to promote rapid healing of the ulcers.

Value of antifungal susceptibility testing in recurrent vulvovaginal Candidiasis by Non -Albicans Candida

2021 ◽  
Vol 30 (1) ◽  
pp. 161-167
Author(s):  
Ghada A. Mokhtar ◽  
Mohamed Sh. Ramadan ◽  
Shymaa Yahia
Keyword(s):  
Amphotericin B ◽  
Candida Species ◽  
Antifungal Susceptibility ◽  
High Sensitivity ◽  
Common Species ◽  
Vulvovaginal Candidiasis ◽  
Recurrent Vulvovaginal Candidiasis ◽  
Sensitivity Pattern ◽  
Vaginal Swabs ◽  
Vitek 2

Background: Vulvovaginal candidiasis (VVC) is regarded as a prevalent vaginal infection and mainly results from Candida albicans. Nevertheless, there has recently been a prominent shift in candidiasis etiology regarding non-albicans Candida (NAC) species with achieving importance. For women with more than three episodes annually are described as recurrent vulvovaginal candidiasis (RVVC). Objectives: To isolate, speciate, and determine the value of antifungal sensitivity pattern of candida species isolated from patients developed (RVVC). Methodology: High vaginal swabs (HVS) were taken from patients with RVVC and cultured on ordinary mycological media. Any significant candida growth was identified and speciated by VITEK 2 system. Their antifungal sensitivity was done by disc diffusion approach governed by CLSI guidelines. Results: A total of 110 Candida species from 250 high vaginal swabs were isolated. Among all candida species isolated from patients with RVCC, C.albicanis accounts for 44% while NAC accounts for 56% with C.glabrata most common species isolated. Voriconazole, amphotericin B, and nystatin showed high sensitivity rates (92 %, 89%, and 84% respectively) on all candida species (C.albicans and NAC) isolated from patients with RVVC. Conclusion: In RVCC there is increase in NAC (56%) with C.glabrata most common species isolated. Voriconazole, Nystatin, and amphotericin B have the best antifungal activity against all spp.

scholarly journals First description of Candida nivariensis in Brazil: antifungal susceptibility profile and potential virulence attributes

2016 ◽  
Vol 111 (1) ◽  
pp. 51-58 ◽  
Author(s):  
Maria Helena Galdino Figueiredo-Carvalho ◽  
Livia de Souza Ramos ◽  
Leonardo Silva Barbedo ◽  
Alessandra Leal da Silva Chaves ◽  
Ilda Akemi Muramoto ◽  
...  
Keyword(s):  
Antifungal Susceptibility ◽  
Candida Nivariensis

scholarly journals Prevalence of vulvovaginal candidiasis among pregnant women in the Ho municipality, Ghana: species identification and antifungal susceptibility of Candida isolates

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Sayanika Devi Waikhom ◽  
Innocent Afeke ◽  
Grace Sefakor Kwawu ◽  
Hintermann Kobina Mbroh ◽  
George Yiadom Osei ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Species Identification ◽  
Antifungal Susceptibility ◽  
Vulvovaginal Candidiasis

Microbiological and clinical characteristics of cryptococcemia: a retrospective analysis of 85 cases in a Chinese hospital

2019 ◽  
Vol 58 (4) ◽  
pp. 478-484 ◽  
Author(s):  
Yiqi Fu ◽  
Min Xu ◽  
Hua Zhou ◽  
Yake Yao ◽  
Jianying Zhou ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Blood Culture ◽  
Retrospective Analysis ◽  
Clinical Characteristics ◽  
Antifungal Susceptibility ◽  
Delayed Diagnosis ◽  
Sequence Type ◽  
Lower Baseline ◽  
Life Threatening ◽  
Cryptococcus Spp

Abstract Cryptococcemia is a life-threatening fungal infection. Sometimes, it is hard to diagnose. The studies to describe the characteristics of cryptococcemia specifically were limited. We performed this retrospective analysis in a Chinese hospital during 2002–2015, including 85 cryptococcemia cases and 52 Cryptococcus spp. isolates. The species, mating type, antifungal susceptibility and multilocus sequence typing of Cryptococcus spp. were determined. C. neoformans var. grubii MATα of sequence type (ST) 5 is the representative strain of cryptococcemia, accounting for 51 isolates. The MIC50/90 values were 0.5/0.5, 1.0/1.0, 2.0/4.0, ≤0.06/0.25, and ≤0.06/≤0.06 μg/ml for amphotericin B, flucytosine, fluconazole, itraconazole, and voriconazole, respectively. Cryptococcemia was the first diagnostic proof of cryptococcosis in 37 patients (43.5%, 37/85). Compared with the patients initially diagnosed of cryptococcosis in other sites (mainly cerebrospinal fluid), the patients firstly diagnosed by blood culture had prolonged time from admission to diagnosis of cryptococcosis (9 days vs. 2 days, P < .001) and higher 30-day mortality (54.1% vs. 20.8%, P = .003), while fewer symptoms of meningitis (45.9% vs. 100%, P < .001). For the patients receiving lumbar puncture, the occurrence of meningitis was similar between the patients firstly diagnosed by blood culture and those firstly diagnosed in other sites (94.1% vs. 100%, P = .26). However, the patients first diagnosed by blood culture had lower baseline intracranial pressure (250 mm H2O vs. 342.5 mm H2O, P = .001). In conclusion, patients with cryptococcemia as the first diagnostic proof of cryptococcosis usually had neglected subtle symptoms of meningitis, which may result in delayed diagnosis and catastrophic outcome.

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