scholarly journals Hepatic Artery Embolization Induces the Local Overexpression of Transforming Growth Factor β1 in a Rat Hepatoma Model

Liver Cancer ◽  
2019 ◽  
Vol 9 (1) ◽  
pp. 63-72
Author(s):  
Eisuke Ueshima ◽  
Hideyuki Nishiofuku ◽  
Haruyuki Takaki ◽  
Yutaka Hirata ◽  
Hiroshi Kodama ◽  
...  
Keyword(s):  
Growth Factor ◽  
Hepatic Artery ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β1 ◽  
Hepatic Artery Embolization ◽  
Artery Embolization ◽  
Hepatoma Model ◽  
Rat Hepatoma

scholarly journals S-adenosylmethionine decarboxylase gene expression in rat hepatoma cells: regulation by insulin and by inhibition of protein synthesis

1996 ◽  
Vol 316 (1) ◽  
pp. 273-277 ◽  
Author(s):  
Tiina SOININEN ◽  
Marja K. LIISANANTTI ◽  
Antti E. I. PAJUNEN
Keyword(s):  
Growth Factor ◽  
Insulin Treatment ◽  
Transforming Growth Factor ◽  
Insulin Response ◽  
Transforming Growth Factor Β1 ◽  
Hepatoma Cells ◽  
Adenosylmethionine Decarboxylase ◽  
The Stability ◽  
Rat Hepatoma ◽  
Rat Hepatoma Cells

We have investigated expression of the S-adenosylmethionine decarboxylase (AdoMetDC) gene in H4-II-E rat hepatoma cells treated with growth factors (epidermal growth factor and transforming growth factor β1) and inducers (cAMP and insulin). Treatment with insulin caused a marked increase in both RNA level and enzyme activity. The stability of AdoMetDC mRNA was not altered by insulin treatment: the accumulation of mRNA in hepatoma cells therefore seems to be due to an increase in the transcription rate. Cycloheximide was found to be a strong inducer of AdoMetDC mRNA transcription and the effects of insulin and cycloheximide were additive, suggesting that they increase expression by separate mechanisms. Chloramphenicol acetyltransferase assays in rat hepatoma cells using 5´ flanking regions of different lengths revealed that the promoter region extending 337 bp upstream from the transcription start site contains elements involved in insulin response.

583: Transforming Growth Factor β1 and its Receptors are Related to the Development, Recurrence and Prgression of Human Bladder Cancers

2005 ◽  
Vol 173 (4S) ◽  
pp. 159-159
Author(s):  
Wun-Jae Kim ◽  
ChangYi Quan ◽  
Pil-Du Jeoung ◽  
Eun-Jung Kim ◽  
Ji-Yeon Kim ◽  
...  
Keyword(s):  
Growth Factor ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β1 ◽  
Human Bladder
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