Association of Estrogen Receptor α Gene Polymorphism and its Expression with Gestational Diabetes Mellitus

2019 ◽  
Vol 85 (1) ◽  
pp. 26-33
Author(s):  
Chao Li ◽  
Binglong Qiao ◽  
Yubin Zhou ◽  
Weihong Qi ◽  
Chunling Ma ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Estrogen Receptor ◽  
Gestational Diabetes ◽  
Gene Polymorphism ◽  
Gestational Diabetes Mellitus ◽  
Estrogen Receptor Α ◽  
Estrogen Receptor Α Gene

scholarly journals Estrogen receptor α gene polymorphism and vascular complications in girls with type 1 diabetes mellitus

2017 ◽  
Vol 437 (1-2) ◽  
pp. 153-161 ◽  
Author(s):  
Bartosz Słomiński ◽  
Jolanta Myśliwska ◽  
Monika Ryba-Stanisławowska ◽  
Maria Skrzypkowska ◽  
Małgorzata Myśliwiec
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Estrogen Receptor ◽  
Gene Polymorphism ◽  
Type 1 Diabetes Mellitus ◽  
Vascular Complications ◽  
Estrogen Receptor Α ◽  
Estrogen Receptor Α Gene

The Association between Maternal/Fetal Insulin Receptor Substrate 1 Gene Polymorphism rs1801278 and Gestational Diabetes Mellitus in a Chinese Population

2021 ◽  
pp. 1-8
Author(s):  
Lingling Wu ◽  
Changping Fang ◽  
Jun Zhang ◽  
Yanchou Ye ◽  
Haiyan Zhao
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gene Polymorphism ◽  
Gestational Diabetes Mellitus ◽  
Insulin Receptor ◽  
Tolerance Test ◽  
Oral Glucose ◽  
Insulin Receptor Substrate ◽  
Single Center ◽  
Insulin Receptor Substrate 1

<b><i>Objectives:</i></b> Insulin receptor substrate 1 (IRS1) is a crucial factor in the insulin signaling pathway. IRS1 gene polymorphism rs1801278 in mothers has been reported to be associated with gestational diabetes mellitus (GDM). However, it is not clear whether IRS1 gene polymorphism rs1801278 in fetuses is associated with their mothers’ GDM morbidity. The purpose of this study is to analyze the association between maternal, fetal, or maternal/fetal <i>IRS1</i> gene polymorphism rs1801278 and GDM risk. <b><i>Design:</i></b> The study was a single-center, prospective cohort study. In total, 213 pairs of GDM mothers/fetuses and 191 pairs of control mothers/fetuses were included in this study. They were recruited after they underwent oral glucose tolerance test during 24–28 weeks of gestation and followed up until delivery. All participants received the conventional interventions (diet and exercise), and no special therapy except routine treatment. <b><i>Methods:</i></b> A total of 213 pairs of GDM mothers/fetuses and 191 pairs of normal blood glucose pregnant mothers/fetuses were ge­notyped using PCR and DNA sequencing from January 2015 to September 2016. Maternal/fetal <i>IRS1</i> gene polymorphism rs1801278 was analyzed and compared between 2 groups. <b><i>Results:</i></b> There were no significant differences in the frequency of individual mothers’ or fetuses’ <i>IRS1</i> rs1801278 polymorphisms between 2 groups; if both the mothers and fetuses carried A allele, significantly lower GDM morbidity was observed in the mothers. <b><i>Limitations:</i></b> The sample size was relatively small as a single-center study. <b><i>Conclusions:</i></b> Our study suggested that maternal/fetal rs1801278 polymorphism of <i>IRS1</i> is a modulating factor in GDM; both mothers/fetuses carrying the A allele of rs1801278 may protect the mothers against the development of GDM.

Association of the Estrogen Receptor-α Gene Polymorphism with the Risk of Endometriosis in Korean Women

2003 ◽  
Vol 26 (2) ◽  
pp. 91
Author(s):  
Sa Ra Lee ◽  
Sung Eun Hur ◽  
Hye Sung Moon ◽  
Hyung-Lae Kim ◽  
Hye Won Chung
Keyword(s):  
Estrogen Receptor ◽  
Gene Polymorphism ◽  
Estrogen Receptor Α ◽  
Korean Women ◽  
Estrogen Receptor Α Gene

Correlation of EPO gene polymorphism with gestational diabetes mellitus

2021 ◽  
Vol 63 (1) ◽  
Author(s):  
Hui ZHANG ◽  
Yanyan JING ◽  
Yongjiao WANG ◽  
Shufang BAI ◽  
Jiadong YU ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gene Polymorphism ◽  
Gestational Diabetes Mellitus

scholarly journals Investigation of Calpain 10 (rs2975760) gene polymorphism in Asian Indians with Gestational Diabetes Mellitus

