Sevoflurane Protects against Intestinal Ischemia-Reperfusion Injury by Activating Peroxisome Proliferator-Activated Receptor Gamma/Nuclear Factor-κB Pathway in Rats

Pharmacology ◽  
2019 ◽  
Vol 105 (3-4) ◽  
pp. 231-242 ◽  
Author(s):  
Chuiliang Liu ◽  
Ruiwen Ding ◽  
Wujian Huang ◽  
Liping Miao ◽  
Junhua Li ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Intestinal Ischemia ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Nuclear Factor Κb ◽  
Peroxisome Proliferator ◽  
Nuclear Factor ◽  
Peroxisome Proliferator Activated Receptor ◽  
Intestinal Ischemia Reperfusion

Role of JNK phosphorylation in intestinal ischemia/reperfusion injury in mice

2010 ◽  
Vol 30 (2) ◽  
pp. 140-143
Author(s):  
De-yi ZHENG ◽  
Jian-ming WNAG ◽  
Yi-tao JIA ◽  
Jin-feng FU ◽  
Kai-yang LU ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Intestinal Ischemia ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Intestinal Ischemia Reperfusion

Dynamic metabolomic analysis of intestinal ischemia–reperfusion injury in rats

IUBMB Life ◽  
2020 ◽  
Vol 72 (5) ◽  
pp. 1001-1011 ◽  
Author(s):  
Die Dai ◽  
Jingchao Chen ◽  
Menglu Jin ◽  
Zunjian Zhang ◽  
Wei‐Hua Chen ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Intestinal Ischemia ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Metabolomic Analysis ◽  
Intestinal Ischemia Reperfusion

scholarly journals Murine Model of Intestinal Ischemia-reperfusion Injury

10.3791/53881 ◽  
2016 ◽  
Author(s):  
Ekaterina O. Gubernatorova ◽  
Ernesto Perez-Chanona ◽  
Ekaterina P. Koroleva ◽  
Christian Jobin ◽  
Alexei V. Tumanov
Keyword(s):  
Reperfusion Injury ◽  
Murine Model ◽  
Intestinal Ischemia ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Intestinal Ischemia Reperfusion

Changes of local and systemic hemorheological properties in intestinal ischemia-reperfusion injury in the rat model

Microsurgery ◽  
2009 ◽  
Vol 30 (4) ◽  
pp. 321-326 ◽  
Author(s):  
Endre Brath ◽  
Norbert Nemeth ◽  
Ferenc Kiss ◽  
Erika Sajtos ◽  
Timea Hever ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Rat Model ◽  
Intestinal Ischemia ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Intestinal Ischemia Reperfusion

Attenuation of lung reperfusion injury after transplantation using an inhibitor of nuclear factor-κB

2000 ◽  
Vol 279 (3) ◽  
pp. L528-L536 ◽  
Author(s):  
Scott D. Ross ◽  
Irving L. Kron ◽  
James J. Gangemi ◽  
Kimberly S. Shockey ◽  
Mark Stoler ◽  
...  
Keyword(s):  
Lung Function ◽  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Graft Function ◽  
Nuclear Factor Κb ◽  
Pyrrolidine Dithiocarbamate ◽  
Nuclear Factor ◽  
Mean Pulmonary Arterial Pressure ◽  
Pulmonary Arterial

A central role for nuclear factor-κB (NF-κB) in the induction of lung inflammatory injury is emerging. We hypothesized that NF-κB is a critical early regulator of the inflammatory response in lung ischemia-reperfusion injury, and inhibition of NF-κB activation reduces this injury and improves pulmonary graft function. With use of a porcine transplantation model, left lungs were harvested and stored in cold Euro-Collins preservation solution for 6 h before transplantation. Activation of NF-κB occurred 30 min and 1 h after transplant and declined to near baseline levels after 4 h. Pyrrolidine dithiocarbamate (PDTC), a potent inhibitor of NF-κB, given to the lung graft during organ preservation (40 mmol/l) effectively inhibited NF-κB activation and significantly improved lung function. Compared with control lungs 4 h after transplant, PDTC-treated lungs displayed significantly higher oxygenation, lower Pco2, reduced mean pulmonary arterial pressure, and reduced edema and cellular infiltration. These results demonstrate that NF-κB is rapidly activated and is associated with poor pulmonary graft function in transplant reperfusion injury, and targeting of NF-κB may be a promising therapy to reduce this injury and improve lung function.

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