In utero Hepatitis B Immunization during Fetal Surgery for Spina Bifida

2019 ◽  
Vol 47 (4) ◽  
pp. 328-332 ◽  
Author(s):  
Ueli Moehrlen ◽  
Julia Elrod ◽  
Nicole Ochsenbein-Kölble ◽  
Christoph Berger ◽  
Roberto F. Speck ◽  
...  
Keyword(s):  
Spina Bifida ◽  
Hepatitis B ◽  
Fetal Surgery ◽  
In Utero

scholarly journals Fetal-maternal surgery for spina bifida in a HIV-infected mother

2022 ◽  
Author(s):  
Julia Elrod ◽  
Nicole Ochsenbein-Kölble ◽  
Luca Mazzone ◽  
Roland Zimmermann ◽  
Christoph Berger ◽  
...  
Keyword(s):  
Spina Bifida ◽  
Hiv Transmission ◽  
A Priori ◽  
Fetal Surgery ◽  
In Utero ◽  
Exclusion Criterion ◽  
Maternal Hiv ◽  
Maternal Hiv Infection ◽  
Selection Of ◽  
Hiv Negative

INTRODUCTION: In select cases, in utero surgery for MMC leads to better outcomes than postnatal repair. However, maternal HIV infection constitutes a formal exclusion criterion due to the potential of vertical HIV transmission. Encouraged by a previous case of a successful fetal spina bifida repair in a Hepatitis Bs antigen positive woman, a plan was devised allowing for fetal surgery. CASE REPORT: In utero MMC repair was performed although the mother was HIV-infected. To minimize the risk of in utero HIV transmission, the mother was treated by HAART throughout gestation as well as intravenous zidovudine administration during maternal-fetal surgery. The mother tolerated all procedures very well without any sequelae. The currently 20 month-old toddler, is HIV negative and has significantly benefitted from fetal surgery. DISCUSSION/CONCLUSION: This case shows that maternal HIV is not a priori a diagnosis that excludes fetal surgery. Rather, it might be a surrogate for moving towards personalized medicine and away from applying too rigorous exclusion criteria in the selection of candidates for maternal-fetal surgery.

scholarly journals 81 A three-layer fetoscopic spina bifida closure has fewer neonatal complications than open in-utero closure

2021 ◽  
Vol 224 (2) ◽  
pp. S56-S57
Author(s):  
Jimmy Espinoza ◽  
Michael A. Belfort ◽  
William Whitehead ◽  
Magdalena Sanz-Cortes ◽  
Ahmed A. Nassr ◽  
...  
Keyword(s):  
Spina Bifida ◽  
In Utero ◽  
Neonatal Complications

scholarly journals ‘We did everything we could’– A qualitative study exploring the acceptability of maternal‐fetal surgery for spina bifida to parents

2021 ◽  
Author(s):  
Neeltje Crombag ◽  
Adalina Sacco ◽  
Bernadette Stocks ◽  
Philippe De Vloo ◽  
Johannes Van Der Merwe ◽  
...  
Keyword(s):  
Spina Bifida ◽  
Qualitative Study ◽  
Fetal Surgery

Impact of maternal-fetal surgery for myelomeningocele on the progression of ventriculomegaly in utero

2005 ◽  
Vol 193 (3) ◽  
pp. 727-731 ◽  
Author(s):  
Amy Adelberg ◽  
Angela Blotzer ◽  
Gary Koch ◽  
Rachael Moise ◽  
Nancy Chescheir ◽  
...  
Keyword(s):  
Fetal Surgery ◽  
In Utero

scholarly journals VP51.04: Options for intrauterine correction of spina bifida by open and fetoscopic fetal surgery: a systematic review

2021 ◽  
Vol 58 (S1) ◽  
pp. 306-306
Author(s):  
L. Lara‐Ávila ◽  
M. Martinez‐Rodriguez ◽  
R. Villalobos‐Gómez ◽  
H. López‐Briones ◽  
R. Cruz‐Martinez
Keyword(s):  
Systematic Review ◽  
Spina Bifida ◽  
Fetal Surgery

scholarly journals Open Spina Bifida: Why Not Fetal Surgery?

2018 ◽  
Vol 45 (6) ◽  
pp. 430-434 ◽  
Author(s):  
Luca Mazzone ◽  
Ueli Moehrlen ◽  
Barbara Casanova ◽  
Samira Ryf ◽  
Nicole Ochsenbein-Kölble ◽  
...  
Keyword(s):  
Spina Bifida ◽  
Fetal Surgery ◽  
Open Spina Bifida

scholarly journals Fetal surgery for spina bifida aperta

2018 ◽  
Vol 103 (6) ◽  
pp. F589-F595 ◽  
Author(s):  
Luc Joyeux ◽  
Enrico Danzer ◽  
Alan W Flake ◽  
Jan Deprest
Keyword(s):  
Spina Bifida ◽  
Prolonged Exposure ◽  
Controlled Trial ◽  
Fetal Surgery ◽  
Neurological Deficits ◽  
Cerebrospinal Fluid Leakage ◽  
Essential Information ◽  
Ventriculoperitoneal Shunting ◽  
Spina Bifida Aperta ◽  
Randomised Controlled

Spina bifida aperta (SBA) is one of the most common congenital malformations. It can cause severe lifelong physical and neurodevelopmental disabilities. Experimental and clinical studies have shown that the neurological deficits associated with SBA are not simply caused by incomplete neurulation at the level of the lesion. Additional damage is caused by prolonged exposure of the spinal cord and nerves to the intrauterine environment and a suction gradient due to cerebrospinal fluid leakage, leading to progressive downward displacement of the hindbrain. This natural history can be reversed by prenatal repair. A randomised controlled trial demonstrated that mid-gestational maternal-fetal surgery for SBA decreases the need for ventriculoperitoneal shunting and hindbrain herniation at 12 months and improves neurological motor function at 30 months of age. This came at the price of maternal and fetal risks, the most relevant ones being increased prematurity and a persistent uterine corporeal scar. Recently minimally invasive fetal approaches have been introduced clinically yet they lack extensive experimental or clinical trials. We aim to provide clinicians with the essential information necessary to counsel SBA parents as the basis for considering referral of selected patients to expert fetal surgery centres. We review the reported clinical outcomes and discuss recent developments of potentially less invasive fetal SBA approaches.

scholarly journals Neurological Outcomes after Human Umbilical Cord Patch for In Utero Spina Bifida Repair in a Sheep Model

2016 ◽  
Vol 06 (03) ◽  
pp. e309-e317 ◽  
Author(s):  
Lovepreet Mann ◽  
Saul Snowise ◽  
Yisel Morales ◽  
Sanjay Prabhu ◽  
Scheffer Tseng ◽  
...  
Keyword(s):  
Spina Bifida ◽  
Umbilical Cord ◽  
In Utero ◽  
Human Umbilical Cord ◽  
Sheep Model ◽  
Neurological Outcomes
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