Meta Gene ◽  
2014 ◽  
Vol 2 ◽  
pp. 299-306 ◽  
Author(s):  
Imran Ali Khan ◽  
Sireesha Movva ◽  
Noor Ahmad Shaik ◽  
Srinivas Chava ◽  
Parveen Jahan ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gene Polymorphism ◽  
Gestational Diabetes Mellitus ◽  
Asian Indians ◽  
Calpain 10

scholarly journals The role of vitamin D receptor gene polymorphisms in gestational diabetes mellitus susceptibility: a meta-analysis

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Sai Liu
Keyword(s):  
Diabetes Mellitus ◽  
Vitamin D ◽  
Gestational Diabetes ◽  
Gene Polymorphism ◽  
Gestational Diabetes Mellitus ◽  
Vitamin D Receptor ◽  
Meta Analysis ◽  
Recessive Model ◽  
Vdr Gene ◽  
Vdr Polymorphisms

Abstract Background Gestational diabetes mellitus (GDM) is a common disease during pregnancy. The association of vitamin D receptor (VDR) polymorphisms with GDM is still controversial. This study aimed to assess the associations between VDR polymorphisms and GDM risk. Methods We searched Cochrane Library, PubMed, and Embase electronic database for all eligible studies published from Jan 1, 1980 to December 31, 2020 to conduct a Meta-analysis. We analyzed four VDR polymorphisms: BsmI (rs1544410), ApaI (rs7975232), TaqI (rs731236), and FokI (rs2228570). Inclusion Criteria: (1) The data can be evaluated; (2) case–control study; and (3) meeting the Hardy–Weinberg’s law. Exclusion criteria: (1) Insufficient or extractable data; (2) Severe publication bias in the data; and (3) duplicate publications. We eventually included 15 studies in seven articles, including 2207 cases and 2706 controls. Results We eventually included 15 studies in seven articles, including 2207 cases and 2706 controls. The data showed that ApaI (rs7975232) VDR gene polymorphism was related with the risk of GDM for the comparison of CC vs AA and recessive model in overall population and FokI (rs2228570) VDR gene polymorphism was associated with the risk of GDM for recessive model in overall population. BsmI (rs1544410) polymorphism was not related with the risk of GDM in overall population. However, in the analysis of subgroups grouped by race, BsmI (rs1544410) has certain correlations. And, the data suggested the TaqI (rs731236) polymorphism was not associated with GDM. Conclusion Based on the meta-analysis, VDR ApaI (rs7975232) and FokI (rs2228570) polymorphisms increase susceptibility to GDM. In the future, it can be used to diagnose and screen molecular biomarkers for GDM patients.

scholarly journals Surfactant Protein D Gene Polymorphism was Associated with the Susceptibility of Gestational Diabetes Mellitus: A Case Control Study

2021 ◽  
Author(s):  
Jingwei Xu ◽  
Yi Chen ◽  
Liangfang Tang ◽  
Xinyuan Teng ◽  
Lin Feng ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gene Polymorphism ◽  
Gestational Diabetes Mellitus ◽  
Gene Polymorphisms ◽  
Surfactant Protein ◽  
Surfactant Protein D ◽  
Coding Region ◽  
Increased Risk ◽  
Relationship Of

Abstract BackgroundSurfactant protein D (SP-D) is a critical component of the innate immune system intrinsically linked to energetic metabolism. However, the relationship of SP-D gene polymorphisms and gestational diabetes mellitus (GDM) remains unclear yet. In this study, we analyzed SP-D gene polymorphisms in GDM patients and non-diabatic controls, and then determined the association of SP-D gene polymorphisms with GDM.MethodsWe examined a common genetic polymorphism located in the SP-D coding region (rs721917, Met31Thr) with GDM patients (n = 147) and healthy pregnant controls (n = 97) by using a PCR-RFLP technique. The level of SP-D protein in serum of GDM patients and non-diabetic controls was determined by ELISA method. The gene and allele frequencies od SP-D and their association with GDM as well as SP-D protein level were analyzed using SPSS software.ResultsWe found that there exists a significant association of the SP-D polymorphism (rs721917) with GDM. SP-D (T/T) genotype had 11.6% and 21.6% in GDM and matched healthy controls, respectively (P<0.05); indicating women with (T/T) genotype have lower prevalence of GDM (OR = 0.473). Women with T/C genotypes showed an increased risk of GDM (OR = 2.440). We did not observe corrections between glucose homeostasis markers and SP-D genotypes in the women patients with GDM. Furthermore, serum SP-D level was higher in the GDM compared to matched healthy controls.ConclusionsThis study has found the first evidence that SP-D gene polymorphism (rs721917) was associated with GDM, which may provide the basis for further study how SP-D plays a regulatory role in GDM.

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