scholarly journals Hepatitis E-Induced Acute Myocarditis in an Elderly Woman

2019 ◽  
Vol 13 (2) ◽  
pp. 342-349 ◽  
Author(s):  
Pratim Sengupta ◽  
Sumanta Biswas ◽  
Tapas Roy

Hepatitis E is a common, mainly water-borne hepatotropic virus prevalent mainly in Southeast Asia, Africa, the Middle East, and Central America. In the eastern part of India epidemics of acute hepatitis E are well reported. Hepatitis E commonly presents as self-limiting acute viral hepatitis among young adults, except for some critical clinical complications during pregnancy. In epidemiological research, subclinical acute hepatitis E infection is also reported from different parts of the world, including developed nations such as the USA (predominantly in the population aged >60 years). Though primarily hepatotropic, in the literature there are reports of rare extrahepatic manifestation of acute hepatitis E. Here we present an elderly lady with acute hepatitis E who primarily presented with acute myocarditis.

2015 ◽  
Vol 62 ◽  
pp. S553-S554
Author(s):  
K.L. Woolson ◽  
A. Forbes ◽  
R.G. Madden ◽  
P. Oppong ◽  
J.G. Hunter ◽  
...  

2013 ◽  
Vol 2013 ◽  
pp. 1-3 ◽  
Author(s):  
Hemanta Kumar Nayak ◽  
Nitish L. Kamble ◽  
Nishant Raizada ◽  
Sandeep Garg ◽  
Mradul Kumar Daga

Acute pancreatitis complicating fulminant viral hepatitis has been well recognized; however, acute pancreatitis occurring in nonfulminant hepatitis is very rare. The case presented describes moderate pancreatitis in a young male, manifesting during the course of nonfulminant acute hepatitis E infection. The diagnosis of acute viral hepatitis E was confirmed by serology and reverse transcriptase polymerase chain reaction (RT-PCR) to demonstrate Hepatitis E virus (HEV) RNA in both stool and serum. Patients with acute viral hepatitis presenting with severe abdominal pain should have a diagnosis of acute pancreatitis suspected and appropriate investigations including serum amylase, lipase, biliary ultrasonography and/or contrast-enhanced computed tomography of the abdomen should be undertaken. The identification of this unusual complication of Hepatitis E is important; however, the prognosis for patients with Acute Pancreatitis Complicating Acute Hepatitis E Virus Infection is good, and uncomplicated recovery with conservative treatment is expected.


2020 ◽  
Author(s):  
Adriana Turculeanu

Hepatitis E virus (HEV) is one of the 7 viruses with mainly hepatic tropism. HEV determines 20 million new infections worldwide every year, 3.4 million acute hepatitis E and 44,000 deaths in 2015 (3.3% of the mortality due to viral hepatitis). Transmitted by the digestive tract mainly (fecal- orally, particularly by water infected with feces), the virus reaches the liver where it does not have a direct cytolytic effect, but immunological phenomena, especially cellular, activated by the replication of the virus in the hepatocytes. Clinically, over 95% of cases of HEV infection are asymptomatic and sel- limiting; in immunocompetent patients in tropics HEV can cause acute hepatitis with clinical features. On rare situations the infection can result in a severe, fulminant hepatitis with acute liver failure. In immunocompromised patients (organ transplant recipients, hematologic malignancies, HIV-infected) HEV may determine chronic hepatitis. In pregnant women or the elderly people or people with underlying liver disease HEV can cause fulminant forms which can become fatal (E.g.: 30% deaths among pregnant women in some parts of the world). Acute and chronic E hepatitis may be accompanied by extrahepatic manifestations: neurological, kidney, pancreatic, hematological diseases, autoimmune diseases with a pathogenesis not fully elucidated.


Pathogens ◽  
2021 ◽  
Vol 10 (1) ◽  
pp. 60
Author(s):  
Thomas Theo Brehm ◽  
Omid Mazaheri ◽  
Thomas Horvatits ◽  
Marc Lütgehetmann ◽  
Julian Schulze zur Wiesch ◽  
...  

In patients with hepatitis E virus (HEV) infections, extrahepatic, particularly renal and hematological manifestations, are increasingly reported in the medical literature but have never been studied compared to a control cohort. We retrospectively analyzed medical records of consecutive patients that were diagnosed with acute hepatitis E (AHE) (n = 69) or acute hepatitis A (AHA) (n = 46) at the University Medical Center Hamburg Eppendorf from January 2009 to August 2019 for demographical, clinical, and laboratory information. Patients with AHE had significantly lower median levels of ALAT (798 U/L) and total bilirubin (1.8 mg/dL) compared to patients with AHA (2326 U/L; p < 0.001 and 5.2 mg/dL; p < 0.001), suggesting a generally less severe hepatitis. In contrast, patients with AHE had significantly higher median serum creatinine levels (0.9 mg/dL vs. 0.8 mg/dL; p = 0.002) and lower median estimated glomerular filtration rate (eGFR) (91 mL/min/1.73 m2 vs. 109 mL/min/1.73 m2; p < 0.001) than patients with AHA. Leucocyte, neutrophil and lymphocyte count, hemoglobin, platelets, red cell distribution width (RDW), neutrophil to lymphocyte ratio (NLR), and RDW to lymphocyte ratio (RLR) did not differ between patients with AHE and those with AHA. Our observations indicate that renal but not hematological interference presents an underrecognized extrahepatic feature of AHE, while inflammation of the liver seems to be more severe in AHA.


Hepatology ◽  
2016 ◽  
Vol 64 (3) ◽  
pp. 1006-1007 ◽  
Author(s):  
Birendra Prasad Gupta ◽  
Ananta Shrestha ◽  
Anurag Adhikari ◽  
Thupten Kelsang Lama ◽  
Binaya Sapkota

2011 ◽  
Vol 51 (3) ◽  
pp. 202-204 ◽  
Author(s):  
Cécile Deniel ◽  
Thierry Coton ◽  
Sarah Brardjanian ◽  
Michel Guisset ◽  
Elisabeth Nicand ◽  
...  

2013 ◽  
Vol 3 (1) ◽  
pp. 39-41
Author(s):  
Salimur Rahman ◽  
Mamun Al-Mahtab ◽  
Faroque Ahmed ◽  
Md Fazal Karim ◽  
Md Dalil Uddin

2015 ◽  
Vol 2015 (mar04 1) ◽  
pp. bcr2014207669-bcr2014207669 ◽  
Author(s):  
E. Theochari ◽  
L. Vincent-Smith ◽  
C. Ellis

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